Team:Patras/Poster

Poster

Authors and Affiliated Institutions

Abstract

Pharmacogenomics is rapidly assuming an integral part of modern health care. Still, its broad applicability relies on the feasibility of performing pharmacogenomic testing in all clinical settings, including in remote areas or resource-limited settings with budget restrictions.

In our project, Hippocrates, we developed a diagnostic tool that aims to introduce the Pharmacogenomics into clinical practice. We present the development of rapid and reliable pharmacogenomics assays using a portable molecular laboratory, namely BentoLab, in the size of a hand-luggage combined with Artificial Intelligence. More specifically, we demonstrate that the genomic analysis of the rs4149056, located within the gene SLCO1B1, can be performed with accuracy on this device. To prove its reliability, all the samples were genotyped using a) the KASP assays referred to as the gold standard and b) using a conventional laboratory equipment. Taking into account the compact size of BentoLab, which directly and positively impacts its portability, and the high accuracy achieved, we conclude that the BentoLab-based genotyping method is warranted for further studies in clinical practices at remote areas and resource-limited as well as time-constrained planetary health settings.

The Artificial Intelligence was used to upgrade the BentoLab and assist the user by directly translating the genetic analysis results into dosing recommendation. The system was established by locating and classifying different objects of interest (OoI) in images of the electrophoresis gels. To perform multiple object detection, a modification of the algorithm Yolo is implemented.

To conclude, the BentoLab-AI system makes Pharmacogenomics’ implementation into clinical practice more accessible than ever before. Through this, personalized medicine can be achieved even by health professionals who have never performed genetic analysis.

Inspiration

Introduction

Problem

Idea

Solution

Wet Lab

Dry Lab

Wet Lab Results

Dry Lab Results

Proof of Concept

Future Directions

Human Practices

References

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Acknowledgements

Parts

Sponsors