Difference between revisions of "Team:Virginia/Awards"

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            Index:
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            <div>Awards</div>
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          <div class="sectionTitle" id="Section 1">Bronze Medal Requirements</div>
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            <h3>Header 1
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          <div class="sectionTitle" id="Section 2">Silver Medal Requirements</div>
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          <div class="sectionTitle" id="Section 4">Special Awards</div>
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            <h3>Best Integrated Human Practices
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            <div class="paragraph">Despite not having access to a lab, we made numerous advancements with online research, learning about our greater role in the synthetic biology community, and designing the best version of our device. A large amount of time was spent finding ways to coordinate our remote working, and we collaborated with other teams to create a Resource Hub which will soon be available on the iGEM site. We also reached out to dozens of researchers, bioethicists, and industry leaders to discuss what place social movements have in science, and our conclusions as a team were compiled into our Code of Ethical Conduct. Lastly, speaking with experts helped refine the design of our device, which is now patent-pending as a foundational advance in metabolic engineering. IHP not only informed our device, but helped us navigate an unusual year and gave us plenty to consider as our team moves forward.<br/>
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            <h3>Best Model
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            <div class="paragraph">Without summer access to wet lab space, a large emphasis of the project was put on experimental planning and computational/mathematical modeling. We built out an extensive modeling pipeline to best inform DNA scaffold design and metabolic flux through the BMC. We developed a promoter model based on our cell kinetics models and evidence from literature to optimize our 14 parts to be used in experimental design. We also successfully investigated the spatial constraints presented by substrate molecules on BMC pore diffusion. Literature-based insight that malonyl-CoA was a limiting factor in the resveratrol metabolic pathway led us to model the diffusion of various substrates through the pore both spatially through PyMol, and metabolically using a custom-built pore-diffusion Matlab model. These models were pivotal in redefining our BMC substrate, and introducing a second scaffold to our inner BMC architecture.<br/>
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            <h3>Best Supporting Entrepreneurship
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            <div class="paragraph">Our team took an interest in the entrepreneurial aspect of the project from the very beginning. Starting with extensive industry and market research, we were able to calculate the theoretical improvement our device would provide to Resveratrol manufacturers. We also reached out to patent lawyers to discuss the importance of preventing prior art disclosure, and attended Cville BioHub meetings (a community for biotech companies and startups) to look at future steps for our team. It was clear we needed a provisional patent, so in August, we successfully filed one. We were then able to share our device plans with experts from around the world who work with the same technology. Finally, we talked to George MacArthur, founder of Virginia iGEM and biotech expert, who pointed us to a company that helps startups test their devices in large-scale bioreactors and monitor the results in real time.<br/><br/><br/><br/>
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Revision as of 02:16, 27 October 2020

Manifold

HOME
Main Abstract Problem Solution
PROJECT
Inspiration Description Design Experiments Results Modeling Implementation Device Notebook Safety
PARTS
New Parts Utilized Parts
OUTREACH
Human Practices Public Engagement Collaborations Contributions Entrepreneurship
TEAM
Members Attributions Gallery
AWARDS
Awards Medals
RESOURCES
Papers Nucleic Acids Protocols Software
Index:
Awards
Bronze Medal Requirements

Header 1

(text here)
Silver Medal Requirements
(text here)
Gold Medal Requirements
(text here)
Special Awards

Best Integrated Human Practices

Despite not having access to a lab, we made numerous advancements with online research, learning about our greater role in the synthetic biology community, and designing the best version of our device. A large amount of time was spent finding ways to coordinate our remote working, and we collaborated with other teams to create a Resource Hub which will soon be available on the iGEM site. We also reached out to dozens of researchers, bioethicists, and industry leaders to discuss what place social movements have in science, and our conclusions as a team were compiled into our Code of Ethical Conduct. Lastly, speaking with experts helped refine the design of our device, which is now patent-pending as a foundational advance in metabolic engineering. IHP not only informed our device, but helped us navigate an unusual year and gave us plenty to consider as our team moves forward.

Best Model

Without summer access to wet lab space, a large emphasis of the project was put on experimental planning and computational/mathematical modeling. We built out an extensive modeling pipeline to best inform DNA scaffold design and metabolic flux through the BMC. We developed a promoter model based on our cell kinetics models and evidence from literature to optimize our 14 parts to be used in experimental design. We also successfully investigated the spatial constraints presented by substrate molecules on BMC pore diffusion. Literature-based insight that malonyl-CoA was a limiting factor in the resveratrol metabolic pathway led us to model the diffusion of various substrates through the pore both spatially through PyMol, and metabolically using a custom-built pore-diffusion Matlab model. These models were pivotal in redefining our BMC substrate, and introducing a second scaffold to our inner BMC architecture.

Best Supporting Entrepreneurship

Our team took an interest in the entrepreneurial aspect of the project from the very beginning. Starting with extensive industry and market research, we were able to calculate the theoretical improvement our device would provide to Resveratrol manufacturers. We also reached out to patent lawyers to discuss the importance of preventing prior art disclosure, and attended Cville BioHub meetings (a community for biotech companies and startups) to look at future steps for our team. It was clear we needed a provisional patent, so in August, we successfully filed one. We were then able to share our device plans with experts from around the world who work with the same technology. Finally, we talked to George MacArthur, founder of Virginia iGEM and biotech expert, who pointed us to a company that helps startups test their devices in large-scale bioreactors and monitor the results in real time.



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