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− | <h1>Combine World with Bone health</h1> | + | <h1 tabIndex="1">Combine World with Bone health</h1> |
| <div class="column full_size"> | | <div class="column full_size"> |
− | <p>Integrated Human Practice connects world and our projects. Inspired by the bone disease of old people, our project centers on osteoporosis and calcium absorption to constitute Bone Appetite. We constantly improve our design and execution by the feedbacks of public engagement, to make sure our project is good and responsible for the old, the whole human, the world.</p> | + | <p>Integrated Human Practice connects the world and our project. Inspired by the bone disease of old people, our project centers on osteoporosis and calcium absorption to constitute <i>Bone Appetite</i>. We constantly improve our design and execution by the feedbacks of public engagement, to make sure our project is good and responsible for the old, the whole human, the world. We compete for both the Silver Medal criterion #3 and the Best Integrated HP prize with this page.</p> |
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− | <h2>Frame and Overview</h2>
| + | <h2>Outline and Overview</h2> |
− | <div class="column full_size">
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− | <img src="https://static.igem.org/mediawiki/2020/6/62/T--Fudan--flowchart_hp.svg" alt="Integration of Human Practice and Bone Appetide Project" />Figure1. Integration of Human Practice and Bone Appetide project | + | <img src="https://static.igem.org/mediawiki/2020/5/58/T--Fudan--Frame.svg" alt="Integration of Human Practice and Bone Appetide Project" /> |
| + | <h6>Figure 1. Integration of Human Practice and Bone Appetide project</h6> |
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| + | <p>Social surveys and Public engagement are the core of our Integrated Human Practices. When we gained our inspiration for bone health, we turned to social surveys and the critical stakeholders for the priority. Besides, picture and design our whole project according to their feedbacks.</p> |
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− | </div> | + | </div> |
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| <h2>Social Surveys</h2> | | <h2>Social Surveys</h2> |
| <div class="column full_size"> | | <div class="column full_size"> |
− | <p>Considering the COVID-19 pandemic, our team specially design an online questionnaire to do relevant social surveys. Due to our care about bone health and osteoporosis, we used widely social study to investigate public awareness and dig the potential need. For the old who has a hard availability of smartphone and the Internet, we visit the elderly community and senior home under the premise of keeping enough social distance and well protective measures. </p> | + | <p>Considering the COVID-19 pandemic, our team specially design an online questionnaire to do relevant social surveys. Due to our care about bone health and osteoporosis, we used widely social study to investigate public awareness and dig the potential need. For the old who has a hard availability of smartphone and the Internet, we visit the elderly community and senior home under the premise of keeping enough social distance and well protective measures. </p> |
− | <img src="https://static.igem.org/mediawiki/2020/a/a9/T--Fudan--questionnairess.png"alt="The questionnaire of social surveys" />Figure2. The questionnaire of social surveys</div> | + | <img src="https://static.igem.org/mediawiki/2020/a/a9/T--Fudan--questionnairess.png" alt="The questionnaire of social surveys" /> |
| + | <h6>Figure 2. The questionnaire of social surveys</h6></div> |
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− | <div class= "column half_size">
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− | <h4>Public general knowledge</h4> | + | <h4>Public general knowledge</h4> |
| <p>The online surveys mainly direct at the people under 60 years old. We analyzed their knowledge of osteoporosis and daily calcium supplement situation. The result showed that the public has a strong awareness of osteoporosis and bone health along with the growing of age. For respondents aged 40 to 60, more than half of them are taking or have taken calcium supplements health care products. </p></div> | | <p>The online surveys mainly direct at the people under 60 years old. We analyzed their knowledge of osteoporosis and daily calcium supplement situation. The result showed that the public has a strong awareness of osteoporosis and bone health along with the growing of age. For respondents aged 40 to 60, more than half of them are taking or have taken calcium supplements health care products. </p></div> |
− | <div class="column half_size"></br></br></br>
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− | <img src="https://static.igem.org/mediawiki/2020/9/95/T--Fudan--hp_chart3.png" alt="Calcium supplements situation of respondents aged 40 to 60" />Figure3. Calcium supplements situation of respondents aged 40 to 60</div>
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− | <div class="column half_size"><img src="https://static.igem.org/mediawiki/2020/1/1b/T--Fudan--hp_chart1.png" alt="Surrounding osteoporosis knowledge with different ages"/>Figure4a. Surrounding osteoporosis knowledge with different ages</div> | + | <div class="column half_size"> <br/><br/><br/> |
| + | <img src="https://static.igem.org/mediawiki/2020/9/95/T--Fudan--hp_chart3.png" alt="Calcium supplements situation of respondents aged 40 to 60" /> |
| + | <h6>Figure 3. Calcium supplements situation of respondents aged 40 to 60</h6></div> |
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− | <div class="column half_size"><img src="https://static.igem.org/mediawiki/2020/e/e3/T--Fudan--hp_chart2.png" alt="Surrounding osteoporosis knowledge with different ages"/>Figure4b. Surrounding osteoporosis knowledge with different ages | + | <div class="column half_size"><img src="https://static.igem.org/mediawiki/2020/1/1b/T--Fudan--hp_chart1.png" alt="Surrounding osteoporosis knowledge with different ages"/> |
− | </div> | + | <h6>Figure 4a. Surrounding osteoporosis knowledge with different ages</h6></div> |
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− | <div class="column half_size">
| + | <div class="column half_size"><img src="https://static.igem.org/mediawiki/2020/e/e3/T--Fudan--hp_chart2.png" alt="Surrounding osteoporosis knowledge with different ages"/> |
− | <h4>The old people interviews</h4>
| + | <h6>Figure 4b. Surrounding osteoporosis knowledge with different ages</h6> |
− | <p>We believe the best suitable way to know the awareness message from the old is talking face to face. Connected with the largest student public-service association of Fudan University, we cooperated with “The Home of elderly” project, which aims at satisfy the need of the old. We interviewed dozens of aged people over 60 years old in a Shanghai elderly community. Then we were surprised by their extremely low awareness of osteoporosis and lack of calcium supplement.</p> </div>
| + | </div> |
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| <div class="column half_size"> | | <div class="column half_size"> |
− | </br></br></br> | + | <h4>Interviews with old people</h4> |
− | <img src="https://static.igem.org/mediawiki/2020/1/1b/T--Fudan--oldcommunity.jpg"" style="width:70%" alt="Interview the old in community"/></br>Figure5. Our teammate interview the old in community</div>
| + | <p>We believe the best suitable way to know the awareness message from the old is talking face to face. Connected with the largest student public-service association of Fudan University, we cooperated with “The Home of Elderly” project, which aims at satisfy the need of the old. We interviewed dozens of aged people over 60 years old in a Shanghai elderly community. Then we were surprised by their extremely low awareness of osteoporosis and lack of calcium supplement.</p> </div> |
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| + | <div class="column half_size"> |
| + | <br/><br/><br/> |
| + | <img src="https://static.igem.org/mediawiki/2020/1/1b/T--Fudan--oldcommunity.jpg" style="width:90%" alt="Interview the old in community"/><h6>Figure 5. Our teammate interview the old in the community</h6></div> |
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− | <div class="highlight decoration_background decoration_A_top"> | + | <div class="highlight decoration_background decoration_B_top"> |
− | <p> | + | <p id="Integrated"> |
− | The series of effective surveys provide us the reality of public awareness of calcium supplements and reveal the elderly’s problem. The evidence from the statistics analysis helped us to unearth the education need of the elderly. <b>Specially, we came up with an idea of educating the younger generation and instructing them to educate their grandparents.</b></p></div> | + | The series of effective surveys provide us the reality of public awareness of calcium supplements and reveal the elderly’s problem. The evidence from the statistics analysis helped us to unearth the education need of the elderly. <b>Specially, we came up with an idea of educating the younger generation and instructing them to educate their grandparents.</b></p> |
− | | + | <p>Bone health is a serious problem for the old. They have a severe need for Calcium supplements. <b>We wanted to know the current treatment of osteoporosis and everyday health care products for Calcium supplement in this case.</b> We carried our thought to interview several key stakeholders and discuss the method to achieve them. Given the outbreak of the COVID-19 pandemic, we took action mainly in online form.</p></div> |
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| <h2>Online Public Engagement</h2> | | <h2>Online Public Engagement</h2> |
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− | <h4>Dr.Dongying Qiu and Weiying Ren</h4> | + | <div class="column two_thirds_size"> |
− | Deputy chief physician of Geriatrics Department of, Zhongshan Hospital, Fudan University. | + | <h4>Dr. Dongying Qiu and Weiying Ren</h4> |
| + | Deputy Chief Physician of Geriatrics Department, Zhongshan Hospital, Fudan University. |
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− | <div class="column two_thirds_size">
| + | <p>We consulted clinical physicians about the current osteoporosis treatment situation and FRAX (WHO Fracture Risk Assessment Tool), which is considered underestimating the Chinese population’s risk. They provided us plenty of important messages. </p> |
− | <p>We consulted clinical physicians about the current osteoporosis treatment situation and FRAX (WHO Fracture Risk Assessment Tool), which is considered underestimating the Chinese population’s risk. They provided us plenty of important messages. </br> | + | <p>First, the consultation rate of osteoporosis was quite low, owing to the old’s low awareness. </p> |
− | First, the consultation rate of osteoporosis was quite low, owing to the old’s low awareness. </br> | + | <p>Second, different assessment tools match various application scope. Guidelines for the diagnosis and management of primary osteoporosis provided by the Chinese Society of Osteoporosis and Bone Mineral Research are used in the clinic but still has question and limitation.</p> |
− | Second, different assessment tools match various application scope. Guidelines for the diagnosis and management of primary osteoporosis provided by the Chinese Society of Osteoporosis and Bone Mineral Research are used in the clinic but still has question and limitation.</br> | + | <p>What’s more, we exhibited our project design and education for older people to them, which gained great admiration. Dr.Qiu shared his own educational experience to instruct us. He suggested we should be careful with our expression, which needs to be scientific. |
− | What’s more, we exhibited our project design and education for older people to them, which gained great admiration. Dr.Qiu shared his own educational experience to instruct us. He suggested we should be careful with our expression, which needs to be scientific.
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| </p></div> | | </p></div> |
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| <div class="column third_size"> | | <div class="column third_size"> |
− | <img src="https://static.igem.org/mediawiki/2020/7/7e/T--Fudan--Dr.Dongying_Qiu.jpg" " style="width:38%" /> | + | <img src="https://static.igem.org/mediawiki/2020/7/7e/T--Fudan--Dr.Dongying_Qiu.jpg" alt="qiu dongying" style="width:38%" /> |
− | <img src="https://static.igem.org/mediawiki/2020/6/69/T--Fudan--Dr.Weiying_Ren.jpg" " style="width:45%" /></div> | + | <img src="https://static.igem.org/mediawiki/2020/6/69/T--Fudan--Dr.Weiying_Ren.jpg" alt="ren weiying" style="width:45%" /></div> |
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− | <h4>Dr.Wei Hong</h4>
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− | Deputy chief physician of Osteoporosis Department, East China Hospital affiliated to Fudan University
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| <div class="column two_thirds_size"> | | <div class="column two_thirds_size"> |
− | <p>Dr.Hong is a professor in the area of osteoporosis who also makes an effort to educate patients. | + | <h4>Dr. Wei Hong</h4> |
− | We discussed the design of the assessment tool and how to improve the current treatment and recovery method. Dr.Hong pointed out the self-assessment tool's difficulty because of the lack of a database that big enough. We learned that the community is the most effective way to carry out education and recovery introduction. The direct contact with the old helps continuous supervision of treatment progress. | + | Deputy Chief Physician of Osteoporosis Department, East China Hospital affiliated to Fudan University |
| + | |
| + | <p>Dr. Hong is a professor in the area of osteoporosis who also makes an effort to educate patients. |
| + | We discussed the design of the assessment tool and how to improve the current treatment and recovery method. Dr.Hong pointed out the self-assessment tool's difficulty because of the lack of a database that big enough. We learned that the community is the most effective way to carry out education and recovery introduction. The direct contact with the old helps continuous supervision of treatment progress. |
| </p></div> | | </p></div> |
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| <div class="column third_size"> | | <div class="column third_size"> |
− | <img src="https://static.igem.org/mediawiki/2020/4/4b/T--Fudan--Dr.Wei_Hong.jpg" style="width:60%"/></div> | + | <img src="https://static.igem.org/mediawiki/2020/4/4b/T--Fudan--Dr.Wei_Hong.jpg" alt="wei hong" style="width:60%"/></div> |
− | <div class="clear"></div>
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− | <h4>Senior home staff and care workers</h4>
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− | Xinguang Senior home
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| <div class="clear"></div> | | <div class="clear"></div> |
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| + | <div class="highlight decoration_background decoration_B_top"> |
| + | <p>The pool assessment tool and low osteoporosis rate reminded us of the difficulty for the old's bone health. To better guarantee more comprehensive bone health, we tried to achieve an effective Calcium supplement method. We analyzed the current way and relevant health care products market. We came up with some questions and existed difficulty: </p><ol> |
| + | <li>Patients usually forget to take supplements, especially for the old. </li> |
| + | <li>Calcium absorption rate drops as the amount of calcium intake increases.</li> </ol> |
| + | <p>Current market is in urgent need of a supplement method that ensures a high calcium absorption rate over a long period of time. This will avoid frequent intake of a large amount of supplement pills and the precipitation of calcium oxalate. We decided to <a href="/Team:Fudan/Design">design</a> a <b>high and sustainable calcium absorption nutrition</b>. </p></div> |
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| <div class="column two_thirds_size"> | | <div class="column two_thirds_size"> |
| + | <h4>Senior home staff and care workers</h4> |
| + | Xinguang Senior Home, Shanghai |
| + | |
| <p>In Xinguang senior home, they have nearly 100 elders aged 60 to 100. We interviewed their staff about the bone health of the old. They reflected several severe fractures caused by osteoporosis and pointed their general bad bone health. | | <p>In Xinguang senior home, they have nearly 100 elders aged 60 to 100. We interviewed their staff about the bone health of the old. They reflected several severe fractures caused by osteoporosis and pointed their general bad bone health. |
| </p></div> | | </p></div> |
| <div class="column third_size"> | | <div class="column third_size"> |
− | <img src="https://static.igem.org/mediawiki/2020/7/7a/T--Fudan--seniorhome.jpg" style="width:80%"/></div> | + | <img src="https://static.igem.org/mediawiki/2020/7/7a/T--Fudan--seniorhome.jpg" alt="senior home" style="width:80%"/></div> |
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− | <h4>Prof.Xinhua Lin</h4>
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− | School of Life Sciences Fudan University
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− | <div class="clear"></div>
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| <div class="column two_thirds_size"> | | <div class="column two_thirds_size"> |
− | <p>The concept of quorum sensing system described was proposed by Fudan 2019. Since MccB17 plays a vital role in the entire quorum sensing system, the better the MccB17 is expressed, the faster the engineered bacteria will achieve the balance of quorum sensing. However, we found that the expression level of MccB17 tested by Team Fudan 2019 last year was so low that the engineered bacteria cannot be competitive enough in the intestine. | + | <h4>Prof. Jinzhong Lin</h4> |
− | </p></div> | + | School of Life Sciences Fudan University |
− | <div class="column third_size">
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− | <img src="https://static.igem.org/mediawiki/2020/8/84/T--Fudan--jinzhonglin.png" style="width:50%"/></div>
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| + | <p>We discussed with Professor Lin, who is engaged in prokaryotic expression work at the Fudan University Academy of Sciences. The concept of quorum sensing system described was proposed by Fudan 2019. To help engineered bacteria be competitive enough in the intestine, MccB17 needed better expressed. We thought about using the high-copy plasmids to express MccB17, but they are more challenging to regulate and respond sensitively and extensively to increase engineered bacteria's expression burden.<br/> |
| + | </div> |
| + | <div class="column third_size"><br/><br/> |
| + | <img src="https://static.igem.org/mediawiki/2020/8/84/T--Fudan--jinzhonglin.png" alt="lin jinzhong" style="width:50%"/></div> |
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| + | <div class="column full_size"><div class="highlight decoration_background decoration_A_top"> |
| + | <p>We designed a peptide (CaAP) containing a series of short peptides that can promote calcium absorption. We let probiotics express and secrete this peptide in the intestine to promote calcium absorption in the intestine.</p> |
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| + | <p>Prof. Lin suggested us to use low-copy plasmids to reduce the expression burden of engineered bacteria. We tried to keep the main part of MccB17 (McbABCD) a relatively low expression and high express the immune part (McbEFG) to achieve high secretion of MccB17.</p></div></div> |
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| <h2>Collaboration</h2> | | <h2>Collaboration</h2> |
| <div class="column third_size"> | | <div class="column third_size"> |
− | <img src="https://static.igem.org/mediawiki/2020/9/93/T--Fudan--TJU.jpg" style = "width:40%"/></div>
| + | <img src="https://static.igem.org/mediawiki/2020/9/93/T--Fudan--TJU.jpg" alt="TJU" /></div> |
| <div class="column third_size"> | | <div class="column third_size"> |
− | <img scr = "https://static.igem.org/mediawiki/2020/a/a6/T--Fudan--SCU.jpg" style = "width:40%"/> | + | <img src = "https://static.igem.org/mediawiki/2020/a/a6/T--Fudan--SCU.jpg" alt="SCU" /> |
| </div> | | </div> |
| <div class="column third_size"> | | <div class="column third_size"> |
− | <p>We collaborate with team TJU held an online summer camp for high school students to introduced the relevant principles and concepts of synthetic biology and shared the concept of iGEM as well as our project. </br> | + | <p>We collaborate with team TJU held an online summer camp for high school students to introduced the relevant principles and concepts of synthetic biology and shared the concept of iGEM as well as our project. More details at |
− | <a href="https://2020.igem.org/Team:Fudan/Collaboration"> Click here to see more details</a></p> | + | <a href="/Team:Fudan/Collaborations">/Team:Fudan/Collaborations</a>.</p> |
| </div> | | </div> |
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| <h4>Model</h4> | | <h4>Model</h4> |
| <p>We establish two models: quorum sensing process and Kill Switch. We refer to the model and data of 2019Fudan team and use the random process to describe it more clearly to model the quorum sensing process in stages and levels. In the kill switch section, we use the 19BNU team’s data, improve the logistic equation, adjust the promoter properties, and make a sensitivity analysis. We can see good results through it. | | <p>We establish two models: quorum sensing process and Kill Switch. We refer to the model and data of 2019Fudan team and use the random process to describe it more clearly to model the quorum sensing process in stages and levels. In the kill switch section, we use the 19BNU team’s data, improve the logistic equation, adjust the promoter properties, and make a sensitivity analysis. We can see good results through it. |
− | </br>
| + | More details at |
− | <a href="/Team:Fudan/Model#killswitch"> Click here to see more details</a></p> | + | <a href="/Team:Fudan/Model#killswitch">/Team:Fudan/Model</a>.</p></div> |
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| <h4>Kill Switch design</h4> | | <h4>Kill Switch design</h4> |
− | <p>We contacted Mr. Feng in BNU, a member of 19BNU-China and very experienced in kill switches, discussing the kill switch and safety issue of antibiotics resistance gene design. </p> | + | <p>We contacted Mr. Feng in BNU, a member of 19BNU-China and very experienced in kill switches, discussing the kill switch and safety issue of antibiotics resistance gene design. </p></div> |
| + | <div class = "column two_thirds_size"> |
| + | <img src="https://static.igem.org/mediawiki/2020/2/26/T--Fudan--BNU2.jpg" alt="BNU2" /></div> |
| + | <div class = "column third_size"> |
| + | <p>We discussed whether the glucose-starvation promotor (BBa_K3036003 from 19BNU-China) would be a suitable response system for our kill switch and hope to obtain their plasmids as a control group directly to save time for constructing it from the beginning. |
| + | Mr. Feng didn’t consider glucose concentration as a distinct signal to trigger glucose response that existed both inside and outside the body. The difference between the two conditions was not very significant. And he also recommended we search some literature on toxin/antitoxin systems. They probably were ideal candidates for carrying eliminating function.</p></div> |
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− | <p>We doubted whether the glucose-starvation promotor (BBa_K3036003 from 19BNU-China) would be a suitable response system for our kill switch and hope to obtain their plasmids as a control group directly to save time for constructing it from the beginning. | + | <div class = "clear"></div> |
− | Mr. Feng didn’t consider glucose concentration as a distinct signal to trigger glucose response that existed both inside and outside the body. The difference between the two conditions was not very significant. And he also recommended we search some literature on toxin/antitoxin systems. They probably were ideal candidates for carrying eliminating function.</p>
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| + | <div class = "column full_size"> |
| <p>After search the advantages of the toxin/antitoxin system, we decided to undergo an overhaul of our kill switch. This consultation helped us summarize the idea of designing a kill switch that kill switch circuit can be divided into two core components: judging whether bacteria leave the set condition and the other component to kill the bacteria when it leaves the set condition. </p> | | <p>After search the advantages of the toxin/antitoxin system, we decided to undergo an overhaul of our kill switch. This consultation helped us summarize the idea of designing a kill switch that kill switch circuit can be divided into two core components: judging whether bacteria leave the set condition and the other component to kill the bacteria when it leaves the set condition. </p> |
| + | |
| <p>Antibiotics resistance genes encoded on a plasmid can transfer to the host’s intestinal flora and hurries the development of antibiotic-resistant strains. To improve our product’s safety factor, we wanted to insert our genetic circuits into the genome to inhibit the horizontal transfer. Mr. Feng told us that verifying genome insertion in experiments would take a significant amount of time and was unlikely to be done within a few months. Using plasmids in the experimental stage is still a preferable way. He commended that multi-copy insertion could be designed as the final form of the product. | | <p>Antibiotics resistance genes encoded on a plasmid can transfer to the host’s intestinal flora and hurries the development of antibiotic-resistant strains. To improve our product’s safety factor, we wanted to insert our genetic circuits into the genome to inhibit the horizontal transfer. Mr. Feng told us that verifying genome insertion in experiments would take a significant amount of time and was unlikely to be done within a few months. Using plasmids in the experimental stage is still a preferable way. He commended that multi-copy insertion could be designed as the final form of the product. |
| </p> </div> | | </p> </div> |
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| <h2>Education</h2> | | <h2>Education</h2> |
− | <div class="column third_size"> | + | |
− | <img src="https://static.igem.org/mediawiki/2020/8/8b/T--Fudan--map_2.svg" alt="map of calcium intake" /> | + | <div class="column full_size"> |
| + | <h4>Educate the old through younger generation.</h4> |
| + | <p>Educating the elderly helps the old keep health and protects them from fraud and mis-information. We used a previous unexplored education approach to educate biologic knowledge to the old. Our main strategy is educating the younger generation and instructing them how to educate their grandparents. Compared with traditional education strategies, our approach offers emotional support from the younger generation and is comfortable for the old.In addition, we combined osteoporosis prevention with traditional Chinese art Crosstalk, and taught it to the old living in a nursing home. In summary, we made brave and compelling attempts to implement science communication between the younger generation and the long-neglected social communities - the old.</p> |
| + | <p>To educate the youth, we held online summer camps for high school students to pass on aged care, in addition to synthetic biology which we have been teaching in the past several years. We developed an online audio course on basic biology knowledge, which could been listened by both the youth and the old. </p> |
| + | |
| + | <p>More details at <a href="/Team:Fudan/Education">/Team:Fudan/Education</a>.</p> |
| </div> | | </div> |
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| + | <h2>Commercialization analysis</h2> |
| <div class="column two_thirds_size"> | | <div class="column two_thirds_size"> |
− | <p><b>Educate the old through younger generation.</b></p> | + | <img src="https://static.igem.org/mediawiki/2020/b/b4/T--Fudan--timeline.jpg" alt="commercialization timeline" /> |
− | <p>Educating the elderly helps the old keep health and protects them from fraud and mis-information. We used a previous unexplored education approach to educate biologic knowledge to the old. Our main strategy is educating the younger generation and instructing them how to educate their grandparents. Compared with traditional education strategies, our approach offers emotional support from the younger generation and is comfortable for the old. In countries like Japan, Korea, Singapore and China, where the bond between grandparents and grandkids is incredibly tight, our approach is undoubtedly effective. </br>
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− | To educate the youth, we have held online summer camps for high school students to pass on aged care, in addition to synthetic biology which we have been teaching in the past several years. We developed an online audio course on basic biology knowledge, which could been listened by both the youth and the old. </p>
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− | <p>In addition, we combined osteoporosis prevention with traditional Chinese art Xiangsheng, and taught it to the old living in a nursing home (we self as the youth). Also, we wrote Xiàng Sheng (a popular traditional art in China) and other outreach materials for people to use. In summary, we made brave and compelling attempts to implement science communication between the younger generation and the long-neglected social communities - the old.</p>
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− | <p><a href="https://2020.igem.org/Team:Fudan/Education">Click here to see more details</a></p>
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| </div> | | </div> |
− | <div class="clear"></div><!-- 一个章节结束需要clear来留白 -->
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− |
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− | <h2> Commercialization analysis</h2>
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| <div class="column third_size"> | | <div class="column third_size"> |
− | <img src="https://static.igem.org/mediawiki/2020/8/8b/T--Fudan--map_2.svg" alt="map of calcium intake" />
| + | <p> We made the market investigations and pitched our commercial plan to potential commercial investors. During these interactions, we improved our existing design for CaAP, and we came up with the CaAsst test strip product, which later got support by our pilot experiments. More details at <a href="/Team:Fudan/Entrepreneurship"> /Team:Fudan/Entrepreneurship</a>.</p></div> |
− | </div>
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− | <div class="column two_thirds_size">
| + | |
− | <p> We made the market investigations and pitched our commercial plan to potential commercial investors. During these interactions, we improved our existing design for CaAP, and we came up with the CaAss test strip product, which later got support by our pilot experiments.</p> | + | |
− | <p> <a href="https://2020.igem.org/Team:Fudan/Entrepreneurship"> Click here to see more details</a></p></div>
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| <div class="clear"></div> | | <div class="clear"></div> |
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| <div class="column full_size"> | | <div class="column full_size"> |
− | <p> | + | <p><b>1. Commercial consult.</b> We contacted factories about our product's cost, more specifically, about the cost of producing pills from lab benches to packages ready for the market. Wescheduled several in-person and online appointments with professional investors in the biochemical industry and corresponded with them back and forth to polish our business plan. We also obtained a letter of intent from them, paving ways for future collaboration. Besides, we asked for advice from peers in the Fudan school of management about our marketing strategies and shaped our business plan to target our potential users more effectively.</p> |
− | <b>1.Commercial consult.</b> We contacted factories about our product's cost, more specifically, about the cost of producing pills from lab benches to packages ready for the market.We scheduled several in-person and online appointments with professional investors in the biochemical industry and corresponded with them back and forth to polish our business plan. We also obtained a letter of intent from them, paving ways for future collaboration. Besides, we asked for advice from peers in the Fudan school of management about our marketing strategies and shaped our business plan to target our potential users more effectively.</p> | + | |
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− | <p><b>2.CaAass developing.</b> To obtain more professional feedback and get our projects wider public known, we participated in the Fanhai Bei innovation competition and won a third-class prize. According the judges' feedback, we modified our business model and found that older people in China lacked an easy method to assess their calcium status. Therefore, we developed our Measurement project CaAss to provide a solution for the old people to measure their blood calcium status in a portable way. <a href="https://2020.igem.org/Team:Fudan/Measurement"> Click here to see more details</a></p></div> | + | <p><b>2. CaAsst developing.</b> To obtain more professional feedback and get our projects wider public known, we participated in the Fanhai Bei innovation competition and won a third-class prize. According the judges' feedback, we modified our business model and found that older people in China lacked an easy method to assess their calcium status. Therefore, we developed our Measurement project CaAsst to provide a solution for the old people to measure their blood calcium status in a portable way. More details at <a href="/Team:Fudan/Measurement">/Team:Fudan/Measurement</a></p></div> |
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| + | <div class="clear extra_space"></div><!-- 一个章节结束需要clear来留白 因为马上最后一幅,建议extra_space --> |
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− | | + | <h2>Summary</h2> |
− | | + | |
− | <div class="clear extra_space"></div><!-- 一个章节结束需要clear来留白 因为马上最后一幅,建议extra_space -->
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| <div class="column full_size"> | | <div class="column full_size"> |
− |
| |
− | <h2>Summary</h2>
| |
| <p>Our project focus on reducing the impact of osteoporosis, trying search the way to making world better. </p> | | <p>Our project focus on reducing the impact of osteoporosis, trying search the way to making world better. </p> |
− | <div class="highlight decoration_background decoration_A_top"> | + | <div class="highlight decoration_background"> |
| <ol> | | <ol> |
| <li> Analyzed the whole ages surveys to investigate public awareness and the current suffering situation of the old people.</li> | | <li> Analyzed the whole ages surveys to investigate public awareness and the current suffering situation of the old people.</li> |
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| </ol> | | </ol> |
| </div> | | </div> |
− | <p> During these interactions, we improved our existing design for CaAP, and we came up with the CaAss test strip product, which later got support by our pilot experiments.Our team successfully integrated Human Practice to design and improve our Bone Appetite project. </p> | + | <p> During these interactions, we improved our existing design for CaAP, and we came up with the CaAsst test strip product, which later got support by our pilot experiments.Our team successfully integrated Human Practice to design and improve our Bone Appetite project. </p> |
| </div> | | </div> |
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| <div class="container"><div class="row"> | | <div class="container"><div class="row"> |
| <div class="col m3 s12 row" | | <div class="col m3 s12 row" |
− | style="margin-top:4rem" > | + | style="margin-top:4rem" tabIndex="0" > |
| <a href="http://www.yfc.cn/" target="_blank"><img class="col s3 m6 l4 FudanSponsors" alt="Yunfeng Capital" src="https://static.igem.org/mediawiki/2020/b/ba/T--Fudan--YFcapital.svg"> </a> | | <a href="http://www.yfc.cn/" target="_blank"><img class="col s3 m6 l4 FudanSponsors" alt="Yunfeng Capital" src="https://static.igem.org/mediawiki/2020/b/ba/T--Fudan--YFcapital.svg"> </a> |
| <a href="http://www.fudan.edu.cn/en/" target="_blank"><img alt="Fudan University" class="col s3 m6 l4 FudanSponsors" src="https://static.igem.org/mediawiki/2020/9/9d/T--Fudan--sponsor2.svg"> </a> | | <a href="http://www.fudan.edu.cn/en/" target="_blank"><img alt="Fudan University" class="col s3 m6 l4 FudanSponsors" src="https://static.igem.org/mediawiki/2020/9/9d/T--Fudan--sponsor2.svg"> </a> |
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| <div class="col s12 l6 row"> | | <div class="col s12 l6 row"> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Description#Project">Project</a></span> | + | <span tabIndex="2"><a href="/Team:Fudan/Description#Project">Project</a></span> |
| <ul><li><a href="/Team:Fudan/Description">Description</a></li> | | <ul><li><a href="/Team:Fudan/Description">Description</a></li> |
| <li><a href="/Team:Fudan/Sustainable">Sustainable</a></li> | | <li><a href="/Team:Fudan/Sustainable">Sustainable</a></li> |
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| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Notebook">Notebook</a></span> | + | <span tabIndex="3"><a href="/Team:Fudan/Notebook">Notebook</a></span> |
| <ul><li><a href="/Team:Fudan/Safety">Safety</a></li> | | <ul><li><a href="/Team:Fudan/Safety">Safety</a></li> |
| <li><a href="/Team:Fudan/Poster">Poster</a></li> | | <li><a href="/Team:Fudan/Poster">Poster</a></li> |
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| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Results">Results</a></span> | + | <span tabIndex="4"><a href="/Team:Fudan/Results">Results</a></span> |
| <ul><li><a href="/Team:Fudan/Contribution">Contribution</a></li><!-- replace Judging --> | | <ul><li><a href="/Team:Fudan/Contribution">Contribution</a></li><!-- replace Judging --> |
| <li><a href="/Team:Fudan/Implementation">Implementation</a></li> | | <li><a href="/Team:Fudan/Implementation">Implementation</a></li> |
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| <div class="col s12 l6 row"> | | <div class="col s12 l6 row"> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Parts">Parts</a></span> | + | <span tabIndex="5"><a href="/Team:Fudan/Parts">Parts</a></span> |
| <ul><li><a href="/Team:Fudan/Parts#Basic">Basic part</a></li> | | <ul><li><a href="/Team:Fudan/Parts#Basic">Basic part</a></li> |
| <li><a href="/Team:Fudan/Parts#Composite">Composite part</a></li> | | <li><a href="/Team:Fudan/Parts#Composite">Composite part</a></li> |
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| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Human_Practices">Outreach</a></span> | + | <span tabIndex="6"><a href="/Team:Fudan/Human_Practices">Outreach</a></span> |
| <ul><li><a href="/Team:Fudan/Human_Practices#Integrated">Integrated HP</a></li> | | <ul><li><a href="/Team:Fudan/Human_Practices#Integrated">Integrated HP</a></li> |
| <li><a href="/Team:Fudan/Education">Education</a></li> | | <li><a href="/Team:Fudan/Education">Education</a></li> |
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| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Team">Team</a></span> | + | <span tabIndex="7"><a href="/Team:Fudan/Team">Team</a></span> |
| <ul><li><a href="/Team:Fudan/Team">Members</a></li> | | <ul><li><a href="/Team:Fudan/Team">Members</a></li> |
| <li><a href="/Team:Fudan/Attributions">Attributions</a></li> | | <li><a href="/Team:Fudan/Attributions">Attributions</a></li> |
| <li><a href="/Team:Fudan/Partnership">Partnership</a></li> | | <li><a href="/Team:Fudan/Partnership">Partnership</a></li> |
| <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li> | | <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li> |
− | <li><a href="https://2019.igem.org/Team:Fudan-TSI/Heritage" target="_blank">Heritage</a></li> | + | <li><a href="/Team:Fudan/Heritage">Heritage</a></li> |
| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> </div> | | <div class="col s12 m4"> </div> |