Team:Beijing 4ELEVEN
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Abstract
Acne vulgaris troubles people as it not only affects human skin but also self-confidence. Traditional treatment to acne vulgaris involving antibiotics triggers resistance in acne pathogenic bacteria, especially Propionibacterium. acnes. Antimicrobial peptides (AMPs) are considered excellent alternatives of antibiotics for their capability of providing effective, broad-spectrum defenses against infections and exhibiting relatively low potential to elicit resistance. Therefore, we aim to create an anti-acne product which consists of biosynthesized rather than costly chemeosynhesized P. acnes killing AMPs, adhesive/cohesive proteins, and tyrosinase. The mixture which we named Acneutralizer forms a thin film when applied to acne-infected skin. This product may be brought to market, helping acne sufferers improve their conditions by easily killing P. acnes.
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Acne Vulgaris (ance) has been bothering our teenagers and sometimes adults for a long time.
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Propionibacterium. acnes is the main pathogen of acne. We decide to solve this pimple problem by utilizing AMPs, capable of providing immediately effective defenses against P.ance, to treat acne infections.
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We aim to produce AMPs through biosynthesis pathway. In the project, we designed plasmids with AMPs sequences and transformed them into Pichia pastoris, regulating expression with AOX1 promoter.
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The AMPs products itself may have limitations due to its high fluidity. Thus, we incorporate adhesive/cohesive proteins, as "bio-glue", into our products. The resulting product, Acneutralizer, cures acne by formation of a long-lasting waterproof coating when applied to acne-infected skin.
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The full "pimple patch" of AMPs and adhesive/cohesive proteins can be brought directly from our lab to the market. With our products, acne sufferers can get rid of their problems at ease.
