Literature review for sensitivity and specificity model
Literature review for ODE model
Literature review for lateral flow assay model
Policy and Practice
Provided information for cost analysis
Collaborated with experts in the field
Collaboration
Biomarker database design and questionnaires
Designed BioBrick instructions for Linkopings
German Meet-Up poster design
Leiden Symposium
Maastricht Journal Initiative
Graphic Design
Social media posts
Presentation design
Video
Promotional video script
Presentation video script and PowerPoint content
Outreach
Planned Perspectives in Women’s Health Panel
Collaborated on infographic designs
Emily Laskey
×
Emily Schiller
Team Leader
Wet Lab
Literature research
Protocols and project design
Lateral flow assay experiments
Menstrual cup sterilization experiments
Modeling
R programming language
Power analysis
Clinical predictive models
Endometriosis clinical predictive model
Sensitivity and specificity of biomarkers through combined odd ratios
Outreach
Upward Bound synthetic biology modules
Sonshine Summer Camp biology experiments
Rochester City School District 5th grade experiments
Planned Perspectives in Women’s Health Panel
Graphic Design
Social media posts
Presentation design
Public Relations
Social media posts
Collaboration
Gender Reproductive Health Care
Biomarker Database
Accessibility
Biomarker Sensing Group
Outreach Workshop
German iGEM Meetup
Symposium on Global Challenges
Journal initiative
iGEM video collaboration
Dance Collaboration
The Transcriptome Blog
Video
Promotional video script
Promotional video audio description
Presentation video script and PowerPoint content
Emily Schiller
×
Ethan Chen
Wiki Designer
Wiki
Wiki Manager
Design the wiki page
Collect and organize the contents for the wiki
Hardware
Centrifuge design and construction
Public Relations
Social media posts
Collaboration
Centrifuge design with UoR Engineers World Health
Ethan Chen
×
Gabe Isaacson
Fundraising Manager
Brainstorming Leader
Wet Lab
Literature research
Protocols and project design
ERE Circuit Design
Modeling
Research on equations and variables
Clinical predictive models
ERE Synthetic Circuit Model
Public Relations
Contributed to posting and material
Fundraising and Finance
Finance and Fundraising Manager
Identify and contact potential sponsors/donors
Coordinate sponsorship benefits
Ran the iGEM Virtual 5k
Managed overall team budget
Video
Promotional video script
Promotional video graphics
Promotional video narration
Gabe Isaacson
×
Heather Shi
Outreach Manager
Wet Lab
Literature research
Outreach
Outreach manager
Upward Bound synthetic biology modules
Sonshine Summer Camp biology experiments
Endometriosis education
Collaboration
Troubleshooting with Queens and Lambert
Leiden Symposium
Outreach collaboration with BITS Goa and IIT Madras
Heather Shi
×
Helen Shammas
Hardware Manager
Hardware
Hardware Manager
Safety proposals
Arduino workshops
Hardware budget management
Lateral flow assay assay detector design
Lateral flow assay experiments
The UVC menstrual cup sterilizer design
Sterilizer experiments
Centrifuge experiments
Vaginal ring
Policy and Practice
Science as Art dance choreography
Accessibility project
Connecting with stakeholders
Collaboration
Dance collaboration with BITS Goa and IIT Madras
Global iGEM meetup
India iGEM Meetup
Centrifuge design with UoR Engineers World Health
Beta Testing for Linkopings
Outreach
Upward Bound synthetic biology modules
Sonshine Summer Camp biology experiments
Endometriosis Education
Elementary School experiments
Public Relations
Social media posts
Endometriosis facts translation
Infographics translation
Wiki
Hardware wiki page design and organization
Helen Shammas
×
Isabel Lopez
Graphic Designer
Wet Lab
Literature research
Protocols and project design
Modeling
Rosetta and protein docking modeling
Policy and Practice
Science as Art
Accessibility project
Graphic Design
Wiki graphics
Team logos
Infographics
Collaboration
Dance collaboration with BITS Goa and IIT Madras
Video
Promotional video script
Promotional video graphics
Isabel Lopez
×
James Tang
Software Manager
Software
Software Manager
Design and create interface for diagnostic models
Design and create interface for the biomarker database
Policy and Practice
Administrative tasks
Outreach
Endometriosis Education
James Tang
×
Linh Hoang
Modeling Manager
Modeling
Modeling manager
Rosetta protein modeling
LFA Model
Hardware
Menstrual cup design
Outreach
Upward Bound synthetic biology modules
Endometriosis education
Video
Promotional video script
Promotional video graphics
Collaboration
German iGEM meetup presentation
Linkopings modeling feedback
Linh Hoang
×
Meghan Martin
Public Relations Manager
Wet Lab
Literature research
Protocols and project design
Lab preparation for experiments
Policy and Practice
Science as Art
Accessibility
American Sign Language
Language Survey
Ethics literature review
Health care disparities literature review
Outreach
Upward Bound synthetic biology modules
Sonshine Summer Camp biology experiments
Elementary School experiments
Endometriosis Education
Public Relations
Public Relations Manager
Manage, create and post social media
Press releases
Collaboration
Accessibility with IIT Madras and BITS Goa
German iGEM Meetup
India iGEM Meetup
Global iGEM Meetup
Video
Video Manager
Promotional video script and graphics
Presentation video powerpoint and script
Co-presented in final video
Meghan Martin
×
Nello Gu
Policy & Practice Manager
Hardware
The UVC menstrual cup sterilizer design
Policy and Practice
Policy and Practice Manager
Connect with stakeholders
Accessibility project
Feasibility analysis
Ethics/Sustainability analysis
Patent management
Outreach
Endometriosis Education
Nello Gu
×
Zivile Vebraite
Collaboration Manager
Collaboration
Collaboration Manager
Coordinated collaborations with other iGEM teams
Connected team with endometriosis experts
Participated in iGEM global meet ups
Policy and Practice
Reproductive Health Care Disparities Survey
Outreach
Endometriosis Education
Public Relations
Social media posts
Video
Promotional video script
Promotional video graphics
Zivile Vebraite
Principal Investigator
×
Anne Meyer
Principal Investigator
General project support
Wet lab design
Presentation coaching
Anne Meyer
Advisors
×
Alexis Stein
Advisor
Wet lab techniques
Alexis Stein
×
Nancy Chen
Advisor
Modelling techniques and strategies
Nancy Chen
×
Omar Soufan
Advisor
Hardware design
Difficult technique support
Omar Soufan
Teaching Assistants
×
Lynn Sidor
Teaching Assistant
Oversees policy and practice meetings
Wet lab techniques
Science experiment design
Presentation coaching
Lynn Sidor
×
Ram Gona
Teaching Assistant
Oversees hardware meetings
Hardware design
Difficult technique support
Ram Gona
×
Roger White
Teaching Assistant
Oversees wet lab meetings
Wet lab techniques
Science experiment design
Roger White
Team Training and Project Start
With the purpose of providing undergraduates with hands-on research experience, the University of Rochester implemented iGEM in 2020 as a two semester eight credit course (BIO228A and BIO228B). There is a mandatory, non-credited summer session where students receive stipends. Additionally, there is an optional half credit writing course that students can take during the Fall Semester (BIO228W). Through an application process, twelve students are selected to participate in the iGEM program. Any student interested in taking the course can learn more about iGEM and obtain a copy of the syllabus from the course instructor. Aside from BIO228A and BIO228B, there are no synthetic biology courses offered by the University of Rochester.
During the first week of February, our team had the opportunity to meet one another and start our creative brainstorming journey. Through the beginning of April, we gave brief presentations to our advisors in order to narrow down our iGEM project idea. On April 16th, our team voted on this year’s project and spent the remainder of the spring semester forming plans for the summer session. However, due to COVID-19 we are unable to access our lab so we shifted our focus into developing more specific wet lab protocols, creating models, designing hardware, science education and integrating our project into society.
Acknowledgements
General support
University of Rochester Department of Biology
Provided laboratory space
Advisors
See above
Teaching Assistants
See above
Project support and advice
Dr. Ashley Gubbels MD, FACOG, Assistant Program Director, Fellowship in Minimally Invasive Gynecologic Surgery, University of Rochester Medical Center, Assistant Professor, Department of OBGYN University of Rochester Medical Center.
Dr. Gubbels gave feedback on our overall project design and endometriosis educational material. She also shared knowledge about endometriosis pathophysiology and connected our team with endometriosis organizations and activists. Additionally, Dr. Gubbels was a panelist in our Perspectives in Women’s Health event.
Dr. Idahliz Flores-Caldera PhD in Molecular Genetics and Microbiology, Professor Department of Basic Sciences- Division of Microbiology Department of Ob-Gyn, Ponce Health Sciences University- School of Medicine, Ponce Research Institution- Chair of Women’s Health Division.
Dr. Flores provided guidance for our wet lab team by meeting with us see every two weeks to discuss biomarker selection and assay design. She also shared her research data for our modeling team to make the endometriosis risk assessment model and gave feedback on our endometriosis infographics.
Dr. Peter K. Gregersen MD, Professor, Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Professor, Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell.
Dr. Gregersen gave us advice on biomarker selection and wet lab assay design. Dr. Gregersen also shared his knowledge about utilizing menstrual blood in diagnostics.
Dr. Christine Metz PhD in Immunology and Pathology, Professor, Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Director, Faculty Affairs, Feinstein Institutes for Medical Research, Associate Dean and Professor, Elmezzi Graduate School of Molecular Medicine, Professor, Molecular Medicine and Obstetrics & Gynecology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell.
Dr. Metz gave us advice on biomarker selection and wet lab assay design. Dr. Metz also shared her knowledge about utilizing menstrual blood in diagnostics.
Dr. Douglas Stockman MD, Clinical Associate Professor in Department of Family Medicine University of Rochester Medical Center, Director of Global and Refugee Health for the Department of Family Medicine University of Rochester Medical Center.
Drawing on his knowledge of global health and experiences practicing medicine in rural Honduras, Dr. Stockman gave our team advice on how to tailor our project design to be accessible in medically underserved areas.
Sophie Zivku Corporate Communications Manager at Diva International Inc.
Sophie gave feedback on our endometriosis education materials and our hardware tools including the U.V. sanitizer, menstrual blood syringe, and menstrual cup.
Amber English Co-Founder of Pixie Cup Inc.
Amber gave feedback on the U.V light sterilizer and gave us more perspective for the marketing potential of sterilizers.
Patrick Crawford A.P. Biology Teacher at Auburn High School.
Mr. Crawford gave our team feedback on our Upward Bound synthetic biology modules. He also gave our team ideas on how to integrate synthetic biology in high school curriculum.
Curtis Birthwright 5th grade elementary school from Rochester City School District.
Mr. Birthwright inspired our team to create experiments for young children to spark their interests in science. The team learned various techniques on how to design and teach the lessons to maximize engagement with the students in an online format.
Kathryn Frank 5th grade elementary school from Rochester City School District.
Mr. Birthwright and Ms. Frank inspired our team to create experiments for young children to spark their interests in science. The team learned various techniques on how to design and teach the lessons to maximize engagement with the students in an online format.
Dr. Noemie Elhadad Associate Professor of Biomedical Informatics, Columbia University, Graduate Program Director, Columbia University Department of Bioinformatics, Creator of PHENDO Mobile App.
Dr. Elhadad gave our modeling team advice on data management, predictive modeling, and how to integrate models into web applications. She also shared her research data for development of our endometriosis risk assessment model. Additionally, Dr. Elhadad was a panelist in our Perspectives in Women’s Health event
Dr. Benjamin Miller Dean’s Professor of Dermatology, Professor of Biochemistry and Biophysics, Biomedical Engineering ,Optics.
Dr. Miller provided insight on methods of developing the hardware and software related to the lateral flow assay model. He also gave advice on what to look out for and how to deal with possible obstacles.
Jeffrey Beard Biomedical engineering PhD Student at the University of Rochester.
Mr. Beard provided insight on methods of developing the hardware and software related to the lateral flow assay model. He also gave advice on what to look out for and how to deal with possible obstacles.
Colleen Maillie PhD Candidate at The Scripps Research Institute
Colleen Maillie helped with navigating and understanding rosetta modeling software and Pymol protein software.
Fundraising help and advice
University of Rochester
Provided FLARE grants to give undergraduates financial support during the summer iGEM session
Biology department provided the Teaching Innovation Grant
University of Rochester Center for Excellence in Learning
Provided grant for iGEM program
University of Rochester Advancement
Organized donation campaigns through alumni
Endometriosis Foundation of America
Partnered with our virtual 5k run and shared donations.
Human Practices support
Dr. Amy Benjamin Board certified gynecologist at the University of Rochester,Director for the Center for Pelvic Pain and Vulvar Disorders,Director of the Minimally Invasive Gynecologic Surgery Fellowship.
Dr. Benjamin reviewed our educational material as well as helping us through the process of creating the content. Stressed the importance of including information for the LGBTQIA+ community. strengthening our determination for creating contents and continue advocacy for LGBTQIA+ community.
Danielle Keiser Executive Director, Menstrual Health Hub.
Danielle, on behalf of the Menstrual Health Hub, gave us feedback on the menstrual and sexual health portion of our endometriosis education materials.
Heather Guidone BCPA, Program Director of the Center for Endometriosis Care.
Heather gave our team feedback on our endometriosis education material and promoted our materials in the Center for Endometriosis Care. She also connected us with other professionals in the field.
Phil Rey Gibbons Musician and Composer
Mr Gibbons gave us permission to use his music Ad Honorem for our endometriosis SAA dance video.
Endometriosis UK Endometriosis UK gave us feedback on our endometriosis educational material and promoted our project through their social media.
Endometriosis Foundation of America The Endometriosis Foundation of America gave us feedback on and distributed our endometriosis educational materials.