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− | <h1>Make calcium supplements sustainable</h1> | + | <h1 tabIndex="1">Make calcium supplements sustainable</h1> |
− | <div class="column full_size">
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− | <h2>Inspiration</h2>
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− | <p>In January, before the COVID-19 outbreak, one of our members, Xinran Li's grandmother, lost her footing and fell slightly to the ground while playing badminton. As the elderly played badminton together, their speed and movements were not severe, but they still broke their bones because they fell on the ground with their hands. It is not the first time. A few years ago, her grandmother had broken her lower back in a fall while active. It reminds her of many similar cases among other relatives in the past few years, especially among women. As a result of a severe fracture caused by a fall, she needs to take care of her family members, especially middle-aged people. If the family has some school-age children in need of care, the elderly cannot continue to help. </p>
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− | <p>It makes us realize the importance of bone health in the elderly, and osteoporosis is a significant cause of fractures in the elderly. In 2018, the National Health Commission of China released an epidemiological survey of osteoporosis in China, which is the first large-scale multi-center epidemiological survey of osteoporosis among Chinese residents based on community population in China. The results show that osteoporosis has become a significant health problem for people over 50 in China, especially middle-aged and older women. The prevalence rate of osteoporosis reached 32.0% in people over 65 years old, 10.7% in men, and 51.6% in women. Due to the state of low bone mass and the lack of apparent clinical manifestations in the early stage of osteoporosis, the lack of public awareness of the importance of osteoporosis prevention, and the insufficient ability of primary medical and health institutions to prevent osteoporosis, the bone mineral density detection rate of Chinese residents is low.</p>
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− | <div class="clear"></div><!-- 一个章节结束需要clear来留白 -->
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− | <h2>每个章节标题用h2 为了搜索引擎全页面只能一个h1标签</h2>
| + | <p>In Asia, many old people suffer from insufficient calcium intake and related diseases such as osteoporosis. Considering that traditional calcium supplementation is not efficient and user-friendly enough, we intended to develop a kind of engineered bacteria based on <i>E. coli</i> that can colonize in the human intestine and secrete peptides to promote calcium absorption. We introduced the quorum sensing system to colonize bacteria in the intestine. Once the bacteria have successfully colonized the intestinal tract, the luxPR promoter will be activated and a series of short peptides that can bind to calcium and promote calcium absorption of intestinal epithelial cells will be expressed. A kill switch is added accordingly for safety. Our project provides a novel delivery method to provide calcium supplements sustainably. And we are actively seeking commercialization possibilities to expand our project impact, to reach more population, for the elderly’s good health and well-being.</p> |
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− | <div class="column half_size">
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− | <div class="highlight decoration_background decoration_A_top">
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− | <p>在宽屏,这部分内容占页面1/2;窄屏就是全幅。添加了column同时 图1/2 + 字1/2 正好宽屏的一幅。这个代码不在 https://2020.igem.org/Resources/Template_Documentation 但是是支持的 China has an estimated 70 million osteo
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− | porosis patien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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− | oporosis patienChina has an estimated 70 million osteoporosis patien</p>
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| </div> | | </div> |
− | </div>
| + | <div class="clear"></div><!-- 一个章节结束需要clear来留白 如果觉得内容间差异大再加上extra_space --> |
− | <div class="clear"></div><!-- 一个章节结束需要clear来留白 -->
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− | <h2>每个章节标题用h2 为了搜索引擎全页面只能一个h1标签</h2> | + | <h2>Inspiration</h2> |
− | <div class="column third_size">
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− | <img src="https://static.igem.org/mediawiki/2020/8/8b/T--Fudan--map_2.svg" alt="map of calcium intake" />
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− | <div class="column two_thirds_size">
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− | <p>在宽屏,这部分内容占页面1/3;窄屏就是全幅。添加了column同时 图1/3 + 字2/3 正好宽屏的一幅。 China has an estimated 70 million osteo
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− | porosis patien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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− | oporosis patienChina has an estimated 70 million osteoporosis patien</p>
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− | </div>
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− | <div class="clear"></div><!-- 一个章节结束需要clear来留白 -->
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− | <div class="column full_size"><!-- 全幅面的文字内容,上面是否留白可选 -->
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− | <p>However, for the Chinese population, the bottlenecks are
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− | as follows:
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− | </p>
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− | <ol>
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− | <li>注意这里列表的写法 页面字会变深 突出内容 ol是编数字的 nts</li>
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− | <li>calcium-supplementing pills daste</li>
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− | <li>The body's absorptioes as calcium intake increases</li>
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− | <li>Vegetables conta列表的写法 页面字会变深 突出内容 ol是编数字的 ul是没有标数字的列表 </li>
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− | </ol>
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− | <p>
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− | However, the currently popular calcium supplement method on the market is either to adjust diet or to consume a lot of calcium supplementing pills. For the elderly, they suffer from poor memory or neglect the importance of calcium pills, often forgetting to consume the supplement; for children, they often refuse to take calcium pills or to maintain some diet high in calcium, thus requiring the "liquid calcium" method to ensure sufficient calcium intake. Ho可以 继续大段内容
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− | <div class="highlight decoration_background decoration_A_top">
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− | 章节内容的分段就用p开p关,额外需要关注的可以套一个highlight的框,有多种版本
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− | </p>
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− | </div>
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− | <p>
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− | 章节内容的分段就用p开p关
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− | </p>
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− | <div class="highlight decoration_B_full">
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− | <p>
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− | 章节内容的分段就用p开p关,额外需要关注的可以套一个highlight的框,细看 https://2020.igem.org/Resources/Template_Documentation#highlight
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− | </p>
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− | </div>
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− | <p>
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− | 章节内容的分段就用p开p关
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− | </p>
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− | <p>
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− | 章节内容的分段就用p开p关 <a href="https://URL"> EXAM 外部链接 href尽量使用https </a>
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− | </p>
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− | <ul>
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− | <li>注意这里列表的写法 页面字会变深 突出内容 ul是没有标数字的列表 nts</li>
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− | <li>calcium-supple menting pills don’t haat taste</li>
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− | <li>Vegetables conta列表的写法 页面字会变深 突出内容 ol是编数字的 ul是没有标数字的列表 </li>
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− | </ul>
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− | <p>
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− | 章节内容的分段就用p开p关
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− | </p>
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− | </div><!-- 每个幅面结束都需要 关div -->
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− | <div class="clear extra_space"></div><!-- 一个章节结束需要clear来留白 如果觉得内容间差异大再加上extra_space -->
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− | <h2>又来个章节 sis</h2>
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| <div class="column full_size"> | | <div class="column full_size"> |
− | <p>引入文字 ion.</p>
| + | <p>Our member Tian Shizheng heard from her grandmother that she suffered from leg pain caused by calcium deficiency when she went home during the holiday, and the effect of taking calcium tablets was not good, so she had to go to the hospital to seek more professional treatment advice. This thing reminds him of insufficient calcium intake,even in the era of rising quality of life when food choices are plentiful.</p> |
− | <p>Firstly, the product is designed for oral use and our target user is the elderly. 英文分项不需要ol或ul</p>
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− | <ol>
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− | <li>The produc</li>
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− | <li>The short pep</li>
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− | <li>The expression level of short peptides has a threshold, preventing any excessive calcium absorption that might lead to hypercalcemia 注意句子超长后的回折</li>
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− | <li>There is a kill swit.</li>
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− | </ol>
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− | <p>
| + | <p>In January, before the COVID-19 outbreak, one of our members, Xinran Li's grandmother, lost her footing and fell slightly to the ground while playing badminton. As the elderly played badminton together, their speed and movements were not severe, but they still broke their bones because they fell on the ground with their hands. It is not the first time. A few years ago, her grandmother had broken her lower back in a fall while active. It reminds her of many similar cases among other relatives in the past few years, especially among women. As a result of a severe fracture caused by a fall, she needs to take care of her family members, especially middle-aged people. If the family has some school-age children in need of care, the elderly cannot continue to help. </p > <p>It makes us realize the importance of bone health in the elderly, and osteoporosis is a significant cause of fractures in the elderly. In 2018, the National Health Commission of China released an epidemiological survey of osteoporosis in China, which is the first large-scale multi-center epidemiological survey of osteoporosis among Chinese residents based on community population in China. The results show that osteoporosis has become a significant health problem for people over 50 in China, especially middle-aged and older women. The prevalence rate of osteoporosis reached 32.0% in people over 65 years old, 10.7% in men, and 51.6% in women. Due to the state of low bone mass and the lack of apparent clinical manifestations in the early stage of osteoporosis, the lack of public awareness of the importance of osteoporosis prevention, and the insufficient ability of primary medical and health institutions to prevent osteoporosis, the bone mineral density detection rate of Chinese residents is low.</p> |
− | Based on relevant research, the product is exp 章节内分段 ina. tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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− | oporosis patienChina has an estimated 70 million osteoporosis pat
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− | </p>
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− | <p>Compared w 章节内分段 ique advantages tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
| + | <p id="Project">At present, there are good medical treatments for osteoporosis, but there is still a big gap in preventing calcium deficiency in the elderly. The existing calcium supplement products still have disadvantages such as low absorption rate, poor user experience, and easy to miss taking. So we want to add a new and convenient daily calcium supplement for the elderly to achieve sustainable calcium supplementation and improve the quality of life and health of the elderly. That's where our project came from.</p > |
− | oporosis patienChina has an estimated 70 million osteoporosis pat tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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− | oporosis patienChina has an estimated 70 million osteoporosis pat tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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− | oporosis patienChina has an estimated 70 million osteoporosis pat.
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− | <th> Header 1 这是igem hq的表格的写法 </th> <th> Header 2 </th>
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− | <td> Content A 2 </td> <td> Content B 2 这是igem hq的表格的写法。表格都需要说明,之前之后都会有p来文字 </td>
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− | <p></p><!-- 无文字p是换行隔开,在关闭的html元素间回车是没有用的 -->
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− | <table class="striped"><!-- 这是另一个版本的表格,间隔行有阴影。一个页面不建议交叉两种格式。太宽表格可以加 responsive-table 方便窄屏 -->
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− | <th>Name</th> <th>Item Name</th> <th>Item Price</th>
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− | <td>Alvin</td> <td>Eclair</td> <td>$0.87</td>
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− | </tr>
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− | <td>Alan</td> <td>Jellybean</td> <td>$3.76</td>
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− | <td>Jonathan</td> <td>Lollipop</td> <td>$7.00</td>
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− | </table>
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− | <p>Calciu 章节内分段 fety. tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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− | oporosis patienChina has an estima
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− | ted 70 million osteoporosis pat tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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− | oporosis patienChina has an estimated 70 mill
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− | ion osteoporosis pattien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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− | oporosis patienChina has an estimated 70 million osteoporosis pat
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− | </p>
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− | <p>From the us 章节内分段 etition.</p>
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| <div class="clear"></div><!-- 一个章节结束需要clear来留白 --> | | <div class="clear"></div><!-- 一个章节结束需要clear来留白 --> |
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− | <h2>再来例子 Market Analysis</h2>
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− | <p>文本在左侧一半,宽屏 According to the Chinese Dietetic Sociietary Nutrient Intakes of Chinese Residents", the calcium requirement for infants and young children increases with age, from 300mg/day to 800mg/day, and the calcium requirement for adolescents reaches 1000mg/day. The amof the required intake, with the small exception of some coastal and pastoral areas 图片在右侧一半</p>
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− | <th> 这是igem hq的表格的写法 </th> <th> Header 2 </th> <th> Header 3 </th>
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− | <td> Content A 1 </td> <td> Content B 1 </td> <td> Content C 1 </td>
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− | <td colspan=2> 列融合 </td> <td> Content C 2 这是igem hq的表格的写法。半幅或者2/3幅可以用。<br/>行融合<br/>就<br/>用br了 </td>
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− | <img src="https://static.igem.org/mediawiki/2020/0/00/T--Fudan--calcium_intake_graph.svg" alt="calcium intake graph">
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− | </div>
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− | <div class="clear extra_space"></div><!-- 一个章节结束需要clear来留白 因为马上最后一幅,建议extra_space -->
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− | <p>每页结束需要小结,可以 ul ol 列表highlight,可以是每页第一段的另一种写法fety. tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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− | oporosis patienChina has an estima
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− | ted 70 million osteoporosis pat tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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− | oporosis patienChina has an estimated 70 mi 每页结束需要小结,可以 ul ol 列表highlight,可以是每页第一段的另一种写法</p>
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| <div class="column full_size"><div id="FudanSignature"> | | <div class="column full_size"><div id="FudanSignature"> |
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| <div class="container"><div class="row"> | | <div class="container"><div class="row"> |
| <div class="col m3 s12 row" | | <div class="col m3 s12 row" |
− | style="margin-top:4rem" > | + | style="margin-top:4rem" tabIndex="0" > |
| <a href="http://www.yfc.cn/" target="_blank"><img class="col s3 m6 l4 FudanSponsors" alt="Yunfeng Capital" src="https://static.igem.org/mediawiki/2020/b/ba/T--Fudan--YFcapital.svg"> </a> | | <a href="http://www.yfc.cn/" target="_blank"><img class="col s3 m6 l4 FudanSponsors" alt="Yunfeng Capital" src="https://static.igem.org/mediawiki/2020/b/ba/T--Fudan--YFcapital.svg"> </a> |
| <a href="http://www.fudan.edu.cn/en/" target="_blank"><img alt="Fudan University" class="col s3 m6 l4 FudanSponsors" src="https://static.igem.org/mediawiki/2020/9/9d/T--Fudan--sponsor2.svg"> </a> | | <a href="http://www.fudan.edu.cn/en/" target="_blank"><img alt="Fudan University" class="col s3 m6 l4 FudanSponsors" src="https://static.igem.org/mediawiki/2020/9/9d/T--Fudan--sponsor2.svg"> </a> |
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| <div class="col s12 l6 row"> | | <div class="col s12 l6 row"> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Description#Project">Project</a></span> | + | <span tabIndex="2"><a href="/Team:Fudan/Description#Project">Project</a></span> |
| <ul><li><a href="/Team:Fudan/Description">Description</a></li> | | <ul><li><a href="/Team:Fudan/Description">Description</a></li> |
| <li><a href="/Team:Fudan/Sustainable">Sustainable</a></li> | | <li><a href="/Team:Fudan/Sustainable">Sustainable</a></li> |
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| </ul></div> | | </ul></div> |
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− | <span><a href="/Team:Fudan/Notebook">Notebook</a></span> | + | <span tabIndex="3"><a href="/Team:Fudan/Notebook">Notebook</a></span> |
| <ul><li><a href="/Team:Fudan/Safety">Safety</a></li> | | <ul><li><a href="/Team:Fudan/Safety">Safety</a></li> |
| <li><a href="/Team:Fudan/Poster">Poster</a></li> | | <li><a href="/Team:Fudan/Poster">Poster</a></li> |
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| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Results">Results</a></span> | + | <span tabIndex="4"><a href="/Team:Fudan/Results">Results</a></span> |
| <ul><li><a href="/Team:Fudan/Contribution">Contribution</a></li><!-- replace Judging --> | | <ul><li><a href="/Team:Fudan/Contribution">Contribution</a></li><!-- replace Judging --> |
| <li><a href="/Team:Fudan/Implementation">Implementation</a></li> | | <li><a href="/Team:Fudan/Implementation">Implementation</a></li> |
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| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Parts">Parts</a></span> | + | <span tabIndex="5"><a href="/Team:Fudan/Parts">Parts</a></span> |
| <ul><li><a href="/Team:Fudan/Parts#Basic">Basic part</a></li> | | <ul><li><a href="/Team:Fudan/Parts#Basic">Basic part</a></li> |
| <li><a href="/Team:Fudan/Parts#Composite">Composite part</a></li> | | <li><a href="/Team:Fudan/Parts#Composite">Composite part</a></li> |
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| </ul></div> | | </ul></div> |
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− | <span><a href="/Team:Fudan/Human_Practices">Outreach</a></span> | + | <span tabIndex="6"><a href="/Team:Fudan/Human_Practices">Outreach</a></span> |
| <ul><li><a href="/Team:Fudan/Human_Practices#Integrated">Integrated HP</a></li> | | <ul><li><a href="/Team:Fudan/Human_Practices#Integrated">Integrated HP</a></li> |
| <li><a href="/Team:Fudan/Education">Education</a></li> | | <li><a href="/Team:Fudan/Education">Education</a></li> |
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| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Team">Team</a></span> | + | <span tabIndex="7"><a href="/Team:Fudan/Team">Team</a></span> |
| <ul><li><a href="/Team:Fudan/Team">Members</a></li> | | <ul><li><a href="/Team:Fudan/Team">Members</a></li> |
| <li><a href="/Team:Fudan/Attributions">Attributions</a></li> | | <li><a href="/Team:Fudan/Attributions">Attributions</a></li> |
| <li><a href="/Team:Fudan/Partnership">Partnership</a></li> | | <li><a href="/Team:Fudan/Partnership">Partnership</a></li> |
| <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li> | | <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li> |
− | <li><a href="https://2019.igem.org/Team:Fudan-TSI/Heritage" target="_blank">Heritage</a></li> | + | <li><a href="/Team:Fudan/Heritage">Heritage</a></li> |
| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> </div> | | <div class="col s12 m4"> </div> |