Presented by Team UCopenhagen 2020
Authors: Aje Al-Awssi, David Nørgaard Essenbæk, Emil Funk Vangsgaard, Endre Lindhardt Garberg, Ignacio Pardo Casado, Jan Weicher, Shivani Pradeep Karnik, Victoria Thusgaard Ruhoff & Vit Zemanek
Abstract
Chronic Inflammatory Diseases (CIDs) are debilitating diseases affecting millions of people worldwide. Optimal treatment requires constant monitoring, but current testing methods are invasive, time-consuming, and costly. CIDosis strives to change this with a non-invasive patch for self-monitoring. Backed by extensive computer modeling, we are developing a biosensor that continuously collects sweat from the skin, and produces a color reflecting the level of inflammation. The biosensor in our patch is based on Saccharomyces cerevisiae cells equipped with interleukin-specific receptors that will associate in the presence of interleukins, resulting in the intracellular complementation of a split protein. A transduction pathway is then triggered, leading to the production of a color, whose intensity is logged by an app and shared with a medical professional. By integrating the wishes of patients living with CIDs, as well as experts within these fields, CIDosis brings a next generation tool for patient empowerment.
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<div class="title">iGEM UCopenhagen brings you our 2020 project: CIDosis</div> | <div class="title">iGEM UCopenhagen brings you our 2020 project: CIDosis</div> | ||
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+ | Presented by Team UCopenhagen 2020 | ||
+ | <br><br> | ||
+ | <b>Authors:</b> Aje Al-Awssi, David Nørgaard Essenbæk, Emil Funk Vangsgaard, Endre Lindhardt Garberg, Ignacio Pardo Casado, Jan Weicher, Shivani Pradeep Karnik, Victoria Thusgaard Ruhoff & Vit Zemanek | ||
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+ | <br><br> | ||
+ | <b>Abstract</b> | ||
+ | <br><br> | ||
+ | Chronic Inflammatory Diseases (CIDs) are debilitating diseases affecting millions of people worldwide. Optimal treatment requires constant monitoring, but current testing methods are invasive, time-consuming, and costly. CIDosis strives to change this with a non-invasive patch for self-monitoring. Backed by extensive computer modeling, we are developing a biosensor that continuously collects sweat from the skin, and produces a color reflecting the level of inflammation. The biosensor in our patch is based on Saccharomyces cerevisiae cells equipped with interleukin-specific receptors that will associate in the presence of interleukins, resulting in the intracellular complementation of a split protein. A transduction pathway is then triggered, leading to the production of a color, whose intensity is logged by an app and shared with a medical professional. By integrating the wishes of patients living with CIDs, as well as experts within these fields, CIDosis brings a next generation tool for patient empowerment. | ||
+ | <br> | ||
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+ | <img src="https://static.igem.org/mediawiki/2020/2/26/T--UCopenhagen--Poster_Description.png"> | ||
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+ | </div> | ||
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Revision as of 09:26, 9 November 2020
Welcome to the UCopenhagen Poster Page!
This page looks a little different from the others, as here you'll find the poster we're going to be using at the Jamboree! We hope you like our blahblah for an interactive poster that almost doesn't suck
iGEM UCopenhagen brings you our 2020 project: CIDosis
Biosensor things
What inspired your team? What motivated you to work on this particular project?
Idea
How are you going to solve the problem? Where did the idea come from?
Section 1
Use this section to explain whatever you would like! Suggestions: Safety, Human Practices, Measurement, etc.
Materializing the Product
Our solution is a sweat-collecting patch that the patient can wear on the go. It consists of three layers.
- Porous nanofilm - A porous nanofilm will allow interleukins to diffuse into the patch and prevent the yeast cells from escaping the patch. This film provides safety for the users and bio-containment.
- Genetically modified yeast-based biosensor - Our yeast biosensor in dry-yeast form, ready to be activated upon contact with sweat.
- Adhesive patch - Common transparent plastic or woven fabric (such as nylon) used by bandage manufacturers.
Section 3
Use this section to explain whatever you would like! Suggestions: Safety, Human Practices, Measurement, etc.
Biosensor things
What inspired your team? What motivated you to work on this particular project?
Idea
How are you going to solve the problem? Where did the idea come from?
Biosensor things
What inspired your team? What motivated you to work on this particular project?
Idea
How are you going to solve the problem? Where did the idea come from?
References and Acknowledgements
If not already cited in other sections of your poster, what literature sources did you reference on this poster? Who helped or advised you?