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− | <h1>This is how we converted our idea into a product.</h1> | + | <h1 tabIndex="1">This is how we converted our idea into a product.</h1> |
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| <p>Our project aims at converting engineered probiotic under current research | | <p>Our project aims at converting engineered probiotic under current research |
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| <h2> Background & Bottleneck:</h2> | | <h2> Background & Bottleneck:</h2> |
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− | <h2 style="margin-top:0px;text-align:center;">"Seniors’ bone health matters to all members of society."</h2> | + | <h4 style="margin:0 auto;text-align:center;">Seniors’ bone health matters to all members of society.</h4> |
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| <p> Nana fractured her hips at the age of 81. She had a hip replacement surgery at the doctor’s recommendation. But everything has changed. Her six children first took turns to take care of her but soon found the amount of work overwhelming. Complaints were bubbling in each family. The siblings eventually pitched in to hire a full-time nurse to stay with her 24/7 as Chinese families and the seniors themselves almost always prefer staying home for cultural and financial reasons. Grandchildren found Nana’s temper starting to deteriorate along with her appetite. They found a big chunk of their lives missing when no one could pick them up after school or check their homework. </p> | | <p> Nana fractured her hips at the age of 81. She had a hip replacement surgery at the doctor’s recommendation. But everything has changed. Her six children first took turns to take care of her but soon found the amount of work overwhelming. Complaints were bubbling in each family. The siblings eventually pitched in to hire a full-time nurse to stay with her 24/7 as Chinese families and the seniors themselves almost always prefer staying home for cultural and financial reasons. Grandchildren found Nana’s temper starting to deteriorate along with her appetite. They found a big chunk of their lives missing when no one could pick them up after school or check their homework. </p> |
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| <p>This mirrors what is happening in families across China. China has an estimated 70 million osteoporosis patients as of 2006 and more than 200 million people with lost bone mass.<sup>[1]</sup> | | <p>This mirrors what is happening in families across China. China has an estimated 70 million osteoporosis patients as of 2006 and more than 200 million people with lost bone mass.<sup>[1]</sup> |
| Seniors are vital cogs in a thriving society, and deteriorating quality of life is just a small consequence of fractured bones: working adults will experience immediate emotional, physical and financial burden, children will lose companionship, family activities start to become inconvenient. <span><b>In short, seniors’ bone health matters to all members of the society.</b></span></p> | | Seniors are vital cogs in a thriving society, and deteriorating quality of life is just a small consequence of fractured bones: working adults will experience immediate emotional, physical and financial burden, children will lose companionship, family activities start to become inconvenient. <span><b>In short, seniors’ bone health matters to all members of the society.</b></span></p> |
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| <p> Despite the lack of recent epidemiological data, it is estimated that the number of those with osteoporosis and loss of bone mass in China has far exceeded the above figures. Calcium intake is a relatively good way to relieve the symptoms of osteoporosis. At the same time, children and the pregnant population also require a significant amount of calcium supplements. However, for the Chinese population, the bottlenecks are as follows: | | <p> Despite the lack of recent epidemiological data, it is estimated that the number of those with osteoporosis and loss of bone mass in China has far exceeded the above figures. Calcium intake is a relatively good way to relieve the symptoms of osteoporosis. At the same time, children and the pregnant population also require a significant amount of calcium supplements. However, for the Chinese population, the bottlenecks are as follows: |
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| <h2> Market analysis </h2> | | <h2> Market analysis </h2> |
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− | <h2 style="margin-top:0px;text-align:center;">“The national calcium market will reach 20 billion in 2020.”</h2> | + | <h4 style="margin:0 auto;text-align:center;">The national calcium market will reach 20 billion in 2020.</h4> |
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| <p> The Chinese Dietetic Society states that calcium requirements for infants and young children increase with age, from 300mg/day to 800mg/day, and calcium requirement for adolescents reaches 1000mg/day. The amount of calcium adults require is 800mg/day. For those over 50 years of age, this figure reaches 1000mg/day.<sup>[2]</sup> The amount of calcium required by pregnant women and breastfeeding also increases accordingly. However, several nationwide nutrition surveys have shown that residents' calcium intake in most areas of China is highly insufficient, only meeting about half of the required intake, with the small exception of some coastal and pastoral areas (Figure 1).<sup>[3]</sup></p> | | <p> The Chinese Dietetic Society states that calcium requirements for infants and young children increase with age, from 300mg/day to 800mg/day, and calcium requirement for adolescents reaches 1000mg/day. The amount of calcium adults require is 800mg/day. For those over 50 years of age, this figure reaches 1000mg/day.<sup>[2]</sup> The amount of calcium required by pregnant women and breastfeeding also increases accordingly. However, several nationwide nutrition surveys have shown that residents' calcium intake in most areas of China is highly insufficient, only meeting about half of the required intake, with the small exception of some coastal and pastoral areas (Figure 1).<sup>[3]</sup></p> |
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| <p>The target user of our product is the elderly group. The reason why the elderly need calcium is mainly due to changes in hormone levels when they age. The elderly with calcium deficiency are prone to osteoporosis, increasing the risk of fractures. Globally, more than 200 million are diagnosed with osteoporosis, and Asia has a high incidence rate of osteoporosis. <span><b>In China alone, about 70 million people over 50 years of age suffer from osteoporosis, and those in their 40’s are also at great risks.</b></span><sup>[1]</sup> In response, the "Healthy China 2030" Planning Outline launches a special action titled "healthy bones". This will not only urge the society to pay more attention to bone health, but also means drastic growth of the calcium market. Relevant research estimates that <span><b>the national calcium market will reach 20 billion in 2020.</b></span><sup>[3]</sup> Fast-growing demand combined with favorable economic policies equates to a booming market for us to explore.</p> | | <p>The target user of our product is the elderly group. The reason why the elderly need calcium is mainly due to changes in hormone levels when they age. The elderly with calcium deficiency are prone to osteoporosis, increasing the risk of fractures. Globally, more than 200 million are diagnosed with osteoporosis, and Asia has a high incidence rate of osteoporosis. <span><b>In China alone, about 70 million people over 50 years of age suffer from osteoporosis, and those in their 40’s are also at great risks.</b></span><sup>[1]</sup> In response, the "Healthy China 2030" Planning Outline launches a special action titled "healthy bones". This will not only urge the society to pay more attention to bone health, but also means drastic growth of the calcium market. Relevant research estimates that <span><b>the national calcium market will reach 20 billion in 2020.</b></span><sup>[3]</sup> Fast-growing demand combined with favorable economic policies equates to a booming market for us to explore.</p> |
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| <p> According to our survey, most consumers are using some sort of calcium supplement product. 37% of the respondents personally know over three seniors who experienced falls and fractures, 41% know one to three seniors with described conditions. This further proves that seniors' bone health is a growing issue in our society. The results of another survey showed that the main factors consumers consider when purchasing calcium supplements are: product effectiveness (58.8%); product quality (51.5%); calcium absorption rate (47.8%); price (45.8%) and brand (28.3%). This indicates that a large amount of consumers value effectiveness and quality of the products over price. This means that we have a large potential market in China.</p> | | <p> According to our survey, most consumers are using some sort of calcium supplement product. 37% of the respondents personally know over three seniors who experienced falls and fractures, 41% know one to three seniors with described conditions. This further proves that seniors' bone health is a growing issue in our society. The results of another survey showed that the main factors consumers consider when purchasing calcium supplements are: product effectiveness (58.8%); product quality (51.5%); calcium absorption rate (47.8%); price (45.8%) and brand (28.3%). This indicates that a large amount of consumers value effectiveness and quality of the products over price. This means that we have a large potential market in China.</p> |
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− | <img src="https://static.igem.org/mediawiki/2020/2/24/T--Fudan--entre_stat1.svg" alt=" figure” /> | + | <h6>Figure 1. Actual vs. recommended monthly calcium intake</h6> |
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− | <i>Figure 1. Actual vs. recommended monthly calcium intake</i> | + | |
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| <h2> Product Analysis </h2> | | <h2> Product Analysis </h2> |
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| <p> Our product is a genetically engineered probiotic that can colonize the intestine and secrete a short peptide. This short peptide increases the amount of soluble calcium by binding to calcium ions, thus increasing the absorption rate of calcium in the intestine and achieving calcium supplementation.</p> | | <p> Our product is a genetically engineered probiotic that can colonize the intestine and secrete a short peptide. This short peptide increases the amount of soluble calcium by binding to calcium ions, thus increasing the absorption rate of calcium in the intestine and achieving calcium supplementation.</p> |
| <p> Firstly, the product is designed for oral use, and our main target user is the elderly. We worked to a great extent to ensure the safety of our product:</p> | | <p> Firstly, the product is designed for oral use, and our main target user is the elderly. We worked to a great extent to ensure the safety of our product:</p> |
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| <li> There is a kill switch in the probiotic, and the probiotic will commit suicide upon leaving the human intestinal environment.</li> | | <li> There is a kill switch in the probiotic, and the probiotic will commit suicide upon leaving the human intestinal environment.</li> |
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| <p> It is expected that our product can increase calcium absorption to over 90%. In this case, the daily calcium absorption of the elderly can reach the level recommended by the Nutrition Society in China.</p> | | <p> It is expected that our product can increase calcium absorption to over 90%. In this case, the daily calcium absorption of the elderly can reach the level recommended by the Nutrition Society in China.</p> |
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− | <h2 style="margin-top:0px;text-align:center;">"Compared with other calcium supplement products such as calcium pills, our product has its unique advantages."</h2> | + | <h4 style="margin:0 auto;text-align:center;">Compared with other calcium supplement products such as calcium pills, our product has its unique advantages.</h4> |
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| <p> Calcium pills are still exogenous calcium supplements. The amounts of calcium absorbed from calcium pills differ amongst individuals, making it challenging to ensure the effectiveness of calcium supplementation, and there is a risk of excessive calcium supplementation. Our product takes into account the dietary habits of Chinese people, calculates the amount of calcium absorption required, and sets an absorption threshold value to ensure sufficient calcium absorption while ensuring safety.</p> | | <p> Calcium pills are still exogenous calcium supplements. The amounts of calcium absorbed from calcium pills differ amongst individuals, making it challenging to ensure the effectiveness of calcium supplementation, and there is a risk of excessive calcium supplementation. Our product takes into account the dietary habits of Chinese people, calculates the amount of calcium absorption required, and sets an absorption threshold value to ensure sufficient calcium absorption while ensuring safety.</p> |
| <p> From the user’s perspective, calcium pills need to be taken daily, which is very inconvenient for the elderly who need regular calcium supplementation. At the same time, the experience of consuming many calcium pills is not great; our probiotic colonizes the intestines and functions within it, meaning that our product has a long-term effect. In theory, the product will always be effective as long as the intestinal flora is stable. Therefore, our product has a great advantage for the elderly population and stands out from market competition. A more detailed competitiveness comparison is demonstrated in this figure. It's easy to tell that our product has its unique advantages.</p> | | <p> From the user’s perspective, calcium pills need to be taken daily, which is very inconvenient for the elderly who need regular calcium supplementation. At the same time, the experience of consuming many calcium pills is not great; our probiotic colonizes the intestines and functions within it, meaning that our product has a long-term effect. In theory, the product will always be effective as long as the intestinal flora is stable. Therefore, our product has a great advantage for the elderly population and stands out from market competition. A more detailed competitiveness comparison is demonstrated in this figure. It's easy to tell that our product has its unique advantages.</p> |
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| <img src="https://static.igem.org/mediawiki/2020/f/fa/T--Fudan--competition_analysis.png" alt="competitive analysis" style="width:100%"/> | | <img src="https://static.igem.org/mediawiki/2020/f/fa/T--Fudan--competition_analysis.png" alt="competitive analysis" style="width:100%"/> |
− | <i>Figure 2. Competitive analysis </i></div> | + | <h6>Figure 2. Competitive analysis</h6></div> |
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− | <p> Our products are basically positioned as probiotics health products. The relatively mature probiotics products in the market include probiotics logos, drops, powders, and capsules. | + | <p> Our products are basically positioned as probiotics health products. The relatively mature probiotics products in the market include probiotics logos, drops, powders, and capsules. |
| Among them, there are many additives in probiotics lozenges, many adhesives, sweeteners, etc. The need to warm up during the molding process will damage the activity of the probiotics. This form is highly acceptable among children, but it is not an efficient way for our target group of older people.</p> | | Among them, there are many additives in probiotics lozenges, many adhesives, sweeteners, etc. The need to warm up during the molding process will damage the activity of the probiotics. This form is highly acceptable among children, but it is not an efficient way for our target group of older people.</p> |
| <p> Probiotics drops use edible oil as a carrier to wrap probiotics with high activity. But probiotics are less stable in liquid form, and without hydrocarbons as nutrients, their activity declines. And the cost is high, low-cost performance.</p> | | <p> Probiotics drops use edible oil as a carrier to wrap probiotics with high activity. But probiotics are less stable in liquid form, and without hydrocarbons as nutrients, their activity declines. And the cost is high, low-cost performance.</p> |
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| <p> The capsule cost is related to the purchase quantity and type, which needs to be discussed and determined after forming the probiotic principle. Currently, the general price is about RMB 400/10,000</p> | | <p> The capsule cost is related to the purchase quantity and type, which needs to be discussed and determined after forming the probiotic principle. Currently, the general price is about RMB 400/10,000</p> |
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− | <img src="https://static.igem.org/mediawiki/2020/a/af/T--Fudan--swot.png" alt="swot analysis" style="width:100%"> | + | |
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| <img src="https://static.igem.org/mediawiki/2020/e/e3/T--Fudan--screenshot.png" alt="competition screenshot" /> | | <img src="https://static.igem.org/mediawiki/2020/e/e3/T--Fudan--screenshot.png" alt="competition screenshot" /> |
− | <i>Figure 3. Presentation at the Innovation Competition</i> | + | <h6>Figure 3. Presentation at the Fanhai Bei Innovation Competition</h6> |
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| <p> We investigated major manufacturers of pills in China, especially those located in the JiangZheHu area, as this is where our production will be initiated. We reached out to three factories and successfully inquired about the production costs of pill production on different scales. We also gathered more information about the cost of preparation for pill production in labs.</p> | | <p> We investigated major manufacturers of pills in China, especially those located in the JiangZheHu area, as this is where our production will be initiated. We reached out to three factories and successfully inquired about the production costs of pill production on different scales. We also gathered more information about the cost of preparation for pill production in labs.</p> |
− | <p> We later had an in-person meeting and many follow-up conversations online with several experienced investors working at RuiShi Inc. as a senior investment advisor. We pitched our polished business plan, and they expressed a very high interest in our project. They pointed out that we need to dig deeper when it comes to the current market’s “pain point” to better target our user group. They also suggested that we utilize more straightforward wording so that investors without any biology background can understand our project with ease. They recommended that we start drafting a letter of intent with investment agencies and reach out for more potential investment opportunities. They continuously expressed their excitement about our project and gave us extensive advice from a professional perspective.We consulted students from the Fudan School of Management about marketing strategies, and we shaped our business plan to effectively target the middle age and seniors.</p> | + | <p> We later had an in-person meeting and many follow-up conversations online with several experienced investors working at RuiShi Inc. as a senior investment advisor. We pitched our polished business plan, and they expressed a very high interest in our project. They pointed out that we need to dig deeper when it comes to the current market’s “pain point” to better target our user group. They also suggested that we utilize more straightforward wording so that investors without any biology background can understand our project with ease. They recommended that we start drafting a letter of intent with investment agencies and reach out for more potential investment opportunities. They continuously expressed their excitement about our project and gave us extensive advice from a professional perspective. Weconsulted students from the Fudan School of Management about marketing strategies, and we shaped our business plan to effectively target the middle age and seniors.</p> |
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− | <embed src="https://static.igem.org/mediawiki/2020/4/47/T--Fudan--letter_of_intent.pdf" width="90%" height="600px" type="application/pdf"> | + | <embed src="https://static.igem.org/mediawiki/2020/4/47/T--Fudan--letter_of_intent.pdf" width="90%" height="600px" type="application/pdf" /> |
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| + | <h6>File 1. Letter of Intent with RuiShi Inc.</h6> |
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− | <i>File 1. Letter of Intent</i>
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− | <i>File 2. Non-disclosure agreement</i>
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| + | <h6>File 2. Non-disclosure Agreement with Ruishi Inc.</h6> |
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| <h2>Timeline</h2> | | <h2>Timeline</h2> |
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| <h2>Reference</h2> | | <h2>Reference</h2> |
− | <p>[1] Weibo Xia, et al."Guidelines for diagnosis and treatment of primary osteoporosis(2017)." Chinese Journal of Osteoporosis 25.03(2019):281-309. doi:. (Chinese)</br> | + | <div class="column full_size"> |
− | [2]."Chinese residents' dietary nutrient reference intake industry standard released." China School Health 38.11(2017):1717. doi:. (Chinese)</br> | + | <p>[1] Weibo Xia, et al. "Guidelines for diagnosis and treatment of primary osteoporosis(2017)." Chinese Journal of Osteoporosis 25.03(2019):281-309. (Chinese)<br/> |
− | [3] ."Research Report of China's Calcium Supplement Industry in-depth Investigation and Investment Prospect Forecast 2020-2025." Chinese Research Institute (2019). doi:. (Chinese)</br> | + | [2] "Chinese residents' dietary nutrient reference intake industry standard released." China School Health 38.11(2017):1717. (Chinese)<br/> |
| + | [3] "Research Report of China's Calcium Supplement Industry in-depth Investigation and Investment Prospect Forecast 2020-2025." Chinese Research Institute (2019). (Chinese)<br/> |
| </p> | | </p> |
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| <div class="column full_size"><div id="FudanSignature"> | | <div class="column full_size"><div id="FudanSignature"> |
| <p>Signature: <a href="/Team:Fudan/Attributions#MoEmily" class="z-depth-2">Emily</a> | | <p>Signature: <a href="/Team:Fudan/Attributions#MoEmily" class="z-depth-2">Emily</a> |
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| <a href="http://www.yfc.cn/" target="_blank"><img class="col s3 m6 l4 FudanSponsors" alt="Yunfeng Capital" src="https://static.igem.org/mediawiki/2020/b/ba/T--Fudan--YFcapital.svg"> </a> | | <a href="http://www.yfc.cn/" target="_blank"><img class="col s3 m6 l4 FudanSponsors" alt="Yunfeng Capital" src="https://static.igem.org/mediawiki/2020/b/ba/T--Fudan--YFcapital.svg"> </a> |
| <a href="http://www.fudan.edu.cn/en/" target="_blank"><img alt="Fudan University" class="col s3 m6 l4 FudanSponsors" src="https://static.igem.org/mediawiki/2020/9/9d/T--Fudan--sponsor2.svg"> </a> | | <a href="http://www.fudan.edu.cn/en/" target="_blank"><img alt="Fudan University" class="col s3 m6 l4 FudanSponsors" src="https://static.igem.org/mediawiki/2020/9/9d/T--Fudan--sponsor2.svg"> </a> |
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− | <span><a href="/Team:Fudan/Description#Project">Project</a></span> | + | <span tabIndex="2"><a href="/Team:Fudan/Description#Project">Project</a></span> |
| <ul><li><a href="/Team:Fudan/Description">Description</a></li> | | <ul><li><a href="/Team:Fudan/Description">Description</a></li> |
| <li><a href="/Team:Fudan/Sustainable">Sustainable</a></li> | | <li><a href="/Team:Fudan/Sustainable">Sustainable</a></li> |
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− | <span><a href="/Team:Fudan/Notebook">Notebook</a></span> | + | <span tabIndex="3"><a href="/Team:Fudan/Notebook">Notebook</a></span> |
| <ul><li><a href="/Team:Fudan/Safety">Safety</a></li> | | <ul><li><a href="/Team:Fudan/Safety">Safety</a></li> |
| <li><a href="/Team:Fudan/Poster">Poster</a></li> | | <li><a href="/Team:Fudan/Poster">Poster</a></li> |
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| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Results">Results</a></span> | + | <span tabIndex="4"><a href="/Team:Fudan/Results">Results</a></span> |
| <ul><li><a href="/Team:Fudan/Contribution">Contribution</a></li><!-- replace Judging --> | | <ul><li><a href="/Team:Fudan/Contribution">Contribution</a></li><!-- replace Judging --> |
| <li><a href="/Team:Fudan/Implementation">Implementation</a></li> | | <li><a href="/Team:Fudan/Implementation">Implementation</a></li> |
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| <div class="col s12 l6 row"> | | <div class="col s12 l6 row"> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Parts">Parts</a></span> | + | <span tabIndex="5"><a href="/Team:Fudan/Parts">Parts</a></span> |
| <ul><li><a href="/Team:Fudan/Parts#Basic">Basic part</a></li> | | <ul><li><a href="/Team:Fudan/Parts#Basic">Basic part</a></li> |
| <li><a href="/Team:Fudan/Parts#Composite">Composite part</a></li> | | <li><a href="/Team:Fudan/Parts#Composite">Composite part</a></li> |
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| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Human_Practices">Outreach</a></span> | + | <span tabIndex="6"><a href="/Team:Fudan/Human_Practices">Outreach</a></span> |
| <ul><li><a href="/Team:Fudan/Human_Practices#Integrated">Integrated HP</a></li> | | <ul><li><a href="/Team:Fudan/Human_Practices#Integrated">Integrated HP</a></li> |
| <li><a href="/Team:Fudan/Education">Education</a></li> | | <li><a href="/Team:Fudan/Education">Education</a></li> |
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| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Team">Team</a></span> | + | <span tabIndex="7"><a href="/Team:Fudan/Team">Team</a></span> |
| <ul><li><a href="/Team:Fudan/Team">Members</a></li> | | <ul><li><a href="/Team:Fudan/Team">Members</a></li> |
| <li><a href="/Team:Fudan/Attributions">Attributions</a></li> | | <li><a href="/Team:Fudan/Attributions">Attributions</a></li> |
| <li><a href="/Team:Fudan/Partnership">Partnership</a></li> | | <li><a href="/Team:Fudan/Partnership">Partnership</a></li> |
| <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li> | | <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li> |
− | <li><a href="https://2019.igem.org/Team:Fudan-TSI/Heritage" target="_blank">Heritage</a></li> | + | <li><a href="/Team:Fudan/Heritage">Heritage</a></li> |
| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> </div> | | <div class="col s12 m4"> </div> |