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− | + | As a leading global cause of preventable blindness and mortality, vitamin A deficiency (VAD) is a serious health problem, particularly in developing regions. Oviita aims to equip these vulnerable regions with a sustainable and community-based solution to VAD. Our solution uses a food-safe strain of <span style="font-style: italic;class="italic">Yarrowia lipolytica</span> modified to produce beta-carotene, a vitamin A precursor. By engineering this yeast to produce cellulase, VAD communities can grow it as their own vitamin A supplement using readily-available plant matter as feedstock. To facilitate community integration, we designed bioreactor schematics based on locally-available resources, and made the yeast auxotrophic to ensure safe growth with no environmental risk. We also created a vitamin A biosensor to improve VAD testing, and included an anthelmintic agent in the yeast to combat poor intestinal health, two contributing factors to VAD. Through these solutions, Oviita aims to be a sustainable and community-based adjunct to global efforts against VAD. Check out our <a href="https://2020.igem.org/Team:Calgary/Description">description page</a> and our <a href="https://video.igem.org/videos/watch/9891caea-e3db-4d84-b759-36c72e756721">project presentation video</a> to learn more about Oviita. </p> | |
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− | < | + | <!-- NAVIGATION GRID --> |
− | + | <div class="content-panel project-icons dynamic-padding"> | |
− | + | <h1>Project Components</h1> | |
− | + | <div class="component-holder" style="margin-top: 0px"> | |
− | + | <div class="component-row"> | |
− | + | <a href="https://2020.igem.org/Team:Calgary/Human_Practices"> | |
− | + | <div | |
+ | class="project-component" | ||
+ | data-link="https://2020.igem.org/Team:Calgary/Human_Practices" | ||
+ | > | ||
+ | <div class="icon"> | ||
+ | <img src="https://static.igem.org/mediawiki/2020/0/09/T--Calgary--hp-logo.png" style="width:50%;"> | ||
+ | </div> | ||
+ | <h2 class="title">Human Practices</h2> | ||
+ | <p class="description"> | ||
+ | We conducted in-depth interviews with nutrition experts and future users of our products | ||
+ | </p> | ||
+ | </div> | ||
+ | </a> | ||
+ | <a href="https://2020.igem.org/Team:Calgary/Engineering"> | ||
+ | <div | ||
+ | class="project-component" | ||
+ | data-link="https://2020.igem.org/Team:Calgary/Engineering" | ||
+ | > | ||
+ | <div class="icon"> | ||
+ | <img src="https://static.igem.org/mediawiki/2020/6/69/T--Calgary--engineering-logo.png" style="width:50%;"> | ||
+ | </div> | ||
+ | <h2 class="title">Engineering</h2> | ||
+ | <p class="description"> | ||
+ | We engineered the yeast strain <i>Yarrowia liplytica</i> to produce exactly what we needed for Oviita | ||
+ | </p> | ||
+ | </div> | ||
+ | </a> | ||
+ | <a href="https://2020.igem.org/Team:Calgary/Model"> | ||
+ | <div | ||
+ | class="project-component" | ||
+ | data-link="https://2020.igem.org/Team:Calgary/Model" | ||
+ | > | ||
+ | <div class="icon"> | ||
+ | <img src="https://static.igem.org/mediawiki/2020/0/01/T--Calgary--modelling-logo-2.png" style="width:60%; margin-bottom:15px; margin-top:0px;"> | ||
+ | </div> | ||
+ | <h2 class="title">Modelling</h2> | ||
+ | <p class="description"> | ||
+ | Computer modelling informed experimental design through every step | ||
+ | </p> | ||
+ | </div> | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="component-row"> | ||
+ | <a href="https://2020.igem.org/Team:Calgary/Implementation"> | ||
+ | <div | ||
+ | class="project-component" | ||
+ | data-link="https://2020.igem.org/Team:Calgary/Implementation" | ||
+ | > | ||
+ | <div class="icon"> | ||
+ | <img src="https://static.igem.org/mediawiki/2020/2/25/T--Calgary--implementation-logo-2.png" style="width:80%; margin-bottom:5px; margin-top:0px;"> | ||
+ | </div> | ||
+ | <h2 class="title">Proposed Implementation</h2> | ||
+ | <p class="description"> | ||
+ | The implementation of Oviita was thought through from start to finish | ||
+ | </p> | ||
+ | </div> | ||
+ | </a> | ||
+ | <a href="https://2020.igem.org/Team:Calgary/Parts"> | ||
+ | <div | ||
+ | class="project-component" | ||
+ | data-link="https://2020.igem.org/Team:Calgary/Parts" | ||
+ | > | ||
+ | <div class="icon"> | ||
+ | <img src="https://static.igem.org/mediawiki/2020/d/de/T--Calgary--parts-logo-2.png" style="width:50%; margin-top:0px;"> | ||
+ | </div> | ||
+ | <h2 class="title">Parts</h2> | ||
+ | <p class="description"> | ||
+ | Several parts were added to the iGEM registry | ||
+ | </p> | ||
+ | </div> | ||
+ | </a> | ||
+ | <a href="https://2020.igem.org/Team:Calgary/Hardware"> | ||
+ | <div | ||
+ | class="project-component" | ||
+ | data-link="https://2020.igem.org/Team:Calgary/Hardware" | ||
+ | > | ||
+ | <div class="icon"> | ||
+ | <img src="https://static.igem.org/mediawiki/2020/4/40/T--Calgary--hardware-logo.png" style="width:60%; margin-bottom:-10px;"> | ||
+ | </div> | ||
+ | <h2 class="title">Hardware</h2> | ||
+ | <p class="description"> | ||
+ | Our Bioreactor and Diagnostic Tool are integral to the implementation of Oviita | ||
+ | </p> | ||
+ | </div> | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="component-row"> | ||
+ | <a href="https://2020.igem.org/Team:Calgary/Software"> | ||
+ | <div | ||
+ | class="project-component" | ||
+ | data-link="https://2020.igem.org/Team:Calgary/Software" | ||
+ | > | ||
+ | <div class="icon"> | ||
+ | <img src="https://static.igem.org/mediawiki/2020/a/a5/T--Calgary--software-logo.png" style="width:60%; margin-bottom:15px; margin-top:0px;"> | ||
+ | </div> | ||
+ | <h2 class="title">Software</h2> | ||
+ | <p class="description"> | ||
+ | We created an array of software models and tools to assist us in creating Oviita | ||
+ | </p> | ||
+ | </div> | ||
+ | </a> | ||
+ | </div> | ||
</div> | </div> | ||
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+ | ><img | ||
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Latest revision as of 05:36, 21 December 2020
A MAJOR PROBLEM
VITAMIN A DEFICIENCY IS A LEADING CAUSE OF CHILDHOOD MORTALITY
AND BLINDNESS.
WE'RE HERE TO CHANGE THAT.
OVIITA DESIGN
As a leading global cause of preventable blindness and mortality, vitamin A deficiency (VAD) is a serious health problem, particularly in developing regions. Oviita aims to equip these vulnerable regions with a sustainable and community-based solution to VAD. Our solution uses a food-safe strain of Yarrowia lipolytica modified to produce beta-carotene, a vitamin A precursor. By engineering this yeast to produce cellulase, VAD communities can grow it as their own vitamin A supplement using readily-available plant matter as feedstock. To facilitate community integration, we designed bioreactor schematics based on locally-available resources, and made the yeast auxotrophic to ensure safe growth with no environmental risk. We also created a vitamin A biosensor to improve VAD testing, and included an anthelmintic agent in the yeast to combat poor intestinal health, two contributing factors to VAD. Through these solutions, Oviita aims to be a sustainable and community-based adjunct to global efforts against VAD. Check out our description page and our project presentation video to learn more about Oviita.