Team:ZJU-China/Collaborations

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• iGEM Community
• Mentorship
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Collaborations

Meetups

Hi, iGEMers! Nice to meet you.

South China Meetup—Topic Selection

In June, we took part in the 2020 South China Meetup and made short video of our project for better visualization. The meetup mainly focused on topic selection and included two parts — online preview and online presentation. Among the 25 teams participated in, we were fortunate to be voted as one of the top 10 popular teams in the preview part and gave the presentation in the online meetup. In the meetup, Dorothy Zhang from iGEM committee gave us a lecture on the main points and changes in human practice this year; Mr. Zhang from Bluepha lab cleared our confusion in efficient teamwork in pandemic; Dr. Meng working on synthetic biology offered us insights into feasibility and meaning of topic selection.

Our presentation caught eyes of many iGEMers. In Q&A part, they also expressed concerns about women’s health, which was the topic we chose, and praised on the value of our topic. Teams centering on medical product had a deep communication. Additionally, they asked more about our choice of single chain antibody fragment (scFv) and how we modify the magnetosome membrane with biological method. We briefly introduced the privilege of scFv over common antibody and talked about the protein display technology to express fusion protein. We bonded relationship with many iGEMers, especially some teams of the same interests as ours, for example SMMU-China centering on antibody bank targeting tumors. We exchange our ideas of the topic chosen and have a free talk on how to fulfill it.

East China Meetup—Project Design

As we staged into project design, we were sincerely welcomed to hear about the suggestions of researchers in a wider range. The meeting invited Mr. Zhu Tianze, CEO of Zenotek Company, as special guest. He offered us valuable experience in making decision and experimental practice. With our up-to-date design of self-assembly system, we gave a presentation in the East China Meetup. After the presentation, we got constructive advice from the Mr. Zhu. For one thing, we could concretize the design concerning the metabolism of MagHER2some, to prove it is relatively safe. For another thing, we could do better in delivering the back-up knowledge of the magnetosome, for example its formation and characteristics. Through this meeting, we learned about the limitations in our project and worked hard towards them.

iGEM Community

To make difference with synthetic biology, we are one.

At the end of August, we were working on the experiments to realize our plan. At the same time, it was also of great importance to hear about others’ voices as well as discuss what we like. We participated in the 7^th CCiC online meeting, which was focused on the topic, From Lab to Fab, this year. Lectures on transformation of scientific and technology research into fabrication inspired us to explore more outreaches beyond the current project. We were determined to perfect our end product by developing a versatile system from its downstream and upstream after iGEM. In the Q&A part, our biological design to tackle the stability of scFv (a targeting element in our project) got recognition from judges, as well as background investigation. We also had a heated discussion on how to ensure and measure the efficiency of our surface display technology and the possible safety problem we need to address. Constructive insights were freely exchanged in the meeting in order to realize our mutual goals of making a difference in the world with synthetic biology.

Mentorship

I will lend you a hand when you need!

Due to the limited laboratory condition, we helped AHUT conduct most of their wet experiments in our lab according to their design. We taught them skills of literature research and helped them adjust the test design to ensure the test was completed successfully. We provided help in exploring the optimal expression conditions for carbonic anhydrase (CA) and measuring the activity of both the wild type and the mutant type. Detailed mentoring record are shown as follows.

Figure 1. Notebook about mentorship with AHUT.

Deeper Collaboration

Hand in hand, to build a bright future!

In the conversation with TJUSLS-China, we gave some feedbacks of our finished work. We had discussion about how they ensured the enzyme activity when improving the thermostability of the PETase in their projects. We also exchange our framework in human practice and our understanding of science communication in our project.

Our participation in science communication of the publicity program, I gotta PhD, held by NCKU-Tainan & CSMU_Taiwan also deepen the friendship among us. We were determined to contribute to the cause of public health education in a joint effort.

Besides, we had an all-around collaboration with NJU-China, including participating in meetup, co-organizing online interview, consulting relevant company, tackling bioethics and biosafety problem, troubleshooting, et al. We will also collaborate in scenario simulation for the Giant Jamboree in November. Further details at Partnership page.

Figure 2. Deeper collaboration with other iGEM teams.

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