Team:SEHS-China/Human Practices/Interview
Interview of pharmaceutical factory
Q:In general, what is the process of drug production? What are the steps from the laboratory to the clinic? Can you give a detailed description of ointments and sprays as examples (each given a common reference)?
A:Drug development is a project with high investment, high risk and long cycle time. For example, chemical drug development process includes initial laboratory lead compound identification, lead compound optimization, pre-clinical animal experiments and clinical trials. The purpose of drug development is to design a high-quality product and a process that can continuously produce a product that meets its expected level of quality. API is an active ingredient in a preparation, which refers to raw materials used for the production of various preparations. Generally speaking, an API needs to go through laboratory research, small trial production, pilot production and industrial production from r&d to production. This is the production of apis. There are special approvals if it is a finished product for clinical use.
Q: We also want to know about the production line of the drug. If there is an opportunity, could you arrange a field visit?
A:For the second question, I have to make an appointment with head office.
Q: We are interested in the distribution of medicines. What are the probable ways of selling them?
A: General drug sales are divided into two categories: OTC drugs are mainly marketed by pharmacies, such as children's sunflower granules or zinc gluconate oral liquid, and otc drugs are mainly prescribed to patients by hospital doctors, which requires academic promotion, introduction of drug characteristics and treatment of side effects
Q: Which brands does your factory contract for? What is the general OEM process like? What materials are needed to start the production of a new product?
A: We do the production of Faeretaxel (piperacillin sodium tazobactam sodium for injection). To carry out the commissioned production of drugs, both parties must obtain the production license and GMP certificate. This means that both the entrusting party and the entrusted party must be pharmaceutical manufacturers in normal production if they want to carry out the entrusting production. The entrusting party cannot meet the demand due to special reasons, so entrusting production is a temporary measure. Second, the entrusting party must obtain the approval of the entrusted varieties. That is to say, the variety of commissioned production must be its own variety.
Interview of the doctor
Q: How do you usually identify the source of your allergy at the hospital?
A: First of all, the outpatient department of the hospital can make a preliminary judgment by asking the patient's medical history and what suspicious substances he or she has been exposed to before the occurrence of allergy. Further, blood can be extracted for allergen detection with a kit. Of course, the type of allergen detection in the latter step is limited, generally more than 10.
Q: How do you prescribe medicine if you are unsure of the source of your allergy? What is the effect of prescribing a drug for an allergen versus prescribing a drug without knowing the allergen? (It usually takes a few days, but what about the recurrence rate?)
A: There is no significant difference in the treatment of anaphylaxis whether or not an allergen is treated. Antihistamine drugs are preferred for controlling allergic reactions, and anti-inflammatory mediators can also be combined. If necessary, with glucocorticoids. After the allergen is identified, reexposure can be avoided and the recurrence of allergic reaction can be reduced.
Q: What do you usually recommend for people with severe allergies, and how do you treat them?
A: Patients with severe allergies first need a combination of antihistamines and glucocorticoids, which can be given orally or intramuscularlyand intravenously in severe cases. Topical medications may also be used in patients who do not have a significant amount of skin lesions. In terms of dermatology, Sergentin cream is an antihistamine for topical use. Topical corticosteroids are available in a wide variety of forms. Ophthalmology and otolaryngology also have topical antihistamine drops or sprays. Practicality and promotion are both feasible [pleasant]