Difference between revisions of "Team:IISER Berhampur"

 
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       <Flash style="animation-duration: 4s;">F</Flash><Flash style="animation-duration: 5s;">R</Flash><Flash style="animation-duration: 6s;">a</Flash><Flash style="animation-duration: 7s;">P</Flash><Flash style="animation-duration: 8s;">P</Flash><Flash style="animation-duration: 9s;">e</Flash><br><br>
 
       <Flash style="animation-duration: 9.5s;font-size: 2vw;">FRET based Ranker for Proteins and Peptides</Flash>
 
       <Flash style="animation-duration: 9.5s;font-size: 2vw;">FRET based Ranker for Proteins and Peptides</Flash>
 
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     <div class="homeimage" style="top: 18%;right: 8vw; text-align: right;"><img src="https://static.igem.org/mediawiki/2020/b/b1/T--IISER_Berhampur--_home101.gif" style="mix-blend-mode: multiply;" alt="Project">
       <p style="line-height: normal;text-align: right;"><-------The virus is here</p>
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       <p style="width:40vw;line-height: normal;text-align: right;">This is our antagonist : the dreaded Dengue Virus or DENV, a Flavivirus that causes Dengue fever and is carried by the Aedes mosquito. Dengue fever, though normally not that harmful, can sometimes progress to Dengue Shock Syndrome which can cost lives all around the world. </p>
 
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     <div style="color:#111111; position: absolute; top: 30%;font-size: 1.5vw;left: 8vw;text-align: left;">
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     <div class="homeimage" style="top: 27%;left: 8vw;text-align: left;"><img src="https://static.igem.org/mediawiki/2020/d/d5/T--IISER_Berhampur--graph2.gif" alt="Project">
       <p style="line-height: normal;text-align: left;">Write informative stuff and <br>put fancy charts and pictures and stuff<br>Now it's here------></p>
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       <p style="width:40vw;line-height: normal;text-align: left;">It has been spreading rapidly over the years and its incidence has increased almost 30 times over the last 50 years, with 390 million infections occurring annually around the world. This virus has now reached 129 countries and has put nearly half the world population at risk.
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</p></div>
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    <div class="homeimage" style="top: 35%;left: 8vw;text-align: left;"><img src="https://static.igem.org/mediawiki/2020/2/2f/T--IISER_Berhampur--countriesinf.gif" alt="Project"></div>
 
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     <div class="homeimage" style="top: 40%;right: 7vw; text-align: right;"><img src="https://static.igem.org/mediawiki/2020/d/dc/T--IISER_Berhampur--capsule2.gif" alt="Project">
       <p style="line-height: normal;text-align: right;"><------------- Here</p>
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       <p style="width:40vw;line-height: normal;text-align: right;">What’s worse is that there are still no viable antiviral drugs or vaccines in action against it. With drug development for such a major disease, usually taking more than 9 years, we came up with a research tool to assist researchers in speeding up the drug discovery process.
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     <div class="homeimage" style="top: 52%;left: 6vw;text-align: left;"><img src="https://static.igem.org/mediawiki/2020/d/dc/T--IISER_Berhampur--reporter2.gif" style="width:40vw;" alt="Project">
       <p style="line-height: normal;text-align: left;">There -------------></p>
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       <p style="width:40vw;line-height: normal;text-align: left;">This brings us to our project, FRaPPe : A FRET based Ranker for Proteins and Peptides, which will use molecular biology tools assembled using Synthetic Biology principles. It will be a fast, cost-effective and high-throughput solution to screen drugs.
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     <div style="color:#111111; position: absolute; top: 67%;font-size: 1.5vw; right: 8vw; text-align: right;">
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     <div class="homeimage" style="top: 65%;right: 8vw; text-align: right;"><img src="https://static.igem.org/mediawiki/2020/e/ed/T--IISER_Berhampur--pepy.gif" style="width:40vw;" alt="Project">
       <p style="line-height: normal;text-align: right;"><------------- Left</p>
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       <p style="width:40vw;line-height: normal;text-align: right;">Peptide drugs are our inhibitors of choice to inhibit the DENV and host protein interactions. Our FRaPPe system, when cloned and transfected in a mammalian cell line, will report which peptides work the best in interrupting the host-virus PPIs.
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     <div class="homeimage" style="top: 75%; left: 8vw;text-align: left;"><img src="https://static.igem.org/mediawiki/2020/f/f1/T--IISER_Berhampur--Versatile.gif" alt="Project">
       <p style="line-height: normal;text-align: left;">Right -------------></p>
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       <p style="width:40vw;line-height: normal;text-align: left;">This versatile system can then be extended to any two interacting proteins and will not just help in ending the Dengue scourge, but also will prove to be an essential asset in the research of many other infectious diseases!
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{{IISER_Berhampur/footer}}
                               
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<h3>IISER<span>Berhampur</span></h3>
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                                <div class="footer-icons">
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<a href="https://www.facebook.com/igem.iiserbpr/"><i class="fa fa-facebook"></i></a>
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<a href="https://twitter.com/igem_iiserbpr?lang=en"><i class="fa fa-twitter"></i></a>
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<a href="https://www.youtube.com/channel/UCQ72pLMqGFVBqjID6uasMWg?app=desktop"><i class="fa fa-youtube"></i></a>
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                                <br><br>
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<p class="footer-company-name">© 2020 FRaPPe IISER Berhampur</p>
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  <p>IISER Transit Campus,<br>
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Engineering School Junction,<br>
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Berhampur, Odisha (760010), India<br>
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                                          </p>
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<i class="fa fa-envelope"></i>
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<p><a href="mailto:igem2020@iiserbpr.ac.in">igem2020@iiserbpr.ac.in</a></p>
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<div class="footer-right">
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<p class="footer-company-about">
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<span>About Us</span>
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We are a curious blend of basic science undergraduate students hailing from diverse disciplines from Indian Institute of Science Education and Research (IISER), Berhampur. This year marks our maiden venture in iGEM and in the exciting arena of Synbio as well. </p>
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Latest revision as of 07:26, 26 October 2020

IISER-BPR IGEM

Home-IISER Berhampur

Project
FRaPPe

FRET based Ranker for Proteins and Peptides
Project

This is our antagonist : the dreaded Dengue Virus or DENV, a Flavivirus that causes Dengue fever and is carried by the Aedes mosquito. Dengue fever, though normally not that harmful, can sometimes progress to Dengue Shock Syndrome which can cost lives all around the world.

Project

It has been spreading rapidly over the years and its incidence has increased almost 30 times over the last 50 years, with 390 million infections occurring annually around the world. This virus has now reached 129 countries and has put nearly half the world population at risk.

Project
Project

What’s worse is that there are still no viable antiviral drugs or vaccines in action against it. With drug development for such a major disease, usually taking more than 9 years, we came up with a research tool to assist researchers in speeding up the drug discovery process.

Project

This brings us to our project, FRaPPe : A FRET based Ranker for Proteins and Peptides, which will use molecular biology tools assembled using Synthetic Biology principles. It will be a fast, cost-effective and high-throughput solution to screen drugs.

Project

Peptide drugs are our inhibitors of choice to inhibit the DENV and host protein interactions. Our FRaPPe system, when cloned and transfected in a mammalian cell line, will report which peptides work the best in interrupting the host-virus PPIs.

Project

This versatile system can then be extended to any two interacting proteins and will not just help in ending the Dengue scourge, but also will prove to be an essential asset in the research of many other infectious diseases!

©iGEM IISER Berhampur