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Revision as of 06:42, 21 October 2020
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Modeling Manifold
The principle of the MANIFOLD system incorporates targeted enzyme fusions to the proteins of a Bacterial Microcompartment into an icosahedral nanocarrier for trans-resveratrol production. The modeling team utilized mathematical and visual models to understand the viability of this system. From our endeavors, we determined the optimized expression of our 14 different parts...
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Research-Driven Analysis
The in silico investigation of MANIFOLD was guided by questions relating to the improved construction and efficiency of our system. In order for our design to present a significant breakthrough in metabolic engineering[manufacturing], we needed quantitative answers. To first construct these questions, the modeling team conducted research driven analysis to determine what parts of our system may already be characterized and which may require further modeling efforts. The bacterial microcompartment shell became the first topic of conversation. The [21-gene] Pdu operon (named for its natural 1,2-propanediol metabolism pathway) derived from citrobacter freundii has been only recently elucidated in literature. The shell is known to be composed of certain pdu proteins with pdu enzymes localized to the interior of the compartment. Our selection of a synthetic pdu operon for [1] (Synthesis of Empty Bacterial Microcompartments) was bolstered by a recent study elucidating the stoichiometric composition of these proteinaceous enclosures. [2] (Decoding the stoich) This resource quantified the ratio between pdu proteins
temporary filler
temporary filler
temporary filler
temporary filler
temporary filler
temporary filler
temporary filler
temporary filler
temporary filler
temporary filler
temporary filler
temporary filler
Modeling Manifold
The principle of the MANIFOLD system incorporates targeted enzyme fusions to the proteins of a Bacterial Microcompartment into an icosahedral nanocarrier for trans-resveratrol production. The modeling team utilized mathematical and visual models to understand the viability of this system. From our endeavors, we determined the optimized expression of our 14 different parts...
temporary filler
temporary filler
temporary filler
temporary filler
temporary filler
Research-Driven Analysis
The in silico investigation of MANIFOLD was guided by questions relating to the improved construction and efficiency of our system. In order for our design to present a significant breakthrough in metabolic engineering[manufacturing], we needed quantitative answers. To first construct these questions, the modeling team conducted research driven analysis to determine what parts of our system may already be characterized and which may require further modeling efforts. The bacterial microcompartment shell became the first topic of conversation. The [21-gene] Pdu operon (named for its natural 1,2-propanediol metabolism pathway) derived from citrobacter freundii has been only recently elucidated in literature. The shell is known to be composed of certain pdu proteins with pdu enzymes localized to the interior of the compartment. Our selection of a synthetic pdu operon for [1] (Synthesis of Empty Bacterial Microcompartments) was bolstered by a recent study elucidating the stoichiometric composition of these proteinaceous enclosures. [2] (Decoding the stoich) This resource quantified the ratio between pdu proteins
temporary filler
temporary filler
temporary filler
temporary filler
temporary filler