avoid harmful pesticides.
We propose a new mechanism, "transcriptional synchronisation", which connects the natural cell response to an input with the reliable expression of a target output, making synthetic gene control less complex and more replicable. With our project we try to match the transcription of an endogenous gene with a synthetically added output. The transcription of the endogenous gene would be intensified in the presence of e.g. pathogens or if induced synthetically. Thus, the transcription of the output will also be increased. The output could be a resistance against pathogens in crops, or it could be an activational signal in E. coli to produce certain compounds. For crops, it is also possible to match multiple resistances to the same or to various different genes so that an evolutionary adaptation to this mechanism is highly unlikely. After the proof of concept in E. coli, Zea mays and Arabidopsis thaliana we hope that our universally applicable method will be used to create sustainable pathogen and disease resistances in crops.
This is a fairytale about a unicorn wandering around through nature and realising that plants are endangered by several threats, such as droughts and a growing number of plant pandemics. On its way through crop fields, the unicorn encounters a special cornfield with genetically modified corn. Our new mechanism can be used to save all plants!Read More