Team:ECUST China


home


DE-Tector

About Us

Abstract

SARS-CoV-2 is highly transmissible and pathogenic. In addition to the nature of RNA virus with high mutation rate, antigenic drift is the main evolutionary mechanism for SARS-CoV-2. Its wide-spreading has currently resulted in the evolutionary variants different from the originate isolate. Therefore, to curb this pandemic, effective surveillance of circulating viruses is much more urgent.
We developed a high throughput POCT platform for the SARS-CoV-2 detection with the help of DMF. A nanomachine called DNA Walker can amplify the region-specific sequence of the virus genome in the specimen. And then it will be read out by E-CRISPR, which can output an electric signal by a Cas9 nickase and corresponding electrode.
We are targeting not only the detection of COVID-19 viruses with alarming dangerous mutations, but also differentiating other related viruses and pathogens. This is not only for managing today’s pandemic, but also for the potential outbreaks of other coronaviruses.

DE-Tector

LOVE
We
Discussion

ECUST_China

EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Shanghai, China

GET IN TOUCH

+86 17553856936

iGEM_ECUST@outlook.com