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</head> | </head> | ||
− | <body style="background-color: #ffffff; overflow-x: hidden"> | + | <body style="background-color: #ffffff; overflow-x: hidden;"> |
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− | src="https://static.igem.org/mediawiki/2020/ | + | src="https://static.igem.org/mediawiki/2020/a/aa/T--Calgary--ruralschoolkids.png" |
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<p> | <p> | ||
− | + | As a leading global cause of preventable blindness and mortality, vitamin A deficiency (VAD) is a serious health problem, particularly in developing regions. Oviita aims to equip these vulnerable regions with a sustainable and community-based solution to VAD. Our solution uses a food-safe strain of <span style="font-style: italic;class="italic">Yarrowia lipolytica</span> modified to produce beta-carotene, a vitamin A precursor. By engineering this yeast to produce cellulase, VAD communities can grow it as their own vitamin A supplement using readily-available plant matter as feedstock. To facilitate community integration, we designed bioreactor schematics based on locally-available resources, and made the yeast auxotrophic to ensure safe growth with no environmental risk. We also created a vitamin A biosensor to improve VAD testing, and included an anthelmintic agent in the yeast to combat poor intestinal health, two contributing factors to VAD. Through these solutions, Oviita aims to be a sustainable and community-based adjunct to global efforts against VAD. Check out our <a href="https://2020.igem.org/Team:Calgary/Description">description page</a> and our <a href="https://video.igem.org/videos/watch/9891caea-e3db-4d84-b759-36c72e756721">project presentation video</a> to learn more about Oviita. </p> | |
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</div> | </div> | ||
<!-- NAVIGATION GRID --> | <!-- NAVIGATION GRID --> | ||
<div class="content-panel project-icons dynamic-padding"> | <div class="content-panel project-icons dynamic-padding"> | ||
<h1>Project Components</h1> | <h1>Project Components</h1> | ||
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<div class="component-row"> | <div class="component-row"> | ||
− | < | + | <a href="https://2020.igem.org/Team:Calgary/Human_Practices"> |
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− | + | data-link="https://2020.igem.org/Team:Calgary/Human_Practices" | |
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− | + | <div class="icon"> | |
− | + | <img src="https://static.igem.org/mediawiki/2020/0/09/T--Calgary--hp-logo.png" style="width:50%;"> | |
− | + | </div> | |
− | + | <h2 class="title">Human Practices</h2> | |
− | + | <p class="description"> | |
− | + | We conducted in-depth interviews with nutrition experts and future users of our products | |
− | + | </p> | |
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</div> | </div> | ||
− | + | </a> | |
− | + | <a href="https://2020.igem.org/Team:Calgary/Engineering"> | |
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− | + | class="project-component" | |
− | < | + | data-link="https://2020.igem.org/Team:Calgary/Engineering" |
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− | + | <img src="https://static.igem.org/mediawiki/2020/6/69/T--Calgary--engineering-logo.png" style="width:50%;"> | |
− | + | </div> | |
− | + | <h2 class="title">Engineering</h2> | |
− | + | <p class="description"> | |
− | + | We engineered the yeast strain <i>Yarrowia liplytica</i> to produce exactly what we needed for Oviita | |
− | + | </p> | |
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</div> | </div> | ||
− | + | </a> | |
− | + | <a href="https://2020.igem.org/Team:Calgary/Model"> | |
− | + | <div | |
− | + | class="project-component" | |
− | < | + | data-link="https://2020.igem.org/Team:Calgary/Model" |
− | + | > | |
− | + | <div class="icon"> | |
− | + | <img src="https://static.igem.org/mediawiki/2020/0/01/T--Calgary--modelling-logo-2.png" style="width:60%; margin-bottom:15px; margin-top:0px;"> | |
− | + | </div> | |
− | + | <h2 class="title">Modelling</h2> | |
− | + | <p class="description"> | |
− | + | Computer modelling informed experimental design through every step | |
− | + | </p> | |
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</div> | </div> | ||
− | + | </a> | |
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<div class="component-row"> | <div class="component-row"> | ||
− | < | + | <a href="https://2020.igem.org/Team:Calgary/Implementation"> |
− | class="project-component" | + | <div |
− | + | class="project-component" | |
− | + | data-link="https://2020.igem.org/Team:Calgary/Implementation" | |
− | + | > | |
− | + | <div class="icon"> | |
− | + | <img src="https://static.igem.org/mediawiki/2020/2/25/T--Calgary--implementation-logo-2.png" style="width:80%; margin-bottom:5px; margin-top:0px;"> | |
− | + | </div> | |
− | + | <h2 class="title">Proposed Implementation</h2> | |
− | + | <p class="description"> | |
− | + | The implementation of Oviita was thought through from start to finish | |
− | + | </p> | |
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</div> | </div> | ||
− | + | </a> | |
− | + | <a href="https://2020.igem.org/Team:Calgary/Parts"> | |
− | + | <div | |
− | + | class="project-component" | |
− | < | + | data-link="https://2020.igem.org/Team:Calgary/Parts" |
− | + | > | |
− | + | <div class="icon"> | |
− | + | <img src="https://static.igem.org/mediawiki/2020/d/de/T--Calgary--parts-logo-2.png" style="width:50%; margin-top:0px;"> | |
− | + | </div> | |
− | + | <h2 class="title">Parts</h2> | |
− | + | <p class="description"> | |
− | + | Several parts were added to the iGEM registry | |
+ | </p> | ||
</div> | </div> | ||
− | + | </a> | |
− | + | <a href="https://2020.igem.org/Team:Calgary/Hardware"> | |
− | + | <div | |
− | + | class="project-component" | |
− | < | + | data-link="https://2020.igem.org/Team:Calgary/Hardware" |
− | + | > | |
− | + | <div class="icon"> | |
− | + | <img src="https://static.igem.org/mediawiki/2020/4/40/T--Calgary--hardware-logo.png" style="width:60%; margin-bottom:-10px;"> | |
− | + | </div> | |
− | + | <h2 class="title">Hardware</h2> | |
− | + | <p class="description"> | |
− | + | Our Bioreactor and Diagnostic Tool are integral to the implementation of Oviita | |
+ | </p> | ||
</div> | </div> | ||
− | <h2 class="title"> | + | </a> |
− | + | </div> | |
− | + | <div class="component-row"> | |
− | + | <a href="https://2020.igem.org/Team:Calgary/Software"> | |
− | + | <div | |
− | + | class="project-component" | |
+ | data-link="https://2020.igem.org/Team:Calgary/Software" | ||
+ | > | ||
+ | <div class="icon"> | ||
+ | <img src="https://static.igem.org/mediawiki/2020/a/a5/T--Calgary--software-logo.png" style="width:60%; margin-bottom:15px; margin-top:0px;"> | ||
+ | </div> | ||
+ | <h2 class="title">Software</h2> | ||
+ | <p class="description"> | ||
+ | We created an array of software models and tools to assist us in creating Oviita | ||
+ | </p> | ||
+ | </div> | ||
+ | </a> | ||
</div> | </div> | ||
− | |||
</div> | </div> | ||
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Latest revision as of 05:36, 21 December 2020
A MAJOR PROBLEM
VITAMIN A DEFICIENCY IS A LEADING CAUSE OF CHILDHOOD MORTALITY
AND BLINDNESS.
WE'RE HERE TO CHANGE THAT.
OVIITA DESIGN
As a leading global cause of preventable blindness and mortality, vitamin A deficiency (VAD) is a serious health problem, particularly in developing regions. Oviita aims to equip these vulnerable regions with a sustainable and community-based solution to VAD. Our solution uses a food-safe strain of Yarrowia lipolytica modified to produce beta-carotene, a vitamin A precursor. By engineering this yeast to produce cellulase, VAD communities can grow it as their own vitamin A supplement using readily-available plant matter as feedstock. To facilitate community integration, we designed bioreactor schematics based on locally-available resources, and made the yeast auxotrophic to ensure safe growth with no environmental risk. We also created a vitamin A biosensor to improve VAD testing, and included an anthelmintic agent in the yeast to combat poor intestinal health, two contributing factors to VAD. Through these solutions, Oviita aims to be a sustainable and community-based adjunct to global efforts against VAD. Check out our description page and our project presentation video to learn more about Oviita.