Team:NAU-CHINA/Model

All models are wrong, but some are useful.

—— George Box

INTRODUCTION

As synthetic biology continues to inject momentum into biomedical, biotechnology, and basic molecular research, mathematical model plays an increasingly important role as a tool. It makes significant sense in quantitative prediction and interpretation of data, as well as guiding the design of artificial systems.

Kill Switch Model

To guide kill switch module design, ensuring the feasibility of kill switch, we established Kill Switch Model according to inhibition principle of CI protein and binding principle of Trigger and Toehold Switch. Through using differential equations, adjusting the RBS and degradation rates of CI protein, we obtained rational combinations enabling kill switch to work. Our model can be extended to analyze other kinds of kill switches by revising our model based on their own conditions.

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Cellular Automaton Model

To provide guidance for earthworm release strategy of our project, we constructed Cellular Automaton Model according to evolution rule. Through the simulation of cellular automaton, we got some results of different release strategies, and then gave feedback on earthworm releasing. Our model, focusing on migration of small soil animals, is an extension of our team's model in last year which was about flying insects in the air.

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