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Notebook

● 2020.05

(1) Set up 2020 UESTC-Software. (2)Team Leaders：Wang Bin、Mo Nan (3)Team members: Dong Haoran、Gao Fan、Han Jingqi、Yang Zhaochang、Liu Mingkang、Mei Yao、Zhou Tao、Min Zhuochao、Qiao Dan、Xiong Huiyu

● 2020.06

(1)Extensive collection of relevant data and synthetic biology are urgently needed (2)The project was designed to build a Domain part library which can provide convenience for protein design (3)Team members brainstorm with PI and seek professional guidance from relevant teachers.

● 2020.07

(1)Many proteins and domain databases (UniProtKB, PDB, Pfam, CATH, SCOP/SCOP2, KEGG, OMIM-, etc.) were investigated） (2)Investigate protein shape matching algorithms. (3)With domain splicing as the theme, we started to make games. (4)Domain data in CATH, SCOP and Scop2 databases were integrated, and cd-HIT was used to eliminate redundant data. (5)A large number of PDB data were crawled and downloaded, and domain-Atom data were extracted and processed. (6）3D Zernike algorithm is used to process the domain stereo file information after extraction and obtain its surface shape features, and then cluster the 121 dimensional shape feature vectors (mean shift, k-means) according to the extracted information.

● 2020.08

(1)Explore the improvement of clustering algorithm, in-depth study of elbow method and its expansion. (2)Improved elbow method, compared multiple clustering algorithms, carried out accuracy evaluation, and determined that K-means was the final clustering algorithm (3)Determination of K-means clustering method, calculation of domain physicochemical properties, collection and annotation of domain-related data information, exploration of domain evolutionary relationship, and construction of evolutionary tree (4)The design and construction of building blocks model, and the production of project website using VUE

● 2020.09

(1)Domain similarity prediction is carried out. (2)Collect, process and analyze functional information of Domain. (3)Domain function information crawling, conduct model validation and project validation. (4)Build a lego brochure and create the synthetic biology promotion song "You Exist"

● 2020.10

(1)To hold the sichuan Science and Technology Museum synthetic Biology promotion activities. (2)Organize project documents and summarize project progress. (3)Write Wiki content and perform aesthetic design related to the project. (4) We invited many iGEM teams and related workers to use our Software and put forward suggestions for improvement.