Presented by: Team IIT Roorkee
Team: Sanjeevani Marcha1, Muskaan Bhambri1, Harkirat Singh Arora1, Kushagra Rustagi1, Pradum Kumar1, Yash Aggrawal1, Nitish Verma1, Siddharth FItwe1, Tishee Natani1, Kartikey Kansal1, Kanishk Sugotra1, Lakshya Jain1, Mihir Sachdeva1, Dr Siva Ram Uppalapati2, Somok Bhowmik2, Professor Naveen K. Navani2, Professor Ranjana Pathania3
1iGEM Student team member
2iGEM Advisor
3iGEM Primary PI
Abstract
Our project is aimed at creating novel antibacterial protein complexes called Seekercins, designed to specifically bind and kill species of multidrug-resistant bacteria. This would be achieved by the fusion of antibacterial proteins called pyocins and bacteriophage tail fibers. Furthermore, it aims to create a system for the easy production of such antimicrobials for the use of the iGEM community, consisting of a collection of parts and software tool. ML algorithms were used to uncover relationships between resistance genes so as to resensitize them to antibiotics. Validation will be done experimentally, targeting the pathogen Acinetobacter baumannii, and production will be done in E. coli.