Difference between revisions of "Team:IIT Roorkee"
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| − | This project is aimed at creating novel antibacterial protein complexes, designed to specifically bind and kill species of multidrug-resistant bacteria. This would be achieved by the fusion of antibacterial proteins called pyocins and bacteriophage tail fibers. Furthermore, it aims to create a system for the easy production of such antimicrobials, consisting of an expression plasmid and software. Validation will be done experimentally, targeting the pathogen Acinetobacter baumannii, and production will be done in E. coli. | + | This project is aimed at creating novel antibacterial protein complexes, designed to specifically bind and kill species of multidrug-resistant bacteria. This would be achieved by the fusion of antibacterial proteins called pyocins and bacteriophage tail fibers. Furthermore, it aims to create a system for the easy production of such antimicrobials, consisting of an expression plasmid and software. Validation will be done experimentally, targeting the pathogen <i>Acinetobacter baumannii</i>, and production will be done in <i>E. coli</i>. |
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Revision as of 16:59, 27 October 2020
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is the story you tell because
“Great stories make great projects and win laurels!”
Sanjeevani Marcha
Muskaan Bhambri
Harkirat Singh Arora
Pradum Kumar
Kushagra Rustagi
Nitish Verma
Yash Aggarwal
Tishee Natani
Kartikey Kansal
Siddharth Suhas Fitwe
Mihir Sachdeva
Kanishk Sugotra
Lakshya Jain
Darshak Bhatt
ABSTRACT
This project is aimed at creating novel antibacterial protein complexes, designed to specifically bind and kill species of multidrug-resistant bacteria. This would be achieved by the fusion of antibacterial proteins called pyocins and bacteriophage tail fibers. Furthermore, it aims to create a system for the easy production of such antimicrobials, consisting of an expression plasmid and software. Validation will be done experimentally, targeting the pathogen Acinetobacter baumannii, and production will be done in E. coli.
The animation explains
the working
mechanism of our
fusion protein.
Machine Learning
The year 2020 provided us with an opportunity to explore new areas and bring them to the iGEM community. Dive in to see how we combine ML with synthetic biology and contribute to AMR research.
Bioinformatics
Our protein design involves bioinformatics based prediction and characterization of tail fibers. Check out how we have deployed interesting biophysical modeling techniques to study and characterize our engineered protein.
Software
Click here to understand the concept and working of our software TailScout, which will enable other researchers to build new Seekercins for other bacterial species in one go!
Human Practices
Understanding the ground level complexities of the Hospital Acquired Infections is important. So, Check out the insights we got and the awareness initiatives we undertook for Antibiotic Use Sensitization & Open Science Communication.
