Presented by: Team IIT Roorkee
Our project is aimed at creating novel antibacterial protein complexes called Seekercins, designed to specifically bind and kill species of multidrug-resistant bacteria. This would be achieved by the fusion of antibacterial proteins called pyocins and bacteriophage tail fibers. Furthermore, it aims to create a system for the easy production of such antimicrobials for the use of the iGEM community, consisting of a collection of parts and software tool. ML algorithms were used to uncover relationships between resistance genes so as to resensitize them to antibiotics. Validation will be done experimentally, targeting the pathogen Acinetobacter baumannii, and production will be done in E. coli.Team: Sanjeevani Marcha, Muskaan Bhambri, Harkirat Singh Arora, Kushagra Rustagi, Pradum Kumar, Yash Aggrawal, Nitish Verma, Siddharth FItwe, Tishee Natani, Kartikey Kansal, Kanishk Sugotra, Lakshya Jain, Mihir Sachdeva.
PI: Prof. Ranjana Pathania, Department of Biotechnology IITR.
Faculty Advisor: Prof. Naveen K. Navani, Department of Biotechnology IITR.