Team:CCU Taiwan/Poster

DENDETX
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Project Goals
  1. Develop a rapid test for dengue fever to improve treatment outcomes.
  2. Develop a method to mass-produce peptides for virus recognition, reducing cost.
  3. Raise awareness of dengue fever in scientifically illiterate and high-risk groups.
Introduction
Dengue fever occurs in tropical and subtropical regions. Half of the world population is now at risk, with 390 million infections every year, causing dengue fever to be listed by WHO as a top 10 health threat.

Dengue fever can progress into more serious conditions like dengue hemorrhagic fever (DHF), which has a 20% mortality rate. If conditions continue to worsen, patients experience dengue shock syndrome (DSS), which has a mortality rate up to 40%. An estimated 500,000 patients develop DHF or DSS, resulting in about 25,000 deaths every year.

Taiwan is in the area under the threat of dengue virus. From 2014 to 2015, there were over 44,000 confirmed cases during a dengue fever outbreak that spread from Tainan to other cities, causing 228 deaths. Recently, there was local transmission of dengue fever in Taoyuan, showing that the potentially affected population keeps increasing.

There is no specific treatment or vaccine for dengue, and health care systems are still facing a challenge from dengue fever.
Inspiration: Interaction between the CLEC5A and E protein suggest proteins might be effective in detection
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Modeling: Interaction between the tandem-repeated sequence peptide and E protein
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The detection kit - DENDETX
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