Presented by Team Paris Bettencourt 2020
Amandine Maire1, Anu Susan Kurian1, Chetan Kumar Velumurugan1, Nicolas Levrier1, Nikola Zarevski1, Valerie March1, Xavier Olessa-Daragon1,
1Student Team Member, 2Team Mentor
Abstract
Line 244: | Line 244: | ||
<!-- This creates a full width section with the id 'skin_microbiome' ---> | <!-- This creates a full width section with the id 'skin_microbiome' ---> | ||
<div class="section full" id="skin_microbiome"> | <div class="section full" id="skin_microbiome"> | ||
− | <img src="https://static.igem.org/mediawiki/2020/ | + | <img src="https://static.igem.org/mediawiki/2020/a/a9/T--Paris_Bettencourt--Poster_TheSkinMicrobiome.jpg"> |
<!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | <!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | ||
Line 261: | Line 261: | ||
<!-- This creates a full width section with the id 'quaranskin' ---> | <!-- This creates a full width section with the id 'quaranskin' ---> | ||
<div class="section two_thirds" id="quaranskin"> | <div class="section two_thirds" id="quaranskin"> | ||
− | <img src="https://static.igem.org/mediawiki/2020/ | + | <img src="https://static.igem.org/mediawiki/2020/5/5b/T--Paris_Bettencourt--Poster_Quaranskin51.jpg"> |
<!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | <!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | ||
Line 276: | Line 276: | ||
<!-- This creates a full width section with the id 'Implementation' ---> | <!-- This creates a full width section with the id 'Implementation' ---> | ||
<div class="section third" id="Implementation"> | <div class="section third" id="Implementation"> | ||
− | <img src="https://static.igem.org/mediawiki/2020/ | + | <img src="https://static.igem.org/mediawiki/2020/9/9b/T--Paris_Bettencourt--Poster_Implementation52.jpg"> |
<!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | <!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | ||
Line 294: | Line 294: | ||
<div class="section full" id="engineer"> | <div class="section full" id="engineer"> | ||
<!--Here is the image used for the full width section, the size is: 1200 x 200 pixels --> | <!--Here is the image used for the full width section, the size is: 1200 x 200 pixels --> | ||
− | <img src="https://static.igem.org/mediawiki/2020/ | + | <img src="https://static.igem.org/mediawiki/2020/4/40/T--Paris_Bettencourt--Poster_Engineering1.jpg"> |
<!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | <!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | ||
Line 319: | Line 319: | ||
<div class="section third" id="epiflex"> | <div class="section third" id="epiflex"> | ||
<!--Here is the image used for the third width section, the size is: 400 x 200 pixels --> | <!--Here is the image used for the third width section, the size is: 400 x 200 pixels --> | ||
− | <img src="https://static.igem.org/mediawiki/2020/ | + | <img src="https://static.igem.org/mediawiki/2020/9/91/T--Paris_Bettencourt--Poster_EpiFlex71.jpg"> |
<!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | <!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | ||
<div class="info"> | <div class="info"> | ||
Line 333: | Line 333: | ||
<div class="section third" id="epiglow"> | <div class="section third" id="epiglow"> | ||
<!--Here is the image used for the third width section, the size is: 400 x 200 pixels --> | <!--Here is the image used for the third width section, the size is: 400 x 200 pixels --> | ||
− | <img src="https://static.igem.org/mediawiki/2020/ | + | <img src="https://static.igem.org/mediawiki/2020/9/9b/T--Paris_Bettencourt--Poster_EpiGlow72.jpg"> |
<!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | <!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | ||
Line 348: | Line 348: | ||
<div class="section third" id="epigrow"> | <div class="section third" id="epigrow"> | ||
<!--Here is the image used for the third width section, the size is: 400 x 200 pixels --> | <!--Here is the image used for the third width section, the size is: 400 x 200 pixels --> | ||
− | <img src="https://static.igem.org/mediawiki/2020/ | + | <img src="https://static.igem.org/mediawiki/2020/b/b0/T--Paris_Bettencourt--Poster_EpiGrow.jpg"> |
<!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | <!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | ||
Line 370: | Line 370: | ||
<div class="section two_thirds" id="future_work_1"> | <div class="section two_thirds" id="future_work_1"> | ||
<!--Here is the image used for the third width section, the size is: 800 x 200 pixels --> | <!--Here is the image used for the third width section, the size is: 800 x 200 pixels --> | ||
− | <img src="https://static.igem.org/mediawiki/2020/ | + | <img src="https://static.igem.org/mediawiki/2020/0/0b/T--Paris_Bettencourt--Poster_FutureWork81.jpg"> |
<!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | <!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | ||
Line 386: | Line 386: | ||
<div class="section third" id="future_work_2"> | <div class="section third" id="future_work_2"> | ||
<!--Here is the image used for the third width section, the size is: 400 x 200 pixels --> | <!--Here is the image used for the third width section, the size is: 400 x 200 pixels --> | ||
− | <img src="https://static.igem.org/mediawiki/2020/ | + | <img src="https://static.igem.org/mediawiki/2020/3/39/T--Paris_Bettencourt--Poster_FutureWork82.jpg"> |
<!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | <!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | ||
Line 401: | Line 401: | ||
<!--This is the ninth row of the poster, it contains the acknowledgements section ---> | <!--This is the ninth row of the poster, it contains the acknowledgements section ---> | ||
− | <!-- | + | <!-- iGEM --> |
<div class="row"> | <div class="row"> | ||
− | <!-- This creates a | + | <!-- This creates a three quarters width section with the id 'iGEM' ---> |
− | <div class="section full" id=" | + | <div class="section full" id="iGEM"> |
− | <img src="https://static.igem.org/mediawiki/2020/ | + | <img src="https://static.igem.org/mediawiki/2020/2/24/T--Paris_Bettencourt--Poster_iGEMExperience1.jpg"> |
<!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | <!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | ||
<div class="info"> | <div class="info"> | ||
<!--Write the title of the section --> | <!--Write the title of the section --> | ||
− | <div class="title"> | + | <div class="title"> iGEM</div> |
<!--Write the text explaining this section --> | <!--Write the text explaining this section --> | ||
<div class="text"> Here you can explain the engineering process behind your project. </div> | <div class="text"> Here you can explain the engineering process behind your project. </div> | ||
Line 418: | Line 418: | ||
<!--This is the tenth row of the poster, it contains the iGEM section ---> | <!--This is the tenth row of the poster, it contains the iGEM section ---> | ||
− | <!-- | + | <!-- Acknowledgements --> |
<div class="row"> | <div class="row"> | ||
− | <!-- This creates a | + | <!-- This creates a quarter width section with the id 'acknowlegments' ---> |
− | <div class="section full" id=" | + | <div class="section full" id="acknowlegments"> |
− | <img src="https://static.igem.org/mediawiki/2020/ | + | <img src="https://static.igem.org/mediawiki/2020/4/42/T--Paris_Bettencourt--Poster_Acknowledgements.jpg"> |
<!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | <!--Info: Place the title and text for this section, it will appear when the user clicks on it--> | ||
<div class="info"> | <div class="info"> | ||
<!--Write the title of the section --> | <!--Write the title of the section --> | ||
− | <div class="title"> | + | <div class="title"> Acknowledgements</div> |
<!--Write the text explaining this section --> | <!--Write the text explaining this section --> | ||
<div class="text"> Here you can explain the engineering process behind your project. </div> | <div class="text"> Here you can explain the engineering process behind your project. </div> |
Presented by Team Paris Bettencourt 2020
Amandine Maire1, Anu Susan Kurian1, Chetan Kumar Velumurugan1, Nicolas Levrier1, Nikola Zarevski1, Valerie March1, Xavier Olessa-Daragon1,
1Student Team Member, 2Team Mentor
1. Sample and Sequence the Human Skin Microbiome
Our first objective, pursued as part of the Quaranskin project, is to study the impact of environmental and behavioral factors on the skin microbiome and to provide a new database to study its composition in the context of reduced social and environmental interactions.
2. Design tools to engineer the bacterium S. epidermidis
Our second objective is to make S. epidermidis an efficient synthetic biology chassis that can be used to monitor the population dynamics of the skin microbiome. This in order to maintain its equilibrium and to avoid pathologies induced by dysbiosis.
In the context of COVID-19 pandemic, we were, as most of the other iGEM teams confined at home.
As this situation was unprecedented, we were wondering if the lockdown could have an impact on human health and more specifically on the composition of our skin microbiome.
We met some dermatologists as Stéphanie Leclerc-Mercier. She pointed out the fact that the new sanitary measures and hygiene habits imposed by the pandemic were a real issue for people with eczema symptoms since they cannot wash their hands as often as healthy people. This discussion drew our interest for dysbiosis induced pathologies and ways to treat them using synthetic biology.
Our team personal values led us to create a project who enters in the framework of Open and Citizen Science. Especially during the lockdown which forced us to be physically isolated of each other, we wanted to find a way to connect people through science.
1. Study the Skin Microbiome
Sample human skin microbiome is a challenge in itself since it implies reaching out to a large enough cohort and collecting human being derived samples. In the context of a pandemic other constraints are added because of social distancing measures.
2. Engineer the Skin Microbiome
1. Quaranskin
Quaranskin is a study collecting skin microbiome samples during the COVID-19 pandemic and observing the impact of environmental factors on the skin microbiome.
2. EpiFlex, EpiGlow, EpiGrow
These three projects aims to develop tools to make S. epidermidis a good chassis for Synthetic biology.