|
|
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| large cohort and collecting human being derived samples. In the context of a | | large cohort and collecting human being derived samples. In the context of a |
| pandemic other constraints are added because of social distancing measures.</p> | | pandemic other constraints are added because of social distancing measures.</p> |
− | <br /> | + | |
| + | <img |
| + | src="https://static.igem.org/mediawiki/2020/8/89/T--Paris_Bettencourt--Poster_SkinMicrobiomeStudy.png"> |
| + | |
| <p><b id="heading">2. Engineer the Skin Microbiome</b></p> | | <p><b id="heading">2. Engineer the Skin Microbiome</b></p> |
| <ul> | | <ul> |
| <li><i>Staphylococcus epidermidis</i> is not used in synthetic biology and no tools are | | <li><i>Staphylococcus epidermidis</i> is not used in synthetic biology and no tools are |
− | currently available to engineer it.</li> | + | currently available to engineer it</li> |
| <li>Thw two main challenges in using <i>S. epidermidis</i> in | | <li>Thw two main challenges in using <i>S. epidermidis</i> in |
| synthetic biology are:</li> | | synthetic biology are:</li> |
| </ul> | | </ul> |
| + | <img |
| + | src="https://static.igem.org/mediawiki/2020/1/1f/T--Paris_Bettencourt--Poster_SkinMicrobiomeEngineering.png"> |
| </div> | | </div> |
| </div> | | </div> |
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| <li>We took <b>ethical considerations</b> very seriously by submitting our project to | | <li>We took <b>ethical considerations</b> very seriously by submitting our project to |
| the French national ethics committee in order to obtain their approval before | | the French national ethics committee in order to obtain their approval before |
− | starting the study. | + | starting the study |
| </li> | | </li> |
| <li>In order to include <b>citizen participation</b>, we designed a smapling kit | | <li>In order to include <b>citizen participation</b>, we designed a smapling kit |
| containing all the material required for sampling the skin microbiome and set up | | containing all the material required for sampling the skin microbiome and set up |
− | mailing system to ship and collect back the samples from participants. | + | mailing system to ship and collect back the samples from participants |
| </li> | | </li> |
− | <li>We are building an <b>Open Database</b> of skin microbiome during the COVID-19 pandemic. | + | <li>We are building an <b>Open Database</b> of skin microbiome during the COVID-19 |
| + | pandemic |
| </li> | | </li> |
| </ul> | | </ul> |
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| <div class="info"> | | <div class="info"> |
| <!--Write the title of the section --> | | <!--Write the title of the section --> |
− | <div class="title"> Skin Microbiome</div> | + | <div class="title"> The Skin Microbiome</div> |
| <!--Write the text explaining this section --> | | <!--Write the text explaining this section --> |
− | <div class="text"> Here you can explain the engineering process behind your project. </div> | + | <div class="text"> |
| + | <p><b id="heading">What is the Skin Microbiome?</b></p> |
| + | <p>The human skin microbiome is a vast and very large ecosystem of microorganisms that |
| + | occupy the human skin at the level of the hypodermis, dermis, and epidermis. It is very |
| + | numerous and very diverse, a real petri dish hidden in plain sight. |
| + | </p> |
| + | <br /> |
| + | <p><b id="heading">How the Skin Microbiome plays a role in the skin health?</b></p> |
| + | <p>The human skin microbiome is very tightly linked to the health of its host in numerous |
| + | ways. First of all the microorganisms of the skin microbiome prevent the colonization of |
| + | the skin by pathological microorganisms, and help to train the immune system to make it |
| + | more prepared to face pathogens. It also directly involved in various pathologies, like |
| + | atopic dermatitis, where its overall diversity is reduced and Staphylococcus aureus is |
| + | over represented. |
| + | </p> |
| + | <br /> |
| + | <p><b id="heading">Why studying the composition of the Skin Microbiome?</b></p> |
| + | <p> |
| + | <ul> |
| + | <li>Most of the previous studies which lead to understand the skin microbiome by |
| + | sampling human volunteers were based on North American subjects. Form these results, |
| + | current evidence suggests a greater microbial diversity to be a beneficial trait, |
| + | however there is a need for greater diversity in the participant pools from which |
| + | this data is derived. Thus, a study observing human skin microbiome among a European |
| + | population would give new data increasing our knowledge of the skin microbiome. |
| + | </li> |
| + | <li>Besides the current global environment wherein a significant number of people are |
| + | minimizing their interactions with other people is a good opportunity to observe |
| + | environmental impact on skin microbiome in a more simplified model. |
| + | </li> |
| + | <li>Also, by taking samples from the skin microbiome during the COVID-19 pandemic, we |
| + | will have preserved evidence of the influence of the social restrictions induced by |
| + | the pandemic on the skin microbiome. |
| + | </li> |
| + | </ul> |
| + | </p> |
| + | <br /> |
| + | <img |
| + | src="https://static.igem.org/mediawiki/2020/8/80/T--Paris_Bettencourt--Poster_SkinMicrobiomeIllustration.png"> |
| + | </div> |
| </div> | | </div> |
| </div> | | </div> |