Team:NJMU-China

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the NJMU's perfect project

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About our project

We are the NJMU iGEM team.

After being bitten by an infected tick, it is necessary to start treatment as quickly as you can.The project that we decided to create is associated with ticks, which are carriers of various diseases that have serious consequences, for example, borreliosis. Ticks are very common in Russia, as well as in general in the middle zone of Eurasia.

Bioinformatics


The first part of the LymeExpress project is Bioinformatics.

It consists of searching for the conserved genome regions between different species of Borrelia and metagenomic analysis of the Ixodes microbiome for possible interference with the biosensor targets from Borrelia sp. Then the molecular type of biosensor targets will be provided.

Biosensor Development

In this part of the project the targeting system (CRISPR-Cas)

In parallel, computer modeling of the biosensor work will be carried out. This step also contains quality check and testing.

Device development

The last step

of LymeExpress project creating a portable spectrophotometer.Then combination of the biosensor and device will be checked and tested.

Project Inspiration and Description

Not Evolved,
not transformed either.

Each year around 500,000 Lyme disease cases caused by tick-borne Borrelia spp. are reported worldwide. Prompt detection of Borrelia infection is crucial for effective treatment. Quick point-of-care detection of the pathogens in an extracted tick is therefore important.

Statistics

Lyme Borreliosis is
the most common tick-borne disease

in both North America and northern Eurasia (Jones, 2009; Nelson et al., 2015). The risk areas coincide with the habitats of the vectors, ticks of Ixodes ricinus species complex (Stanek et al., 2012)⁠.

Wet lab

basis of the biosensor
not transformed either.

we performed a series of ‘wet’ laboratory experiments. We focused on working with split β-lactamase fused with dCas9 from Streptococcus pyogenes.

All-Old Techniques

Not Evolved,
not transformed either.

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All-Old Techniques

Not Evolved,
not transformed either.

Lorem ipsum, dolor sit amet consectetur adipisicing elit. Laborum nisi illum rem recusandae. Tempore consequuntur nihil cumque quis nam deserunt earum atque et ullam facere accusamus cum natus, autem numquam.

24 July 2020
Our Team
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26 December 2019
Our project
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20 August 2020
Our Model
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