We are HK_HCY!

Reducing biofilm formation in Lactobacillus fermentum:

Targeting intervention on the AI-2/LuxS quorum sensing system

1 / 8
Our Team
2 / 8
Our Team
3 / 8
Our Team
4 / 8
Research Team
5 / 8
Human Practice & Interview Team
6 / 8
IT Team
7 / 8
Graphic Design Team
8 / 8


Lactobacillus sp. are the most abundant bacterial contaminants in biofuel. Among them, L. fermentum is the most common one, accounting for 50% relative abundances of microbial species in bioethanol production. In our proposed study, L. fermentum 2-1, with a special quorum sensing (QS)-related feature given its higher level of production of autoinducer-2 (AI-2), would be examined for the effects of a dual-pronged intervention of the AI-2/LuxS QS system on biofilm formation.

One of the quorum quenching approaches would be to inhibit the activity of LuxS (AI-2 synthase) using a putative high-affinity peptide ligand that has been shown to specifically inhibit LuxS in Streptococcus suis.

The second approach would be to degrade AI-2 molecules extracellularly using the kinase LarK. We hope to achieve an effective inhibition in the formation of biofilm in biofuel through our dual-pronged intervention.

Promotional Video