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Revision as of 09:57, 23 October 2020

Description Design Implementation Poster
Engineering Success Modeling/Simulation Parts Overview Results Protocols Notebook Safety
Integrated Human Practices Entrepreneurship Education
Collaborations Partnership Our Contribution
Judging Form Medals
Team Members Attributions Sponsors

Partnership

Intro

“Early on in our iGEM journey we discovered that Aalto-helsinki was working on a biosensor project, just as us. Initial conversations lead to the discovery of shared goals between our teams -mainly our wish to develop comprehensive ODE modelling and incorporate ethical considerations in our project work. Our dry-lab collaboration soon proved beneficial for our teams, and this lead to a partnership throughout the season eventually extending to human practice collaborations as well.The professional (and social) exchange has not only provided us with directly useful ideas and trouble-shooting, but inspired us throughout our whole process to be open minded and think critically about our models and assumptions. It has help us understand how to communicate our project in various levels of details and convey our ideas successfully. We are extremely happy to have had the pleasure of working with Aalto-Helsinki!

Dry lab timeline

1st meeting

On 14th May we talked with Aalto-Helsinki for the first time (it was during a coffee hour organized by us via zoom). We thought there might be some space for collaboration in the future and so we agreed on staying in touch.

2nd meeting

In June we decided it was time to see how the projects were going and we initiated electronic correspondence concerning viability of dry-lab collaboration. Aalto was positive and we informed each other about modeling prospects.This led to a first meeting on June 16th, focused solely on the dry lab. We discussed our projects, designs, modeling ambitions. Aalto told us about their intentions with Rosetta which positively influenced our own project development. We agreed that maintaining mutual collaboration and planning more meetings makes sense for both teams.

3rd meeting

As agreed, both teams shared their current models in July and played around with the models of the other team. To talk more in depth, we scheduled another meeting on 4th August. This was a nice, dense meeting where both parties exchanged lots of great suggestions, tips and tricks. Major areas to improve included descriptions, comments and graphs, but also addressing shortcomings of current models.

4th meeting

During August, both teams implemented feedback they had gotten, and another meeting was scheduled for 14th September. This meeting went through in a good pace as all presented models improved greatly in quality, so that there was less trivialities to discuss. We were glad that Aalto-Helsinki discovered a bug in our code which we promptly fixed. We agreed the collaboration had been very beneficial for both teams so far. We agreed the next step will be reviewing each other’s modeling wikis.




“Since the beginning of our conversations with the Copenhagen team, we came to realize we had similar projects in mind: building biosensors to help improve life on Earth. Concretely, our main common idea was to use modelling in order to help our biosensors come true. What first started as a simple collaboration ended up being a solid partnership from which both teams have benefited a lot. This partnership started as a dry-lab partnership and further extended to a human practices partnership as well. Not only we shared thoughts about each other’s models, but we also participated in the Nordic Ethics Workshop together. We are extremely thankful for the opportunity of working with the Copenhagen team. It has helped us to be more critical with our own project and gain insights on the ideas of other teams and how other teams work. Thank you Copenhagen team for this great partnership, it has been a pleasure!” - Aalto-Helsinki 2020.

Human Practice Timeline

We knew early on that we wanted to troubleshoot the ethical aspects of our project with another iGEM team. We had already identified aspects of our project where ethical work would need to be done. However, in order to ensure that we did not have any major blindspots we contacted our dry-lab partners Aalto iGEM team in order to get an outside perspective. Aalto shared our interest in doing ethical work. After our first meeting we decided to organize a workshop focusing on ethics. In order to make the workshop as inclusive and comprehensive as possible, we decided to reach out to other iGEM teams from the nordic countries. We found out that several teams in the nordic countries was working on biosensors, so it made sense to make a workshop focusing specifically on issues pertaining to that. The workshop was held in collaboration with iGEM teams from Aalto, Stockholm and Trondheim. The guiding questions were:
how to dispose of biosensors
the risks of using GMOs
guidelines for end-users using our biosensors
Who will benefit and who might be opposed to the projects
Sustainable production of the biosensors
Public perception of GMO
The Workshop itself was very educational. The teams took turns troubleshooting the other projects.

We then had a second meeting with Aalto-Helsinki to reflect upon the workshop. In this meeting we went in depth with some prepared comments of each others projects. We had decided to mainly focus on the ethics regarding the possible environmental impact of Aalto-Helsinkis project, should they start to manufacture it. We created a framework for estimating carboon footprint and went through the estimation with calculations reflecting possible assumptions for their project.
Aalto had chosen to focus on ethics regarding our products use on humans. They had prepared many questions concerning the usability of our product and the skin-yeast interactions. This helped us improve our project presentation and collect unanswered questions.
  1. Zola H. Analysis of receptors for cytokines and growth factors in human disease. Dis Markers. 1996;12(4):225-240. doi:10.1155/1996/807021 ↩
  2. Gunde T, Barberis A. Yeast growth selection system for detecting activity and inhibition of dimerization-dependent receptor tyrosine kinase. Biotechniques. 2005;39(4):541-549. doi:10.2144/000112011↩

About us

Comprising this team are nine ambitious students from various walks of life, who have come together to produce CIDosis - a non-invasive device that can help people with chronic inflammatory diseases visualize their level of inflammation.

Helpful Links

The Team
Promotional Video
Team Poster
Achievements

Address

University of Copenhagen
Thorvaldsensvej 40, Frederiksberg C
Denmark

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