The biomanufacturing of food, drugs, and biomaterials in outer space is necessary for humans to venture into the cosmos and colonize extraterrestrial bodies. Advances in synthetic biology enable the sustainable production of these resources on earth. However, in-space bioproduction, for which maintaining cultures in bioreactors for extended periods is essential, has proved challenging. Microgravity induces global changes in gene expression profiles, triggering a stress response in cells. For example, Saccharomyces cerevisiae, a model organism and biomanufacturing chassis, exhibits a microgravity-induced stress response characterized by aberrant cell polarity, budding, and separation, which affects cell growth and productivity in space. To solve this problem, we are engineering a yeast strain that is resistant to the microgravity-induced stress response. We named it Astroyeast.