Neo-Epitope Discovery for DNA-launched RNA Replicons:
Paving The Way To Effcient Breast Cancer
breas cancer is one of the mos aggressive breas cancer subtypes.
It is characterized by a generally poor prognosis and srong resisance to traditional therapies.
In the frs Phase of our project, we focused on designing a novel immunotherapeutic approach using
DNA-launched RNA Replicons (DREP).
We utilized our hotspot detection tool, “Cusommune”, to generate a lis of candidate
neo-epitopes, validated them in silico, modeled the behavior of our suggesed circuits
and optimized them to ensure maximal safety and efcacy.