Difference between revisions of "Team:IIT Roorkee"

 
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                      Gold Medalist • iGEM IIT Roorkee •
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                      Gold Medalist • iGEM IIT Roorkee •
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           <h1 class="wiki-h wiki-h1 wiki-white">PYOMANCER</h1>
 
           <h1 class="wiki-h wiki-h1 wiki-white">PYOMANCER</h1>
 
           <p class="wiki-p wiki-white" style="font-size: 18px;">
 
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             Novel Antibacterial Protien Complexes
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             Novel Antibacterial Protein Complexes
 
             <br/>
 
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             for MDR Infections
 
             for MDR Infections
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           <h2 class="wiki-h wiki-h2 wiki-white">PYOMANCER</h2>
 
           <h2 class="wiki-h wiki-h2 wiki-white">PYOMANCER</h2>
 
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             Novel Antibacterial Protien Complexes
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             Novel Antibacterial Protein Complexes
 
             for MDR Infections
 
             for MDR Infections
 
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             <video autoplay="" class="home-video" controls="" muted="" src="https://static.igem.org/mediawiki/2020/5/5d/T--IIT_Roorkee--videos--iGEM_IIT_Roorkee_Promo_Video.mp4"></video>
 
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            <div class="wiki-graphic-reference" style="text-align: center;">Project Promotion Video</div>
 
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               This project is aimed at creating novel antibacterial protein complexes, designed to specifically bind and kill species of multidrug-resistant bacteria. This would be achieved by the fusion of antibacterial proteins called pyocins and bacteriophage tail fibers. Furthermore, it aims to create a system for the easy production of such antimicrobials, consisting of an expression plasmid and software. Validation will be done experimentally, targeting the pathogen Acinetobacter baumannii, and production will be done in E. coli.
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               This project is aimed at creating novel antibacterial protein complexes, designed to specifically bind and kill species of multidrug-resistant bacteria. This would be achieved by the fusion of antibacterial proteins called pyocins and bacteriophage tail fibers. Furthermore, it aims to create a system for the easy production of such antimicrobials, consisting of an expression plasmid and software. Validation will be done experimentally, targeting the pathogen <i>Acinetobacter baumannii</i>, and production will be done in <i>E. coli</i>.
 
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                   Click here to understand the concept and working of our software TAILSCOUT, which will enable other researchers to build new Seekercins for other bacterial species in one go!              </p>
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                   Click here to understand the concept and working of our software TailScout, which will enable other researchers to build new Seekercins for other bacterial species in one go!              </p>
 
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          <a class="wiki-link-button" href="https://2020.igem.org/Team:IIT_Roorkee/Poster">Poster</a>
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Latest revision as of 17:20, 18 December 2020

<!DOCTYPE html> PYOMANCER

Gold Medalist • iGEM IIT Roorkee •
Gold medal
Gold Medalist • iGEM IIT Roorkee •
Gold medal
Project
Project Promotion Video


ABSTRACT

This project is aimed at creating novel antibacterial protein complexes, designed to specifically bind and kill species of multidrug-resistant bacteria. This would be achieved by the fusion of antibacterial proteins called pyocins and bacteriophage tail fibers. Furthermore, it aims to create a system for the easy production of such antimicrobials, consisting of an expression plasmid and software. Validation will be done experimentally, targeting the pathogen Acinetobacter baumannii, and production will be done in E. coli.



The animation explains
the working
mechanism of our
fusion protein.

Pyomancer mechanish GIF



Gene detection

Machine Learning

The year 2020 provided us with an opportunity to explore new areas and bring them to the iGEM community. Dive in to see how we combine ML with synthetic biology and contribute to AMR research.

Gene detection

Bioinformatics

Our protein design involves bioinformatics based prediction and characterization of tail fibers. Check out how we have deployed interesting biophysical modeling techniques to study and characterize our engineered protein.

Gene detection

Software

Click here to understand the concept and working of our software TailScout, which will enable other researchers to build new Seekercins for other bacterial species in one go!

Gene detection

Human Practices

Understanding the ground level complexities of the Hospital Acquired Infections is important. So, Check out the insights we got and the awareness initiatives we undertook for Antibiotic Use Sensitization & Open Science Communication.




Poster