Difference between revisions of "Team:IISER Berhampur/Model"

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  <h1> Overview</h1>
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      <p>Our journey throughout our project was not that easy. We got a lot of questions and doubts at every step of our project. Many of them were easy to answer through experience or logic, but some needed to be worked on. Hence, we took help of modelling to answer a few of them. We took an approach of ‘Imagine each step -> Ask Questions: Why? How? -> Modelling to answer the questions -> Integrate the answers into the project -> Proceed ahead.</p><br>
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      <p>The flow chart above gives an overview of all such questions and how we tried to answer them. More details on each modelling part is described in the following sections.The whole modelling aspect is divided into 6 sub-sections which are as follows-</p><br>
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        <li>Epidemiological Studies- To understand the problem of growing dengue cases and why it is an important topic to move ahead with. Further details are below.(Read more)</li>
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        <li>Mutational Analysis- To understand and justify why targeting Non-structural proteins can be a good target for targeting the inhibition of the protein-protein interactions.</li>       
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        <li>Target PPI studies- A brief literature review and studies were done to select a set of protein-protein interactions. This part mainly aims towards the validation of the reporter system. </li>
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        <li>Peptide Inhibitor Designing-  After a particular PPI was selected for the validation of the system, the peptide inhibitors were designed and appropriate chemical modifications were done. The designed peptide inhibitors were then to be ranked by our reporter system to check the efficiency of the system.</li>       
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        <li>Molecular dynamics analysis-  To facilitate the designing of the reporter system. </li>       
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        <li>Mathematical Formalisms- To mathematically depict the pipeline for using our reporter system to quantify the efficiency of peptide inhibitors. </li>
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Revision as of 20:14, 22 October 2020

IISER-BPR IGEM
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Overview

Our journey throughout our project was not that easy. We got a lot of questions and doubts at every step of our project. Many of them were easy to answer through experience or logic, but some needed to be worked on. Hence, we took help of modelling to answer a few of them. We took an approach of ‘Imagine each step -> Ask Questions: Why? How? -> Modelling to answer the questions -> Integrate the answers into the project -> Proceed ahead.


The flow chart above gives an overview of all such questions and how we tried to answer them. More details on each modelling part is described in the following sections.The whole modelling aspect is divided into 6 sub-sections which are as follows-


  • Epidemiological Studies- To understand the problem of growing dengue cases and why it is an important topic to move ahead with. Further details are below.(Read more)
  • Mutational Analysis- To understand and justify why targeting Non-structural proteins can be a good target for targeting the inhibition of the protein-protein interactions.
  • Target PPI studies- A brief literature review and studies were done to select a set of protein-protein interactions. This part mainly aims towards the validation of the reporter system.
  • Peptide Inhibitor Designing- After a particular PPI was selected for the validation of the system, the peptide inhibitors were designed and appropriate chemical modifications were done. The designed peptide inhibitors were then to be ranked by our reporter system to check the efficiency of the system.
  • Molecular dynamics analysis- To facilitate the designing of the reporter system.
  • Mathematical Formalisms- To mathematically depict the pipeline for using our reporter system to quantify the efficiency of peptide inhibitors.






1. Content


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1. This is different content


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1. This is ALSO different content


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©iGEM IISER Berhampur