|
|
Line 1: |
Line 1: |
| {{IGEM_TopBar}} | | {{IGEM_TopBar}} |
| {{Fudan}} | | {{Fudan}} |
− | <html> | + | <html> |
| <link rel="stylesheet" href="/wiki/index.php?title=Template:Fudan/materialize.min.css&action=raw&ctype=text/css"> | | <link rel="stylesheet" href="/wiki/index.php?title=Template:Fudan/materialize.min.css&action=raw&ctype=text/css"> |
| <style> | | <style> |
Line 221: |
Line 221: |
| html代码不在乎多个空格,仅显示一个 | | html代码不在乎多个空格,仅显示一个 |
| --> | | --> |
− | <h1>Make calcium supplements sustainable</h1> | + | <h1 tabIndex="1">Make calcium supplements sustainable</h1> |
| | | |
| <div class="column full_size"> | | <div class="column full_size"> |
| | | |
− | <p>In Asia, many old people suffer from insufficient calcium intake and related diseases such as osteoporosis. Considering that traditional calcium supplementation is not efficient and user-friendly enough, we intended to develop a kind of engineered bacteria based on <i>E. coli</i> that can colonize in the human intestine and secrete peptides to promote calcium absorption. We introduced the quorum sensing system to colonize bacteria in the intestine. Once the bacteria have successfully colonized the intestinal tract, the luxpR promoter will be activated and a series of short peptides that can bind to calcium and promote calcium absorption of intestinal epithelial cells will be expressed. A kill switch is added accordingly for safety. Our project provides a novel delivery method to provide calcium supplements sustainably. And we are actively seeking commercialization possibilities to expand our project impact, to reach more population, for the elderly’s good health and well-being.</p> | + | <p>In Asia, many old people suffer from insufficient calcium intake and related diseases such as osteoporosis. Considering that traditional calcium supplementation is not efficient and user-friendly enough, we intended to develop a kind of engineered bacteria based on <i>E. coli</i> that can colonize in the human intestine and secrete peptides to promote calcium absorption. We introduced the quorum sensing system to colonize bacteria in the intestine. Once the bacteria have successfully colonized the intestinal tract, the luxPR promoter will be activated and a series of short peptides that can bind to calcium and promote calcium absorption of intestinal epithelial cells will be expressed. A kill switch is added accordingly for safety. Our project provides a novel delivery method to provide calcium supplements sustainably. And we are actively seeking commercialization possibilities to expand our project impact, to reach more population, for the elderly’s good health and well-being.</p> |
| </div> | | </div> |
| <div class="clear"></div><!-- 一个章节结束需要clear来留白 如果觉得内容间差异大再加上extra_space --> | | <div class="clear"></div><!-- 一个章节结束需要clear来留白 如果觉得内容间差异大再加上extra_space --> |
Line 237: |
Line 237: |
| <p id="Project">At present, there are good medical treatments for osteoporosis, but there is still a big gap in preventing calcium deficiency in the elderly. The existing calcium supplement products still have disadvantages such as low absorption rate, poor user experience, and easy to miss taking. So we want to add a new and convenient daily calcium supplement for the elderly to achieve sustainable calcium supplementation and improve the quality of life and health of the elderly. That's where our project came from.</p > | | <p id="Project">At present, there are good medical treatments for osteoporosis, but there is still a big gap in preventing calcium deficiency in the elderly. The existing calcium supplement products still have disadvantages such as low absorption rate, poor user experience, and easy to miss taking. So we want to add a new and convenient daily calcium supplement for the elderly to achieve sustainable calcium supplementation and improve the quality of life and health of the elderly. That's where our project came from.</p > |
| </div> | | </div> |
− | <div class="clear"></div><!-- 一个章节结束需要clear来留白 -->
| |
− |
| |
− |
| |
− |
| |
| | | |
| <div class="clear"></div><!-- 一个章节结束需要clear来留白 --> | | <div class="clear"></div><!-- 一个章节结束需要clear来留白 --> |
| | | |
− |
| |
| <div class="column full_size"><div id="FudanSignature"> | | <div class="column full_size"><div id="FudanSignature"> |
| <p>Signature: <a href="/Team:Fudan/Attributions#TianSZ" class="z-depth-2">Shizheng</a> | | <p>Signature: <a href="/Team:Fudan/Attributions#TianSZ" class="z-depth-2">Shizheng</a> |
Line 262: |
Line 257: |
| <div class="container"><div class="row"> | | <div class="container"><div class="row"> |
| <div class="col m3 s12 row" | | <div class="col m3 s12 row" |
− | style="margin-top:4rem" > | + | style="margin-top:4rem" tabIndex="0" > |
| <a href="http://www.yfc.cn/" target="_blank"><img class="col s3 m6 l4 FudanSponsors" alt="Yunfeng Capital" src="https://static.igem.org/mediawiki/2020/b/ba/T--Fudan--YFcapital.svg"> </a> | | <a href="http://www.yfc.cn/" target="_blank"><img class="col s3 m6 l4 FudanSponsors" alt="Yunfeng Capital" src="https://static.igem.org/mediawiki/2020/b/ba/T--Fudan--YFcapital.svg"> </a> |
| <a href="http://www.fudan.edu.cn/en/" target="_blank"><img alt="Fudan University" class="col s3 m6 l4 FudanSponsors" src="https://static.igem.org/mediawiki/2020/9/9d/T--Fudan--sponsor2.svg"> </a> | | <a href="http://www.fudan.edu.cn/en/" target="_blank"><img alt="Fudan University" class="col s3 m6 l4 FudanSponsors" src="https://static.igem.org/mediawiki/2020/9/9d/T--Fudan--sponsor2.svg"> </a> |
Line 272: |
Line 267: |
| <div class="col s12 l6 row"> | | <div class="col s12 l6 row"> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Description#Project">Project</a></span> | + | <span tabIndex="2"><a href="/Team:Fudan/Description#Project">Project</a></span> |
| <ul><li><a href="/Team:Fudan/Description">Description</a></li> | | <ul><li><a href="/Team:Fudan/Description">Description</a></li> |
| <li><a href="/Team:Fudan/Sustainable">Sustainable</a></li> | | <li><a href="/Team:Fudan/Sustainable">Sustainable</a></li> |
Line 280: |
Line 275: |
| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Notebook">Notebook</a></span> | + | <span tabIndex="3"><a href="/Team:Fudan/Notebook">Notebook</a></span> |
| <ul><li><a href="/Team:Fudan/Safety">Safety</a></li> | | <ul><li><a href="/Team:Fudan/Safety">Safety</a></li> |
| <li><a href="/Team:Fudan/Poster">Poster</a></li> | | <li><a href="/Team:Fudan/Poster">Poster</a></li> |
Line 288: |
Line 283: |
| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Results">Results</a></span> | + | <span tabIndex="4"><a href="/Team:Fudan/Results">Results</a></span> |
| <ul><li><a href="/Team:Fudan/Contribution">Contribution</a></li><!-- replace Judging --> | | <ul><li><a href="/Team:Fudan/Contribution">Contribution</a></li><!-- replace Judging --> |
| <li><a href="/Team:Fudan/Implementation">Implementation</a></li> | | <li><a href="/Team:Fudan/Implementation">Implementation</a></li> |
Line 298: |
Line 293: |
| <div class="col s12 l6 row"> | | <div class="col s12 l6 row"> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Parts">Parts</a></span> | + | <span tabIndex="5"><a href="/Team:Fudan/Parts">Parts</a></span> |
| <ul><li><a href="/Team:Fudan/Parts#Basic">Basic part</a></li> | | <ul><li><a href="/Team:Fudan/Parts#Basic">Basic part</a></li> |
| <li><a href="/Team:Fudan/Parts#Composite">Composite part</a></li> | | <li><a href="/Team:Fudan/Parts#Composite">Composite part</a></li> |
Line 305: |
Line 300: |
| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Human_Practices">Outreach</a></span> | + | <span tabIndex="6"><a href="/Team:Fudan/Human_Practices">Outreach</a></span> |
| <ul><li><a href="/Team:Fudan/Human_Practices#Integrated">Integrated HP</a></li> | | <ul><li><a href="/Team:Fudan/Human_Practices#Integrated">Integrated HP</a></li> |
| <li><a href="/Team:Fudan/Education">Education</a></li> | | <li><a href="/Team:Fudan/Education">Education</a></li> |
Line 312: |
Line 307: |
| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> | | <div class="col s12 m4"> |
− | <span><a href="/Team:Fudan/Team">Team</a></span> | + | <span tabIndex="7"><a href="/Team:Fudan/Team">Team</a></span> |
| <ul><li><a href="/Team:Fudan/Team">Members</a></li> | | <ul><li><a href="/Team:Fudan/Team">Members</a></li> |
| <li><a href="/Team:Fudan/Attributions">Attributions</a></li> | | <li><a href="/Team:Fudan/Attributions">Attributions</a></li> |
| <li><a href="/Team:Fudan/Partnership">Partnership</a></li> | | <li><a href="/Team:Fudan/Partnership">Partnership</a></li> |
| <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li> | | <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li> |
− | <li><a href="https://2019.igem.org/Team:Fudan-TSI/Heritage" target="_blank">Heritage</a></li> | + | <li><a href="/Team:Fudan/Heritage">Heritage</a></li> |
| </ul></div> | | </ul></div> |
| <div class="col s12 m4"> </div> | | <div class="col s12 m4"> </div> |