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| − | <h2>每个章节标题用h2 为了搜索引擎全页面只能一个h1标签</h2>
| + | <h2>The target group</h2> |
| − | <div class="column two_thirds_size">
| + | <p>Our project comes from the elderly calcium problem. China already has a population of 1.4 billion, and the economy develops rapidly. People are asking for a better life now. Among them, the bone and calcium problem is a problem we can not ignore. </p> |
| − | <img src="https://static.igem.org/mediawiki/2020/8/8b/T--Fudan--map_2.svg" alt="map of calcium intake" />
| + | <p>China is an ancient civilization, and Chinese food culture is of great antiquity and well-known globally. However, China's dietary structure also has brought trouble for people's calcium problems. In the traditional diet of East Asians, including Chinese people, vegetarians are the leading food, supplemented by meat, and rarely consume animal dairy products, leading to a low calcium intake. Some plants also contain many oxalates, phosphate, and other elements, which complex calcium ions and reduced calcium ions' absorption rate. </p> |
| − | </div>
| + | <p>Statistics show that the average Chinese consumes less calcium than the recommended daily intake and many Chinese face serious bone problems. It is estimated that in 2006, there were nearly 70 million osteoporosis patients in China, and the number of bone loss has exceeded 200 million. Despite the lack of recent epidemiological data, estimates of osteoporosis and bone loss in China far exceed these figures. The problem of osteoporosis is more severe in the elderly, and there are deaths due to falls and fractures every year. Therefore, we limited our target population to the elderly.</p> |
| − | <div class="column third_size">
| + | <h2>Product form</h2> |
| − | <p> 在宽屏，这部分内容占页面1/ 3；窄屏就是全幅。添加了column同时 图2/ 3 + 字1/ 3 正好宽屏的一幅。 China has an estimated 70 million osteo | + | <p>Our project aims to design a genetically engineered probiotic that colonizes and secretes a short peptide in the gut. This short peptide binds to calcium ions to increase soluble calcium and increases the absorption rate of calcium in the intestine, thus achieving calcium supplementation.</p> |
| − | porosis patien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
| + | <p>Our project aims to design a genetically engineered probiotic that colonizes and secretes a short peptide in the gut. This short peptide binds to calcium ions to increase soluble calcium and increases the absorption rate of calcium in the intestine, thus achieving calcium supplementation.</p> |
| − | oporosis patienChina has an estimated 70 million osteoporosis patien</p>
| + | <p>Our products are basically positioned as probiotics health products. The relatively mature probiotics products in the market include probiotics lozenges, drops, powders, and capsules. And we chose to make our program available to the target population in the form of probiotic capsules. Compared with other forms of probiotics, the capsule has unique advantages, such as high bioactivity and mature technology. Besides, the commonly used capsule shell is plant fiber shell, which is less than the traditional gelatin capsule additive and more suitable for the elderly.</p> |
| − | </div>
| + | <p>Commonly used probiotic lozenges can add more additives and adhesives, sweeteners, and molding needs heating, which will damage the probiotics' activity. Due to many additives, although easily accepted by children, older people won't care about whether the drug will taste good. A lot of additives can add the burden on the health of the elderly, instead of other forms such as drops, dry powder each have advantages, but there are not easy to save, the shortcomings of high cost, it is not a good choice for the elderly.</p> |
| − | <div class="clear"></div><!-- 一个章节结束需要clear来留白 -->
| + | <h2>business plan</h2> |
| | + | <p>We have a long-term plan for the realization of our project, and we have won the investors' approval.</p> |
| | + | <p>The first milestone is two months later. We plan to obtain all plasmids by Cai Lab and prove that all components can function normally. But we still need to contact medical laboratories for the future's clinical trial. If we want our project to apply, it is a necessary step. We also need to contact investment institutions for financial support.</p> |
| | + | <p>After six months, we are supposed to successfully import all components into the recipient bacteria and make sure that all imported parts function as expected. We also want to consult experts and doctors and pay attention to relevant laws and regulations that enable our project to process smoothly. </p> |
| | + | <p>Ten months later, we may start our experiment on the mouse, and confirm that the successful preclinical trial has passed the review of FDA in the same period, obtain the approval of clinical trial, and apply for clinical trial.</p> |
| | + | <p>One year later, we may start our phase I, II, and III clinical trials. And then, we're continually tweaking our programs based on the results of the clinical trials.</p> |
| | + | <p>Five years later, some pharmaceutical companies may prepare our test data for new drug applications to the FDA following the application procedures. At that time, our products may be used by the public.</p> |
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| − | <h2>每个章节标题用h2 为了搜索引擎全页面只能一个h1标签</h2>
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| − | <div class="column half_size">
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| − | <img src="https://static.igem.org/mediawiki/2020/8/8b/T--Fudan--map_2.svg" alt="map of calcium intake" />
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| − | </div>
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| − | <div class="column half_size">
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| − | <p>在宽屏，这部分内容占页面1/2；窄屏就是全幅。添加了column同时 图1/2 + 字1/2 正好宽屏的一幅。这个代码不在 https://2020.igem.org/Resources/Template_Documentation 但是是支持的 China has an estimated 70 million osteo
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| − | porosis patien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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| − | oporosis patienChina has an estimated 70 million osteoporosis patien</p>
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| − | <div class="clear"></div><!-- 一个章节结束需要clear来留白 -->
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| − | <h2>每个章节标题用h2 为了搜索引擎全页面只能一个h1标签</h2>
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| − | <div class="column third_size">
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| − | <img src="https://static.igem.org/mediawiki/2020/8/8b/T--Fudan--map_2.svg" alt="map of calcium intake" />
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| − | <div class="column two_thirds_size">
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| − | <p>在宽屏，这部分内容占页面1/3；窄屏就是全幅。添加了column同时 图1/3 + 字2/3 正好宽屏的一幅。 China has an estimated 70 million osteo
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| − | porosis patien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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| − | oporosis patienChina has an estimated 70 million osteoporosis patien</p>
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| − | <div class="clear"></div><!-- 一个章节结束需要clear来留白 -->
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| − | <p>However, for the Chinese population, the bottlenecks are
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| − | <li>注意这里列表的写法 页面字会变深 突出内容 ol是编数字的 nts</li>
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| − | <li>calcium-supplementing pills daste</li>
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| − | <li>The body's absorptioes as calcium intake increases</li>
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| − | <li>Vegetables conta列表的写法 页面字会变深 突出内容 ol是编数字的 ul是没有标数字的列表 </li>
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| − | However, the currently popular calcium supplement method on the market is either to adjust diet or to consume a lot of calcium supplementing pills. For the elderly, they suffer from poor memory or neglect the importance of calcium pills, often forgetting to consume the supplement; for children, they often refuse to take calcium pills or to maintain some diet high in calcium, thus requiring the "liquid calcium" method to ensure sufficient calcium intake. Ho可以 继续大段内容
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| − | <div class="highlight decoration_background decoration_A_top">
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| − | 章节内容的分段就用p开p关，额外需要关注的可以套一个highlight的框，有多种版本
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| − | 章节内容的分段就用p开p关
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| − | <div class="highlight decoration_B_full">
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| − | 章节内容的分段就用p开p关，额外需要关注的可以套一个highlight的框，细看 https://2020.igem.org/Resources/Template_Documentation#highlight
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| − | 章节内容的分段就用p开p关
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| − | 章节内容的分段就用p开p关 <a href="https://URL"> EXAM 外部链接 href尽量使用https </a>
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| − | <li>注意这里列表的写法 页面字会变深 突出内容 ul是没有标数字的列表 nts</li>
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| − | <li>calcium-supple menting pills don’t haat taste</li>
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| − | <li>Vegetables conta列表的写法 页面字会变深 突出内容 ol是编数字的 ul是没有标数字的列表 </li>
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| − | <p>
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| − | 章节内容的分段就用p开p关
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| − | </div><!-- 每个幅面结束都需要 关div -->
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| − | <div class="clear extra_space"></div><!-- 一个章节结束需要clear来留白 如果觉得内容间差异大再加上extra_space -->
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| − | <h2>又来个章节 sis</h2>
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| − | <div class="column full_size">
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| − | <p>引入文字 ion.</p>
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| − | <p>Firstly, the product is designed for oral use and our target user is the elderly. 英文分项不需要ol或ul</p>
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| − | <ol>
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| − | <li>The produc</li>
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| − | <li>The short pep</li>
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| − | <li>The expression level of short peptides has a threshold, preventing any excessive calcium absorption that might lead to hypercalcemia 注意句子超长后的回折</li>
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| − | <li>There is a kill swit.</li>
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| − | Based on relevant research, the product is exp 章节内分段 ina. tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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| − | oporosis patienChina has an estimated 70 million osteoporosis pat
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| − | </p>
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| − | <p>Compared w 章节内分段 ique advantages tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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| − | oporosis patienChina has an estimated 70 million osteoporosis pat tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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| − | oporosis patienChina has an estimated 70 million osteoporosis pat tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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| − | oporosis patienChina has an estimated 70 million osteoporosis pat.
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| − | <th> Header 1 这是igem hq的表格的写法 </th> <th> Header 2 </th>
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| − | <td> Content A 1 </td> <td> Content B 1 </td>
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| − | <td> Content A 2 </td> <td> Content B 2 这是igem hq的表格的写法。表格都需要说明，之前之后都会有p来文字 </td>
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| − | <p></p><!-- 无文字p是换行隔开，在关闭的html元素间回车是没有用的 -->
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| − | <table class="striped"><!-- 这是另一个版本的表格，间隔行有阴影。一个页面不建议交叉两种格式。太宽表格可以加 responsive-table 方便窄屏 -->
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| − | <th>Name</th> <th>Item Name</th> <th>Item Price</th>
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| − | <td>Alvin</td> <td>Eclair</td> <td>$0.87</td>
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| − | <td>Alan</td> <td>Jellybean</td> <td>$3.76</td>
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| − | <td>Jonathan</td> <td>Lollipop</td> <td>$7.00</td>
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| − | <p>Calciu 章节内分段 fety. tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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| − | oporosis patienChina has an estima
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| − | ted 70 million osteoporosis pat tien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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| − | oporosis patienChina has an estimated 70 mill
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| − | ion osteoporosis pattien China has an estimated 70 million osteoporosis patien China has an estimated 70 million osteoporosis patienChina has an estimated 70 million oste
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| − | oporosis patienChina has an estimated 70 million osteoporosis pat
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| − | <p>From the us 章节内分段 etition.</p>
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| − | <div class="clear"></div><!-- 一个章节结束需要clear来留白 -->
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| − | <h2>再来例子 Market Analysis</h2>
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| − | <p>文本在左侧一半，宽屏 According to the Chinese Dietetic Sociietary Nutrient Intakes of Chinese Residents", the calcium requirement for infants and young children increases with age, from 300mg/day to 800mg/day, and the calcium requirement for adolescents reaches 1000mg/day. The amof the required intake, with the small exception of some coastal and pastoral areas 图片在右侧一半</p>
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| − | <th> 这是igem hq的表格的写法 </th> <th> Header 2 </th> <th> Header 3 </th>
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| − | <td> Content A 1 </td> <td> Content B 1 </td> <td> Content C 1 </td>
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| − | <td colspan=2> 列融合 </td> <td> Content C 2 这是igem hq的表格的写法。半幅或者2/3幅可以用。<br/>行融合<br/>就<br/>用br了 </td>
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| − | <img src="https://static.igem.org/mediawiki/2020/0/00/T--Fudan--calcium_intake_graph.svg" alt="calcium intake graph">
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