Team:Ionis Paris
Bactail - IGEM IONIS
Target
Kill
Self-destroy
An innovative way to fight against antimicrobial resistance
They are considered as one of the biggest therapeutic advances of the 20th century !
Antibiotics managed to increase our life expectancy by several decades.
However, the overuse or misuse of certain antibiotics conducted to a phenomenon
called antimicrobial resistance, meaning that the antibiotic loses its ability
to treat the bacterial infection.1
10
Million
10 million deaths could occur annually by 2050 if effective
intervention methods against antimicrobial resistance are not made.2
Antimicrobial resistance
"a serious threat [that] is no longer a prediction for the future, it is happening
right now in every region of the world….".3
World Health Organization
Nosocomial Infections in France
In hospitals, for example, this resistance leads to an increase in
nosocomial infections due to particularly resistant germs such as
Escherichia coli. According to Health Minister, nosocomial infections cause
3 500 to 9 000 deaths per year in France.4
Data for France from 2001 to September 20175
So we created Bactail !
1
Target
Recognize and bind the target bacteria thanks to the presence of
specific
recognition binding proteins originally from bacteriophages.
2
Kill
Lyse the target bacteria by expressing and secreting antimicrobial peptides.
3
Self destroy
Induce self-destruction via a kill-switch once the mission fulfilled to prevent
dissemination.
Achievements
We won a Gold medal
Nomination
Best Therapeutics Project
We got nominated for Best Therapeutics Project
[1] Shrivastava, S. R., Shrivastava, P. S., & Ramasamy, J. (2018). World health organization
releases global priority list of antibiotic-resistant bacteria to guide research, discovery, and
development of new antibiotics. JMS - Journal of Medical Society, 32(1), 76–77.
https://doi.org/10.4103/jms.jms_25_17
[2] de Kraker, M. E. A., Stewardson, A. J., & Harbarth, S. (2016). Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050? PLoS Medicine, 13(11), 1002184.
https://doi.org/10.1371/ journal.pmed.1002184
[3] WHO. (2014). WHO’s first global report on antibiotic resistance reveals serious, worldwide threat to public health. WHO.
[4] Deniau et al. (2020). DÉCÈS LIÉS AUX INFECTIONS NOSOCOMIALES : BILAN 2008-2017 DES SIGNALEMENTS EXTERNES EN FRANCE – FOCUS SUR LES BACTÉRIÉMIES À STAPHYLOCOCCUS AUREUS. Santé publique France, Saint-Maurice, France.
https://www.santepubliquefrance.fr/content/download/259192/2637737
[5] Bulletin épidémiologique hebdomadaire, santé publique France
https://doi.org/10.4103/jms.jms_25_17
[2] de Kraker, M. E. A., Stewardson, A. J., & Harbarth, S. (2016). Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050? PLoS Medicine, 13(11), 1002184.
https://doi.org/10.1371/ journal.pmed.1002184
[3] WHO. (2014). WHO’s first global report on antibiotic resistance reveals serious, worldwide threat to public health. WHO.
[4] Deniau et al. (2020). DÉCÈS LIÉS AUX INFECTIONS NOSOCOMIALES : BILAN 2008-2017 DES SIGNALEMENTS EXTERNES EN FRANCE – FOCUS SUR LES BACTÉRIÉMIES À STAPHYLOCOCCUS AUREUS. Santé publique France, Saint-Maurice, France.
https://www.santepubliquefrance.fr/content/download/259192/2637737
[5] Bulletin épidémiologique hebdomadaire, santé publique France