Journal

January 2020

31/01/2020: Team meeting at the library - in this session we discussed our individual interests and brainstormed for potential project ideas.

February 2020

6/02/2020: Meeting at the library - further discussion of skin cancer and sunscreens, found link to coral bleaching.

19/02/2020: Meeting with Professors Breitling and Takano at Manchester Institute of Biotechnology (MIB) - presented our initial ideas for feedback.

17/02/2020: Meeting with Daniel Schindler - narrowed down our project options to Hipposol.

18/02/2020: Meeting in Hive to meet new team members.

23/02/2020: Meeting in SU and discussion of the Hipposol concept.

26/02/2020: Meeting in MIB about the function of biobricks and synthetic approaches to begin to understand how synthetic biology solutions are implemented.

March 2020

1/03/2020: Meeting in SU – began literature research into Hipposudoric Acid.

4/03/2020: Meeting with Professor Professor Breitling, Registration of the iGEM team.

10/03/2020: Meeting and Introduction of the new member to the team.

18/03/2020: First set up of the Zoom meeting. Discussion of Challenges brought by Coronavirus: Sponsors and Hippo samples. Experimental design planning. Introduction to RetroPath2.0, discussion of aims, and targets. Introduction to wiki design. UK brings up sudden lockdown measures, social distancing measures forces the project to go remote over an undefined period of time.

25/03/2020: Second Zoom meeting, meeting with Professor Breitling. Discussion of Sudden COVID changes, possibilities for in vivo, and in silico experimental research. Discussion of the current working conditions of team members and possibilities of creating content. Majority of the team had to leave for their homes as the University campus closes.

April 2020

1/04/2020: Meeting with Professor Breitling, discussion of Logo ideas and Wiki Design and organization. Agreement on decisions and organisation of wiki workshop.

8/04/2020: Zoom meeting discussing market research and human practices. Introduction of the main market tendencies in the sun care market, discussion of papers and research.

13/04/2020: Zoom meeting by the part of the team working on RetroPath2.0. Introduction to metabolic engineering and modelling through KNIME platform. Discussed the different forms of metabolic modelling we could perform as unknown whether laboratory work would be possible during the summer.

15/04/2020: Meeting with Ruth concerning RetroPath2.0.

16/04/2020: Meeting with Logo decisions and ideas, Decision on the potential product name. Introduction of the whole team to RetroPath2.0. Introduction of Benchling platform.

17/04/2020: Meeting with Daniel Schindler. Discussion of RetroPath2.0 Introduction, Further discussion on the project planning and decisions on new creative human practices options such as analysing social media.

19/04/2020: Abstract planning and discussion.

21/04/2020: Meetings with further discussion and work on logo and video, work on the market analysis of the most commonly used sunscreens. Decisions on the direction of market research and planning of business report. Beginning to plan Essential Entrepreneurship Resource based off discussions about our experience thus far.

22/04/2020: Meeting with Professor Professor Breitling, discussion of the uploaded preview on changed rules of iGEM during coronavirus. Decision made on project being entirely focused on dry lab work. Our computational dry lab results will act as our proof of concept.

23/04/2020: Ambassador iGEM meeting. Meeting with Ruth to discuss potential RetroPath2.0 results, challenges and troubleshooting opportunities.

24/04/2020: Team meeting discussing protocols and potential lab requirements. Analysis of important papers and documents.

25/04/2020: Team meeting, wrote our Revive and Restore grant applications and funding.

30/04/2020: Wiki Workshop held by Sandrina and Jana to teach others how to upload content. Introduction to HTML and formatting.

Exam period

May 2020

6/05/2020: Meeting with Professor Breitling, updates on a grant application, logos. Meeting with Ruth to discuss potential mistakes in RetroPath2.0 analysis.

7/05/2020: Team meeting to check progress of each individual component of the project.

7/05/2020: Results validation.

12/05/2020: Wiki meeting to discuss design, structure and colour scheme.

18/05/2020: Wiki meeting to test uploading.

20/05/2020: Validation of RetroPath2.0 results show they were false positive. Decision to turn the proof of concept by chemistry analysis based on hypotheses for the formation of Hipposudoric Acid in primary literature.

June 2020

1/06/2020: Meeting with Professor Breitling, discussion of the grant discussion of slack and communication through social media, docking simulation software.

3/06/2020: Meeting with Professor Breitling to receive feedback on logo edits as well as promo video feedback. Finalized chosen logo with a hippopotamus.

5/06/2020: We got awarded the Revive and Restore grant (thank you) and discussed the potential ways we could use the funding in the future for wet lab experiments.

7/06/2020: Final selection of logo, discussion of promo video materials to be made, market report progress checkup, discussion of surveys and survey distribution, wiki progress and protocols.

9/06/2020: Registration of the team for German IGEM meetup 2020, discussion of seminars and workshops attended.

10/06 /2020: Meeting with the professor Professor Breitling, discussion of objectives for the team and update.

11/06/2020: Wiki troubleshooting meeting.

12/06/2020: Meeting with the professor Professor Breitling, the final decision on the logo. Afterward, the second wiki workshop ran by team members Jana and Sandrina.

15/06/2020: Team meeting, discussion on the presentation for the German and UK iGEM meetups. Wiki planning session.

18/06/2020: Team meeting and presentation rehearsal and script discussion.

19/06/2020: UK IGEM meetup, presentations, and networking with other teams. Discussion with St Andrews about similarities and differences in our project vision, determination of similar targets, and potential collaboration.

20/06/2020: Update with Daniel Schindler.

24/06/2020: Team meeting to discuss possibilities of collaboration with St Andrews ad preparation for the iGEM German meetup.

24/06/2020: Team update.

26/06/2020: Meeting with Daniel Schindler with the discussion of the progress and potential course of a project.

29/06/2020: Meeting with Phil Shapira’s team to discuss the project’s objectives and course of a project, as well as market targets. Team meeting afterward to discuss potential future decisions on market research, market sunscreen testing, surveys on sunscreen damage, synbio attitude, and science comprehension. Discussion about wiki meta-analysis.

July 2020

2/07/2020: Presentation in video form for German iGEM meetup. Meeting with Phill Shapira to discuss human practices approaches and a meeting with St Andrews to further discuss expanding our collaboration into a partnership. Discussion of shift In teams priorities, moving away from surveys and skin test towards stakeholder map, wiki study, and lifecycle analysis.

4-6/07/2020: German IGEM meetup. Networking with several European teams, attendance of seminars and workshops, including a talk with Daniel Schindler from UoM. Attendance of other team’s presentations.

7/07/2020: Team meetup to discuss changes in priorities, project updates, and collaboration prospects with St Andrews, PEST analysis work.

8/07/2020: Meeting to discuss wiki development and design.

10/07/2020: Meetup with sta Andrews to discuss common stakeholders and potential interest overlaps for collaboration.

13/07/2020: Meeting with Daniel for updates and team activity discussion.

14/07/2020: Team meetup. Discussion of PEST analysis and Assumption Testing.

16/07/2020: Zoom interview with the Coral researcher from Dr. Hennige, discussed the mechanism behind sunscreen-induced coral bleaching.

17/07/2020: Meeting with Daniel Schindler to discuss project progress and partnership with St Andrews. Discussion of Essential Entrepreneurship resource redesign. Team meeting to discuss the completion of the resource and the design of ribbon that would be awarded to teams for completion.

22/07/2020: Meeting with Professor Professor Breitling and Team meeting later. Discussion of team objectives: Progress of PEST analysis, completion of a learning resource, human practice surveys. Analysis of the iGEM videos of previous 3 years.

23/07/2020: Meeting with Phil Shapira to discuss changes to our survey experimental design.

25/07/2020: Team meeting over the Promo video completion.

27/07/2020: Finalised PEST analysis.

28/07/2020: Meeting with the IP lawyer to discuss intellectual property in relation to biotechnology. Collaboration with St Andrews to identify key stakeholders. Meeting with the team to discuss afterwards.

29/07/2020: Meeting with Phill Shapira’s team to discuss surveys and human practices section modifications. Meeting with Ruth to discuss potential results of the RetroPath2.0. Discussion of modification of existing surveys.

30/07/2020: Safety Workshop meeting.

31/07/2020: Meeting with Heilderberg and Imperial, first planning session of the Wiki study.

August 2020

3/08/2020: Meeting with Ruth to discuss RetroPath2.0.

4/08/2020: Team meeting for Track selection. Discussion of human practices including finalising plan for YouTube analysis and entrepreneurship sections.

5/08/2020: Global Meeting .Completion of thematic analysis of YouTube using Nvivo. Completion of workshop version of resource and script.

7/08/2020: Meeting with Daniel Schindler for preparation for iGEM global meetup. Team meeting to discuss sharing market report data with St. Andtrws, completed previous teams’ resources on Dual Use.

13/08/2020: Meeting with Will Wright Chairman and Albert Anis Co-chairman of EPIC: iGEM’s entrepreneurship course for guidance on our Essential Entrepreneurship Learning Resource.

14/08/2020: Revive & Restore meeting. Team meeting to discuss Global IGEM meetup. Discussion of the team presentations, Human Practices and resources to be presented.

18/08/2020: Team meeting, discussion of surveys.

19/08/2020: Meeting with Louisa Liang co-founder of people4ocean, producers of reef-safe sunscreen to discuss project values and consumer preferences.

20/08/2020: First day of Global IGEM meetups.

21/08/2020: Second day of global IGEM meetups. Essential Entrepreneurship resource presented by the members of our team in the form of summarizing webinar.

24/08/2020: Meeting with semi-professional sailor Angus Elliman to find out what sailors value in sunscreens.

26/08/2020: Meeting with Prof. Breitling , discussion of the need for SWOT analysis as a part of our business section. Meeting with Dr Valdehuesa. Discussion of needed chemistry analysis aspects and possibilities to do it without reaching experimental methods.

28/08/2020: Meeting with Daniel Schindler. Biochemistry meeting with Dr Valdelhuesa. Possible polymerisation ways and biochemical basis of it discussed.

September 2020

1/09/2020: First meeting with Hong to begin constraint-based modelling.

2/09/2020: Meeting with Prof. Breitling. Discussion of finished drafts for YouTube analysis. Discussion of team video creation.

4/09/2020: Meeting with Daniel Schindler. Discussion of team progress.

8/08/2020: Meeting with Prof. Breitling to discuss the team progress and activities.

9/08/2020: Meeting with Phil Shapira to discuss survey analysis and YouTube Report.

10/09/2020: Mentored St Andrew’s on the sunscreen market in a webinar.

11/08/2020: Meeting with Daniel Schindler to discuss team progress. Team discusses change of plans as some of the members of the team in Manchester had contacted COVID.

12/09/2020: Team meeting to discuss the pipeline of the project, and research of possible suitable lab methods and cloning protocols, discussed the efficiency of different strain types with Kris Valdehuesa.

15/09/2020: Meeting with an expert dermatologist to talk about mechanisms of sunscreen failure and to better understand the complicated relationship between the skin and UV.

19/09/2020: St Andrew’s enterprise mentoring meeting.

22/09/2020: Team meeting to discuss the survey finish and video content creation. Start of final wiki content collection and design.

23/09/2020: Discussion of wiki final decisions and deadline.

25/09/2020: Meeting with Daniel Schindler. Discussion of promo video submission.

26/09/2020: Science Slam with Team Heidelberg!

30/09/2020: Team meeting to discuss the finalization of the Learning Resource and demographic data collection and analysis.

October 2020

3/10/2020: Team meeting. Discussion of Survey finalization and statistical analysis method.

7/10/2020: Team meeting. Discussion of wiki deadlines and upload of content.

9/10/2020: Team meeting. Discussion of the final presentation finalization and script. Meeting with Dr Zeng to discuss progression on FBA.

13/10/2020: Meeting with St. Andrews to discuss survey outcomes and results, as well as prospect use of data in project context.

14/10/2020: Meeting with Prof. Breitling . Discussion of wiki deadline and the content needed for upload and final presentation preparation.

16/10/2020: Team meeting. Discussion of the promo video creation.

19/10/2020: Team meeting on final project presentation scripts and wiki content editing.

23/10/2020: Performed grouped-contribution method to find out the free energy change for our chemistry report.

    
     igem2020manchester@gmail.com

Team:Manchester/Journal

Journal

January 2020

31/01/2020: Team meeting at the library - in this session we discussed our individual interests and brainstormed for potential project ideas.

February 2020

6/02/2020: Meeting at the library - further discussion of skin cancer and sunscreens, found link to coral bleaching.

19/02/2020: Meeting with Professors Breitling and Takano at Manchester Institute of Biotechnology (MIB) - presented our initial ideas for feedback.

17/02/2020: Meeting with Daniel Schindler - narrowed down our project options to Hipposol.

18/02/2020: Meeting in Hive to meet new team members.

23/02/2020: Meeting in SU and discussion of the Hipposol concept.

26/02/2020: Meeting in MIB about the function of biobricks and synthetic approaches to begin to understand how synthetic biology solutions are implemented.

March 2020

1/03/2020: Meeting in SU – began literature research into Hipposudoric Acid.

4/03/2020: Meeting with Professor Professor Breitling, Registration of the iGEM team.

10/03/2020: Meeting and Introduction of the new member to the team.

April 2020

1/04/2020: Meeting with Professor Breitling, discussion of Logo ideas and Wiki Design and organization. Agreement on decisions and organisation of wiki workshop.

8/04/2020: Zoom meeting discussing market research and human practices. Introduction of the main market tendencies in the sun care market, discussion of papers and research.

13/04/2020: Zoom meeting by the part of the team working on RetroPath2.0. Introduction to metabolic engineering and modelling through KNIME platform. Discussed the different forms of metabolic modelling we could perform as unknown whether laboratory work would be possible during the summer.

15/04/2020: Meeting with Ruth concerning RetroPath2.0.

16/04/2020: Meeting with Logo decisions and ideas, Decision on the potential product name. Introduction of the whole team to RetroPath2.0. Introduction of Benchling platform.

17/04/2020: Meeting with Daniel Schindler. Discussion of RetroPath2.0 Introduction, Further discussion on the project planning and decisions on new creative human practices options such as analysing social media.

19/04/2020: Abstract planning and discussion.

22/04/2020: Meeting with Professor Professor Breitling, discussion of the uploaded preview on changed rules of iGEM during coronavirus. Decision made on project being entirely focused on dry lab work. Our computational dry lab results will act as our proof of concept.

23/04/2020: Ambassador iGEM meeting. Meeting with Ruth to discuss potential RetroPath2.0 results, challenges and troubleshooting opportunities.

24/04/2020: Team meeting discussing protocols and potential lab requirements. Analysis of important papers and documents.

25/04/2020: Team meeting, wrote our Revive and Restore grant applications and funding.

30/04/2020: Wiki Workshop held by Sandrina and Jana to teach others how to upload content. Introduction to HTML and formatting.

Exam period

May 2020

6/05/2020: Meeting with Professor Breitling, updates on a grant application, logos. Meeting with Ruth to discuss potential mistakes in RetroPath2.0 analysis.

7/05/2020: Team meeting to check progress of each individual component of the project.

7/05/2020: Results validation.

12/05/2020: Wiki meeting to discuss design, structure and colour scheme.

18/05/2020: Wiki meeting to test uploading.

20/05/2020: Validation of RetroPath2.0 results show they were false positive. Decision to turn the proof of concept by chemistry analysis based on hypotheses for the formation of Hipposudoric Acid in primary literature.

June 2020

1/06/2020: Meeting with Professor Breitling, discussion of the grant discussion of slack and communication through social media, docking simulation software.

3/06/2020: Meeting with Professor Breitling to receive feedback on logo edits as well as promo video feedback. Finalized chosen logo with a hippopotamus.

5/06/2020: We got awarded the Revive and Restore grant (thank you) and discussed the potential ways we could use the funding in the future for wet lab experiments.

7/06/2020: Final selection of logo, discussion of promo video materials to be made, market report progress checkup, discussion of surveys and survey distribution, wiki progress and protocols.

9/06/2020: Registration of the team for German IGEM meetup 2020, discussion of seminars and workshops attended.

10/06 /2020: Meeting with the professor Professor Breitling, discussion of objectives for the team and update.

11/06/2020: Wiki troubleshooting meeting.

12/06/2020: Meeting with the professor Professor Breitling, the final decision on the logo. Afterward, the second wiki workshop ran by team members Jana and Sandrina.

15/06/2020: Team meeting, discussion on the presentation for the German and UK iGEM meetups. Wiki planning session.

18/06/2020: Team meeting and presentation rehearsal and script discussion.

19/06/2020: UK IGEM meetup, presentations, and networking with other teams. Discussion with St Andrews about similarities and differences in our project vision, determination of similar targets, and potential collaboration.

20/06/2020: Update with Daniel Schindler.

24/06/2020: Team meeting to discuss possibilities of collaboration with St Andrews ad preparation for the iGEM German meetup.

24/06/2020: Team update.

26/06/2020: Meeting with Daniel Schindler with the discussion of the progress and potential course of a project.

July 2020

4-6/07/2020: German IGEM meetup. Networking with several European teams, attendance of seminars and workshops, including a talk with Daniel Schindler from UoM. Attendance of other team’s presentations.

7/07/2020: Team meetup to discuss changes in priorities, project updates, and collaboration prospects with St Andrews, PEST analysis work.

8/07/2020: Meeting to discuss wiki development and design.

10/07/2020: Meetup with sta Andrews to discuss common stakeholders and potential interest overlaps for collaboration.

13/07/2020: Meeting with Daniel for updates and team activity discussion.

14/07/2020: Team meetup. Discussion of PEST analysis and Assumption Testing.

16/07/2020: Zoom interview with the Coral researcher from Dr. Hennige, discussed the mechanism behind sunscreen-induced coral bleaching.

17/07/2020: Meeting with Daniel Schindler to discuss project progress and partnership with St Andrews. Discussion of Essential Entrepreneurship resource redesign. Team meeting to discuss the completion of the resource and the design of ribbon that would be awarded to teams for completion.

22/07/2020: Meeting with Professor Professor Breitling and Team meeting later. Discussion of team objectives: Progress of PEST analysis, completion of a learning resource, human practice surveys. Analysis of the iGEM videos of previous 3 years.

23/07/2020: Meeting with Phil Shapira to discuss changes to our survey experimental design.

25/07/2020: Team meeting over the Promo video completion.

27/07/2020: Finalised PEST analysis.

28/07/2020: Meeting with the IP lawyer to discuss intellectual property in relation to biotechnology. Collaboration with St Andrews to identify key stakeholders. Meeting with the team to discuss afterwards.

29/07/2020: Meeting with Phill Shapira’s team to discuss surveys and human practices section modifications. Meeting with Ruth to discuss potential results of the RetroPath2.0. Discussion of modification of existing surveys.

30/07/2020: Safety Workshop meeting.

31/07/2020: Meeting with Heilderberg and Imperial, first planning session of the Wiki study.

August 2020

3/08/2020: Meeting with Ruth to discuss RetroPath2.0.

4/08/2020: Team meeting for Track selection. Discussion of human practices including finalising plan for YouTube analysis and entrepreneurship sections.

5/08/2020: Global Meeting .Completion of thematic analysis of YouTube using Nvivo. Completion of workshop version of resource and script.

7/08/2020: Meeting with Daniel Schindler for preparation for iGEM global meetup. Team meeting to discuss sharing market report data with St. Andtrws, completed previous teams’ resources on Dual Use.

13/08/2020: Meeting with Will Wright Chairman and Albert Anis Co-chairman of EPIC: iGEM’s entrepreneurship course for guidance on our Essential Entrepreneurship Learning Resource.

14/08/2020: Revive & Restore meeting. Team meeting to discuss Global IGEM meetup. Discussion of the team presentations, Human Practices and resources to be presented.

18/08/2020: Team meeting, discussion of surveys.

19/08/2020: Meeting with Louisa Liang co-founder of people4ocean, producers of reef-safe sunscreen to discuss project values and consumer preferences.

20/08/2020: First day of Global IGEM meetups.

21/08/2020: Second day of global IGEM meetups. Essential Entrepreneurship resource presented by the members of our team in the form of summarizing webinar.