Team:GunnVistaPingry US/Attributions
Advisors
- Dr. Samuel David Perli: Principal Investigator for team, helped in explanation of biological concepts to team members. Introduced and explained variables that affect sgRNA accuracy reviewed the algorithm and made suggestions
- Yamanaka Lab in Gladstone Institute, UCSF: provided RT qRT-PCR data for several gene knockdowns
- Professor Shinya Yamanaka: allowed Navya for an internship opportunity, which led her to develop this software project
- Craig M. Trester: already experienced iGEM once before, helped guide us
- Siva Palagummi: helped in debugging the Weissman code when it was outdated, and later helped in advising and reviewing our software
- Lauren Turetsky: Helped guide us in website design and format
Team Contribution
- Navya Lam: formed and led the project team, implemented human practices, and worked on the algorithm
- Aaron Chacko Mundanilkunathil: worked on the algorithm by studying the Weissman Lab files, normalizing the scores, debugging the code, and exploring the training sets
- Alisha Saboowala: focused on improving the model through graphical representations of the variables and by debugging the code
- Charuthi Arul: primarily worked on exploring the UCSC genome browser for protein information and doing the voice over for team videos
- Sanjana Biswas: surveyed the literature on CRISPR and explored other biological aspects to improve the model
- Stephanie Muggler: explored ViennaRNA to analyze secondary structure impact. Also, led in design and animation
- Dia Dhariwal: worked on outreach, validating the model and exploring the use of polynomial regressions
- Aditi Sadwelkar: worked on improving the algorithm and implementing off-target stringency
- Dorothy Lam: worked on website design and researched the background on the relevant genes
