Difference between revisions of "Team:UCopenhagen"
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| − | < | + | <h2 style="text-align: center;">Chronic Inflammatory Diseases</h2> |
Chronic Inflammatory Diseases (CIDs) are debilitating diseases, leaving your well-being | Chronic Inflammatory Diseases (CIDs) are debilitating diseases, leaving your well-being | ||
at the mercy of your flare-ups and remissions. Due to the complexity of these diseases, | at the mercy of your flare-ups and remissions. Due to the complexity of these diseases, | ||
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| − | < | + | <h2>Our Solution</h2> |
To supplement current testing methods, we have designed a sweat collecting patch | To supplement current testing methods, we have designed a sweat collecting patch | ||
that patients with CIDs can use to monitor their inflammation status on the go. | that patients with CIDs can use to monitor their inflammation status on the go. | ||
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| − | < | + | <h2>What does this mean for the patients?</h2> |
Our tool stands for patient empowerment. Our self-monitoring device is | Our tool stands for patient empowerment. Our self-monitoring device is | ||
suitable for home use, and does not have to interfere with patients' daily | suitable for home use, and does not have to interfere with patients' daily | ||
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| − | < | + | <h2>The Science</h2> |
Our patch will contain genetically modified yeast expressing engineered interleukin | Our patch will contain genetically modified yeast expressing engineered interleukin | ||
receptors. These interleukin receptors will bind and react to the inflammatory biomarkers (interleukins) | receptors. These interleukin receptors will bind and react to the inflammatory biomarkers (interleukins) | ||
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| − | < | + | <h2>Three Tiers of Biosensor Design</h2> |
Our scientific design has gone through many iterations, guided especially | Our scientific design has gone through many iterations, guided especially | ||
by our human practices and dry lab findings. Through our engineering work, | by our human practices and dry lab findings. Through our engineering work, | ||
Revision as of 01:07, 17 October 2020
Rubor. Calor. Tumor. Dolor
. Sensor.
Chronic Inflammatory Diseases
Chronic Inflammatory Diseases (CIDs) are debilitating diseases, leaving your well-being at the mercy of your flare-ups and remissions. Due to the complexity of these diseases, no two patients' experiences are the same. Likewise, the right treatment for two people, even if they have the same disease, can be different, and to treat these diseases properly, patients therefore need to monitor the progression of their disease closely to gather as much information about it as possible.
Our Solution
To supplement current testing methods, we have designed a sweat collecting patch that patients with CIDs can use to monitor their inflammation status on the go. The plaster will sit on the patient's skin and change color depending on the patient's level of inflammation, as it reflects itself in the patient's sweat. This'll grant them an easy-to-use, non-invasive device that'll give them insight into the progression of their disease, and provide them and their healthcare professionals with valuable information about their illness, without the uncomfort surrounding current, more invasive testing methods.What does this mean for the patients?
Our tool stands for patient empowerment. Our self-monitoring device is suitable for home use, and does not have to interfere with patients' daily lives or act as a reminder of their illness. Instead, patients can go about their day, knowing that they're collecting data on their disease while performing other tasks.It allows for transparency for the patient regarding the progression of their CID, can aid them in discovering the best self-management strategies that work for them, and most of all, the collected data can help better guide healthcare professionals in evaluating the efficacy of current or new treatment plans, allowing for faster treatment adjustment.
CIDosis brings you the data needed to get a clearer picture of your disease.
The Science
Our patch will contain genetically modified yeast expressing engineered interleukin receptors. These interleukin receptors will bind and react to the inflammatory biomarkers (interleukins) found in sweat, whereby a fused intracellular split protein will be recomplemented. The recomplementation of the split protein then triggers a signaling pathway, in which our signal is amplified, eventually resulting in the production of a pigment, which will act as our reporter.For more information on our engineered interleukin receptors and biosensor components, check out our project design page!
Three Tiers of Biosensor Design
Our scientific design has gone through many iterations, guided especially by our human practices and dry lab findings. Through our engineering work, we've come up with three different designs, in which we have three different tiers of signal amplification, and three different intracellular modifications to our interleukin receptors.
For our design and engineering processes, check out our design page, modeling page, human practices page, and engineering success page!