Authors: Aje Al-Awssi, David Nørgaard Essenbæk, Emil Funk Vangsgaard, Endre Lindhardt Garberg, Ignacio Pardo Casado, Jan Weicher, Shivani Pradeep Karnik, Victoria Thusgaard Ruhoff & Vit Zemanek
Chronic Inflammatory Diseases (CIDs) are debilitating diseases affecting millions of people worldwide. Optimal treatment requires constant monitoring, but current testing methods are invasive, time-consuming, and costly. CIDosis strives to change this with a non-invasive patch for self-monitoring. Backed by extensive computer modeling, we are developing a biosensor that continuously collects sweat from the skin, and produces a color reflecting the level of inflammation. The biosensor in our patch is based on Saccharomyces cerevisiae cells equipped with interleukin-specific receptors that will associate in the presence of interleukins, resulting in the intracellular complementation of a split protein. A transduction pathway is then triggered, leading to the production of a color, whose intensity is logged by an app and shared with a medical professional. By integrating the wishes of patients living with CIDs, as well as experts within these fields, CIDosis brings a next generation tool to improve patient quality of life.