HQ:all info.js

// JavaScript Document

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{'name':'Break','link':'https://2020.igem.org/Team:Break','region':'-','location':'-','track':'Break','time':'11,16,1100,30','title':'-','description':'-','event_type':'Break','video_link_promotion':'-','video_link_presentation':'-','section':'-','parts_link':'-','poster_link':'-','poster_session':'-','poster_location':'-'}, {'name':'Poster Session A','link':'https://2020.igem.org/Team:Poster Session A','region':'-','location':'-','track':'Poster Session','time':'11,14,0530,90','title':'-','description':'Teams presenting in this session are: <a href='2020.igem.org/Team:AHUT-ZJU-China'>AHUT-ZJU-China</a>, <a href='2020.igem.org/Team:ASTWS-China'>ASTWS-China</a>, <a href='2020.igem.org/Team:BIT'>BIT</a>, <a href='2020.igem.org/Team:BIT-China'>BIT-China</a>, <a href='2020.igem.org/Team:BJ101HS'>BJ101HS</a>, <a href='2020.igem.org/Team:BNDS_China'>BNDS_China</a>, <a href='2020.igem.org/Team:BUCT-China'>BUCT-China</a>, <a href='2020.igem.org/Team:CCU_Taiwan'>CCU_Taiwan</a>, <a href='2020.igem.org/Team:CPU_CHINA'>CPU_CHINA</a>, <a href='2020.igem.org/Team:CSMU_Taiwan'>CSMU_Taiwan</a>, <a href='2020.igem.org/Team:ECNUAS'>ECNUAS</a>, <a href='2020.igem.org/Team:ECUST_China'>ECUST_China</a>, <a href='2020.igem.org/Team:Fudan'>Fudan</a>, <a href='2020.igem.org/Team:GDSYZX'>GDSYZX</a>, <a href='2020.igem.org/Team:HK_HCY'>HK_HCY</a>, <a href='2020.igem.org/Team:HZAU-China'>HZAU-China</a>, <a href='2020.igem.org/Team:Jiangnan_China'>Jiangnan_China</a>, <a href='2020.igem.org/Team:JNFLS'>JNFLS</a>, <a href='2020.igem.org/Team:Korea_HS'>Korea_HS</a>, <a href='2020.igem.org/Team:Mingdao'>Mingdao</a>, <a href='2020.igem.org/Team:Nanjing_high_school'>Nanjing_high_school</a>, <a href='2020.igem.org/Team:Nanjing-China'>Nanjing-China</a>, <a href='2020.igem.org/Team:NCKU_Tainan'>NCKU_Tainan</a>, <a href='2020.igem.org/Team:NEFU_China'>NEFU_China</a>, <a href='2020.igem.org/Team:NJTech_China'>NJTech_China</a>, <a href='2020.igem.org/Team:NTHU_Taiwan'>NTHU_Taiwan</a>, <a href='2020.igem.org/Team:NUDT_CHINA'>NUDT_CHINA</a>, <a href='2020.igem.org/Team:NYU_Abu_Dhabi'>NYU_Abu_Dhabi</a>, <a href='2020.igem.org/Team:SCU-China'>SCU-China</a>, <a href='2020.igem.org/Team:SEHS-China'>SEHS-China</a>, <a href='2020.igem.org/Team:Shanghai_city'>Shanghai_city</a>, <a href='2020.igem.org/Team:SHSBNU_China'>SHSBNU_China</a>, <a href='2020.igem.org/Team:SJTU-BioX-Shanghai'>SJTU-BioX-Shanghai</a>, <a href='2020.igem.org/Team:SUSTech_Shenzhen'>SUSTech_Shenzhen</a>, <a href='2020.igem.org/Team:SZU-China'>SZU-China</a>, <a href='2020.igem.org/Team:Tongji_China'>Tongji_China</a>, <a href='2020.igem.org/Team:UM_Macau'>UM_Macau</a>, <a href='2020.igem.org/Team:Worldshaper-Wuhan'>Worldshaper-Wuhan</a>, <a href='2020.igem.org/Team:Xiamen_city'>Xiamen_city</a>, <a href='2020.igem.org/Team:XJTU-China'>XJTU-China</a>, <a href='2020.igem.org/Team:ZJU-China'>ZJU-China</a>','event_type':'Poster 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D','region':'-','location':'-','track':'Poster Session','time':'11,15,1130,90','title':'-','description':'-','event_type':'Poster Session','video_link_promotion':'-','video_link_presentation':'-','section':'-','parts_link':'-','poster_link':'-','poster_session':'-','poster_location':'-'}, {'name':'Poster Session E','link':'https://2020.igem.org/Team:Poster Session E','region':'-','location':'-','track':'Poster Session','time':'11,16,0530,90','title':'-','description':'-','event_type':'Poster Session','video_link_promotion':'-','video_link_presentation':'-','section':'-','parts_link':'-','poster_link':'-','poster_session':'-','poster_location':'-'}, {'name':'Poster Session F','link':'https://2020.igem.org/Team:Poster Session F','region':'-','location':'-','track':'Poster Session','time':'11,16,1130,90','title':'-','description':'-','event_type':'Poster Session','video_link_promotion':'-','video_link_presentation':'-','section':'-','parts_link':'-','poster_link':'-','poster_session':'-','poster_location':'-'}, {'name':'Aachen','link':'https://2020.igem.org/Team:Aachen','region':'Europe','location':'Germany','track':'Foundational Advance','time':'11,16,0800,30','title':'M.A.R.S. - Magnetic ATP Recycling System','description':'The complex regeneration of biochemical energy sources represents a cost-intensive hurdle for many production and research processes. With M.A.R.S., we want to establish an innovative strategy to create light-powered, mitochondrion-like protocells and a bioreactor that will recycle those cells by magnetism. Through the design of our reusable recycling system it will be able to power every ATP-driven enzyme cascade, making M.A.R.S. universally applicable. By extracting bacteriorhodopsin out of Halobacterium salinarum, a phototrophic archaea species, and combining it with an ATP synthase from Saccharomyces cerevisiae in self-produced polymersomes and liposomes, we get simple but effective chassis, which make it possible to cover the energy requirement of any enzyme reaction cascade. Binding those chassis to magnet particles via anchor peptides enables the reuse of the entire protocell system within the reactor by means of magnetic purification, whereby they can be fed directly into enzyme cascades, without depending on living cells.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/bff60010-a0a8-4d37-92ec-da263d7cc9af','video_link_presentation':'https://video.igem.org/videos/watch/ed599430-bf4e-4a96-a29c-debb62facc99','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Aachen','poster_link':'https://2020.igem.org/Team:Aachen/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 1, Poster Number 178'}, {'name':'Aalto-Helsinki','link':'https://2020.igem.org/Team:Aalto-Helsinki','region':'Europe','location':'Finland','track':'Environment','time':'11,15,1000,30','title':'SINISENS - A step towards cleaner waters','description':'The presence of macrolide antibiotics in nature is a growing concern as they have been on the `watch-list` of pharmaceuticals for EU-wide monitoring in aquatic environments for several years. They can be harmful for the environment and human health because they are persistent and can remain biologically active. Additionally, they may promote the development of antimicrobial resistance. According to various experts, there will likely be regulations regarding the monitoring of macrolide antibiotics in the near future. However, current methods for measuring them are time-consuming, expensive and require expertise. Our solution, SINISENS, is designed to aid wastewater treatment plants to monitor the concentrations of macrolide antibiotics and could be used to optimize the removal process. SINISENS is an optical on-site biosensor based on a genetic circuit that utilises a transcription factor called MphR to detect macrolide antibiotics. In the presence of these compounds, SINISENS produces green fluorescence as an output signal.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/0bd66f9d-6113-4810-b8ed-7389d2c3f642','video_link_presentation':'https://video.igem.org/videos/watch/adf95d5a-25d5-4736-bca3-611c129c4646','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Aalto-Helsinki','poster_link':'https://2020.igem.org/Team:Aalto-Helsinki/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 1, Poster Number 90'}, {'name':'AFCM-Egypt','link':'https://2020.igem.org/Team:AFCM-Egypt','region':'Africa','location':'Egypt','track':'Therapeutics','time':'11,15,0730,30','title':'Neo-epitope discovery for DNA-launched RNA replicons: paving the way to efficient breast cancer vaccination','description':'Triple negative breast cancer is one of the most aggressive breast cancer subtypes. It is characterized by a generally poor prognosis and strong resistance to traditional therapies. This season, we focused on designing a novel immunotherapeutic approach involving DNA-launched RNA Replicons (DREP). We utilized our hotspot detection tool, `Custommune`, to generate a list of candidate neo-epitopes from clinically prioritized neoantigens thus reducing the need for extensive sequencing approaches. After in silico validation of our generated neo-epitope predictions, we devised a DREP-based platform to effectively deliver our multi-neo-epitope vaccine. The platform utilizes the inherent self-amplification ability of RNA-replicons to ensure enhanced neo-antigen uptake and presentation leading to the mounting of efficient cellular and humoral immune responses against TNBC. Embedded with optimized subgenomic regulation and linker-peptides alongside glycine-alanine repeats (GAr), a miRNA-based immune evasion mechanism and an OFF-switch, our platform is predicted to be highly safe and efficient through experimentally-driven mathematical simulations.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/2e5cadac-c18d-4a54-a998-011c9754d681','video_link_presentation':'https://video.igem.org/videos/watch/11752254-cdab-4145-8abc-729de3f6a2db','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=AFCM-Egypt','poster_link':'https://2020.igem.org/Team:AFCM-Egypt/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 1, Poster Number 92'}, {'name':'AHUT-ZJU-China','link':'https://2020.igem.org/Team:AHUT-ZJU-China','region':'Asia','location':'China','track':'Environment','time':'11,14,0800,30','title':'carbonic anhydrase 3.0','description':'Greenhouse gas emissions lead to a rise in global average temperatures, which will endanger human lives and lives. We decided to use the biomimetic method of enzyme (carbonic anhydrase), which has the advantages of safety, high catalytic efficiency and environment-friendly compared with other methods of capturing and concentrating CO2. We designed an efficient and stable CA by improving the catalytic performance of CA from thermophilic bacteria and the biological stability of capturing CO2. We use computer-aided analysis software to predict the ideal mutation site of the protein. Then we carried out enzyme-substrate molecular docking and enzyme-solvent kinetics simulation, constructed wild-type and mutant CA prokaryotic expression vectors, and expressed and purified the protein. Finally, we carried out functional identification to determine whether the activity of the mutant protein changed and whether the thermal stability was significantly improved.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/d7b887c3-7884-4139-999e-0165f19745f2','video_link_presentation':'https://video.igem.org/videos/watch/65d61563-a410-4ec0-b0df-e6b50d1ecd88','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=AHUT-ZJU-China','poster_link':'https://2020.igem.org/Team:AHUT-ZJU-China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 1, Poster Number 1'}, {'name':'Aix-Marseille','link':'https://2020.igem.org/Team:Aix-Marseille','region':'Europe','location':'France','track':'Environment','time':'11,14,0930,30','title':'Make some Rham-Noise','description':'Since the 70`s green algae have been proliferating and forming what are called green tides on certain beaches in France, but also in China and the United States. This is mainly due to nitrogen-rich fertilizers used in intensive agriculture The green algae on the beach decompose and produce hydrogen sulfide a deadly gas for animals and humans. One very promising route for recovery is the production of bioethanol that could be blended with gasoline and used by adapted vehicles. The objective of our project is to define an efficient process to transform ulvan, a sugar polymer present in large quantities in the wall of Ulva into rhamnose and other fermentable sugars using the enzymes from Formosa Agariphila inserted in Saccharomyces cerevisiae and then transform it into bioethanol using the fermentation capacity of Saccharomyces cerevisiae and Pichia stipitis. Thanks to this Ulva could become a renewable and profitable source of energy.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ef1375fa-6bfd-4858-bb68-6f147c6ac0d7','video_link_presentation':'https://video.igem.org/videos/watch/e1013f30-2bec-4f34-afe5-906aa0543c78','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Aix-Marseille','poster_link':'https://2020.igem.org/Team:Aix-Marseille/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 1, Poster Number 2'}, {'name':'Alma','link':'https://2020.igem.org/Team:Alma','region':'North America','location':'United States','track':'Environment','time':'11,16,1030,30','title':'Poisoned River','description':'The Pine River is found in central Michigan, near the campus of Alma College. Following the closure of the Velsicol Chemical Plant in 1978, many environmental pollutants -- such as DDT -- were improperly disposed of and allowed to leach into the surrounding soil and Pine River. These organochlorides are endocrine disruptors as well as possible carcinogens that have wreaked havoc on the local avian population. Several species of animals have estrogen receptors known to bind DDT, a known xenoestrogen. Linking this binding process to a reporting gene, such as RFP, within a microbe will allow for the detection of organochlorides, which can enhance broad spectrum screening of these contaminated areas both locally and globally. Ultimately, this biosensor has the potential to save thousands of dollars in the pollution cleanup effort as well as provide a basis for the development of future synthetic biology tools for the bioremediation of DDT.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/5a8e20cd-a763-4fa2-ae07-3e1a1b4aab65','video_link_presentation':'https://video.igem.org/videos/watch/e8dd4d59-79f2-4853-b1a0-fb847fec8554','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Alma','poster_link':'https://2020.igem.org/Team:Alma/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 1, Poster Number 181'}, {'name':'Amsterdam','link':'https://2020.igem.org/Team:Amsterdam','region':'Europe','location':'Netherlands','track':'Information Processing','time':'11,16,0830,30','title':'Forbidden FRUITS: stable microbial production strategies for non-native compounds','description':'Genetically engineered cellular systems can be used to produce industrially valuable compounds in a sustainable way. A challenge is that it is more beneficial for cells to use their resources exclusively for growth, resulting in a loss of production ability. Therefore, we have developed Forbidden FRUITS, a pipeline that can solve this problem by calculating and optimizing engineering strategies to couple a product forming pathway to microbial growth. Multiple databases, constraint-based programming and gene-protein-reaction associations are used to devise suitable strategies. These strategies are then optimized using pathfinding methods and sequence optimization. As proof-of-principle, we applied Forbidden FRUITS to salicylic acid, lactate and mannitol production in Synechocystis PCC6803, lactate in Synechococcus UTEX 2973 and salicylic acid in Escherichia Coli. Forbidden FRUITS is shown to be flexible and allow for the fast development of stable production strains, making the full-potential of biotechnology evermore attainable.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/c7ae3f52-f3c0-4ca9-83c8-88ef3865a42a','video_link_presentation':'https://video.igem.org/videos/watch/2441d14b-0440-49cf-8ae0-1e3f5a551df0','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Amsterdam','poster_link':'https://2020.igem.org/Team:Amsterdam/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 1, Poster Number 183'}, {'name':'AshesiGhana','link':'https://2020.igem.org/Team:AshesiGhana','region':'Africa','location':'Ghana','track':'Environment','time':'11,14,0800,30','title':'The Coastbusters: Saving the Coast One bottle at the time','description':'Did you know that each year, more than 8 million tons of plastic waste are dumped into the ocean, harming the marine ecosystem? In response the sea seems to be fighting back through coastal erosion, which is threatening human settlements across the globe. This project aims to design a living sea defense system (bio-concrete tetrapods) by incorporating organisms capable of carrying out plastics and bio-cementation bioremediation. Several plasmids will be design to breakdown the plastic and carry out the bio-cementation process, and some plasmids will have the genes under a constitutive promoter; others would have it under a pH-responsive promoter to maintain the optimal pH for the ecosystem while others would be under a light-inducible promoter, which will be activated in the presence of increased light due to occurring cracks in the tetrapod. We are aiming to identify the conditions necessary to initiate the ecosystem and for making it self-balancing.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/4e1c8b4a-a4ee-499a-9be5-ccbf4694967c','video_link_presentation':'https://video.igem.org/videos/watch/8ddf129b-1df3-4612-85c7-0c643c4a52dd','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=AshesiGhana','poster_link':'https://2020.igem.org/Team:AshesiGhana/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 1, Poster Number 4'}, {'name':'ASTWS-China','link':'https://2020.igem.org/Team:ASTWS-China','region':'Asia','location':'China','track':'High School','time':'11,14,1000,30','title':'When Microplastics Meet Biofilms: Enhanced Degradation of Environmental Plastics by Biosorption','description':'Microplastics from household waste are easily entered into our water system, which is one of the most difficult environmental pollutants to degrade. The newly developed biodegradation technology can effectively degrade highly polyester contaminants, such as PET plastics, which can be efficiently degraded using PETase. On the other hand, biosorption can effectively collect microplastic particles. Therefore, in this study, we hypothesize that genetically enhanced biofilms can promote PET microplastic degradation through the proximity effect of the enzyme and substrate, thus benefiting future environmental governance applications.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/dbae9f96-c1e0-4685-9c5b-161cf81cb1ce','video_link_presentation':'https://video.igem.org/videos/watch/fb5b55be-a39d-4671-87ab-0e12282330a3','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=ASTWS-China','poster_link':'https://2020.igem.org/Team:ASTWS-China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 1, Poster Number 3'}, {'name':'Athens','link':'https://2020.igem.org/Team:Athens','region':'Europe','location':'Greece','track':'Manufacturing','time':'11,14,0730,30','title':'Morphæ: An engineered biofilm for the production of a novel structurally coloured material','description':'Colours in nature can be the result either of chemical pigments or of the physical structure of surfaces. Certain bacterial strains exhibit structural colour when they form biofilms, a phenomenon caused by spatial geometries in the micron scale. In this iGEM project we utilize bacteria from the Flavobacterium genus that display structural colour naturally, to create a material that is coloured due to that property. In order for ​Flavobacteriia to secrete a cellulose based extracellular matrix that retains this property, genes from the bcs operon of Komagataeibacter xylinus will be transferred. A biophysical mass-spring model of the cell will be developed to simulate the gliding motility mechanism based on the mechanical interactions between the cells, along with a simulation predicting the optical properties of a known structure. A kinetic modeling for the cellulose biosynthesis will also be implemented to better predict the final structure of the biomaterial.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f0df5dfe-605b-49c2-adf0-829c295e7643','video_link_presentation':'https://video.igem.org/videos/watch/18b3b52d-e508-44b5-a6ce-cb0600b7a30d','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Athens','poster_link':'https://2020.igem.org/Team:Athens/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 1, Poster Number 6'}, {'name':'AUC-EGYPT','link':'https://2020.igem.org/Team:AUC-EGYPT','region':'Africa','location':'Egypt','track':'Therapeutics','time':'11,14,0800,30','title':'A SynBio-based SARS-CoV-2 therapeutic solution: orchestrating inducible interference using virus-like particles, toehold riboswitches and siRNAs.','description':'The COVID-19 pandemic is without doubt the biggest health crisis of the 21st century. Currently, there is no specific treatment or vaccine for the disease. In this phase-I project, we propose a SynBio-based therapeutic solution for COVID-19. Our approach consists of a SARS-CoV-2-like particle that is capable of targeting cells expressing the ACE2 receptor. Upon delivery, our sensing moiety (Toehold Riboswitch adjusted for mammalian systems) is constitutively expressed. If SARS-CoV-2 triggers are present within the cell, the sensor will unfold initiating a GAL4-VP16-dependent interference pathway. Consequently, we designed two de novo siRNAs that play a critical role in our antiviral therapeutic approach. They inhibit viral replication via RISC-mediated degradation of the replicase region of SARS-CoV-2 mRNA. We also created a deterministic model to predict the levels of siRNAs as well as a structural model to predict the thermodynamic stability of our toehold riboswitches.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/2bb9dd02-d8cb-41ec-bfda-035447f11e64','video_link_presentation':'https://video.igem.org/videos/watch/884e77ea-4e50-43e5-a790-7f4802af6c27','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=AUC-EGYPT','poster_link':'https://2020.igem.org/Team:AUC-EGYPT/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 1, Poster Number 8'}, {'name':'Austin_UTexas','link':'https://2020.igem.org/Team:Austin_UTexas','region':'North America','location':'United States','track':'Diagnostics','time':'11,16,1000,30','title':'PhastPhage','description':'Bacterial contamination of drinking water is a huge problem worldwide, causing 780,000 deaths on average each year. With PhastPhage, we intend to create a phage-based biosensor for detecting the presence of E. coli contamination in water sources. Using the stoichiometric gene expression simulator Pinetree, we modeled the genome of bacteriophage T7 in order to determine how we could engineer it to produce large amounts of GFP and shorten the time it takes to lyse bacterial cells during an infection cycle. We determined that the most effective way to achieve this was to place a GFP gene, as well as move a holin gene responsible for lysis proteins, into the genome adjacent to gene 10A, which encodes for a major capsid protein and has the highest level of expression of all of T7`s genes. In the future we hope to engineer phage with these changes and confirm our model`s predictions experimentally.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/9b01db28-76b8-4a09-93d1-1c28aae126c4','video_link_presentation':'https://video.igem.org/videos/watch/463f6118-4444-4c1d-8346-ba6200e1c4c3','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Austin_UTexas','poster_link':'https://2020.igem.org/Team:Austin_UTexas/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 1, Poster Number 186'}, {'name':'Baltimore_BioCrew','link':'https://2020.igem.org/Team:Baltimore_BioCrew','region':'North America','location':'United States','track':'High School','time':'11,14,1030,30','title':'Improving Iron Uptake and Processing in Synechococcus CB0101 to Bolster Marine Ecosystems','description':'In 1/3 of the world`s oceans, the iron concentration limits phytoplankton growth. Iron is required for photosynthesis and is critical for the base of the marine food web. A better ability to capture iron could increase phytoplankton populations which would have benefits such as reducing atmospheric carbon dioxide by acting as a carbon sink. We decided to engineer Synechococcus (cyanobacteria) because it consumes high levels of CO2, has a high replication rate, and has been used by many previous iGEM teams. Our project will engineer cyanobacteria to transport iron into cells and reduce it to the bioavailable Fe(II) form. The increased iron utilization will increase photosynthesis and growth of phytoplankton. To prevent harmful phytoplankton blooms, a kill switch will also be added to the cells to prevent overgrowth of cells if iron concentration increased significantly. These modifications will stabilize the marine food chain and absorb CO2 from the atmosphere.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/61812375-c32d-4ff4-bc39-bbd729d4a0ca','video_link_presentation':'https://video.igem.org/videos/watch/019e3187-1b4f-4fae-a1c8-8eea0e4b5105','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Baltimore_BioCrew','poster_link':'https://2020.igem.org/Team:Baltimore_BioCrew/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 1, Poster Number 10'}, {'name':'Beijing_4ELEVEN','link':'https://2020.igem.org/Team:Beijing_4ELEVEN','region':'Asia','location':'China','track':'High School','time':'11,16,0830,30','title':'Acneutralizer','description':'Acne vulgaris troubles teenagers and sometimes adults as it not only affects the skin but also self-confidence. Traditional treatment to acne vulgaris involving antibiotics may trigger drug resistance in acne pathogenic bacteria, especially Propionibacterium. acnes. Antimicrobial peptides (AMPs) are considered excellent alternatives of antibiotics for their capability of providing effective, broad-spectrum defenses against infections and exhibiting relatively low potential to elicit resistance. However, AMP curing products nowadays are not abundant, and most AMPs are produced via chemosynthesis, a rather costly method incapable of yielding AMPs with great antimicrobial potency. Therefore, we aim to create an anti-acne product which consists of biosynthesized P. acnes killing AMPs, adhesive/cohesive proteins, and tyrosinase. The mixture which we named Acneutralizer forms a thin film when applied to acne-infected skin. This product may be brought to market, helping acne sufferers improve their conditions by easily killing P. acnes.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/5e37b5c2-634a-476c-833f-36a10b027a0c','video_link_presentation':'https://video.igem.org/videos/watch/06beb4e4-7a67-459e-99bd-8e91205a9eb6','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Beijing_4ELEVEN','poster_link':'https://2020.igem.org/Team:Beijing_4ELEVEN/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 1, Poster Number 177'}, {'name':'BGU-Israel','link':'https://2020.igem.org/Team:BGU-Israel','region':'Asia','location':'Israel','track':'Environment','time':'11,16,0830,30','title':'WIPEOUT - Wipes out wet wipes of the environment!','description':'Over the last two decades, the use of wet wipes has become commonplace across the globe. Disposal of wet wipes through the toilet and their accumulation in the sewer systems cause extensive damage; In Israel alone, repairing the wet wipes damage to sewer systems is estimated by 3,360,000$ per year! `Wipeout` presents a leading and innovative solution to this unsolved, global problem of biodegradation of domestic contamination of sewage and water systems. We aim to utilize biological methods, including genetically engineering the sewer systems` bacterial populations, using bacterial surface- display systems. Our final goal is to solve the clogging problems caused by an accumulation of cellulose fibered wipes in sewer systems and prevent a generation of `fatbergs`, which are thousands of wipes stacked together with other flushed solids and fats. By finding a solution to this problem we may be able to prevent both ecological and economic damages.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/70a9a146-0e81-4907-8b6c-138cbcd80499','video_link_presentation':'https://video.igem.org/videos/watch/c90d06bc-4c6e-49ef-95c2-9732c4091c4d','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=BGU-Israel','poster_link':'https://2020.igem.org/Team:BGU-Israel/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 1, Poster Number 179'}, {'name':'BHSF','link':'https://2020.igem.org/Team:BHSF','region':'Asia','location':'China','track':'High School','time':'11,16,0930,30','title':'Khronos: The Timer Yeast','description':'When baking at home, people always have their bread over-fermented due to the of experience and disturbance from other matters. However, fermentation is the most important process in baking. Therefore, we came up with the idea of modifying the genes in auxotroph baking yeast to stop fermentation at appropriate times. We designed a circuit based on toggle switch. Before we add the inducer galactose, the switch is kept at `off` state, where a protein that complements the auxotroph gets to express, after the galactose is added, the switch is turned on by accumulation of the previously repressed gene, the expression of the other gene is then shut down, along with the gene of the complimentary protein, leading to a drop in their concentrations and terminating fermentation over a certain period of time.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/c6a0d94e-ccea-44ed-9558-36763063149d','video_link_presentation':'https://video.igem.org/videos/watch/c51c0170-9bd6-4582-9cd1-764408951aa9','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=BHSF','poster_link':'https://2020.igem.org/Team:BHSF/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 1, Poster Number 180'}, {'name':'Bielefeld-CeBiTec','link':'https://2020.igem.org/Team:Bielefeld-CeBiTec','region':'Europe','location':'Germany','track':'Diagnostics','time':'11,16,0800,30','title':'WavySense: Don`t take your hormones, measure them!','description':'Have you ever thought about contraception? Did you know most contraceptives are invasive and can have severe side effects? A new, innovative and non-invasive method is needed. One that reliably reports the user`s fertility. Therefore, we developed WavySense: Contributing to gender equality by supporting and empowering women, lacking any side effects. WavySense enables users to determine the current fertility by directly measuring the characteristic sex hormones estrogen, progesterone and luteinizing hormone in urine using the surface acoustic wave technique. An electronic module induces waves in a piezoelectric crystal, which are phase-shifted by mass changes on the surface. We produced hormone-specific antibodies in E. coli and single chain variable fragments for comparison. Immobilized on the gold-coated surface of the crystal, antibody-antigen binding leads to a phase shift which is detected by the electronics and transferred to our user-friendly app. It tracks, evaluates and visualizes recent measurements, displaying the current fertility status.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/2b291dad-45db-4e31-b196-eed8364c7017','video_link_presentation':'https://video.igem.org/videos/watch/9b094c66-fa04-4998-9cbd-96ef7850ae31','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Bielefeld-CeBiTec','poster_link':'https://2020.igem.org/Team:Bielefeld-CeBiTec/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 2, Poster Number 189'}, {'name':'BIT','link':'https://2020.igem.org/Team:BIT','region':'Asia','location':'China','track':'Diagnostics','time':'11,14,0730,30','title':'Dr. Watson：j.o.h.n:judge of COVID- 19 handling','description':'Since the outbreak of the COVID-19 at the end of 2019, it has caused great harm to public health safety. Although the current detection methods are diverse, most of the main applications are hospitals with certain qualifications and conditions. This is no small challenge for people in developed, developing, and underdeveloped countries. Therefore, it is very necessary to have a simple operation and easy-to-carry testing equipment that can be used in communities and rural hospitals. Therefore, this year`s BIT team is committed to designing related integrated detection systems. Based on the designed biosensing module, centrifugal chip module， smart phone module, and the COVID-19 related protein markers （Convert it into a nucleic acid signal） are fast, sensitive, portable and low-cost. Testing, providing effective testing programs for the new coronavirus in places with low medical testing resources.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/85a2496a-866b-4ef0-822b-38fb2d048c2d','video_link_presentation':'https://video.igem.org/videos/watch/5488d1bd-81f3-4ecf-8dcd-5e52990a84c1','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=BIT','poster_link':'https://2020.igem.org/Team:BIT/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 1, Poster Number 5'}, {'name':'BIT-China','link':'https://2020.igem.org/Team:BIT-China','region':'Asia','location':'China','track':'Manufacturing','time':'11,14,0830,30','title':'Lemon CP','description':'Our team BIT-China designed and constructed a double oscillation dynamic regulation system to produce flavonoids. By using this system, we can use an intelligent dynamic regulation method to regulate E. coli and Yeast, to match the growth rate, upstream, and downstream pathways of the two. It also means that we successfully produce saccharoid using a combination of E. coli and Yeast`s advantages in their respective production processes.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f239fea2-5e8e-4bfb-911b-32779ce01ec5','video_link_presentation':'https://video.igem.org/videos/watch/96229901-db49-496c-8989-3832c3d1acd1','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=BIT-China','poster_link':'https://2020.igem.org/Team:BIT-China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 1, Poster Number 7'}, {'name':'BITSPilani-Goa_India','link':'https://2020.igem.org/Team:BITSPilani-Goa_India','region':'Asia','location':'India','track':'Food and Nutrition','time':'11,15,1000,30','title':'SugarGain','description':'Sugarcane faces the issue of post-harvest sucrose deterioration. This loss is caused by the activity of an enzyme called invertase. Post harvest, invertase cleaves sucrose which reduces sugar retrieval rates by up to 10.25%. We wanted to devise a solution that initiated grassroots-level changes for farmers. The farmer would administer our novel polymer-based inoculant, which would release our bacteria into the stem of the sugarcane, by employing an injector mechanism. Once inside, our genetic circuit inside the bacterial E.coli chassis is designed to exhibit anti-invertase activity, regulated by the amount of fructose inside the sugarcane in a continuous and controlled manner, through a biosensor mechanism. We propose to use a modified type II ccdA-ccdB toxin-antitoxin system as our kill switch that is activated upon exposure to atmospheric concentrations of oxygen. We have also kept in mind the significance of biosafety and designed a robust three-tier failsafe mechanism.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/7e504a75-b11e-4426-9137-c696071a8807','video_link_presentation':'https://video.igem.org/videos/watch/23e8cbfc-bac6-44ef-8e18-7c53208d87c9','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=BITSPilani-Goa_India','poster_link':'https://2020.igem.org/Team:BITSPilani-Goa_India/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 1, Poster Number 89'}, {'name':'BJ101HS','link':'https://2020.igem.org/Team:BJ101HS','region':'Asia','location':'China','track':'High School','time':'11,14,1000,30','title':'Mother Yeast','description':'The inspiration for our project came from knowing nursing mothers faced lots of breastfeeding problems, including insufficiency of milk production and inconveniences of suckling. Realizing that there were significant differences between formula milk and breast milk, we came up with creating a breast milk substitute that better fits human nutritional needs. We learned that present formula milk lacks of important proteins like β casein, κ casein, lactoferrin, and α-lactalbumin. Thus, we paid our attention to these proteins and hoped we could produce them using synthetic biology methods. We chose yeasts as our engineering bacteria because they are welcoming for human bodies. We transfected CSN2, CSN3, LTF, and LALBA that are responsible for making the proteins that mentioned above into yeasts, and cultivated them. Finally, we got our targeted proteins and created a product. We hope following iGEMers can produce more materials like amylose to fix the disadvantages of formula milk.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/7c30f8a1-53dd-4632-80ed-c93ba27b319e','video_link_presentation':'https://video.igem.org/videos/watch/15f6f977-9dac-4bb1-b63a-a2548941dd21','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=BJ101HS','poster_link':'https://2020.igem.org/Team:BJ101HS/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 1, Poster Number 9'}, {'name':'BNDS_China','link':'https://2020.igem.org/Team:BNDS_China','region':'Asia','location':'China','track':'High School','time':'11,14,0930,30','title':'BACLOTH','description':'Wild animal`s leathers have great values for the clothing and fashion industry. Some luxury products like crocodile bag even require leather from rare species. This profitable business drives poachers to illegally hunt and hurt those wild animals. The demands of leather put the wild animals in a dangerous place and the harms caused by poaching for species conservation is unthinkable. Therefore, we aimed to integrate bacterial cellulose and protein crosslinking to manufacture artificial leather for animal conservation. Specifically, we utilized G. xylinus to synthesize bacterial cellulose. Moreover, we engineered E. coli and P. Pastoris to purify collagen-like protein and spider fibroin with SpyCatcher003 and SpyTag003 for protein crosslinking. This synthetic biological method provides an alternative way to supply raw material for leather industry, while ensuring animal and environment conversation.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/8bd38a4f-ed47-4c98-b21e-96637e8287eb','video_link_presentation':'https://video.igem.org/videos/watch/22a8da31-c354-4d6d-898d-e8e5ee515208','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=BNDS_China','poster_link':'https://2020.igem.org/Team:BNDS_China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 1, Poster Number 11'}, {'name':'BNU-China','link':'https://2020.igem.org/Team:BNU-China','region':'Asia','location':'China','track':'Foundational Advance','time':'11,16,0730,30','title':'Automatic Barcode Creator (ABC)','description':'Tracing the lineage of cells is essential in answering diverse and fundamental questions in biology. In recent years, the method combing CRISPR/Cas9 and barcode, a DNA sequence as genetic marker, has attracted extensive attention in lineage tracing. However, the diversity of barcodes is limited and the constitutively expressed Cas9 consumes barcodes quickly. These make barcodes infeasible for the tracking purpose after several generations. We propose to track more generations by two ways. First, we build an inducible expression module of Cas9 in association with cell division to label each cell automatically without wasting barcodes. Second, we use homing guide RNA (hgRNA) to replace the small guide RNA (sgRNA) so that the diversity of barcodes can be increased greatly. In order to make the barcode sequence read at RNA level, we design a double promoter module, so that we can obtain the lineage information together with transcriptomic information.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/db7eb70d-983c-40f5-833d-7c51e9f65799','video_link_presentation':'https://video.igem.org/videos/watch/a2890042-301a-4a16-982f-a47cfdce952c','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=BNU-China','poster_link':'https://2020.igem.org/Team:BNU-China/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 1, Poster Number 182'}, {'name':'BOKU-Vienna','link':'https://2020.igem.org/Team:BOKU-Vienna','region':'Europe','location':'Austria','track':'Therapeutics','time':'11,14,1000,30','title':'Phangel – Taking Phage Therapy Ahead','description':'Our vision is to alleviate bacterial infections and their systemic consequences by not only eliminating hostile bacteria but also, in a second step, capturing their toxic components released during bacterial lysis. Our goal is to recombinantly engineer a T7 bacteriophage that by infection forces its target bacterium to produce gelsolin, a protein able to bind the endotoxin LPS. Firstly, we designed our experiments in silico to contribute our parts to the iGEM registry. We then cloned the plasmids containing the recombination system necessary for engineering our phage. The genes to be inserted into the phage genome were amplified. Additionally, we designed a safety measure to inhibit the engineered phage`s ability to reproduce autonomously. To support our experimental findings we modelled the interaction between T7 bacteriophages and E.coli. Furthermore, to gain more insight into the biology of the T7 bacteriophage, we collaborated with team TU Delft to characterize the wildtype.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/268f3747-e86c-4e83-9e0f-e19b62b0c199','video_link_presentation':'https://video.igem.org/videos/watch/d6fb60e5-96f1-4d76-89ee-c86456af83cf','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=BOKU-Vienna','poster_link':'https://2020.igem.org/Team:BOKU-Vienna/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 2, Poster Number 12'}, {'name':'Botchan_Lab_Tokyo','link':'https://2020.igem.org/Team:Botchan_Lab_Tokyo','region':'Asia','location':'Japan','track':'Environment','time':'11,16,0800,30','title':'nico-friendly','description':'About 4.5 trillion cigarette butts are deposited somewhere in the environment every year. Out of the waste collected by coastal cleanups every year, cigarette butts comprise the largest percentage of this, which account for approximately 19 - 38 % of total waste products by count. Nicotine from cigarette butts negatively affect marine environment. Pseudomonas putida S16 can metabolite nicotine. We are planning to introduce this pathway into Escherichia coli. We expect that Escherichia coli gets ability to degrade nicotine. Through the pathway, nicotine is changed to 2,5-dihydroxypyridine. 2,5-dihydroxypyridine is a precursor of 5-aminolevulinic acid which is the main material of fertilizer and pharmaceuticals. We hope that our project helps stop littering cigarettes. And we hope that living things are more safely and peacefully.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/3dfb535c-34b6-4e5b-bafe-46a954ba47df','video_link_presentation':'https://video.igem.org/videos/watch/3622cb66-0cb5-45ca-9e62-f1fe30afddb9','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Botchan_Lab_Tokyo','poster_link':'https://2020.igem.org/Team:Botchan_Lab_Tokyo/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 1, Poster Number 184'}, {'name':'Brno_Czech_Republic','link':'https://2020.igem.org/Team:Brno_Czech_Republic','region':'Europe','location':'Czech Republic','track':'Environment','time':'11,16,0800,30','title':'CYANOTRAP','description':'CYANOTRAP is a synthetic biology system developed to lyse cyanobacteria and degrade their toxins. The host bacterium Bacillus subtilis will be immobilized on a cellulose matrix in a flow through device. It will also produce a collection of extracellular protein complexes attached to its cell wall based on the naturally occurring structures called cellulosomes. These structures will display enzymes carrying out the functions mentioned above. In the first step of our project, we aimed to immobilize the engineered cells on cellulose microbeads. For this we used a synthetic gene containing a cellulose binding module connected by a linker to LysM domain, anchoring the fusion protein to the cell wall of the host organism. We`ve carried out a number of experiments including cloning of the synthetic gene into a target plasmid, integrating the plasmid into the chromosome of Bacillus subtilis, cultivating the engineered cells, producing and testing the synthetic protein.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/1f60e0de-5814-4c59-b6bb-5493c67d78d8','video_link_presentation':'https://video.igem.org/videos/watch/0397f3b4-b14b-467d-8006-da3e33319695','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Brno_Czech_Republic','poster_link':'https://2020.igem.org/Team:Brno_Czech_Republic/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 2, Poster Number 192'}, {'name':'BUCT','link':'https://2020.igem.org/Team:BUCT','region':'Asia','location':'China','track':'Environment','time':'11,16,0930,30','title':'Legolas•Microcystin: An innovation treatment of algal blooms and microcystin','description':'Every summer, many lakes around the world are covered with some disgusting, green microbes. They are cyanobacteria, which produce cyanobacteria toxins, such as microcystins. It can cause brain fever, skin allergies; even induce tumor genesis and liver cancer. In our project, we use a special chassis -cyanophage. We try to add two parts to the phage: a functional part that can be used to degrade the toxin and a control part that prevents the release of the cyanophage. Our functional part consists of MLR gene cluster, which produces microcystin-LR degrading enzymes to decompose the long-lasting cyclic peptide into harmless amino acids. Our control part consists of Unnatural amino acid systems. It can be used to limit the proliferation of the cyanophage. By putting our designed recombinant cyanobacteria into water bodies, we hope this will be a more safe and effective treatment in algal blooms and toxins degradation.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/46918a08-9f87-417c-a1cd-968b98104f5d','video_link_presentation':'https://video.igem.org/videos/watch/8e7c0fff-d5e1-4831-b15b-b9e9958cc845','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=BUCT','poster_link':'https://2020.igem.org/Team:BUCT/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 1, Poster Number 185'}, {'name':'BUCT-China','link':'https://2020.igem.org/Team:BUCT-China','region':'Asia','location':'China','track':'Environment','time':'11,14,0930,30','title':'Biodegradation of plastics and further utilization of the degradation products for biopolymer synthesis','description':'Plastic is a remarkable substance that has multiple advantages for many applications. But it also brought huge disasters to our ecological environment. Over time, that plastic material does not biodegrade, but breaks down into tiny particles known as microplastics, and enter the food chain. Last year, we observed a strain, which can degrade PE and PS. This year, based on last year`s study, we made some improvements and conducted further exploration work. Our project have two parts. The first part is to degrade PE into alkanesIn. We construct an artificial metabolic pathway and use surface display to express Laccase on the surface of spores, making the reaction more efficient and intuitive. The second part is to use those metabolites to synthesize environmentally-friendly material PHFA (poly hydroxyl fatty acid). Based on genome sequencing and synthetic biology, we constructed another engineered bacteria to utilize plastics to synthetic value-added products such as PHFA.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/94a9c99c-a1a7-4638-8a8f-f419529d54fb','video_link_presentation':'https://video.igem.org/videos/watch/4fe8f31e-65da-4a6e-bba6-62dd48b832a3','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=BUCT-China','poster_link':'https://2020.igem.org/Team:BUCT-China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 2, Poster Number 14'}, {'name':'Calgary','link':'https://2020.igem.org/Team:Calgary','region':'North America','location':'Canada','track':'Food and Nutrition','time':'11,15,1030,30','title':'Oviita: A Community-Based Approach to Vitamin A Deficiency','description':'As a leading global cause of preventable blindness and mortality, vitamin A deficiency (VAD) is a serious health problem, particularly in developing regions. Oviita aims to equip these vulnerable regions with a sustainable and community-based solution to VAD. Our solution uses a food-safe strain of Yarrowia lipolytica modified to produce beta-carotene, a Vitamin A precursor. By engineering this yeast to produce cellulase, VAD communities can grow it as their own vitamin A supplement using readily-available plant matter as feedstock. To facilitate community integration, we designed bioreactor schematics based on locally-available resources, and made the yeast auxotrophic to ensure safe growth with no environmental risk. We also created a Vitamin A biosensor to improve VAD testing, and included an anthelmintic agent in the yeast to combat poor intestinal health, two contributing factors to VAD. Through these solutions, Oviita aims to be a sustainable and community-based adjunct to global efforts against VAD.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/741a26c8-d1e3-423a-83d0-74fb89958d01','video_link_presentation':'https://video.igem.org/videos/watch/9891caea-e3db-4d84-b759-36c72e756721','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Calgary','poster_link':'https://2020.igem.org/Team:Calgary/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 1, Poster Number 94'}, {'name':'CAU_China','link':'https://2020.igem.org/Team:CAU_China','region':'Asia','location':'China','track':'Environment','time':'11,15,0730,30','title':'Abaddon Remedy','description':'In Revelation, Abaddon is the king of locusts who brought disasters to the world. In fact, locust swarms have caused chaos throughout history. To solve the problem of food insecurity caused by locust, CAU_China did project: ABADDON REMEDY. We are interested in finding a efficient biopesticide which can kill locust based on RNAi. We hope that ABADDON REMEDY will bring us a world with less locusts, and also less pesticide contamination.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/eb51ba4a-14aa-4f8c-8952-95500d8d3eb9','video_link_presentation':'https://video.igem.org/videos/watch/42250ff5-fec6-4b10-b291-47e30dd0ae68','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=CAU_China','poster_link':'https://2020.igem.org/Team:CAU_China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 1, Poster Number 91'}, {'name':'CCA_San_Diego','link':'https://2020.igem.org/Team:CCA_San_Diego','region':'North America','location':'United States','track':'High School','time':'11,15,1030,30','title':'Acefate: Degradation of the Pesticide Acephate Using Genetic Modification','description':'The bio-degradation of the insecticide acephate using genetically modified Escherichia coli is studied in this project. Acephate exposure causes severe environmental and human side effects as well as paralysis or death. In this study, we enriched samples of acephate-treated soil for 5 weeks to propagate the growth of acephate-degrading bacteria. 10g from each sample was diluted 10-fold. DNA was subsequently extracted from bacterial colonies using the genomic etNA extraction and the 16S rRNA gene was sequenced. Degradation was monitored with HPLC and LC-MS. Certain genes, such as OPD, were isolated and analyzed using bioinformatics tools including CDD. Amplified genes were inserted into base plasmid pMMB206 using restriction digest protocol into E. coli K12. BetI, a transcription factor-based kill-switch, was added to the plasmid. While experiments could not be performed, MATLAB modeling and literature indicate the approach provides an effective pathway, with >99% degradation of acephate and all harmful intermediates.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f19eeaa6-cea3-415e-810d-5f265eddea51','video_link_presentation':'https://video.igem.org/videos/watch/df5aeb21-9200-4843-8e97-99b0e9786c6a','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=CCA_San_Diego','poster_link':'https://2020.igem.org/Team:CCA_San_Diego/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 1, Poster Number 96'}, {'name':'CCU_Taiwan','link':'https://2020.igem.org/Team:CCU_Taiwan','region':'Asia','location':'Taiwan','track':'Diagnostics','time':'11,14,1030,30','title':'Peptide-based dengue virus detection - DENDEX','description':'Dengue fever is listed as one of the `Top Ten Health Threats` by the World Health Organization, which threatens approximately 3.95 billion people in tropical and subtropical regions. C-type lectin domain family 5 member A (CLEC5A), a receptor locating on the surface of macrophages, could interact with the envelope protein of dengue virus and trigger the signal transduction to cause the life-threatening cytokine storm. Based on this knowledge, we tried to develop a dengue virus detection kit `DENDEX` using the peptides based on the partial sequences from CLEC5A. First, we confirmed the interaction of these peptides and the envelope protein using docking simulation. Then, we produced these peptides massively using a novel technique, called linear array epitope (LAE). These peptides will be used for detecting dengue virus in our kit, which contains gold nanoparticles as indicators. We hope this type of detection kit will provide a new diagnostic perspective.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/07e50dfa-0f9a-4b5d-ac09-52149c60b500','video_link_presentation':'https://video.igem.org/videos/watch/9c8b3eae-9a31-4497-adf3-4c737d41bb25','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=CCU_Taiwan','poster_link':'https://2020.igem.org/Team:CCU_Taiwan/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 2, Poster Number 16'}, {'name':'Chalmers-Gothenburg','link':'https://2020.igem.org/Team:Chalmers-Gothenburg','region':'Europe','location':'Sweden','track':'Environment','time':'11,16,0930,30','title':'No Time to Waste','description':'Generating 70 million tonnes of textile waste each year, the fashion industry oftentimes goes unmentioned in the climate debates. Yet, the great environmental problem posed by the fashion persists and is further aggravated by the inclusion of synthetic textile blends, which renders a large portion of garments un-recyclable. Our teams` attempt at tackling this problem focuses on the addition of the synthetic fibre elastane to garments, an addition that makes fibre separation a difficult process, and as such, poses a large problem for recycling. By including nine different enzymes to the bacteria E. Coli, our team attempted to create an enzymatic system capable of degrading the elastane fibre through biological means, effectively providing a biological solution to an environmental problem. A large part of our project has also been to communicate this large waste impact of the fashion industry, and to show that we really have No Time to Waste.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/eb3c0c71-1d88-4340-a225-ffebf894f876','video_link_presentation':'https://video.igem.org/videos/watch/061f6e61-6689-4204-8be8-740c699e3037','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Chalmers-Gothenburg','poster_link':'https://2020.igem.org/Team:Chalmers-Gothenburg/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 2, Poster Number 194'}, {'name':'CLS_CLSG_UK','link':'https://2020.igem.org/Team:CLS_CLSG_UK','region':'Europe','location':'United Kingdom','track':'High School','time':'11,16,0800,30','title':'Project CocEels','description':'As a school located on the banks of the River Thames in London, we are focussing on the impact of cocaine upon the critically endangered European Eel, Anguilla anguilla. Concentrations of cocaine as low as 30 ng/L have been shown by studies to have detrimental impacts upon their migration and breeding patterns. In addition to this, high drug concentrations have even been detected in drinking water in countries such as Brazil due to lack of effective filtration systems. We aim to solve this problem by using genetically modified E. coli bacteria immobilised in the primary sedimentation tanks of the sewers. We also designed a novel, hypoxia induced toxin-antitoxin kill switch which will destroy our bacteria in the presence of standard anaerobic processes in wastewater treatment plants and hence prevent our bacteria from spreading into the wider ecosystem.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/18084fdb-850b-4cee-98dc-4cc1edab736b','video_link_presentation':'https://video.igem.org/videos/watch/f6d0cf5c-0602-491d-84cc-729437a310b0','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=CLS_CLSG_UK','poster_link':'https://2020.igem.org/Team:CLS_CLSG_UK/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 2, Poster Number 197'}, {'name':'Concordia-Montreal','link':'https://2020.igem.org/Team:Concordia-Montreal','region':'North America','location':'Canada','track':'Software','time':'11,15,1030,30','title':'AstroBio, open-source database for gene expression in microgravity & AstroYeast, resistant strains to microgravity-induced stress','description':'Advances in synthetic biology, including cellular agriculture, enable the sustainable production of food on Earth. However, in-space biomanufacturing, for which maintaining cultures in bioreactors for extended periods is essential, has proved challenging. Microgravity induces global changes in gene expression profiles, triggering stress responses in cells. For example, Saccharomyces cerevisiae exhibits stress responses characterized by aberrant cell polarity, budding, and separation, which affects cell growth and productivity in space. There is also a lack of bioinformatics tools for microgravity researchers. To fill this gap, we developed AstroBio, an open-source database compiling literature findings on microgravity-induced gene expression changes in different model organisms. The database informs our development of AstroYeast, yeast strains that are resistant to microgravity-induced stress. This will be done in a high-throughput manner either by strain adaptive evolution, or genome-wide overexpression and knockdown screens. AstroYeasts can be used to sustainably and renewably produce nutrients in space under microgravity conditions.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/55dc25fd-5817-4957-9f9b-dd1fd1cda6f7','video_link_presentation':'https://video.igem.org/videos/watch/75938c3b-03dd-4e11-9dac-2156a70620c7','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Concordia-Montreal','poster_link':'https://2020.igem.org/Team:Concordia-Montreal/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 1, Poster Number 98'}, {'name':'Cornell','link':'https://2020.igem.org/Team:Cornell','region':'North America','location':'United States','track':'Therapeutics','time':'11,14,1030,30','title':'Lumicure','description':'This year, Cornell iGEM aims to design a bacteriotherapy treatment and tracking system for cancerous malignant tumors. This system aims to take advantage of the fact that cancerous tumors have an immunoprivileged microenvironment and that malignancies migrate through the bloodstream to other parts of the body. To our bacteria, we will introduce genetic constructs coding for a therapeutic: trichosanthin. We have designed a lactate-inducible toxin-antitoxin system (GhoS/GhoT) which ensures the E. coli do not survive outside of the high-lactate environment of the tumor. These E. coli cells will also be engineered to constitutively express mCardinal, a fluorescent protein, detectable by our fluorescence detection system. This detection system will consist mainly of: an excitation filter and emission filter, a dichroic mirror, a laser, and a raspberry pi microcontroller. We hope that we can effectively demonstrate a proof-of-concept for this treatment system in treating real cancerous tumors later on down the line.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/28d926b4-f877-40ef-bea6-6acc06a3b922','video_link_presentation':'https://video.igem.org/videos/watch/dbd063fd-eadc-4e7e-a9d3-b84cb0901858','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Cornell','poster_link':'https://2020.igem.org/Team:Cornell/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 2, Poster Number 15'}, {'name':'CPU_CHINA','link':'https://2020.igem.org/Team:CPU_CHINA','region':'Asia','location':'China','track':'Therapeutics','time':'11,14,0930,30','title':'Prevention methods of alcoholic liver disease by inflammation control and intestinal flora regulation','description':'We engineered a synthetic organism capable of expressing and secreting anti-inflammatory cytokines IL-22, which will get to liver first due to First Pass Effect after its absorption into bloodstream and perform anti-inflammation function to protect the injured liver part from further inflammation damage. We also endowed the chasis with anti-E.faecalis function controlled by quorum sensing system. We chose bacteriocins JM79, plwα and plwβ with high specificity towards E.faecalis, the bacteriocins will function in situ to kill the over-reproduced E.faecalis to balance the intestinal flora, thus protect the liver from further immunoreaction at immunogen level. The chasis applied is E.coli Nissle 1917, which is a type of probiotic that can be taken orally in capsule. The system is expected to protect the liver with alcohol-induced inflammation from further pathological progression and is possible to be used as an adjuvant therapy in the future.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/e087d35b-b444-4df2-993a-88cdbcbd647a','video_link_presentation':'https://video.igem.org/videos/watch/f12b1f97-cec9-455c-b5d3-6b957eff6355','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=CPU_CHINA','poster_link':'https://2020.igem.org/Team:CPU_CHINA/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 2, Poster Number 18'}, {'name':'CSMU_Taiwan','link':'https://2020.igem.org/Team:CSMU_Taiwan','region':'Asia','location':'Taiwan','track':'Diagnostics','time':'11,14,0930,30','title':'miRNA.doc—a novel detection method for oral cancer','description':'The mortality rate of oral cancer is ranked fifth out of all cancers in Taiwan. The most common way to diagnose the disease is visual examination. However, this method frequently results in false-negative outcomes. We aim to develop a simple and systematic approach to assist doctors in diagnosing and treating oral cancers in the early stage, ultimately decreasing the mortality rate of the disease. We chose the miRNAs present in the patient`s saliva as our biomarker. When they bind to our designed toehold switches, the loop on the toehold unwinds and translates the enzyme, invertase, which can break down sucrose into glucose. The amount of glucose can be measured by a glucometer, and doctors can use the measured data to assist diagnosis of oral cancer. Our project not only helps doctors with the diagnosis but also increases patients` survival rate and their life quality.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/4b70f7ac-a852-48f4-82c9-7464b4cd1057','video_link_presentation':'https://video.igem.org/videos/watch/1dd87b93-0b43-4fda-ae6e-c39ef8384435','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=CSMU_Taiwan','poster_link':'https://2020.igem.org/Team:CSMU_Taiwan/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 2, Poster Number 20'}, {'name':'CSU_CHINA','link':'https://2020.igem.org/Team:CSU_CHINA','region':'Asia','location':'China','track':'Environment','time':'11,16,1000,30','title':'Clean the Contamination of Cadmium ( CcC )','description':'Recently, the cadmium-contaminated rice circulating in the market. Long-term intake of cadmium will jeopardize human bodies. To deal with the problem, we utilize engineered Synechocystis as a competent cadmium absorber. Moreover, with blue-ray/antitoxin suicide system, the reformed alga will be appropriately contained. The cadmium can be recycled as the microorganisms will be calcined after absorption. The application of engineered alga will minimize human potential cadmium intake.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/afa0332b-45fa-4633-ab92-39ed31e12e62','video_link_presentation':'https://video.igem.org/videos/watch/b06ab02a-a7f7-40fc-b56a-4c84535530be','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=CSU_CHINA','poster_link':'https://2020.igem.org/Team:CSU_CHINA/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 1, Poster Number 187'}, {'name':'CU-Boulder','link':'https://2020.igem.org/Team:CU-Boulder','region':'North America','location':'United States','track':'Environment','time':'11,16,1030,30','title':'Engineering Self-Fertilizing Plants','description':'All plants need nitrogen to survive, but cannot use nitrogen (N2) directly from the atmosphere. They must receive their nitrogen as ammonia (NH3) that has been fixated by other sources such as symbiotic bacteria, decomposing plants, or synthetic fertilizers. Today, the world population is only sustainable if ammonia-rich fertilizers are used to increase crop production. However, fertilizer is an environmental hazard due to the extensive release of carbon dioxide. Also, fertilizer runoff causes algae populations to grow faster than the ecosystem can handle, creating oxygen-depleted dead zones within the ocean. Due to growing environmental concerns, genetically engineering plants to contain the bacterial enzyme, nitrogenase, may allow plants to become self-fertilizing. Nitrogenase is extremely sensitive to radical oxygen and may not survive in plant cells. Our team has proposed a protein engineering solution by coupling an enzyme that scavenges radical oxygen (superoxide dismutase) directly to nitrogenase; allowing for self-fertilization.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/4ea7c6ef-33ba-4742-99bd-b11f23927d2f','video_link_presentation':'https://video.igem.org/videos/watch/13078108-bdaf-493f-bd86-b1e103eee046','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=CU-Boulder','poster_link':'https://2020.igem.org/Team:CU-Boulder/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 3, Poster Number 200'}, {'name':'DeNovocastrians','link':'https://2020.igem.org/Team:DeNovocastrians','region':'Asia','location':'Australia','track':'Environment','time':'11,16,0730,30','title':'Engineering microbes to detect and degrade pollutants','description':'Through our project we hope to eliminate benzene in polluted environments using bioremediation, a process which utilises microbes to degrade hazardous substances. Compared to traditional remediation practices, bioremediation is cheaper and more sustainable. First, we are creating a biosensor that will easily detect and measure environmental levels of benzene and catechol through a fluorescent protein expression system. Next, our project will identify and isolate the benABCDE gene cluster (benzene transport and degradation genes) from specialized bacteria that naturally import benzene into their cells and break it down into energy intermediates for growth in contaminated environments. Following this, we will insert these genes into a plasmid cloning vector and transform the model laboratory species Escherichia coli into a practically useful benzene degrader to clean up polluted sites on land and in water.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/4b3ede63-d0af-4c12-9554-cdb143185969','video_link_presentation':'https://video.igem.org/videos/watch/5b83f48a-cd4a-4cd5-a523-9b543677e558','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=DeNovocastrians','poster_link':'https://2020.igem.org/Team:DeNovocastrians/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 2, Poster Number 188'}, {'name':'DNHS_SanDiego_CA','link':'https://2020.igem.org/Team:DNHS_SanDiego_CA','region':'North America','location':'United States','track':'High School','time':'11,14,1030,30','title':'PreeclampsiRNA: Degrading sFlt1-14 mRNA with shRNA via lentiviral vectors to treat preeclampsia','description':'Preeclampsia is a dangerous condition, characterized by high blood pressure during pregnancy. It affects many pregnancies globally, and although most women survive preeclampsia, untreated it can lead to severe complications, and even death. Despite extensive research, there is, unfortunately, no reliable treatment for preeclampsia. The goal of this project is to produce an effective theoretical siRNA treatment, PreeclampsiRNA, using recombinant lentiviral vectors to carry and deliver shRNA to the trophoblast to inhibit the translation of soluble Fms-like tyrosine kinase (sFlt1-14), an antiangiogenic pseudo-receptor that captures placental growth factor (PlGF) and prevents it from binding the proper receptor, which would signal for angiogenesis. We would test several different shRNA sequences to see which causes the most effective reduction of sFlt1-14. By degrading the mRNA of sFlt1-14 using siRNA, we aim to reduce the placental levels of this molecule (which is overproduced in preeclamptic patients, leading to hypertension) and thus alleviate symptoms.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/dceea871-bd9e-4060-89d0-539f05526bf2','video_link_presentation':'https://video.igem.org/videos/watch/cda5d0b5-f9eb-46b0-9704-6aff30b8e902','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=DNHS_SanDiego_CA','poster_link':'https://2020.igem.org/Team:DNHS_SanDiego_CA/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 2, Poster Number 17'}, {'name':'DTU-Denmark','link':'https://2020.igem.org/Team:DTU-Denmark','region':'Europe','location':'Denmark','track':'Manufacturing','time':'11,16,0830,30','title':'RESHAPE: Tuning morphology and secretion in Aspergillus niger for improved industrial applications','description':'Every week, almost 6 billion people use products made with the aid of fungal cell factories. Many of these fungi stem from the Aspergillus genus. We aim to improve the production efficiency of Aspergillus niger by creating a synthetic biology toolbox that focuses on mycelial morphology and secretion. Morphology has a significant effect on productivity of certain compounds, while proper secretion is important for later recovery and purification of a compound. We have approached our goal in three ways: 1) Characterising morphological changes of A. niger by engineering seven morphology related genes. 2) Establishing a computational model of mycelium growth based on imaging data. 3) Developing a library of native and synthetic signal peptides for protein secretion. By improving the efficiency of bio-based production processes, we can improve the economic incentive to use them, and decrease our heavy reliance on oil-based substrates in the chemical industry.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/783218d4-be53-4926-999a-a117e0b9c70d','video_link_presentation':'https://video.igem.org/videos/watch/d7ba162c-ffff-4290-ba6c-071abd3d1bb9','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=DTU-Denmark','poster_link':'https://2020.igem.org/Team:DTU-Denmark/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 3, Poster Number 203'}, {'name':'Duesseldorf','link':'https://2020.igem.org/Team:Duesseldorf','region':'Europe','location':'Germany','track':'Environment','time':'11,14,1000,30','title':'Mossphate: Yesterday`s wastewater can fuel tomorrow`s crops','description':'Phosphate is an essential element that fulfills diverse cellular functions in all living organisms. It is a key limiting factor of plant growth and therefore used for the production of fertilizers. However, phosphate is a non-renewable resource and its natural reserves are dramatically decreasing, while the growing world population has led to a growing demand of phosphate fertilizers. Our project is to accumulate phosphate from wastewater and reuse it for the agricultural sector using the moss Physcomitrella patens. The moss has been genetically engineered to accumulate phosphate in the form of polyphosphate granules through the introduction of polyphosphate kinases and additional phosphate transporters. With these modifications, we hope to provide a sustainable way to filter phosphate from wastewater and grow phosphate-rich moss plants. These mosses can be directly used as fertilizer to provide crops with recycled phosphate.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/60e0c39c-238d-4c9a-82c4-58b99a3067af','video_link_presentation':'https://video.igem.org/videos/watch/08547273-7b69-4927-9890-4ae10eb8f220','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Duesseldorf','poster_link':'https://2020.igem.org/Team:Duesseldorf/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 2, Poster Number 19'}, {'name':'DUT_China','link':'https://2020.igem.org/Team:DUT_China','region':'Asia','location':'China','track':'Foundational Advance','time':'11,15,0830,30','title':'Reboot T4','description':'With the increasing antibiotic resistance of pathogenic bacteria, we are entering the post-antibiotic era with no antibiotics available. Phage therapy is one of the promising strategies to fight against pathogenic bacteria. Synthetic biology provides the feasibility to engineer natural phages with desired properties suitable for phage therapy. Here, we are developing a yeast-based platform to genetically manipulate and reboot Coliphage T4, whose 168.9 kbp-sized genome is too huge to manipulate through existing methodologies. The whole T4 genome is amplified and assembled hierarchically through overlapping extension PCR, yeast transformation associated assembly, and CRISPR/Cas9-facilitated homologous recombination assembly. The reconstituted T4 genome is then electroporated into E. coli to generate phage particles. We expect that our platform is suitable for the manipulation of huge phages with large-sized genomes.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/3ad82991-a1d1-4693-8463-3ac1aa04d6d2','video_link_presentation':'https://video.igem.org/videos/watch/3d3ce429-5e4c-494d-8846-6739f6e3d8d3','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=DUT_China','poster_link':'https://2020.igem.org/Team:DUT_China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 1, Poster Number 93'}, {'name':'ECNUAS','link':'https://2020.igem.org/Team:ECNUAS','region':'Asia','location':'China','track':'High School','time':'11,14,0930,30','title':'Development of an Experimental Platform for Screening GR antagonist against T2DM','description':'T2DM is characterized by relative insulin deficiency caused by β-cell dysfunction and insulin resistance. Hepatic glucose metabolism is modulated by glucocorticoid, and the effect of glucocorticoid is usually mediated by glucocorticoid receptor (GR). Increasing of glucocorticoids has the side effect of aggravating blood glucose level, and the GR antagonists have been reported to improve blood glucose level. Therefore, it is important to establish a platform for screening GR antagonists. In our study, GR transactivation assay is established to verify the antagonistic effect of drugs on GR. Dexamethasone (Dex) as a GR agonist activates reporter gene expression efficiently, and mifepristone as a GR antagonist antagonizes Dex-induced reporter gene stimulation. Success of our experiments will boost research on GR-related medication.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/71c089e2-56e5-40dd-ae70-08383d9025b7','video_link_presentation':'https://video.igem.org/videos/watch/4d81d282-6daf-4db5-b655-f3855ad95f0e','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=ECNUAS','poster_link':'https://2020.igem.org/Team:ECNUAS/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 2, Poster Number 22'}, {'name':'ECUST_China','link':'https://2020.igem.org/Team:ECUST_China','region':'Asia','location':'China','track':'New Application','time':'11,14,0730,30','title':'D-E-tector for SARS-CoV-2','description':'SARS-CoV-2 is highly transmissible and pathogenic. In addition to the nature of RNA virus with high mutation rate, antigenic drift is the main evolutionary mechanism for SARS-CoV-2. Its wide-spreading has currently resulted in the evolutionary variants different from the originate isolate. Therefore, to curb this pandemic, effective surveillance of circulating viruses is much more urgent. We developed a high throughput POCT platform for the SARS-CoV-2 detection with the help of DMF. A nanomachine called DNA Walker can amplify the region-specific sequence of the virus genome in the specimen. And then it will be read out by E-CRISPR, which can output an electric signal by a Cas9 nickase and corresponding electrode. We are targeting not only the detection of COVID-19 viruses with alarming dangerous mutations, but also differentiating other related viruses and pathogens. This is not only for managing today`s pandemic, but also for the potential outbreaks of other coronaviruses.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/47ddb00f-1cdd-4afb-aea7-19828eb36916','video_link_presentation':'https://video.igem.org/videos/watch/e7b9f355-a8be-453f-81ba-c753c655c38b','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=ECUST_China','poster_link':'https://2020.igem.org/Team:ECUST_China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 3, Poster Number 24'}, {'name':'Edinburgh','link':'https://2020.igem.org/Team:Edinburgh','region':'Europe','location':'United Kingdom','track':'Environment','time':'11,14,0830,30','title':'Finding NEMO – The transcription-only biosensing platform','description':'We are Edinburgh`s iGEM team, Finding NEMO! This year, we wanted to create something truly innovative and impactful. That`s why we developed Finding NEMO, a transcription only and cell-free system for biosensing. By stripping back the material necessities, we made biosensing faster, cheaper, safer and more accessible. To achieve this we have utilised fluorescent RNA aptamers to replace the conventional GFP protein reporters. We then devised an isothermal amplification and rudimentary logic processing system mediated by synthetic RNA transcription bubbles and T7-RNA-Polymerase. To this base system, we have studied the integration of conventional biosensing modalities such as transcription factors, transcriptional riboswitches and direct oligonucleotide sensing. Our case study application is environmental water testing and we have spoken to industry leaders and regulatory authorities. At every stage we have championed open science and the UN`s sustainable development goals to ensure our design is beneficial to all and the environment.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/a28573d1-0476-41a1-8f74-acd394f181b6','video_link_presentation':'https://video.igem.org/videos/watch/ee10bb21-23ab-4b91-b71e-b6b0bf9739be','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Edinburgh','poster_link':'https://2020.igem.org/Team:Edinburgh/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 2, Poster Number 21'}, {'name':'EPFL','link':'https://2020.igem.org/Team:EPFL','region':'Europe','location':'Switzerland','track':'Food and Nutrition','time':'11,15,0730,30','title':'EspressEAU: test your water','description':'Water is an essential resource that we regularly use for drinking, cooking and food processing. Hence, it is important to ensure that it is safe for consumption. EspressEAU serves as an analysis of general water quality. We aimed to create a safe, low-cost, and easy-to-use system that can enable on-site testing of water at home or in small communities. We hypothesized that genetically engineered yeast could be used as biosentinels by hijacking the yeast stress response pathway using either deletion strains or fluorescent reporter strains that are sensitive to water contaminants. These biosentinels are grown in a DIY system with temperature control, stirring, and two optical detectors for fluorescence and density, allowing us to monitor growth and fluorescence of the yeast, and thus detect the presence of contaminants in the water sample. We hope our project will facilitate frequent water testing of local water sources.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/db864d31-d101-41c2-a634-3393137863ff','video_link_presentation':'https://video.igem.org/videos/watch/69ca781a-5406-44be-b574-78487ae9755c','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=EPFL','poster_link':'https://2020.igem.org/Team:EPFL/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 2, Poster Number 100'}, {'name':'Estonia_TUIT','link':'https://2020.igem.org/Team:Estonia_TUIT','region':'Europe','location':'Estonia','track':'Manufacturing','time':'11,15,0730,30','title':'SPARKLE: Solar potentiated Artificially Knitted Lipid Enclosures','description':'Yeasts have the potential to be used as cell factories to produce lipids (biodiesel, high-value lipids, etc.). However, bio-production is costly compared to chemical synthesis, as it is highly energy-consuming for the cell and product extraction is laborious. To increase competitiveness, we engineer yeast to accumulate high lipid levels by using light both as an inductor for metabolic switch and as an electron source. Further, yeast is designed to self-lyse after production. First, we introduce extra copies of lipid synthesizing enzymes controlled by light-inducible promoters. Next, we coat the cells with light-absorbing nanoparticles to enable the cells to use light as an electron source for NADPH formation – a critical cofactor for lipid synthesis. This leads to increased carbon flux to lipid production. To ease the product extraction, the cells are designed to autolyse by induction of cell wall degrading glucanases that are targeted to cell wall via anchor proteins.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ce1e729b-95ca-4a73-9bc8-d81ae41abde2','video_link_presentation':'https://video.igem.org/videos/watch/3aa422b2-1a2a-4fe9-89ae-ccd458fd55a4','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Estonia_TUIT','poster_link':'https://2020.igem.org/Team:Estonia_TUIT/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 2, Poster Number 102'}, {'name':'Evry_Paris-Saclay','link':'https://2020.igem.org/Team:Evry_Paris-Saclay','region':'Europe','location':'France','track':'New Application','time':'11,15,1000,30','title':'Rosewood','description':'Illegal wildlife trade is a scourge that affects biodiversity, destroys the fragile equilibrium of natural ecosystems, leads to accelerated extinction of species, and adversely impacts humankind. Elephant`s ivory, rhinoceros` horn, tiger`s fur are all well-known examples, but the most trafficked wildlife product in the world is Rosewood. To the naked eye, Rosewood logs are indistinguishable from other non-protected wood species. However, it can be distinguished at the genetic level with high precision. Here, we are developing cheap, portable and easy-to-use biosensors, based on toehold switches. Our biosensor uses engineered molecular machinery of the common gut bacterium to sense nucleic acid signatures specific to the Rosewood tree. We demonstrate how to go from the design to the final application, identifying the trafficked Rosewood to the family, phylum, or the species level. Deployment of portable and cost-effective rosewood biosensors will enable on-site surveillance and help to protect this rare and valuable species.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f07a3e9c-0481-49a2-8907-6383c2dbf78f','video_link_presentation':'https://video.igem.org/videos/watch/f9657d5f-0634-4902-9808-1083f38816f4','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Evry_Paris-Saclay','poster_link':'https://2020.igem.org/Team:Evry_Paris-Saclay/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 2, Poster Number 104'}, {'name':'Exeter','link':'https://2020.igem.org/Team:Exeter','region':'Europe','location':'United Kingdom','track':'Environment','time':'11,14,0830,30','title':'CalcifEXE: A Bacterial Method of Calcium Carbonate Precipitation','description':'Traditional calcium carbonate production methods emit large amounts of carbon dioxide as well as many toxic compounds due to the reliance on fossil fuels in the manufacturing process. Our team is developing a novel precipitation method using bacteria engineered with enzymes capable of producing the carbonate ions required for precipitation of calcium carbonate. One enzyme we are focusing on is carbonic anhydrase (CA), an enzyme that facilitates the interconversion of carbon dioxide and bicarbonate in solution. CA should not only increase carbonate production, but also allow for atmospheric carbon dioxide to be used as the feedstock for the carbonate ions. Our method has the potential capability to be employed with a 3D-bioprinter that will print structures comprising a hydrogel and our engineered bacteria. On precipitation the calcium carbonate should take the shape of the hydrogel structure. One potential application, is the production of coral backbones used to facilitate coral regrowth.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f3c28b4c-ec8f-4fe5-b01b-59d98332234e','video_link_presentation':'https://video.igem.org/videos/watch/b874a8be-8fbf-4429-b90e-9be927989cd4','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Exeter','poster_link':'https://2020.igem.org/Team:Exeter/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 3, Poster Number 23'}, {'name':'FAFU-CHINA','link':'https://2020.igem.org/Team:FAFU-CHINA','region':'Asia','location':'China','track':'New Application','time':'11,16,0730,30','title':'Design an integrated fermentation system with Juncao as raw material','description':'This year, we want to use Juncao to make bioethanol. We designed an integrated fermentation system that consists 3 chassis (E. coli & K. Marxianus & Pichia Pastoris) and the control elements that link them. The biosensor based self-regulation is realized by sensing the changes in the concentration of various intermediates during fermentation. Through the above design, each reaction stage can be organically combined without interference. In addition, we also want to modify the fiber corporeal through rational design of proteins, so that it has the ability to break down the structure of cell wall, and finally achieve the effect of degrading lignin, cellulose and hemicellulose.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/549b57d8-686f-4184-a6be-2f6e5ea70454','video_link_presentation':'https://video.igem.org/videos/watch/8b5fea61-6b98-4171-8aec-569d4ace9d70','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=FAFU-CHINA','poster_link':'https://2020.igem.org/Team:FAFU-CHINA/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 2, Poster Number 190'}, {'name':'FCB-UANL','link':'https://2020.igem.org/Team:FCB-UANL','region':'Latin America','location':'Mexico','track':'Environment','time':'11,15,1030,30','title':'Synbiofoam: a synthetic alternative to fluorosurfactants','description':'Mexico`s northern biogeographic region is home to wide biodiversity, which is at risk due to the frequent forest wildfires. One of the strategies to combat fires involves the use of firefighting foams, but these usually contain fluorosurfactants (PFAS), which pose an environmental threat. Therefore, our goal is to produce an eco-friendly alternative to this type of threatening substances. To do so, we plan to employ synbio tools to produce four of the Ranaspumin proteins present in the bubble nests of Leptodactilidae frogs, and regulating B. subtilis` natural complex metabolic pathway in charge of synthesizing its biofilm`s matrix components for us to substitute PFAS as foaming agents in firefighting mixtures. Not only will our project aid the environment, but it will also allow underfunded fire departments to access these tools because, as there are no foam producers in this country, current foams are very expensive due to importation costs.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/1c6e9c56-60c9-4943-84cb-95835d52a8be','video_link_presentation':'https://video.igem.org/videos/watch/bb5d13e9-29f8-4b5f-a0bf-6c5732bfe3cb','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=FCB-UANL','poster_link':'https://2020.igem.org/Team:FCB-UANL/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 2, Poster Number 106'}, {'name':'FDR-HB_Peru','link':'https://2020.igem.org/Team:FDR-HB_Peru','region':'Latin America','location':'Peru','track':'High School','time':'11,15,1000,30','title':'Fishing for Cadmium','description':'Our project seeks to tackle the issue of cadmium contamination in fishmeal. We chose this issue because it affects the health of humans, ecosystems, and our local economy. To tackle this issue we have designed a plasmid capable of detecting the concentration of cadmium in blended fish. We have plans to implement a cell free system to make our solution more accessible to fishermen as well as an affordable heated shaking incubator to make the culturing of bacteria easier. Lastly, we have taken strides to make science education more accessible for young adults in Peru, by creating videos, evaluating articles for a young science journal, and subtitling our previous TEDx talk.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/037b7f90-59da-4cbc-8abe-f1622f8135dd','video_link_presentation':'https://video.igem.org/videos/watch/226955cf-eaf5-4ec8-86bb-2686e4a2d139','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=FDR-HB_Peru','poster_link':'https://2020.igem.org/Team:FDR-HB_Peru/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 2, Poster Number 108'}, {'name':'FSU','link':'https://2020.igem.org/Team:FSU','region':'North America','location':'United States','track':'Environment','time':'11,15,1000,30','title':'SPLASH: Sewage Purification Limiting Antibiotic Spread in Habitats','description':'Antibiotic resistance is an increasing global emergency. Microorganisms continue to evolve ways to render antibiotic therapies less effective causing 2.8 million infections in the US and 750,000 deaths worldwide each year. In Florida, dolphins are serving as a sentinel species. A longitudinal study on dolphins in the Indian River Lagoon found that 88.2% of bacterial isolates were resistant to at least one antibiotic. Resistance to erythromycin was highest among all the bacteria at 91.6%. Antibiotics are entering our environment via animal husbandry and disposal of antibiotics. We`ve designed an engineered E. coli that expresses EreA and EreB enzymes, which will degrade erythromycin in the secondary portion of wastewater treatment plants and a genetic system that is intended to prevent the engineered cells from escaping. Our project can be implemented in water treatment plants across the world to curb the rapid spread of antibiotic resistance.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f1967d07-1011-4548-ab2e-9c4240e45375','video_link_presentation':'https://video.igem.org/videos/watch/de8f7a6c-bdb7-4f6c-9c82-4dbf1e410cdb','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=FSU','poster_link':'https://2020.igem.org/Team:FSU/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 2, Poster Number 110'}, {'name':'Fudan','link':'https://2020.igem.org/Team:Fudan','region':'Asia','location':'China','track':'Food and Nutrition','time':'11,14,0800,30','title':'Bone appetite: make calcium supplements sustainable','description':'In Asia, many old people suffer from insufficient calcium intake and related diseases such as osteoporosis. Considering that traditional calcium supplementation is not efficient and user-friendly enough, we intended to develop a kind of engineered bacteria based on E. coli that can colonize in the human intestine and secrete peptides to promote calcium absorption. We introduced the quorum sensing system to colonize bacteria in the intestine. Once the bacteria have successfully colonized the intestinal tract, the luxpR promoter will be activated and a series of short peptides that can bind to calcium and promote calcium absorption of intestinal epithelial cells will be expressed. A kill switch is added accordingly for safety. Our project provides a novel delivery method to provide calcium supplements sustainably. And we are actively seeking commercialization possibilities to expand our project impact, to reach more population, for the elderly`s good health and well-being.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/7a0fee51-a637-4caf-aa97-a1d9bcafd3ba','video_link_presentation':'https://video.igem.org/videos/watch/cb2d852a-e3de-48da-9648-2f1bbc545483','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Fudan','poster_link':'https://2020.igem.org/Team:Fudan/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 3, Poster Number 26'}, {'name':'GA_State_SW_Jiaotong','link':'https://2020.igem.org/Team:GA_State_SW_Jiaotong','region':'North America','location':'United States','track':'Environment','time':'11,15,0800,30','title':'Syn-biodinium','description':'Coral bleaching, the loss of necessary algal symbionts for the survival of cnidarian reef organisms, is a disastrous environmental issue that is mainly caused by anthropogenic global warming. Genetically modifying corals` symbiotic microalgae, Symbiodinium, to better withstand heat stress may combat coral bleaching. We have attempted several transformations, creatively designed an algae house, and built a temperature-ecological amplitude model based on the Shelford`s Law of Tolerance to find the best conditions for culturing Symbiodinium. In addition, we have successfully designed a recombinant plasmid by inserting a GUS reporter gene and the most appropriate modified heat resistant gene, heat shock factor, into a dinoflagellate-optimized expression DinoIII plasmid. We will perform a biolistics gene gun-mediated transformation. Because the commercial gene gun is so expensive, we will use 2018 iGEM team Worcester`s design to build our own gene gun. Hopefully, the corals will uptake the modified algae, increasing their resistance to bleaching.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/fa637515-3a73-4e28-9e73-2a7033e9c1be','video_link_presentation':'https://video.igem.org/videos/watch/089c6e29-36c6-4604-8ddd-9135a70d19a0','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=GA_State_SW_Jiaotong','poster_link':'https://2020.igem.org/Team:GA_State_SW_Jiaotong/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 3, Poster Number 113'}, {'name':'Gaston_Day_School','link':'https://2020.igem.org/Team:Gaston_Day_School','region':'North America','location':'United States','track':'Environment','time':'11,14,1030,30','title':'Eliminating Kudzu to Restore Natural Habitats for Crops and Endangered Species','description':'In order to remove kudzu, farmers and power companies often have to spray harmful chemicals on their land. These chemicals, along with many other kudzu removal options, are expensive and can pose harmful effects to human health and the ecosystem. Pseudomonas syringae pv. phaseolicola has been found to affect legumes specifically by producing the phytotoxin phaseolotoxin. Our team plans to replicate the phaseolotoxin production pathway in Escherichia coli and utilize the toxin as a more environmentally friendly option to remove kudzu. After the removal of kudzu, local endangered species can regrow without competition. Additionally, we developed three models to simulate the spread of infectious plant diseases like Asian Soybean Rust using kudzu as a vector, simulate the ROTCase production and activity under promoters with different strengths, and predict the spread and management cost of kudzu in a local area.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/1e8ef43f-7426-42e2-856c-57a0c3ebb572','video_link_presentation':'https://video.igem.org/videos/watch/c8bf3ec1-2dc3-4bef-a98c-6d8deddf175e','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Gaston_Day_School','poster_link':'https://2020.igem.org/Team:Gaston_Day_School/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 3, Poster Number 25'}, {'name':'GDSYZX','link':'https://2020.igem.org/Team:GDSYZX','region':'Asia','location':'China','track':'High School','time':'11,14,0730,30','title':'Cultural Great Adventure to Rice','description':'Chinese Traditional medicine such as honeysuckle has excellent efficacy in treating Novel Corona Virus, many patent medicine are now commonly used for treatment of COVID-19. One of the main active ingredient of honeysuckle is Chlorogenic acid (CGA), which synthesized under the key enzyme HQT. We tried to transfer HQT of honeysuckle into rice to increase the rice seeds`content of CGA. Thus We constructed GluD-1pro::HQT and 35Spro::HQT vector with rice seed specific promoter GluD-1 and 35S promoter respectively. We transferred this two vectors into the rice protoplast individually. We detected the expression of HQT gene by Western Blot and synthesis of CGA by high performance liquid chromatography (HPLC) in 35Spro::HQT vector transfected protoplasts as we expected. We provide a method that can increase the content of CGA in rice to improve human immunity.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/cd22577e-d0f0-434c-b14c-313d2e249349','video_link_presentation':'https://video.igem.org/videos/watch/7d0913a5-df8c-4942-bba3-c1943e151fb7','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=GDSYZX','poster_link':'https://2020.igem.org/Team:GDSYZX/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 3, Poster Number 28'}, {'name':'GO_Paris-Saclay','link':'https://2020.igem.org/Team:GO_Paris-Saclay','region':'Europe','location':'France','track':'Information Processing','time':'11,16,0730,30','title':'HuGenesS: a project on gene entanglement','description':'HuGenesS is based on the concept of overlapping genes, where a DNA stretch encodes two genes, depending on the reading frame. The genes are interlaced, as if in a loving hug! While such genetic arrangements exist in nature, this phenomenon could not be easily harnessed for synthetic biology until the CAMEOS software was developed by Harris Wang`s Team. We used it to generate several entangled genes encoding reporter and antibiotic resistance proteins. We cloned the sequence encoding GFP and KNT. Since the cloned entangled genes lost functionality, we improved CAMEOS to generate sequences preserving conserved amino acids and to choose the best overlap. We have written comprehensive tutorials on utilizing CAMEOS. The improved software generated sequences that are currently tested by a research team optimizing lipid synthesis in yeast. Genetic entanglement has many potential applications from designing minimal genomes to developing improved, safer and more stable genetic constructs. Confined hugs!','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/86861753-9ece-4160-8480-ab4a8fbd7cb3','video_link_presentation':'https://video.igem.org/videos/watch/67ad505a-6199-43a3-b6b2-188a3985320c','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=GO_Paris-Saclay','poster_link':'https://2020.igem.org/Team:GO_Paris-Saclay/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 3, Poster Number 205'}, {'name':'GreatBay_SCIE','link':'https://2020.igem.org/Team:GreatBay_SCIE','region':'Asia','location':'China','track':'High School','time':'11,16,1000,30','title':'ShroomSweeper','description':'We produced ALFA (Aptamer Lateral-Flow Assay), an efficient, membrane-based test kit for amatoxins. Replacing antibodies with aptamers - a type of oligonucleotide - in LFIAs (Lateral Flow ImmunoAssay), several drawbacks that antibodies present (low heat stability, heavy reliance on immunogenicity of target molecules, etc.) are eliminated. Simultaneously, we developed a sandwich assay involving both aptamers and antibodies, combining the benefits of using either ligand. scFvs (Single-Chained antibody Fragments) have simpler structures and can be made through regular protein synthesis procedures, while conventional processes involve the mammalian immune system. Applying ELISA (Enzyme-Linked ImmunoSorbent Assay) to our design, we immobilize purified scFv onto the ALFA pad, then coat our samples - amanitin - onto the scFvs. BSA-conjugated aptamers are then coated to the amanitin. Hopefully, this test kit will assist in identification of common species of poisonous mushrooms, reducing cases of poisonings worldwide.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/44d243df-3b8a-4b04-8e2a-64844db2df67','video_link_presentation':'https://video.igem.org/videos/watch/a91aebc6-3068-4e1f-a3da-4485e9f014fc','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=GreatBay_SCIE','poster_link':'https://2020.igem.org/Team:GreatBay_SCIE/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 2, Poster Number 191'}, {'name':'GreatBay_SZ','link':'https://2020.igem.org/Team:GreatBay_SZ','region':'Asia','location':'China','track':'High School','time':'11,16,1030,30','title':'BIOT','description':'The Greatbay_SZ 2020 team aims to develop a moisture-driven energy harvesting device utilizing biotechnology: BIOT. The core of BIOT is engineered-protein filament nanowires, which spontaneously generate and maintain electric potential energy. We optimize BIOT`s cost and power supply performance by mutating the pilA gene (of protein monomer) and RBSs. For future implementations, our team plans to provide a stable power supply for IoT (Internet of Things) devices. BIOT is the first application of biotechnology in the IoT field. Its advantages in low environmental restrictions, green and environmentally-friendly materials, stable power generation, long power-harvest duration, low cost, and large-scale applications will promote further global IoT development.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f06967c6-a8b2-432c-8de4-c8ee87529cdd','video_link_presentation':'https://video.igem.org/videos/watch/9500753f-8fa8-4e36-9bf1-ef808f2d3e17','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=GreatBay_SZ','poster_link':'https://2020.igem.org/Team:GreatBay_SZ/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 2, Poster Number 193'}, {'name':'Grenoble_Alpes','link':'https://2020.igem.org/Team:Grenoble_Alpes','region':'Europe','location':'France','track':'Therapeutics','time':'11,14,0800,30','title':'Innovative biotreatment for P.aeruginosa biofilm infections using an engineered E.coli','description':'We aimed at conceiving an engineered e.coli able to sense P.aeruginosa`s biofilm and settle on it. Then, thanks to a synchronized lysis system, therapeutic molecules will be released to destroy P.aeruginosa and its biofilm. Our bacteria named Pyobusters works thanks to a complex genetic network based on the quorum sensing and designed by our biologists. To test the effectiveness of our therapeutic , our engineers conceived a testing bench able to emulate the different infection sites of P.aeruginosa. This way, we can monitor our therapeutic bacteria and train themselves in diverse fields. We succeeded in building a functional testing bench and delivered proofs of concept for several pieces of our genetic network. Further experiments and researches will be needed to test and unveil the full potential of our innovative treatment.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/6a28e00b-5d9f-4ce3-80dd-d8294c0fff60','video_link_presentation':'https://video.igem.org/videos/watch/2e7cec5e-bd32-4b3c-9b4d-7214cc5eb6f0','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Grenoble_Alpes','poster_link':'https://2020.igem.org/Team:Grenoble_Alpes/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 3, Poster Number 27'}, {'name':'Groningen','link':'https://2020.igem.org/Team:Groningen','region':'Europe','location':'Netherlands','track':'Food and Nutrition','time':'11,14,0730,30','title':'RootPatch','description':'Potatoes are an important crop for many cultures. They provide more carbohydrates, proteins, minerals and vitamins per unit area of land and time as compared to other crops and are therefore a popular choice for many farmers and consumers. However, the growth of the potato plant is severely affected by parasitic nematodes that feed on the roots of the plant. Per year, around 460 million dollar is lost due to these nematodes. Our project RootPatch provides a solution to this problem. RootPatch is a bacterial layer around the roots of the potato plant. The bacteria in RootPatch are engineered to produce neuropeptide-like proteins, a class of neuropeptides which specifically influence the behaviour of the parasitic nematodes, making them avoid the root system of the plant. To guarantee safety, the engineered bacteria are dependent on the potato plant, making sure that they stay where they are supposed to be.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/094df117-c96f-4c7b-820b-a8bf8d62d4c6','video_link_presentation':'https://video.igem.org/videos/watch/7599d5fe-1917-4843-8df7-a9af36e9e75f','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Groningen','poster_link':'https://2020.igem.org/Team:Groningen/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 3, Poster Number 29'}, {'name':'GunnVistaPingry_US','link':'https://2020.igem.org/Team:GunnVistaPingry_US','region':'North America','location':'United States','track':'High School','time':'11,15,1030,30','title':'Odigos: An Improved CRISPR-Cas9 Effective Guide RNA Predictor','description':'Abstract: CRISPRi is a powerful tool for modulating gene expression in human cells. By designing a gRNA homologous to the target gene of interest, one can achieve targeted knockdown of the specific gene of interest. However, with current methodologies, one has to screen multiple gRNA sequences for efficient targeting while minimizing off-target effects. We present a prediction model for identifying the best gRNA sequence for efficient gene targeting in human cells. Starting with experimental data from knocking down specific genes using several gRNAs in iPS cells, we leverage machine learning to inform better selection of the gRNA. Our tool will be invaluable for designing gene targeting gRNAs and will reveal underlying biochemical principles governing CRISPR efficiency.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/9e64f472-73de-4e06-bf32-1cd5738cc11f','video_link_presentation':'https://video.igem.org/videos/watch/a8686af6-ec52-4189-837c-2f4563638039','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=GunnVistaPingry_US','poster_link':'https://2020.igem.org/Team:GunnVistaPingry_US/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 3, Poster Number 115'}, {'name':'GW_DC','link':'https://2020.igem.org/Team:GW_DC','region':'North America','location':'United States','track':'Environment','time':'11,16,1000,30','title':'BactoLEAD the Way to Cleaner Water','description':'Lead is a heavy metal that can contaminate potable water through lead pipes, solder, paint, and household fixtures. This potentially fatal heavy metal is a neurotoxin that accumulates in soft tissue and bones, leading to neurological disorders. In 2017, exposure to lead caused one million deaths worldwide. Current water filtration solutions are effective; however, they are not affordable, sustainable, or renewable. Our team is genetically engineering a bacteria that naturally filters lead to have biosensing properties, allowing easy detection of lead ion levels in solution by monitoring lead operon activation for lead filtration. The modified bacteria will express fluorescent proteins that allow us to visually monitor lead ion concentration sustainably and affordably. Our goal is to provide a user-friendly, accessible lead detection and filtration device to ensure safe drinking water globally.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ef5e9ee8-100a-492d-a7e2-1ac3a8eed747','video_link_presentation':'https://video.igem.org/videos/watch/726c1084-bffd-4be5-932e-a48081a37bab','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=GW_DC','poster_link':'https://2020.igem.org/Team:GW_DC/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 3, Poster Number 208'}, {'name':'GZ_HFI','link':'https://2020.igem.org/Team:GZ_HFI','region':'Asia','location':'China','track':'High School','time':'11,15,0930,30','title':'P-Erfume: Engineering Probiotics to Reduce Intestinal Undesirable Odor','description':'The unpleasant odor of farting leads to social embarrassment. Besides, patients who undergo enterostomy are confronting social distancing because of the acrid smell released from the stoma on their bellies. To solve the problems above, We genetically engineered probiotic Escherichia coli to decrease the production of main molecules that contribute to intestinal acrid smell (ammonia and hydrogen sulfide) and produce an aroma substance (myrcene). We mutate argA into argAfbr and knockout argR to enhance the conversion of ammonia into arginine, create several mutants of cysE gene to promote the conversion of hydrogen sulfide into cysteine, and construct a three-plasmids-system to produce myrcene. The result shows we significantly improved e.coli`s ammonia production and cysteine synthesis; myrcene was produced successfully in relatively low production. For human practices, we did a series of activities (survey, expert visits, collaboration, exhibitions, lectures, etc) to improve our product design and promote the education of synthetics biology.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/cb0ab6b6-5dcf-41a9-982f-e8c09217b89d','video_link_presentation':'https://video.igem.org/videos/watch/508873d8-eef1-4d31-80eb-3b450041e8f9','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=GZ_HFI','poster_link':'https://2020.igem.org/Team:GZ_HFI/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 1, Poster Number 95'}, {'name':'Hainan_China','link':'https://2020.igem.org/Team:Hainan_China','region':'Asia','location':'China','track':'High School','time':'11,16,0930,30','title':'CHLORIS：Coral HeaLth bOost and Reinforcement In Symbiosis','description':'Coral reefs are secret gardens under the sea. Accelerated anthropogenic CO2 emission has led to elevation of surface temperature and acidification of the seawater. Symbiont Zooxanthellae cells are then expelled by corals, leading to coral bleaching. If the coral reefs remain bleached, they would proceed to eventual death, and destruction of the marine ecosystem. Hainan_China aims to develop a nutritional enhancement strategy to safeguard coral reefs against the devastation by coral bleaching. We plan to introduce synthetically engineered `probiotics` to stimulate coral microbiota for sustainability of Zooxanthellae-bacterial interaction and viable metabolic functioning of the coral systems. The probiotics would enable production of nutrients, such as N, P, Fe, and Vitamin B12 to nourish the coral symbiosis against environmental stresses. We will then design and fabricate a microfluidic chip to study in-depth the coral-Zooxanthellae symbiosis for large scale applications.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/fd7dcdb9-61ae-4463-9429-2c006bed0cfe','video_link_presentation':'https://video.igem.org/videos/watch/e813476f-53c2-4234-b7b1-be0cfa52bc6e','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Hainan_China','poster_link':'https://2020.igem.org/Team:Hainan_China/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 2, Poster Number 195'}, {'name':'Hamburg','link':'https://2020.igem.org/Team:Hamburg','region':'Europe','location':'Germany','track':'Food and Nutrition','time':'11,14,0830,30','title':'Unicorn - an aMAIZEing concept','description':'Synthetic biologists imagine fancy synthetic circuits, which perform well in silico but have unforeseen effects in applications. In many cases we add synthetic control instruments (e.g. promoters) to already complicated cells, hoping everything works as planned even in the cellular context. But this additional complexity can pose a problem, due to unknown interactions with regulatory processes. Our aim is to make synthetic gene control easier. Cells possess specific responses to external stimuli, like pathogen infection. We propose a new mechanism which connects the natural cell response with the reliable expression of a target output, making synthetic gene control less complex and more replicable. After the proof of concept in E. coli, Zea mays and Arabidopsis thaliana we hope that our universally applicable method will be used to create sustainable pathogen and disease resistances in crop plants.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f5b3b1c9-79c1-4d42-a6c4-75fa3c44a4cf','video_link_presentation':'https://video.igem.org/videos/watch/9e755b19-cda9-49be-987a-9307d041e4cd','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Hamburg','poster_link':'https://2020.igem.org/Team:Hamburg/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 3, Poster Number 31'}, {'name':'Hannover','link':'https://2020.igem.org/Team:Hannover','region':'Europe','location':'Germany','track':'Diagnostics','time':'11,14,1030,30','title':'InToSens – Development of an Inflammatory Toxin Sensor for detecting implant associated inflammations','description':'The placement of implants is one of the most frequently performed operations in hospitals all over the world, still increasing in number. Unfortunately, the risk to develop an implant-associated inflammation after such surgeries is very high. The origin of an implant-associated inflammation is often biofilms, which attach to the implant surface. Targeted treatment of such bacterial biofilms is challenging. A typical therapeutic approach with antibiotics often fails. In the worst case, a generous removal of the region is mandatory. Therefore, it would be helpful to detect the formation of a biofilm at an early stage, increasing the probability of successful treatment. Our project aims to develop a sensor that makes this possible. The sensor is realized by genetically-engineered cells, which can recognize bacterial toxins and produce biomarkers as a response. Throughout the development, we looked at our project from different points of view in conjunction with social and ethical aspects.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/121090e7-5421-427f-8a69-1bd0a39ed234','video_link_presentation':'https://video.igem.org/videos/watch/e636f04c-1461-425a-9faa-f25b78b855e5','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Hannover','poster_link':'https://2020.igem.org/Team:Hannover/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 3, Poster Number 33'}, {'name':'Harvard','link':'https://2020.igem.org/Team:Harvard','region':'North America','location':'United States','track':'Therapeutics','time':'11,16,1030,30','title':'MOTbox: A COVID-19 Antibody Therapeutic Based on Machine Learning and DNA Origami Sequence Delivery','description':'MOTbox is a COVID-19 therapeutic that couples machine learning and DNA origami to design an optimized anti-SARS-CoV-2 antibody and deliver its mRNA sequence to immune cells in infected patients. It is intended to serve as an interim treatment in a pandemic scenario that can be manufactured cheaply and quickly with limited lab access while a vaccine is developed. Using ensemble machine learning and differential evolution algorithms, we optimized anti-SARS-CoV-2 antibody sequences to enhance binding affinity and therapeutic potential. We designed and computationally validated a novel DNA origami nanostructure to selectively deliver the optimized antibody sequences to immune cells for rapid antibody production in vivo. The high potency of the optimized antibodies and the specificity of DNA origami delivery reduce the minimum therapeutic dose, thereby reducing treatment cost. Our work is a proof-of-concept of a rapid, cost-effective antibody treatment for COVID-19 that can also be extended to treating other emerging diseases.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/2a7d0b90-4f74-4239-970d-e8b2bacfb69c','video_link_presentation':'https://video.igem.org/videos/watch/148842ac-a92d-42fb-bf31-0400b405216a','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Harvard','poster_link':'https://2020.igem.org/Team:Harvard/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 4, Poster Number 211'}, {'name':'Heidelberg','link':'https://2020.igem.org/Team:Heidelberg','region':'Europe','location':'Germany','track':'Foundational Advance','time':'11,14,1030,30','title':'The Legend of Cellda – A Link Between Proteins','description':'DNA, RNA and proteins are the fundamental building blocks of synthetic biology and life itself. Of them all, fusion proteins, which are often too large and inflexible, take the spotlight, allowing for a modular approach to protein engineering. To mediate interactions between all three core components of life more flexible we aim to harness the power and flexibility of RNAs We apply machine learning to design flexible RNA modules and binding proteins for assembling complexes of protein domains, RNA and DNA in a sequence-specific manner. In addition, we engineer trans-splicing ribozymes to reconfigure our RNAs and proteins at the transcript level. Also, we apply molecular modelling to provide tools to design specific RNA-binding proteins. Taken together, we provide a controllable, compact, and dynamical alternative to fusion proteins with applications to drug delivery and expand the toolbox of synthetic biology.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/105313e6-0691-4504-95d9-83f54fdf007f','video_link_presentation':'https://video.igem.org/videos/watch/abcd9438-346d-4197-b6e6-2b5148f744eb','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Heidelberg','poster_link':'https://2020.igem.org/Team:Heidelberg/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 4, Poster Number 35'}, {'name':'HK_CPU-WFN-WYY','link':'https://2020.igem.org/Team:HK_CPU-WFN-WYY','region':'Asia','location':'Hong Kong','track':'High School','time':'11,16,1000,30','title':'Cutinases - the Terminators of Microplastics','description':'Polyethylene terephthalate (PET) is the most common thermoplastic polymer resin of the polyester family. Our team is searching for one or more suitable cutinases to degrade PET from plastic packages. We found that cutinases can convert lcPET to terephthalic acid (TPA) and ethylene glycol (EG). Therefore, we aim at reducing the harm of PET to the environment by using cutinases with a lower cost safely. First, we will determine the optimum working conditions of cutinases. Different kind of cutinases will be compared on their ability, efficiency, and optimum condition of degradation. Furthermore, those cutinases will be chosen and we will focus on the degradation rate of PET. We will consider not only the efficiency but the safety of using cutinases to degrade PET. Hence, we are here to try our utmost to solve plastic pollution through Synthetic Biology to digest plastic.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/81734f14-a7bb-4f4c-a36b-1d9f817cf748','video_link_presentation':'https://video.igem.org/videos/watch/d29ce2ba-43cd-4266-95fc-2c4a7d47a8f6','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=HK_CPU-WFN-WYY','poster_link':'https://2020.igem.org/Team:HK_CPU-WFN-WYY/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 2, Poster Number 196'}, {'name':'HK_HCY','link':'https://2020.igem.org/Team:HK_HCY','region':'Asia','location':'Hong Kong','track':'High School','time':'11,14,0730,30','title':'Reducing biofilm formation in Lactobacillus fermentum: Targeting intervention on the AI-2/LuxS quorum sensing system','description':'Lactobacillus sp. are the most abundant bacterial contaminants in biofuel. Among them, L. fermentum is the most common one, accounting for 50% relative abundances of microbial species in bioethanol production. In our proposed study, L. fermentum 2-1, with a special quorum sensing (QS)-related feature given its higher level of production of autoinducer-2 (AI-2), would be examined for the effects of a dual-pronged intervention of the AI-2/LuxS QS system on biofilm formation. One of the quorum quenching approaches would be to inhibit the activity of LuxS (AI-2 synthase) using a putative high-affinity peptide ligand that has been shown to specifically inhibit LuxS in Streptococcus suis. The second approach would be to degrade AI-2 molecules extracellularly using the kinase LarK. We hope to achieve an effective inhibition in the formation of biofilm in biofuel through our dual-pronged intervention.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/10ef253a-2112-4414-9575-b515fec81cb3','video_link_presentation':'https://video.igem.org/videos/watch/6bf655a3-c345-434e-99db-6f75cf5a2f05','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=HK_HCY','poster_link':'https://2020.igem.org/Team:HK_HCY/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 3, Poster Number 30'}, {'name':'HK_SSC','link':'https://2020.igem.org/Team:HK_SSC','region':'Asia','location':'Hong Kong','track':'High School','time':'11,16,1000,30','title':'Production of PdRp-CBD complex for recovery of palladium from palladium ions','description':'Palladium is widely adapted in industrial processes such as catalytic converters or ceramic capacitors. It also holds biomedical applications such as acting as a drug carrier and is utilised in cancer treatment. However, palladium is an environmental pollutant and difficult to be recycled. In this project, twenty-five palladium(II) reducing peptides (PdRp) are modified from a selection of known palladium binding peptides. The PdRp are fused to a cellulose binding domain 3 (CBD 3) derived from Clostridium thermocellum which acts as an affinity tag. The PdRp-CBD complex is expressed in Escherichia coli BL21(DE3) in pETBlue-2 vector and purified using regenerated amorphous cellulose (RAC). Peptide-Palladium interactions are determined by computational methods of Molecular Dynamics. Downstream analysis and further experiments will be performed to determine the efficiency and performance of the PdRp with potassium hexachloropalladate.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ccf9f95b-a8d0-4930-986c-c4a50c2d013b','video_link_presentation':'https://video.igem.org/videos/watch/7f03ecf4-9257-4c49-b55c-5d05581bcfd7','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=HK_SSC','poster_link':'https://2020.igem.org/Team:HK_SSC/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 2, Poster Number 198'}, {'name':'HKUST','link':'https://2020.igem.org/Team:HKUST','region':'Asia','location':'Hong Kong','track':'Manufacturing','time':'11,15,0800,30','title':'Green textile system: Biodegradable hagfish slime intermediate filament and non-toxic chromoprotein-based dye for fabric production','description':'The conventional textile industry is causing noxious pollution to the hydrosphere. Non-biodegradable Synthetic fibers, such as nylon, are causing microplastic pollution. While chemical dyes discarded in factories` sewage are mostly poisoning to aquatic lives. In view of the issue, our project targets to replace these fibers and dye by producing recombinant hagfish slime intermediate filaments (IF) with a chromoprotein dyeing system. A novel protein purification approach is also designed as an industrial solution. The hagfish slime IF is a competitive candidate to replace the polluting man-made fiber. While being biodegradable, it possesses outstanding mechanics that outscore Kevlar. When compared to other developing alternatives, like spider dragline silk, its simpler protein architecture facilitates the production process. We also developed an eco-friendly dyeing method for our threads. By fusing non-toxic chromoproteins to the IF, they can grant a wide range of vivid colors for the fabric, making it a viable clothing material.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/18312403-1fb1-49e7-a49d-d792cac70d97','video_link_presentation':'https://video.igem.org/videos/watch/ef657c4f-7b36-49c2-8c15-294b3f5eea5d','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=HKUST','poster_link':'https://2020.igem.org/Team:HKUST/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 1, Poster Number 97'}, {'name':'Hong_Kong_CityU','link':'https://2020.igem.org/Team:Hong_Kong_CityU','region':'Asia','location':'Hong Kong','track':'Environment','time':'11,15,0830,30','title':'Plastilicious Coli: a rational design approach for biodegradation of plastic wastes','description':'The extensive use of plastics in recent decades has led to an increasing amount of plastic wastes which consist of non-biodegradable and non-incinerable plastics such as polyethylene terephthalate (PET) and polyurethane (PUR). These wastes are discarded into the environment causing serious environmental pollution problems. This has inspired our team to search for effective scientific options to help reduce plastic pollution. In this project, we have adopted an in-silico mutagenesis approach to design two PUR-degrading enzymes - papain and polyurethanase esterase A (PueA) - that could be used to enhance PET and PUR biodegradation. Ultimately, we are aiming to construct a multi plastic-degrading E. coli bug by combining the genes of the two mutant enzymes (papain and PueA) with the well-studied polyethylene terephthalate hydrolase (PETase) gene in a single biobrick. It is hoped that this technology will contribute to reducing plastic wastes and help better protect our environment.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ce573003-467b-4cd0-ad12-60691e37226a','video_link_presentation':'https://video.igem.org/videos/watch/33f9af45-c59d-4ad7-905e-779279a3de12','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Hong_Kong_CityU','poster_link':'https://2020.igem.org/Team:Hong_Kong_CityU/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 1, Poster Number 99'}, {'name':'Hong_Kong_HKU','link':'https://2020.igem.org/Team:Hong_Kong_HKU','region':'Asia','location':'Hong Kong','track':'Foundational Advance','time':'11,15,0730,30','title':'Beyond Unicellular: Recombinase circuits to develop monoculture phenotypic heterogeneity with precise ratiometric control','description':'Some natural populations of unicellular organisms exhibit uniquely high levels of cooperativity and labor division by sustaining phenotypic variation, which allows them to handle complex tasks efficiently. Similarly, achieving high degrees of compartmentalization in monocultures of engineered cells can bring tremendous benefits to multiple applications of synthetic biology, including healthcare, industrial use, and environmental remediation. Our project aims to develop a versatile set of tools that can help create and maintain stable phenotypic variation in cellular monocultures using bacteriophage-derived Cre recombinases, which recognize and invert a loxP-flanked genetic sequence in a stochastic manner. We introduced and assessed different mutations in the Cre enzyme to improve its accuracy and conducted pilot experiments for establishing ratiometric control of cellular phenotypes. To confirm the experimental phenotypic ratios, we built computational simulations that successfully predicted the phenotypic ratios and assessed phenotypic populations` stability and convergence with the coefficient of variation.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/2050666f-325f-4a58-b7a1-4917120b5d4e','video_link_presentation':'https://video.igem.org/videos/watch/0b30637f-60a5-48ea-9c82-fbdde6a82c85','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Hong_Kong_HKU','poster_link':'https://2020.igem.org/Team:Hong_Kong_HKU/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 2, Poster Number 101'}, {'name':'HZAU-China','link':'https://2020.igem.org/Team:HZAU-China','region':'Asia','location':'China','track':'New Application','time':'11,14,0830,30','title':'Tooth Fairy','description':'Enamel, the basic material of tooth is a kind of hydroxyapatite whose arrangement is ordered and tight, making it the hardest part in human body. Nevertheless, it suffers from damages in our daily life due to many reasons such as physical knock, acid erosion and bacterial infection. In the early stage of enamel damage, it is usually difficult to notice changes on the teeth or in the oral environment. However, in the later stage, when a tooth is decayed or ruptured, even doctors are unable to completely repair the damaged tooth. Besides, the treatment is painful and expensive. Our Tooth Fairy project could be an innovative solution to this problem. A tooth fairy contains several genetic circuits that enable her to provide automatic and personalized repair for the damaged tooth enamel. In addition, users can also know their oral status owing to the report ability of a tooth fairy.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/83e2fc53-7123-49f8-9943-55bd4ac95cdc','video_link_presentation':'https://video.igem.org/videos/watch/4db7c1ef-16d8-46cc-b1c8-e12b2f0eb9c0','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=HZAU-China','poster_link':'https://2020.igem.org/Team:HZAU-China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 3, Poster Number 32'}, {'name':'HZNFHS_Hangzhou','link':'https://2020.igem.org/Team:HZNFHS_Hangzhou','region':'Asia','location':'China','track':'High School','time':'11,16,0930,30','title':'biological/inorganic hybrid catalysis system for CO2 conversion','description':'CO2 is the main greenhouse gas causing global warming. Using renewable electricity to reduce CO2 to chemicals is a sustainable strategy for greenhouse gas mitigation and renewable electricity storage. To overcome the disadvantages of CO2 electrochemical reduction with inorganic catalysts, developing a biological/inorganic hybrid catalysis system for efficient CO2 conversion is promising. In this study, lycopene will be obtained in the hybrid catalysis system by combining electrochemical hydrogen evolution reaction and biological CO2 conversion with genetically engineered Ralstonia eutropha. In this hybrid catalysis system, bacteria can use CO2 and H2 as substrates to produce lycopene. As a result, CO2 can be transformed to valuable chemicals with electricity input and renewable electrical energy derived from wind and solar energy can be stored as chemical energy simultaneously.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/286bca49-5d6c-498b-9f56-abb3db0ff2d1','video_link_presentation':'https://video.igem.org/videos/watch/a800bd75-33c4-4305-95ed-275e05799069','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=HZNFHS_Hangzhou','poster_link':'https://2020.igem.org/Team:HZNFHS_Hangzhou/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 3, Poster Number 199'}, {'name':'iBowu-China','link':'https://2020.igem.org/Team:iBowu-China','region':'Asia','location':'China','track':'High School','time':'11,15,0830,30','title':'Sureloc (Surely Locates Cancer)','description':'Non-small cell lung carcinoma (NSCLC) is a common type of epithelial cancer, which is not sensitive to chemotherapy or radiotherapy. To address this issue, our team developed a therapy based on magneto-hyperthermia. We designed a vector that codes for magnetic protein crystals (MPCs) through the use of a tumor-specific promoter. Liposomes with surface PEG GE11 modifications carrying MPC vectors will target NSCLC cells. Post transfection, targeted tumor cells will express MPCs, which enable the binding of iron. Iron-loaded MPCs will then respond to localized alternating magnetic fields and induce cell death. The active targeting ligand, tumor-specific promoter, and localized alternating magnetic fields provide triple targeting security. Currently, we completed the in vitro isolation and purification of the MPCs with successful confirmation of their magnetism. The successive steps are to control the MPCs` size, add the internal targeting ligand, and experiment the targeting capabilities in vivo.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/d7d03968-47a2-4778-9d38-0c6f857acc78','video_link_presentation':'https://video.igem.org/videos/watch/70495773-cd36-47f8-9513-a7ee2f070022','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=iBowu-China','poster_link':'https://2020.igem.org/Team:iBowu-China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 2, Poster Number 103'}, {'name':'ICS_BKK','link':'https://2020.igem.org/Team:ICS_BKK','region':'Asia','location':'Thailand','track':'High School','time':'11,16,0830,30','title':'Project Trojan Horse','description':'Our project aims to treat tonsillitis utilizing phage therapy as an alternative to antibiotics, whose drawback is resistance. Our ultimate goal is to create a mouthwash containing engineered Lactococcus lactis strains capable of releasing a phage to deactivate Streptococcus pyogenes. For computational lab, we modified over 300 strains of Phage P2, natural phage of Lactococcus lactis, to bind to S. pyogenes and achieved the highest binding affinity of -6.38 kcal/mol, compared with the original affinity of -4.50 kcal/mol between P2 and S. pyogenese. For the wet lab approach, we conducted biopanning, a screening method to identify peptides with high affinity to a given target, on Staphylococcus aureus, a common virulent gram-positive bacteria in respiratory tracts. We successfully binded one strand of Phage M13 to S. aureus. The successful binding results in both approaches lay a foundation for next year`s modification of bacteriophage-containing bacteria in mouthwash delivery.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/41378b2f-104c-4113-94c5-ef3eab10bbe6','video_link_presentation':'https://video.igem.org/videos/watch/f50b8cd5-68e3-4768-81ba-0f7385dc7146','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=ICS_BKK','poster_link':'https://2020.igem.org/Team:ICS_BKK/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 3, Poster Number 201'}, {'name':'IISER_Berhampur','link':'https://2020.igem.org/Team:IISER_Berhampur','region':'Asia','location':'India','track':'Foundational Advance','time':'11,15,0930,30','title':'FRaPPe: A FRET based Ranker for Proteins and Peptides','description':'FRaPPe by team iGEM IISER Berhampur, is a reporter system which aims to validate efficiency of therapeutics targeting protein-protein interactions (PPIs). This reporter, assembled with mammalian promoters, modulatory domains (Chemically Induced Dimerization modules), fluorescence tags (Fluorescence Resonance Energy Transfer modules) and the coding sequences of proteins of interest will be developed in E. coli and transfected into Human Embryonic Kidney cells. This tool will enable modulation of the extent of PPIs and their quantification via fluorescence readout, offering possibilities for a high-throughput screening system for drug efficiency in attenuating these interactions in vitro.The utility of FRaPPe will be demonstrated using interference peptides that will disrupt the Dengue Virus Non-Structural Protein and host STAT2 interaction thus modulating the host interferon signalling pathway. We propose FRaPPe as a one-stop solution for studying host-viral PPIs and also a tool to screen inhibitors of these interactions against several viral diseases.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/c2dada58-dabc-495e-924c-9bd17de59eda','video_link_presentation':'https://video.igem.org/videos/watch/6466dbfc-0581-479e-8728-831762308319','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=IISER_Berhampur','poster_link':'https://2020.igem.org/Team:IISER_Berhampur/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 2, Poster Number 105'}, {'name':'IISER_Bhopal','link':'https://2020.igem.org/Team:IISER_Bhopal','region':'Asia','location':'India','track':'Therapeutics','time':'11,16,0930,30','title':'THE BIG PIE: Beta Cells In Gut Produce Insulin using E.coli (Tackling Diabetes Without Injections!)','description':'Globally, over 463 million adults suffer from diabetes, with the number estimated to exceed 575 million by 2030. Insulin, the ideal therapeutic for diabetics worldwide, is available only in an injectable form. Our project presents an out-of-the-box approach to tackle diabetes based on transdifferentiation. Our delivery vector, E. coli Nissle 1917, would be programmed to attach to crypt cells through expression of a crypt cell-specific antibody Lgr5. This would be followed by translocation of the three transcription factors - PDX1, MAFA & NGN3 - via the Type 3 Secretion System (a molecular syringe) into the cells to convert them into glucose-responsive beta-islet like cells. An inbuilt kill switch would ensure organisms egested from the body do not survive. Proof of concept will be established in the E. coli K-12 strain. The objective is to design a smart and viable alternative for insulin injections.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f866d71b-ebbe-43b1-941c-cef802e18e9d','video_link_presentation':'https://video.igem.org/videos/watch/4ea49882-139b-44c7-9a58-d9ee1a8fceaf','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=IISER_Bhopal','poster_link':'https://2020.igem.org/Team:IISER_Bhopal/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 3, Poster Number 202'}, {'name':'IISER-Pune-India','link':'https://2020.igem.org/Team:IISER-Pune-India','region':'Asia','location':'India','track':'Therapeutics','time':'11,15,0830,30','title':'Anopheles: The Half-Blood Princess','description':'The WHO estimated that 228 million people contracted Malaria globally and 405,000 people died from it in 2018. Our project aims to develop a library of inhibitory peptide drugs against certain essential human parasite protein interactions; resistance to current antimalarial therapeutics is on the rise. We intend to use cyclotides as stable protein scaffolds for these peptides. Using in-silico modelling, our dry lab team has designed short peptides that will potentially inhibit the protein interactions crucial for the invasion and survival of malaria parasites inside a human host. Our wet lab team has designed various experiments to clone and express the interacting host and parasite proteins, characterize the drug and reduce the toxicity of the grafted cyclotides. To address issues related to poor diagnostics, we have developed a diagnostic tool using convolutional neural networks which will be able to identify patients with malaria based on images of their blood smears.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f004803a-7d17-41e4-92f9-5d1ccca35be8','video_link_presentation':'https://video.igem.org/videos/watch/5c7c0476-938b-45a6-92d6-bc43fbb866ae','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=IISER-Pune-India','poster_link':'https://2020.igem.org/Team:IISER-Pune-India/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 2, Poster Number 107'}, {'name':'IISER-Tirupati_India','link':'https://2020.igem.org/Team:IISER-Tirupati_India','region':'Asia','location':'India','track':'Environment','time':'11,16,1000,30','title':'In-situ Bioremediation of Antibiotics for Combating Antimicrobial Resistance (AMR)','description':'The irresponsible and off-label use of antibiotics in animal husbandry as growth promoters have contributed significantly to antimicrobial resistance (AMR). Phage therapy, the current best solution, is also failing due to CRISPR and other innate bacterial defences. To combat antibiotic pollution, we have developed a proof-of-concept model to engineer E. coli harnessing a two-component sulfonamide degrading system that degrades the sulfonamides present in poultry waste below the Predicted No Effect Concentrations, preventing selection for resistant strains. Our system renders the poultry waste antibiotic-free and makes it safe to use as manure. Surface exclusion genes have been integrated into the bacteria to reduce horizontal gene transfer. A user modulated `kill switch` with a DNA degrading mechanism is also engineered to prevent the escape of AMR genes to the environment and ensure biosafety. This proof-of-concept model can be extended for other antibiotics by switching the antibiotic degrading genes involved.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/b35b09c9-6db0-4d58-be0a-e548d92b2d77','video_link_presentation':'https://video.igem.org/videos/watch/6bcf6cbf-50e5-4294-a485-89d2f8619a1b','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=IISER-Tirupati_India','poster_link':'https://2020.igem.org/Team:IISER-Tirupati_India/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 3, Poster Number 204'}, {'name':'IIT_Roorkee','link':'https://2020.igem.org/Team:IIT_Roorkee','region':'Asia','location':'India','track':'Therapeutics','time':'11,15,0800,30','title':'Pyomancer: Super specific combat system against superbugs','description':'Hospital Acquired Infections are the main cause of most of the ICU deaths and it`s imperative to build alternative solutions to treat Bacterial infections and break the wall of antibiotic dependence. Our project provides a narrow spectrum treatment for the Multi-Drug Resistant Bacteria, A. baumannii, through the engineering of naturally found elements, namely, Bacteriophage and Pyocins. Pyocins, as produced by P. aeruginosa, provide single-hit killing kinetics. These are engineered to retarget their specificity by the fusion of a tail fiber of the AP22 Phage (specific to A. baumannii). We have conceptualised a modular system, that can be used to produce a portfolio of designers proteins against the bacterial species we wish to target. Our work also includes the development of a software which computationalizes the protein design process and are applying interesting Machine Learning algorithms to predict which genes are responsible for imparting resistance & susceptibility to strains of bacteria.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/1c07c603-fe21-4128-99fd-10c211df7257','video_link_presentation':'https://video.igem.org/videos/watch/9e93cd55-3ca2-4e5e-a9fc-9aa9002b6340','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=IIT_Roorkee','poster_link':'https://2020.igem.org/Team:IIT_Roorkee/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 2, Poster Number 109'}, {'name':'Imperial_College','link':'https://2020.igem.org/Team:Imperial_College','region':'Europe','location':'United Kingdom','track':'Software','time':'11,16,0730,30','title':'SOAP Lab: Automating DNA Design & Assembly','description':'DNA assembly is a vital first step in most synthetic biology projects. As genetic design spaces become larger with more complex genetic circuits and greater diversity of parts, the ability to construct sizable genetic libraries with high accuracy in a cost and time-efficient manner is imperative. While automation is an attractive and increasingly affordable solution, programming remains a technical challenge for many wet-lab scientists. To make automated workflows a practical reality, we developed SOAP Lab, an open-source web UI that infers genetic circuit designs from SBOL data files and customizes an assembly plan based on the user`s specifications. This is then used to generate ready-to-run scripts for the liquid handlers, along with set-up instructions and logs for traceability and debugging. SOAP Lab is integrable into larger software pipelines through the use of SBOL data standards, empowering labs with access to a wider suite of tools available for computer-aided biology.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/dd7842e8-38be-45d6-8375-594716834601','video_link_presentation':'https://video.igem.org/videos/watch/e62b2bbd-f7b8-4d2d-ba61-7247a03edf56','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Imperial_College','poster_link':'https://2020.igem.org/Team:Imperial_College/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 4, Poster Number 214'}, {'name':'Ionis_Paris','link':'https://2020.igem.org/Team:Ionis_Paris','region':'Europe','location':'France','track':'Therapeutics','time':'11,14,0730,30','title':'BacTail : Target, Kill and Self-Destroy, an innovative way to fight against antimicrobial resistance','description':'Since the discovery of antibiotics, their massive and repeated use has led to the appearance of resistant bacteria for which no treatment exists. This is a major healthcare issue to which the IONIS Paris 2020 team is trying to respond. BacTail aims at designing tailor made therapeutic bacteria with three main abilities: Target, Kill and Self-Destroy. The first step is inspired by the specific recognition capabilities of bacteriophages. We will express their binding proteins on the surface of our bacteria. After binding to the pathogenic target, our bacteria will secrete specific antimicrobial peptides to kill it. For environmental and safety purposes, in order to prevent their dissemination, our bacteria is designed with an integrated kill-switch system. Once its mission is completed, it will self-destroy. All in all, BacTail is an innovative way to safely and locally target and kill antibiotic resistant bacteria.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/9590110a-e2b2-44d2-acf0-012f446699f7','video_link_presentation':'https://video.igem.org/videos/watch/0e6e7e39-a8fc-4dc6-983c-da686e39db35','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Ionis_Paris','poster_link':'https://2020.igem.org/Team:Ionis_Paris/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 4, Poster Number 38'}, {'name':'JACOXH_China','link':'https://2020.igem.org/Team:JACOXH_China','region':'Asia','location':'China','track':'High School','time':'11,16,1000,30','title':'Earthworm Yakult','description':'Soil has always been important to humans, providing a resource that can be used for shelter and food production. Prevention of contaminated soil is closely related to health problems in soil-plant-animal-human system. Here, we designed a `walking` biological platform for the detection and remediation of mercury contaminated soil. Multifunctional engineering bacteria were cultured, with MerR-dependent hypersensitive switch, mercury monitor, and mercury stabilizer. Once mercury ions are found in the soil, multifunctional engineering bacteria scattered in the soil can be activated, releasing chromogenic protein and stabilizing mercury ions in the form of HgS with low toxicity. Moreover, considering engineering bacteria move slowly in the soil and is greatly affected by the environment, we choose earthworm as the walking carrier. The engineering bacteria will be reproduced in the earthworm body and move through soil followed with the earthworm to monitor and remedy mercury contaminated soil movably.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/50879a75-db35-4296-80e0-118b52efa7b6','video_link_presentation':'https://video.igem.org/videos/watch/5e7cfbff-2a4a-4d1e-8a80-2c92bbf11b92','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=JACOXH_China','poster_link':'https://2020.igem.org/Team:JACOXH_China/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 3, Poster Number 206'}, {'name':'Jiangnan_China','link':'https://2020.igem.org/Team:Jiangnan_China','region':'Asia','location':'China','track':'Manufacturing','time':'11,14,0800,30','title':'Sophorolipid: Biosynthesis of fine-tuned acid/ lactone ratio in Starmerella bombicola based on CRISPR/Cas9','description':'Cyanobacteria blooms have gradually evolved into a global problem of water pollution. Sophorolipid, an eco-friendly biosurfactant, can degrade cyanobacteria effectively. Acid sophorolipids have better surfactant activity and lactone sophorolipids have better bacteriostatic effect. However, the sophorolipids produced by wild-type Starmerella bombicola are random mix of these two types. To obtain the higher yield of sophorolipid and combine the advantages of these two types, Jiangnan_China constructed a CRISPR/Cas9 gene-editing system in Starmerella bombicola to over-express UDP-glucosyltransferase B (UGTB) and adjust the lactonase (SBLE) expression level by using different promoters. Finally, a recombinant strain consistent with our expectation was constructed and produces sophrolipids with appropriate ratio that achieves the maximum efficiency of degrading cyanobacteria.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/681ab7de-7703-49d5-967d-9b47117373d8','video_link_presentation':'https://video.igem.org/videos/watch/43dc3e3b-2996-4dc0-8494-d8d592f2849f','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Jiangnan_China','poster_link':'https://2020.igem.org/Team:Jiangnan_China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 4, Poster Number 34'}, {'name':'Jilin_China','link':'https://2020.igem.org/Team:Jilin_China','region':'Asia','location':'China','track':'Open','time':'11,15,1030,30','title':'iGame','description':'This year, an unexpected disease has struck the world. Professor John Conway, who has invented the Game of Life, unfortunately passed away due to this pandemic. The Game of Life is a cellular automaton as well as a self-regulating simulation game. Inspired by this, we design another `Game of Life` by synthetic biology means in which microorganisms compete for survival under player`s light-control. The game contains three plans. Under different plans, player bacteria fight against enemy bacteria with antibiotics system, sensing system and toxin-antitoxin system correspondingly. To optimize players` gaming experience, we conduct experiments in the lab and collect relative parameters and data. Then we make it a videogame so that players can simply click on buttons on the screen to set the light for their battle and within several minutes they can get the game result.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/0eae4a80-0177-4233-8ddb-def1b38405cf','video_link_presentation':'https://video.igem.org/videos/watch/806ff47e-4683-489f-8ce7-72a78372cb0d','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Jilin_China','poster_link':'https://2020.igem.org/Team:Jilin_China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 3, Poster Number 112'}, {'name':'JNFLS','link':'https://2020.igem.org/Team:JNFLS','region':'Asia','location':'China','track':'High School','time':'11,14,0930,30','title':'Bacterial cellulose applied for making mask','description':'Now there are more than 200 million nonbiodegradable masks abandoned to the environment every day due to the pandemic novel coronavirus. We are trying to make a new antibacterial and color-changing mask using bacterial cellulose which is biodegradable. And its translucency is very benefit for facial recognition without taking off the mask.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/c0ded663-f843-423d-81ef-828e49831bcc','video_link_presentation':'https://video.igem.org/videos/watch/62a5467e-8279-4550-9717-23be32cc0c91','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=JNFLS','poster_link':'https://2020.igem.org/Team:JNFLS/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 4, Poster Number 37'}, {'name':'KAIT_Japan','link':'https://2020.igem.org/Team:KAIT_Japan','region':'Asia','location':'Japan','track':'New Application','time':'11,16,0930,30','title':'E. coli that Create a Creative Environment','description':'Our goal in this iGEM jamboree is development of `E. coli that create a creative environment` We`ve all suffered from the unpleasant odor of culturing E. coli .Therefore, we wanted to make unpleasant odors comfortable by development of E. coli that biosynthesize aromatic components. We decided on the sweet-smelling vanillin as the aromatic substance. In this research, the metabolic pathway to biosynthesize vanillin, we selected a pathway that metabolizes glucose to L-phenylalanine and introduces an enzyme gene to metabolize it to vanillin. Making the E. coli smell like vanilla may help alleviate unpleasant odors during the experiment and make it more enjoyable, allowing you to be more creative with your experiments.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/b0a2bd5f-afdd-4369-8ebd-d96487ab2346','video_link_presentation':'https://video.igem.org/videos/watch/b92f3193-34da-4aae-8d33-cd5b147c1af0','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=KAIT_Japan','poster_link':'https://2020.igem.org/Team:KAIT_Japan/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 3, Poster Number 207'}, {'name':'KCL_UK','link':'https://2020.igem.org/Team:KCL_UK','region':'Europe','location':'United Kingdom','track':'Therapeutics','time':'11,15,0730,30','title':'Creation of a 3D-bioprinted polycaprolactone scaffold with mussel-foot protein Pvfp-5β-based bioadhesive coating for biomedical applications.','description':'Annually, between 250,000 and 500,000 individuals worldwide suffer from a spinal cord injury (SCI). SCI is characterised by damage to the spinal cord followed by a complex pathophysiological response and loss of neuronal function below the site of injury. The limited regenerative abilities of the CNS combined with the inhibitory environment created by the glial scar at the affected area pose numerous challenges to restoring function. Working towards a therapy for SCI, we have designed and modelled a biodegradable scaffold composed of polycaprolactone, that incorporates a synthetic mussel-foot protein based bioadhesive coating, to encourage axonal attachment, and can be produced using 3D-bioprinting methods. Our scaffold is customisable and contains the necessary micro- and macro-architectures predicted to topographically encourage axonal regrowth and withstand the mechanical forces in the spine. We have further investigated in silico the physicochemical properties of our chosen protein Pvfp-5β to better understand its biotherapeutic use.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/7f90851a-3d85-4feb-9ce0-1b0e5d87aa5b','video_link_presentation':'https://video.igem.org/videos/watch/215bd9f6-cc6f-4af3-8ed6-8096f465697f','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=KCL_UK','poster_link':'https://2020.igem.org/Team:KCL_UK/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 3, Poster Number 117'}, {'name':'KEYSTONE','link':'https://2020.igem.org/Team:KEYSTONE','region':'Asia','location':'China','track':'High School','time':'11,16,0930,30','title':'B.B.Bin','description':'The aim of our project is to address PET plastic recycling coverage flaws as well as improving the tourists` experiences through fragrance in natural tourist areas. It will incorporate elements that will educate the public about the importance of plastic degradation and environmental protection. The accomplishment of the our iGEM project this year has two main sectors-- the experiments, which includes the fragrance and plastic degradation, and the hardware. The first experiment was used to insert leaf compost cutinase genes into the E. coli and optimize conditions for translation of the LCC enzyme as well as the conditions for degradation of the PET plastic. Another experiment was inserting the geraniol synthase and linalool synthase gene to produce the linalool fragrance. The mechanical trash can that we designed will assemble these synthetic biology part to degrade plastic. It is comprised of three parts— the shredder, the power source, and the decomposer.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/0ca5a8c9-1d3c-4e3c-8d24-e1c9c9ef9d90','video_link_presentation':'https://video.igem.org/videos/watch/84e6a622-3df6-4742-82c3-44b91dfbfc79','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=KEYSTONE','poster_link':'https://2020.igem.org/Team:KEYSTONE/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 3, Poster Number 209'}, {'name':'KEYSTONE_A','link':'https://2020.igem.org/Team:KEYSTONE_A','region':'Asia','location':'China','track':'High School','time':'11,15,1000,30','title':'Bacterial cellulose-based living Gaoyao for arthritis treatment','description':'In this aging society, arthritis haunts 355 million people around the world, but we still have no radical cure for it. Inspired by `Gaoyao` (an active patch with medical properties) in traditional Chinese medicine, we aim to tackle arthritis by designing a living Gaoyao. Its matrix is bacterial cellulose, a biomaterial with excellent biological compatibility and physical properties. It is embedded with engineered mammalian therapeutic cells harboring a modular genetic circuit, which contains: (1) a sensor with (2) an amplifier to detect trace amounts of inflammation signals at the early stage; (3) an effector that can secret antagonists of pro-inflammatory cytokines to suppress inflammation, BMP2 to activate skeletal stem-cells, and glucosamine to provide building blocks for cartilage; (4) a safety switch, enabling people to externally control the system. It can provide long-term treatment for arthritis, which not only suppresses inflammation before damages and pains arise, but also promotes cartilage regeneration.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/799eaf43-fdcc-482d-97c9-a8886c733355','video_link_presentation':'https://video.igem.org/videos/watch/e12eed4c-7c5e-42e3-aac5-c39b328ca44c','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=KEYSTONE_A','poster_link':'https://2020.igem.org/Team:KEYSTONE_A/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 3, Poster Number 114'}, {'name':'Korea_HS','link':'https://2020.igem.org/Team:Korea_HS','region':'Asia','location':'Korea, Republic Of','track':'High School','time':'11,14,0730,30','title':'Design and characterization of hyperstable cell-penetrating scFv targeting RAS','description':'Antibodies are being developed as therapeutic agents. However, the targets of currently used antibodies are restricted to cell surface proteins due to their inability to go into the cell and maintain their function in the reducing environment of the cell. We have chosen a hyperstable single chain variable fragments(scFv(P5)) as a scaffold and this antibody was engineered to recognize human RAS protein by changing residues in the antigen-binding site(scFv(RAS)). We attached cell-penetrating peptide to the N-terminus to develop an antibody that can go into the cell(CPP-scFv(RAS)). We cloned, expressed, purified, and tested if CPP-scFv(RAS) works as designed. The development of antibodies that can work inside the cell will dramatically broaden the range of target molecules and the diseases that can be treated with therapeutic antibodies.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/2512d662-51fb-44af-a1f5-a691fad0a1bc','video_link_presentation':'https://video.igem.org/videos/watch/58e2f83f-e294-4f97-b341-7561c985196a','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Korea_HS','poster_link':'https://2020.igem.org/Team:Korea_HS/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 4, Poster Number 39'}, {'name':'Korea-SIS','link':'https://2020.igem.org/Team:Korea-SIS','region':'Asia','location':'Korea, Republic Of','track':'High School','time':'11,16,0930,30','title':'Reducing Post-Harvest Losses During Storage of Grain Crops to Strengthen Food Security in Developing Nations','description':'Rice is a staple food for many countries in Asia. Rice needs to be dried and stored under specific conditions after harvest. If not, it loses its merchantability and affects the total yield. In Sri Lanka, it affects the livelihood of 1.8 million farmers and the lack of proper post-harvest technology is costing them 2393 million dollars annually. The fungi that are present in the storage of rice are Aspergillus spp. In this project, we establish a stringent post-harvest management system for rice by measuring the concentration of aflatoxin B1, a toxin produced by Aspergillus spp. To measure the concentration of AFB1, we used the enzyme, cytochrome P450 1A2. Reactions between AFB1 and CYP1A2 result in compounds with epoxide residue, which can be used for the detection. Here, we also proposed a nonparametric MARS model designed to capture possible inter-dependent effects of environmental factors on fungal infection of stored rice.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/484e61a4-bf30-4116-aae3-8a634217bc6b','video_link_presentation':'https://video.igem.org/videos/watch/dad47439-dff8-4da1-87af-db3286cd43c8','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Korea-SIS','poster_link':'https://2020.igem.org/Team:Korea-SIS/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 4, Poster Number 210'}, {'name':'KSA_KOREA','link':'https://2020.igem.org/Team:KSA_KOREA','region':'Asia','location':'Korea, Republic Of','track':'High School','time':'11,16,0930,30','title':'Ligninatior: Biological Lignin Degradation Method for Paper Recycling','description':'Production of high-quality recycled paper through biodegradation of lignin can decrease chemical byproducts and wastewater generated by existing paper production processes to significant environmental and economic benefit. Treating box paper and newspaper with laccase and dye decolorizing peroxidase (DyP) during the recycling process produced paper with improved brightness, texture, and permanence. The results demonstrate that synthetic biology can be used to produce recycled paper in a more environmentally friendly manner compared to chemical treatments used to produce recycled paper today. In addition, we have developed a biosensor and fluorometer pair to detect and measure phenolic compounds that are produced when lignin is dissolved. The pair can be used to monitor progress of lignin degradation in the paper recycling process and detect phenolic compounds in the environment. By expressing transporter of phenolic compounds in E.Coli, we have been able to obtain improved sensitivity compared to existing biosensors.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/7bbf561e-578b-455f-8b1b-30fdb97f84bd','video_link_presentation':'https://video.igem.org/videos/watch/5807372c-0412-4eda-8706-b020e0915d92','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=KSA_KOREA','poster_link':'https://2020.igem.org/Team:KSA_KOREA/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 4, Poster Number 212'}, {'name':'KU_ISTANBUL','link':'https://2020.igem.org/Team:KU_ISTANBUL','region':'Europe','location':'Turkey','track':'New Application','time':'11,14,0930,30','title':'The Living Laser: Transforming Cells into Lasers','description':'Systems approach in many domains of biological sciences requires large amounts of imaging data across different length and time scales. To step up into high throughput screening methods required for diagnostics and basic research purposes, multiplexed labeling, uniquely tagging, and tracking individual cells, and increasing the penetration depth of light into tissues are demanded. In order to meet these necessities, here we are demonstrating the living laser which is a morphosis of cells into lasers by building natural resonators on the surface of cells using novel gene circuits. We will be exploring the stability, feasibility, and practicality of these biological lasers in four main application domains: picking quality oocytes for IVF, tracking cancer cells over long periods of time, sensing internal and external changes of cells and creating a novel technique for characterization of cells and tissues.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/6e672799-1921-4296-a732-ab0b5813f3a6','video_link_presentation':'https://video.igem.org/videos/watch/5d488d97-0565-4cdb-a2fb-1971a028069e','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=KU_ISTANBUL','poster_link':'https://2020.igem.org/Team:KU_ISTANBUL/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 4, Poster Number 40'}, {'name':'KUAS_Korea','link':'https://2020.igem.org/Team:KUAS_Korea','region':'Asia','location':'Korea, Republic Of','track':'Open','time':'11,15,0930,30','title':'Thermopatch : What`s your body temperature now?','description':'One of the key factors to South Korea`s success in controlling COVID-19 is early detection. Aside from aggressive COVID-19 testing, South Korea also deployed temperature checks at entries of every indoor public facilities for screening purposes. However, the current screening methods such as contactless thermometers and infrared cameras are not efficient because of the high costs of resources needed for setting up screening booths and its failure to monitor temperature continuously. Our `Thermopatch` is a device that complements these limitations. In the process, we utilized light-up RNA aptamer(`Catalytic Hairpin Assembly(CHA)` method specifically) and thermosensing RNA. We ultimately hope our `Thermopatch` can help people get through these difficult times.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/65bac94c-3c82-44b4-890f-cfe8d8977d7c','video_link_presentation':'https://video.igem.org/videos/watch/6a5372d6-ba65-42fd-8f00-2d0d234dd70a','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=KUAS_Korea','poster_link':'https://2020.igem.org/Team:KUAS_Korea/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 3, Poster Number 116'}, {'name':'Lambert_GA','link':'https://2020.igem.org/Team:Lambert_GA','region':'North America','location':'United States','track':'High School','time':'11,15,0830,30','title':'AgroSENSE','description':'Over 23.5 million Americans face food insecurity or have limited access to affordable and fresh produce, leading to nutrient deficiency. Aquaponics is a pragmatic solution to address food insecurity, but maintenance and costs are barriers to implementation. Lambert iGEM`s AgroSENSE utilizes modular hardware, nutrient biosensors, and iOS/Android compatible software to monitor and analyze nutrient levels and environmental conditions to optimize plant growth. Our Arduino sensors measure environmental conditions while biosensors are utilized to monitor phosphate and nitrate nutrient balance. We characterized BioBricks based on E. coli`s native PHO and NAR signaling pathways. The expression of GFP in the presence of these nutrients is analyzed by Fluoro-Q, our improved frugal fluorometer. The data will be quantified by our Agro-Q mobile app, enabling end-users to make informed decisions regarding aquaponics systems. With an emphasis on integration of educational curriculum, AgroSENSE serves as a model for future agricultural biotechnology innovations.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f43ed716-3089-4c22-b363-9bd95017a440','video_link_presentation':'https://video.igem.org/videos/watch/e58286f8-156f-450d-8653-9e6c7f0bb413','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Lambert_GA','poster_link':'https://2020.igem.org/Team:Lambert_GA/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 3, Poster Number 119'}, {'name':'Leiden','link':'https://2020.igem.org/Team:Leiden','region':'Europe','location':'Netherlands','track':'Diagnostics','time':'11,14,1000,30','title':'Rapidemic: A novel modular point-of-care diagnostic tool for rapid epidemic response','description':'This year`s COVID-19 outbreak demonstrated how the world is impacted by a pandemic, causing over one million deaths worldwide and severely damaging the quality of life of billions. Rapid diagnostics are vital to keep an outbreak under control and reduce the need for disrupting measures. Here, we present an innovative, modular technique called Rapidemic that allows for the rapid detection of nucleic acids of pathogenic species in a future outbreak. By combining targeted amplification (RPA), nickase-based GQ DNAzyme generation (LSDA), and DNAzyme-catalyzed oxidation, our method reliably and rapidly detects pathogenic DNA or RNA and provides the user with a simple colorimetric output. Because it does not require a lab or external power source, our technology enables point-of-care testing in both high- and low-resource areas. This way, Rapidemic offers a global solution to a global problem and allows us to be one step ahead in tackling Disease X!','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f2f9e2a7-625c-479d-b119-1f3cbda113df','video_link_presentation':'https://video.igem.org/videos/watch/87557433-15d6-456a-8b7a-c6e32d91b7f1','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Leiden','poster_link':'https://2020.igem.org/Team:Leiden/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 4, Poster Number 42'}, {'name':'Lethbridge','link':'https://2020.igem.org/Team:Lethbridge','region':'North America','location':'Canada','track':'Food and Nutrition','time':'11,14,1030,30','title':'FriGEM ® Engineering Potatoes to Express Antimicrobial Peptides for Agriculture and Human Health','description':'Fusarium is a fungus causing dry rot in potatoes on the field and during storage. We want to express AMPs within the potato plant to provide a biological control of Fusarium. We also want to engineer E. coli to produce the desired AMPs instead and apply them on the plants/tubers.This would have the advantage that the potatoes are not GMOs. Additionally, we want to address human health and the negative perception of GM food. We want to produce AMPs that also enhance the potatoes nutritional value and health effects. AMPs useful against Fusarium may also have effects against human pathogens, making their ingestion beneficial. One example is the bovine AMP BMAP-18, which has antimicrobial effects against trypanosoma, the cause of sleeping sickness. By creating GMOs with beneficial effects for consumers, we hope to alleviate the stigma of GM food and increase its public acceptance.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/5c30e5df-e5ed-42bd-a72c-170c96f7d28a','video_link_presentation':'https://video.igem.org/videos/watch/c6c8ad66-c401-40e7-a832-2f54bbaec845','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Lethbridge','poster_link':'https://2020.igem.org/Team:Lethbridge/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 4, Poster Number 44'}, {'name':'Lethbridge_HS','link':'https://2020.igem.org/Team:Lethbridge_HS','region':'North America','location':'Canada','track':'High School','time':'11,15,1030,30','title':'tPectinACE: Targeting Pectin to Accelerate Compost Enzymatically','description':'Landfills are growing and a large portion of the items occupying this landfill space is food waste. When food waste enters landfills, there are a variety of environmental consequences. This is due to the copious amounts of greenhouse gases emitted during the production of our food. Additionally, food shipping utilizes cardboard and plastic for shipping, which harms our environment significantly. Although food waste disposal services are available, they release methane and are not economically productive. Furthermore, composting facilities do assist in combating the issue of food waste but are oftentimes not readily available or advertised. While some do have access to home composting, this is an inefficient method of reducing food waste and may attract pests. Therefore, we propose a system that employs an engineered biological catalyst that breaks down food waste in a closed container, keeping animals out and ensuring chemicals do not enter the environment.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/e345f8b9-bb2e-4454-a930-0d723262fc77','video_link_presentation':'https://video.igem.org/videos/watch/98c85940-0e56-4362-8b7b-48bedc87c5bb','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Lethbridge_HS','poster_link':'https://2020.igem.org/Team:Lethbridge_HS/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 3, Poster Number 121'}, {'name':'Linkoping','link':'https://2020.igem.org/Team:Linkoping','region':'Europe','location':'Sweden','track':'Software','time':'11,15,1000,30','title':'ClusteRsy: A user-friendly software for transcriptomic analysis and biomarker discovery','description':'Asthma is a chronic and inflammatory disease that affects the airways of 339 million people around the world yet the specific causes and triggers of asthma are still unknown. There is an increasing demand for refined diagnostic methods and in the age of Big data, the advancement of powerful algorithms provides an approach different from traditional methods. With the creation of the web-based software ClusteRsy we empower clinicians and biologists to analyze any RNA-seq data without the need of a bioinformatician. Through the use of ClusteRsy and our designed workflow, differentially expressed genes and pathways can be determined, which is pivotal to understand the mechanisms of diseases and find potential biomarkers. With the processed information, we have designed a theoretical biosensor to detect and distinguish asthma from similar conditions, hereby simultaneously striving to decipher the etiology of asthma and improving the diagnosis for the disease.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/8d31cb32-93cb-411b-8b8d-497922ab1d8c','video_link_presentation':'https://video.igem.org/videos/watch/5c0586d7-1ca4-4ad3-b7b5-bee33fcfa696','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Linkoping','poster_link':'https://2020.igem.org/Team:Linkoping/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 4, Poster Number 124'}, {'name':'LINKS_China','link':'https://2020.igem.org/Team:LINKS_China','region':'Asia','location':'China','track':'High School','time':'11,15,0800,30','title':'PICACHU: PIlin Constructed nAnowires production CHassis Unlocking','description':'Electronic conductive pili (e-pili) is an electricity conduction material produced by microbes, which has been proved for its electricity production in humid environments. Recently, various e-pilis were discovered but not suitable for large-scale production due to the severe cultivation conditions and bio-safety concern. This year, LINKS_China designed PICACHU, an E.coli chassis to express different e-pilis. We manufactured a pili-generator consists of 12 genes for pili assembly, expressed three pilins, and created a new measurement to verify the pili production. Furthermore, we renovate the generator and optimize the growth condition of the cells to increase the yield. Ultimately, we transformed the e-pilis product into a nanowire battery and expect it to provide sustainable clean energy. We are aiming to apply PICACHU to track migrant birds, to monitor the wetland, and to trace the trash flowing movement in the ocean. Hopefully, more possibilities of e-pili application will be explored in the future.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/b1c2c6aa-c01a-4540-9200-d6375af54ee3','video_link_presentation':'https://video.igem.org/videos/watch/1fe36ffa-7c61-4b47-8872-15ebe0971e79','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=LINKS_China','poster_link':'https://2020.igem.org/Team:LINKS_China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 3, Poster Number 118'}, {'name':'Lund','link':'https://2020.igem.org/Team:Lund','region':'Europe','location':'Sweden','track':'Environment','time':'11,14,1000,30','title':'Protecto - A biopesticide production system for preventing late blight in potatoes','description':'We have designed a system for producing antimicrobial peptides (AMPs) and attempted to demonstrate that it is functioning. Escherichia coli BL21 (DE3) and pET-11 is used to produce a cocktail of AMPs with either Thioredoxin A or Glutathione S-Transferase as a fusion partner, that will be cleaved by recombinant Enterokinase carried by another plasmid in the same cell. After AMP and subsequent protease expression, we will trigger the already developed Deadman kill switch and sonicate the cells in order to make sure that no live genetically modified microorganisms will be present in the product and that the AMPs are free in the solution. The resulting product is a cell extract containing soluble AMPs, which will serve as a biopesticide. We have also developed a computer model that generates and evaluates peptide sequences based on their potential as antifungal agents.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/5e1ed83e-19c3-4e8a-a6ca-8bb4aa1197d3','video_link_presentation':'https://video.igem.org/videos/watch/8ca40a79-0efe-42d8-b4e5-8bb3ef8ecbba','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Lund','poster_link':'https://2020.igem.org/Team:Lund/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 5, Poster Number 46'}, {'name':'Manchester','link':'https://2020.igem.org/Team:Manchester','region':'Europe','location':'United Kingdom','track':'Environment','time':'11,15,0930,30','title':'HippoSol – The sunscreen for the future','description':'Regular unprotected exposure to the sun can result in multiple skin disorders, including skin cancer. Skin cancer is the fifth most common type of cancer in the UK, yet 60% of cases are preventable. Sunscreens are therefore important to use, but when used while swimming in the sea, conventional sunscreen ingredients cause oxidative stress on coral reefs, resulting in serious coral bleaching. Our team aims to produce a novel non-toxic, bactericidal, mammal-derived broad-spectrum UV filter to address this problem. Our target compound polymerises naturally into an unreactive molecule minimising environmental effects. Our goal is to produce the novel sunscreen in bacteria, as a reef-safe alternative to commercially available sunscreens. We use innovative retrosynthesis methods to design a biosynthetic pathway to our target compound and utilise techniques like entrepreneurship, stakeholder engagement, and media analysis to ensure that our product meets an urgent real-world need in a safe and responsible way.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/af92cb52-afbf-450e-8fd9-d96cf428642e','video_link_presentation':'https://video.igem.org/videos/watch/f9624ab1-dbd1-4b6b-89ee-5c499e1ceee4','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Manchester','poster_link':'https://2020.igem.org/Team:Manchester/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 4, Poster Number 126'}, {'name':'MichiganState','link':'https://2020.igem.org/Team:MichiganState','region':'North America','location':'United States','track':'Environment','time':'11,16,1030,30','title':'BeeTox','description':'Since 2005, bee populations have been declining at an alarming rate. Our team decided to address one major factor contributing to these deaths: pesticides. Project BeeTox is a probiotic that allows bees to detoxify imidacloprid, a common neonicotinoid pesticide. We divided into 3 subteams to address different aspects of the project. The Device team designed a feeder to administer the probiotic in sugar water, incorporating an image recognition biocontainment mechanism. The Gene Engineering team worked to create a designer strain of Snodgrassella alvi, a microbe that colonizes the bee gut and can be effectively transformed. Our efforts were directed towards modifying the type I secretion system of S. alvi to export enzymes for detoxifying imidacloprid. The Bioinformatics team computationally modelled imidacloprid-degrading enzymes and analyzed the metabolic profile of imidacloprid breakdown. Successful implementation of this technology has the potential to save countless bees and the plants they pollinate.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/a08cc910-b458-422d-9be4-d09fb20ae1b4','video_link_presentation':'https://video.igem.org/videos/watch/458ad502-d235-4eb7-afea-b8ecf2470cc1','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=MichiganState','poster_link':'https://2020.igem.org/Team:MichiganState/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 4, Poster Number 216'}, {'name':'Mingdao','link':'https://2020.igem.org/Team:Mingdao','region':'Asia','location':'Taiwan','track':'High School','time':'11,14,0800,30','title':'Cleandy, a candy that cleans your teeth','description':'Tooth decays are globally highly prevalent among children. Commensal oral microbiome balance plays a pivotal role in maintaining oral health. Nowadays, probiotic treatment is attractive but with limited effectiveness. As a result, we designed a probiotic that can eliminate Streptococcus mutans, the main cause of dental caries. We genetically modified a E. coli probiotic strain, Nissle (EcN) with pyruvate oxidase (SpxB) gene to generate H2O2, aquaporin (AQP) gene to facilitate H2O2 transport, and catalase (KatG) gene to revive from oxidative stress by decomposing H2O2 into oxygen and water. We successfully presented a proof of concept in H2O2 assay, growth inhibition and antagonistic test against the growth of S. mutans. Furthermore, we developed a prototype, Cleandy, a candy can clean your teeth. The Cleandy composed of sugar alcohols and our engineered probiotic (GM EcN) was demonstrated in our experiment showing effective antagonistic activity against S. mutans by producing H2O2.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/e7b28b71-4008-4179-ac36-201c811c43ac','video_link_presentation':'https://video.igem.org/videos/watch/2d51aac4-6a1c-4f0c-8c06-e75d7918171a','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Mingdao','poster_link':'https://2020.igem.org/Team:Mingdao/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 4, Poster Number 41'}, {'name':'MIT','link':'https://2020.igem.org/Team:MIT','region':'North America','location':'United States','track':'Therapeutics','time':'11,14,0830,30','title':'No title','description':'No abstract','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/df52135b-d1cd-4803-96d1-9f775d098f50','video_link_presentation':'https://video.igem.org/videos/watch/b321916d-9247-45b7-9798-4f047c689ca7','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=MIT','poster_link':'https://2020.igem.org/Team:MIT/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 5, Poster Number 48'}, {'name':'MIT_MAHE','link':'https://2020.igem.org/Team:MIT_MAHE','region':'Asia','location':'India','track':'Therapeutics','time':'11,15,1030,30','title':'Breaking Bond','description':'Pollution is a direct result of man`s ever-increasing need for natural resources and energy, one of the notorious pollutants being – mercury. Mercury in water bodies is converted by anaerobic microbes into methylmercury. This toxic compound, gets Biomagnified and Bioaccumulated through the aquatic trophic levels. At the level of humans, it can be dangerously high. It is no coincidence that this was responsible for one of the world`s worst environmental disasters, i.e. the Minamata Disease. Previous projects attempted to solve the problem of methylmercury poisoning using bioremediation - converting free methylmercury (95% absorption) to elemental mercury (<0.01% absorption). However, these don`t account for the methylmercury already inside millions of fish. We wish to develop a probiotic bacterium with similar capabilities, this exploits the fact that Hg is inert in the gut and prevents absorption of organic mercury. We will also have a system that will help in reducing mercury-induced inflammations.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/8fa79012-4879-4e43-aa37-2c80630c0fce','video_link_presentation':'https://video.igem.org/videos/watch/3f2d8ce6-8e30-43b6-b4ca-07cee6b10f86','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=MIT_MAHE','poster_link':'https://2020.igem.org/Team:MIT_MAHE/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 3, Poster Number 120'}, {'name':'Montpellier','link':'https://2020.igem.org/Team:Montpellier','region':'Europe','location':'France','track':'Therapeutics','time':'11,15,0930,30','title':'Phagent: Phage-mediated reprogramming of the tumor microbiome to fight cancer','description':'Phagent is a global approach against cancer involving bacteria of the tumor microbiome and phages. Our goal is to engineer phages that will hack the tumor microbiome and make the infected bacteria produce oncolytic molecules. We focused on dacA, which triggers the cGAS-sting pathway, azurin which interferes with the tumor suppressor p53, and VHH-PL1, a nanobody interacting with the immune system. The phages are injected in the tumor and transform the bacteria of the microbiome. The choice of the phage depends uponthe target cancer and its microbiome. Then, the bacteria will produce the therapeutic proteins that will interfere with cancer cells and trigger apoptosis. Phagent would complement classical treatments that may be not effective to fight some types of tumor.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/1b23db34-8049-4ae1-bced-7330d0defa4f','video_link_presentation':'https://video.igem.org/videos/watch/ce210908-336f-4bfe-ba68-24a159e51352','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Montpellier','poster_link':'https://2020.igem.org/Team:Montpellier/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 4, Poster Number 128'}, {'name':'Moscow','link':'https://2020.igem.org/Team:Moscow','region':'Europe','location':'Russian Federation','track':'Diagnostics','time':'11,15,0930,30','title':'HaploSense','description':'As viruses mutate quickly, different genotypes among one species can develop. For some viral diseases, genotype detection is crucial for successful treatment, and hepatitis C is one of them. Nobel Prize 2020 was awarded for the fight against hepatitis С, a major global health problem that causes cirrhosis and liver cancer. Hepatitis C is caused by hepatitis C virus (HCV) that has at least six different genotypes. Recombinant variant RF2k/1b is common in Russia, but it is often mistaken for genotype 1 that leads to incorrect treatment. However, a lot of infected people in Russia do not know their HCV genotype because of expensive testing or the impossibility to perform tests in peripheral regions. So, we are developing an easy-to-use portable Cas-based device `HaploSense` to solve this problem. HaploSense can be optimized for genotypes detection of any RNA viruses, including HIV or Sars-CoV-2, and may become a universal detection platform.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/02607432-cf7e-47e9-807b-c051cbed6cd6','video_link_presentation':'https://video.igem.org/videos/watch/4d568c96-59d3-49de-a612-0ffb79839f1a','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Moscow','poster_link':'https://2020.igem.org/Team:Moscow/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 4, Poster Number 130'}, {'name':'Moscow-Russia','link':'https://2020.igem.org/Team:Moscow-Russia','region':'Europe','location':'Russian Federation','track':'Diagnostics','time':'11,15,1030,30','title':'Genomus – a preconceptional screening system of four most frequent and almost incurable autosomal-recessive diseases','description':'Autosomal-recessive diseases, such as cystic fibrosis, phenylketonuria, galactosemia and sensorineural hearing loss affect thousands of people worldwide. There`s no widely-available treatment for these diseases yet. We consider that the best way to give birth to a healthy child is proper pregnancy planning and genetic screening before the conception. During the iGEM 2020 season, our team has developed Genomus – a preconceptional screening system which is capable of significantly reducing the amount of autosomal-recessive mutations in the human population. Genomus consists of three parts: 1. Laboratory where we collect and proceed blood or saliva samples and perform genotyping; 2. Secure database with over 1500 potential parents` genotypes, website and mobile application with algorithms of genotypes comparison using QR-codes for authorized comparison access. 3. User-friendly notification & pregnancy planning guidance system. The main idea of Genomus is to integrate genetic screening in pregnancy planning programms, make it popular and avaible for everyone.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/34f01a3d-2971-4faa-89dd-6aba89d8b7aa','video_link_presentation':'https://video.igem.org/videos/watch/dc80a16d-935b-4daa-9037-91515432f357','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Moscow-Russia','poster_link':'https://2020.igem.org/Team:Moscow-Russia/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 4, Poster Number 132'}, {'name':'MRIIRS_FARIDABAD','link':'https://2020.igem.org/Team:MRIIRS_FARIDABAD','region':'Asia','location':'India','track':'Environment','time':'11,15,0800,30','title':'Li-Koff: To Detect and Degrade N-Nitrosamines','description':'N-Nitrosamines are group of compounds formed from the reaction between nitrites and secondary and tertiary amines. Majority of these compounds are known to be potent carcinogens. They are found in pharmaceuticals, cosmetics, processed meats, alcoholic beverages, cigarette smoke, suspended particulate matter (spm) etc. But, their presence in potable water post disinfection stage in water treatment plants is most alarming; as their formation depends upon temperature and pH and not on the precursor molecules forming them. Quantifying them through conventional techniques of LC/MS, GC/MS, HPLC, etc., is time consuming, labour intensive and an costly affair. Hence, li-koff pitches in as an alternate synbio solution for an easy detection and estimation of these compounds in water samples. Further, it also degrades some of these compounds upon detection.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/aefae00f-fb22-46df-a943-60e3902c8349','video_link_presentation':'https://video.igem.org/videos/watch/23d44625-d46d-4d39-868d-92e32ed50d77','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=MRIIRS_FARIDABAD','poster_link':'https://2020.igem.org/Team:MRIIRS_FARIDABAD/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 4, Poster Number 122'}, {'name':'MSP-Maastricht','link':'https://2020.igem.org/Team:MSP-Maastricht','region':'Europe','location':'Netherlands','track':'Environment','time':'11,16,1000,30','title':'MSP-Maastricht combating the OPC invasive species with Oak Shield, a biological pesticide','description':'In the past few decades, the Oak Processionary Caterpillar (OPC) has spread towards Northern parts of Europe, far from its natural southern predators. This invasive species is noxious for oaks trees but also dangerous for animals and humans due to its toxic bristle. Therefore, this year`s MSP-Maastricht iGEM team has decided to join the fight against the OPC. Our aim is to provide an eco-friendly pesticide - Oak Shield - specifically targeting the caterpillar as current pesticides harm other insects. We identified potential target sequences unique to the OPC genome and planned to modify bacteria to make them produce interfering RNA complementary to those sequences. Algorithms allowed us to estimate the decrease in population. Prior to Oak Shield we started Geneducation, a YouTube channel focusing on the popularization of syn-bio and genetic engineering. Additionally, we launched a proceedings journal for iGEM teams, containing peer-reviewed articles from more than 30 teams!','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/74282bd9-81b5-4a59-a269-08a4d28c81dc','video_link_presentation':'https://video.igem.org/videos/watch/c20481c5-bcf5-4f6c-a2ff-0db6eacece8e','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=MSP-Maastricht','poster_link':'https://2020.igem.org/Team:MSP-Maastricht/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 4, Poster Number 219'}, {'name':'Nanjing_high_school','link':'https://2020.igem.org/Team:Nanjing_high_school','region':'Asia','location':'China','track':'High School','time':'11,14,0830,30','title':'Accuriculture` --- with phosphorus solubilizing bacteria','description':'RePhos. is developing methods to make better use of phosphorus in soil. Our project aims to increase crop yield and minimize pollution caused by phosphorus runoffs. By genetically editing phosphorus solubilizing bacteria, we insert a gene important for bacteria`s survivals. This can constrict the area where bacteria can survive, so they are only close to the rhizosphere. The products are fertilizer adjuvants for farmers and agent kits for scientists. These create a Smart and Accurate form of agriculture, called `accuriculture`. To provide practical solutions to the issue, we also researched the market and interviewed some target customers. We communicated with professors in the area in order to prepare a more useful product. Finally, we made a business plan to attract investors and funding. We provide a comprehensive solution that even has the practical potential to be applied on broader aspects.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/82c43f0c-9840-49b5-8cfa-964f29e35cf6','video_link_presentation':'https://video.igem.org/videos/watch/4c79019c-54a5-427a-abbd-a9ad05365b96','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Nanjing_high_school','poster_link':'https://2020.igem.org/Team:Nanjing_high_school/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 4, Poster Number 43'}, {'name':'Nanjing_NFLS','link':'https://2020.igem.org/Team:Nanjing_NFLS','region':'Asia','location':'China','track':'High School','time':'11,16,1000,30','title':'MIDAS: MFCs Improved in Different Aspects Safely','description':'Microbial Fuel Cells (MFCs) are devices that convert chemical energy (even from waste water, applied in pollution treatment) to electrical energy by the action of microorganisms. In our project, we engineer electricity-production-bacteria (like Pseudomonas aeruginosa), by over-expressing genes of phzM, nadE, and rhlA (respectively responsible for three crucial electron producing processes in P. aeruginosa), to improve the electricity output of bacteria incubated MFCs. To ensure safety, we introduce a light controlled kill-switch, `supernova` gene: when bacteria release into the bright environment from the dark chamber of MFCs, light will activate the gene which produces superoxide radical anions to kill the cells. Meanwhile, we intend to modify the hardware of MFCs: infuse certain concentration of heavy metal ions into the anode to facilitate the electricity generation, and use graphite combined with Mn2+/Fe2+ as the cathode so that the cathode can create Fenton reagent to degrade some recalcitrant chemicals.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ae637f0e-9190-4165-856b-5db7dea29339','video_link_presentation':'https://video.igem.org/videos/watch/97636454-2853-4707-b51e-3768f79739bc','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Nanjing_NFLS','poster_link':'https://2020.igem.org/Team:Nanjing_NFLS/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 4, Poster Number 213'}, {'name':'Nanjing-China','link':'https://2020.igem.org/Team:Nanjing-China','region':'Asia','location':'China','track':'New Application','time':'11,14,1000,30','title':'PolyP Pro','description':'There are many problems with synthetic chemical materials, such as the contamination and safety risks in production process. By means of Synthetic Biology, we hope to biosynthesis the inorganic material polyphosphates, which is commonly used in chemistry, with biomolecular proteins in order to obtain a new environmental friendly material, which not only maintains the original function of the biomolecule but also optimize its chemical properties.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/6da10980-16dd-4293-8aaa-553f7d2f4db7','video_link_presentation':'https://video.igem.org/videos/watch/5afa1fba-826f-4f50-9de7-705203e1508c','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Nanjing-China','poster_link':'https://2020.igem.org/Team:Nanjing-China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 5, Poster Number 45'}, {'name':'Nantes','link':'https://2020.igem.org/Team:Nantes','region':'Europe','location':'France','track':'Environment','time':'11,16,0830,30','title':'A3 Project - Algal Acquired Acid','description':'Green macroalgae (Ulva spp.) have been poisoning oceanic coastlines for decades through the production of a toxic gas: hydrogen sulfide (H2S). The collection of algae is currently a costly and unprofitable process. Our project aims to enhance the value of the collected algae. To do so, we plan to target ulvan, the main component of green algae`s cell wall, using degradation enzymes and recombinant sulfatases. Once produced by transformed bacteria, the enzymes will be added to a tank of a bioreactor, filled with algae and sulfate-reducing bacteria (SRBs) which are responsible for the production of H2S. The H2S produced in the tank will be transformed into sulfuric acid (H₂SO₄), a useful compound for many industries such as the production of detergents, textiles and many others products. Our project could constitute a proof of concept for a subsequent industrial optimization.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/cadee7a4-a117-436a-8cee-3477a3ec16c9','video_link_presentation':'https://video.igem.org/videos/watch/dc656442-f25b-438a-a24b-2b00848e3b10','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Nantes','poster_link':'https://2020.igem.org/Team:Nantes/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 5, Poster Number 222'}, {'name':'NAU-CHINA','link':'https://2020.igem.org/Team:NAU-CHINA','region':'Asia','location':'China','track':'Environment','time':'11,16,0800,30','title':'Soil lead immobilization magician(SLIM):earthworms carrying engineered Bacillus subtilis','description':'Lead pollution in soil has brought great losses to agriculture and human health. However, traditional approaches such as physicochemical repair and plant enrichment will cause other hazards and have lower efficiency, respectively. Therefore, it is urgent to develop new strategies for lead pollution treatment. This year, to make up for the deficiency of traditional methods, NAU-CHINA combined earthworms (Eisenia foetida) and bacteria (Bacillus subtilis) to immobilize soil lead. Earthworms was used as carrier of bacteria, and we transformed bacteria to secrete phytase specifically by using oxygen-regulated switch to hydrolyze phytate in the intestines of earthworms. Lead ions can be precipitated into insolubles by combining with phosphate and chloride ions, thus purifying soil. Meanwhile, we added suicide module considering the biosafety of using genetically modified organisms in the environment. Affected by COVID-19, we cannot do experiments. So we collected data from literature and constructed mathematical models to predict results and feasibility.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/51ad3c62-6367-41a1-9be4-6050ea1cba0f','video_link_presentation':'https://video.igem.org/videos/watch/ac718e72-bd8c-44d1-b56b-0c0cb63c679d','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NAU-CHINA','poster_link':'https://2020.igem.org/Team:NAU-CHINA/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 4, Poster Number 215'}, {'name':'NCKU_Tainan','link':'https://2020.igem.org/Team:NCKU_Tainan','region':'Asia','location':'Taiwan','track':'Therapeutics','time':'11,14,0830,30','title':'Eye kNOw: Envisioning the future of glaucoma treatment','description':'Glaucoma is characterized by progressive loss of visual field without any early symptoms. A leading cause of irreversible blindness, glaucoma affects millions of people worldwide and causes heavy burden on healthcare systems. The only proven effective treatment is reducing the patients` intraocular pressure (IOP), which is usually done by providing eyedrops with IOP-lowering effect, like nitric oxide. However, due to ineffective IOP management and warning strategies, blindness is still a problem. Therefore, iGEM NCKU-Tainan developed a revolutionary solution, Eye kNOw, a pair of contact lenses that contains engineered bacteria producing nitric oxide in response to IOP fluctuation. We also developed Eye Screen, an affordable and portable detection device that utilizes ultrasound to measure IOP and identify the high-risk groups. With Eye kNOw and Eye Screen, IOP can be controlled in a real-time manner, and glaucoma can be detected and monitored with a low-cost device, saving more people from life-long darkness.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/eaef5b84-2f7e-4ab7-9ef4-f85422194bf1','video_link_presentation':'https://video.igem.org/videos/watch/32c0cf33-9bff-4052-a828-558959262288','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NCKU_Tainan','poster_link':'https://2020.igem.org/Team:NCKU_Tainan/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 5, Poster Number 47'}, {'name':'NCTU_Formosa','link':'https://2020.igem.org/Team:NCTU_Formosa','region':'Asia','location':'Taiwan','track':'Foundational Advance','time':'11,15,1000,30','title':'E. Hybrid','description':'Large scale biosynthesis in producing valuable molecules and proteins come into its embryonic stage for more sustainable and renewable ways of manufacturing and simultaneously faces multiple challenges in bioengineering. Incorporation of light-driven proton pump into non-phototrophic bacteria to produce additional proton motive force has gained interest in recent years as several bacterial rhodopsins are utilized for generating larger amounts of adenosine-5`-triphosphate(ATP) for alleviating the metabolic stress caused by excessive reliance on glucose and supporting bioengineering reactions. We expressed functional Gloeobacter rhodopsin from ancient bacteria, Gloeobacter violaceus, on E. coli Lemo-21 and evaluated its growth and metabolic reactions and found it potent in creating alternative proton motive force for oxidative phosphorylation and eventually proved it to be ideal for improving protein and molecule yields. Gloeobacter rhodopsin-based E. coli serves as a fundamental strain that uses light as energy sources, thus paving promising avenues for biosynthesis and creative daily usages.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/6aba20a8-7692-4a62-94af-9bd8e94c7ee8','video_link_presentation':'https://video.igem.org/videos/watch/44e04ea1-694a-4f52-b52a-a01cc36fd46c','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NCTU_Formosa','poster_link':'https://2020.igem.org/Team:NCTU_Formosa/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 4, Poster Number 125'}, {'name':'NEFU_China','link':'https://2020.igem.org/Team:NEFU_China','region':'Asia','location':'China','track':'New Application','time':'11,14,0800,30','title':'Bio-optical Landmine Detection','description':'Currently, at least 110 million landmines are still buried in the field worldwide. These landmines cause not only tens of thousands of human casualties each year, but also serious environmental pollution. To help deminers detect landmines in a fast and safe way, our team designed a bio-optical landmine detection device. We engineered an E. coli strain harboring a gene circuit to sense the dinitrotoluene (DNT), a typical chemical released by landmines. DNT can trigger the bioluminescence generation module in our engineered bacteria, and emitted optical signal can be captured and converted to digital output by the device, which is uploaded to an on-site computer. Through data processing, we will be able to create a probabilistic heat map of the landmines in a particular area. Eventually, an optimized landmine clearance route can be proposed to assist manual landmine detection with a minimal risk of deminers` injury.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/b5a5d8a5-8f93-4681-899d-ecf14ada4303','video_link_presentation':'https://video.igem.org/videos/watch/c9a64825-b840-4f1d-a9c2-056ef5179f7d','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NEFU_China','poster_link':'https://2020.igem.org/Team:NEFU_China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 5, Poster Number 49'}, {'name':'NEU_CHINA','link':'https://2020.igem.org/Team:NEU_CHINA','region':'Asia','location':'China','track':'Diagnostics','time':'11,16,0830,30','title':'Rapid detection of environmental Covid-19 using genetically engineered Ace2-PmrA-PmrB system','description':'Traditional detection of environmental Covid-19 employs quantitative PCR method, with a minimum turnaround time of 6-hour. Here, we developed a rapid protocol, in which the presence of Covid-19 S protein is readily detected by genetically engineered Ace2-PmrA-PmrB system. In our work, we recombined the PmrA-PmrB two-component system derived from Salmonella to the surface of E. coli, and replaced the Fe(III) recognition site of PmrB with the core region of human angiotensin-converting enzyme 2 (ACE2)，which could recognize the surface spike glycoprotein (S protein) of SARS-CoV-2. Upon recognition, the downstream signal pathways and the reporter gene are activated. Furthermore, an amplifier (Hrp regulatory machinery) and extra cytoplasmic function (ECF) σ factor were used to improve the sensitivity of the biosensor. A TEV protease-based post-translational regulation system to reduce the leakage is also used. In summary, our system shortens the time frame and reduces the cost and lab labors for detection.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/34b6d6d1-6668-4ef4-951e-0c5c0e013cb7','video_link_presentation':'https://video.igem.org/videos/watch/72b6d7fe-9465-43b9-9381-f53d120caa93','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NEU_CHINA','poster_link':'https://2020.igem.org/Team:NEU_CHINA/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 4, Poster Number 217'}, {'name':'NFLS','link':'https://2020.igem.org/Team:NFLS','region':'Asia','location':'China','track':'High School','time':'11,16,1030,30','title':'A System for Degrading Waste Cellulose and Generating Electricity','description':'Things made from cellulose can be seen everywhere in our life, such as paper and straw. Although some methods for recycling used paper have reached good efficiency, there is still large amounts of waste paper that cannot reach the standard of being recycled and have no chance to be put into a second use together with many materials composed of cellulose. Some of those cellulose materials can only be buried or burnt, which creates pollution for the environment. To deal with those materials, we come up with an idea of using genetically engineered E.colis to transform cellulose into glucose with the help of enzymes, including endoglucanases(cex), exoglucanases(cen), and β-glucosidases, and the E.colis generate electricity in Microbial Fuel Cells. We hope to imply this synthetic biological method to deal with waste cellulose and more environmental issues.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/c5d4f13a-1467-4f82-aad3-2231a4210a4c','video_link_presentation':'https://video.igem.org/videos/watch/96a48d58-a4d9-4215-88ed-d431fc5956ac','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NFLS','poster_link':'https://2020.igem.org/Team:NFLS/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 4, Poster Number 218'}, {'name':'NJMU-China','link':'https://2020.igem.org/Team:NJMU-China','region':'Asia','location':'China','track':'Diagnostics','time':'11,16,0730,30','title':'Sound of Silence: Domestic autism screening based on urinary metabolites','description':'Autistic Spectrum Disorder (ASD), with its prevalence increasing dramatically over past decades, brings severe burden on both families and the society. Nowadays, the screening of ASD mainly bases on behavioral scale, neglecting the genetic and metabolic alterations. Meanwhile, it calls for test methods with lower price and higher privacy. Our project consists two parts: a test strip for domestic tests based on urinary metabolites and further, a parallel screening strategy that increases sensitivity. As for the test strip, it is embedded with whole cell biosensors of elevated urinary serotonin, which was previously reported to play a critical role in ASD development. And the biosensor was constructed utilizing the Qurom-Sensing system in P. aeruginosa in this project. As for the parallel screening strategy, we employed machine learning algorithm and find a combination of metabolites for screening that performs best by representing most of the heterogenous patient population.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/1d6db3cf-a7e0-43d9-a57c-dccade816493','video_link_presentation':'https://video.igem.org/videos/watch/bd9c956e-2488-45bb-a4d8-60678a84be5a','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NJMU-China','poster_link':'https://2020.igem.org/Team:NJMU-China/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 4, Poster Number 220'}, {'name':'NJTech_China','link':'https://2020.igem.org/Team:NJTech_China','region':'Asia','location':'China','track':'Foundational Advance','time':'11,14,0730,30','title':'Pheromone revolution: mating pathway-based promoter engineering','description':'Cell fusion is a fundamental biological process required for the entire development of most eukaryotic organisms, from fertilization to organogenesis. Pheromone-mediated mating in the budding yeast Saccharomyces cerevisiae provides a genetically accessible model system to investigate cell-cell fusion. However, the high price of pheromone limits the development of related research. In our project, we constructed mutants to reshape signaling pathway, trying to build a chassis that responds to cheaper inducers. We characterized the intensity of three mostly pheromone responsive promoters, pfus2, pprm1, and pfig1. We innovatively evaluated the efficiency of these promoters (natural and synthetic) with pheromone responsive elements (PRE) of various copy numbers and directions. Our results expand the promoter toolbox to finely tune gene expression levels for efficient cell factories and biosensors.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/436204a0-92bd-4828-905c-01292ac78123','video_link_presentation':'https://video.igem.org/videos/watch/fa1b7053-d5e2-4c91-b9f1-e4c026eb1912','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NJTech_China','poster_link':'https://2020.igem.org/Team:NJTech_China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 5, Poster Number 51'}, {'name':'NJU-China','link':'https://2020.igem.org/Team:NJU-China','region':'Asia','location':'China','track':'Therapeutics','time':'11,15,1000,30','title':'ExosomeBomb SiRNA','description':'siRNAs offer an opportunity to specifically target mRNAs and modulate the expression of therapeutic targets which can facilitate cancer treatment. Here, we designed composable and programmable genetic circuits that used the liver as a tissue chassis to direct the self-assembly of exogenous siRNAs into secretory exosomes. The circuits include core parts which expressed siRNAs that not only inhibit the cancer cells, but also remove the disguise cancer use to evade the immune system; enhancing parts which facilitated the production of more anti-cancer exosomses, and guidance parts which directed the exosome to target cancer cells. Taken together, the genetic parts assembled into anti-tumor exosomes, secreted into circulation, delivered to cancer cells and eliminate them. The strategy provided a controllable, efficient and convenient cancer treatment which may even provide a personalized treatment strategy that can address a broad range of problems in biomedicine.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/d19831bd-ae68-4ac1-9fed-276876ff4543','video_link_presentation':'https://video.igem.org/videos/watch/42853b30-84cd-41b2-bc8b-d4b254f64d03','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NJU-China','poster_link':'https://2020.igem.org/Team:NJU-China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 4, Poster Number 127'}, {'name':'NOFLS_YZ','link':'https://2020.igem.org/Team:NOFLS_YZ','region':'Asia','location':'China','track':'High School','time':'11,16,1030,30','title':'Discovery of FXR antagonist against T2DM','description':'Farnesoid X receptor (FXR), as a member of nuclear receptors is tightly associated with glucose metabolism. Accumulated evidence indicated that FXR antagonist relates to the treatment of type 2 diabetes mellitus (T2DM), although the related mechanisms remain unclear. Therefore, our aim is to screen a small molecule FXR antagonist as a probe to explore the mechanism of FXR regulating glucose metabolism. Here, we used AlphaScreen assay to screen FXR antagonist. Among the compounds, H7 was finally selected for its highly antipathogenic activity against FXR. Finally, H7 antagonized GW4064-induced reporter gene stimulation in transactivation assay, indicating that H7 was a FXR antagonist.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/2fc9e9fb-bece-48cc-ab00-469ad1d64dcd','video_link_presentation':'https://video.igem.org/videos/watch/4b348aed-c002-4b17-9346-a130899cfbc1','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NOFLS_YZ','poster_link':'https://2020.igem.org/Team:NOFLS_YZ/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 5, Poster Number 221'}, {'name':'Nottingham','link':'https://2020.igem.org/Team:Nottingham','region':'Europe','location':'United Kingdom','track':'Therapeutics','time':'11,14,1000,30','title':'NeuroTone: The microbiome and neurodegeneration','description':'The University of Nottingham iGEM team have been developing a novel biotherapeutic to delay the onset and progression of neurodegenerative diseases, using synthetic biology. By engineering the bacterium Clostridium sporogenes to secrete the ketone D-β-Hydroxybutyrate (DBHB), we achieve neuroprotection by ketone-mediated relief of oxidative stress in the brain. This will occur via delivery of our C.sporogenes spores to the gut, where an established culture will produce DBHB - which enters the blood stream and crosses the blood-brain barrier, utilising the gut-brain axis. Using mathematical modelling, we identified a pathway to favour microbial DBHB production and have investigated how the culture size and metabolic activity could be regulated. Recognising potential concerns regarding genetically modified organisms, we designed strict controls to ensure our biotherapeutic cannot escape into the environment. Through several outreach projects alongside consultations with key stakeholders, we have engaged the wider community to inform and shape our work.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/6d55c197-ab8c-4121-97fa-11ee4ed21d55','video_link_presentation':'https://video.igem.org/videos/watch/1221507a-3547-4b1c-91e8-df95af55f1cc','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Nottingham','poster_link':'https://2020.igem.org/Team:Nottingham/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 5, Poster Number 50'}, {'name':'NOVA_LxPortugal','link':'https://2020.igem.org/Team:NOVA_LxPortugal','region':'Europe','location':'Portugal','track':'Environment','time':'11,15,0800,30','title':'Introducing Pseudomonas putida in the fight against the pine wood nematode Bursaphelenchus xylophilus','description':'Pinus pinaster is a tree species native to the Mediterranean region and susceptible to Pine Wilt Disease (PWD), a deadly pest caused by a nematode, Bursaphelenchus xylophilus, that affects several areas across the globe, including Portugal. The transmission of this disease is mediated by insect vectors, pine sawyer beetles of the genus Monochamus, that carry B. xylophilus inside their tracheal system and on their body surfaces. Currently, the most used control methods include the elimination of attacked trees, the use of traps to capture the vector insect or spraying trees with insecticides to prevent the insect vector`s maturation feeding. We aim using our knowledge in synthetic biology to prevent the economic and environmental damage caused by PWD by introducing in the pine tree`s microbiome a genetically engineered Pseudomonas putida, capable of producing the nematicidal compound spectinabilin when triggered by the tree`s stress response under the attack of the insect vector.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/c5427580-1be5-4f5c-b264-053048f61754','video_link_presentation':'https://video.igem.org/videos/watch/8cb12a36-2d5e-4c4a-aba6-5a07b994b94e','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NOVA_LxPortugal','poster_link':'https://2020.igem.org/Team:NOVA_LxPortugal/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 5, Poster Number 134'}, {'name':'NTHU_Taiwan','link':'https://2020.igem.org/Team:NTHU_Taiwan','region':'Asia','location':'Taiwan','track':'Manufacturing','time':'11,14,0930,30','title':'BioSquad','description':'Quantum dots are zero-dimensional tiny speck of material effectively concentrated into a single point known as artificial atoms which can revolutionize everything ranging from home lights and computer displays to solar cells and biological warfare detectors. Our Team NTHU_Taiwan design a concept for biosynthesis of quantum dots utilizing industrial heavy metal containing wastewater. Hereby we hypothesized to gain multiple benefits from single project. We first aimed of bio-synthesizing quantum dots using E-coli. Secondly, we planned to use cadmium rich industrial wastewater as a source of metal ions. Under normal conditions bacteria itself cannot manage efficient internalization of metals which might leads to cellular oxidative stress and bacterial death. So, we used gene editing techniques and promoter genes to control internalization of cadmium ion and production of cadmium sulfide quantum dots. We are successful on genetically modifying E coli, to seek highly efficient productivity of QDs.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/2875e200-070f-4b1b-8fe4-2cfad3842c53','video_link_presentation':'https://video.igem.org/videos/watch/67cb10a7-21e1-4498-91ea-f59d831c0ae1','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NTHU_Taiwan','poster_link':'https://2020.igem.org/Team:NTHU_Taiwan/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 5, Poster Number 53'}, {'name':'NUDT_CHINA','link':'https://2020.igem.org/Team:NUDT_CHINA','region':'Asia','location':'China','track':'Foundational Advance','time':'11,14,1000,30','title':'Predator Pro: a modularized toolbox for signal-controlled Targeted Protein Degradation','description':'Exactitude temporal control of protein abundance is critical for the robustness and dynamics of synthetic circuits. While multiple approaches have been developed to manipulate the protein synthesis, few tools have been demonstrated to precisely control untagged protein degradation. Here, we present Predator Pro, a modularized and signal-controllable method for target protein degradation, on the basis of the Predator system we demonstrated in iGEM 2018-19. By rationally reengineer the Trim21 protein, we demonstrated that the interaction between Trim21 and antibody Fc domain can be replaced with other constitutive or inducible protein dimerization pairs. We demonstrated that constitutive DocS-Coh2 interaction or rapamycin-induced FRP-FKBP interaction enabled constitutive or drug-controlled degradation of untagged EGFP protein. As an effective expansion of the current synthetic biological tools for protein abundance control, this system may provide a modularized and convenient platform for controlled protein degradation, which might be applied in fundamental researches and clinical applications.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/a7d97dc6-2c87-420c-a64d-5bf9aceef04d','video_link_presentation':'https://video.igem.org/videos/watch/3e6fc03f-b1e2-438e-9ca6-9c9e9f04b73f','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NUDT_CHINA','poster_link':'https://2020.igem.org/Team:NUDT_CHINA/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 5, Poster Number 55'}, {'name':'NWU-CHINA-A','link':'https://2020.igem.org/Team:NWU-CHINA-A','region':'Asia','location':'China','track':'Therapeutics','time':'11,15,0830,30','title':'Avenger assemble','description':'The rising risk of severe side-effects and potential resistance of antibiotics have limited their usage. Moreover, non-biodegradable medical product loaded antibiotic is one of global pollutions. To solve these problems, our team aimed to design a medical dressing based on novel human defensins (HBDs) and polyhydroxyalkanoate (PHA) from micro-organisms. HBDs, kinds of novel antimicrobial peptide (AMP) from human, which has excellent blood compatibility and effective anti-bacteria without drug resistance and immunogenicity. In order to combine HBDs on the surface of flexible PHA film in vitro, we built a fusion protein by using a natural PHA surface binding protein (PhaP). All parts of the completely biodegradable medical dressing, including HBDs, PHA and PhaP, are designed and produced in engineering bacteria. We hope that the combination of HBDs and PHA could boost the persistent anti-bacteria and histocompatibility of adhesive bandages. Besides, implementing the concept to medical field would be our future jobs.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/aedbd84e-8f56-4c4e-bcbc-fe3f1be15fdd','video_link_presentation':'https://video.igem.org/videos/watch/0dce6450-f684-4433-ace0-db8a1d1baf76','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NWU-CHINA-A','poster_link':'https://2020.igem.org/Team:NWU-CHINA-A/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 4, Poster Number 129'}, {'name':'NWU-CHINA-B','link':'https://2020.igem.org/Team:NWU-CHINA-B','region':'Asia','location':'China','track':'Therapeutics','time':'11,16,1000,30','title':'Let`K dissolve（Let Kaempferol dissolve）','description':'Kaempferol has excellent anti-inflammatory and antiviral abilities, and is a common ingredient in Chinese herbal medicines against COVID-19. However, the poor water solubility limits its application. Two UDP glycosyltransferases were obtained by constructing recombinant engineering bacteria to catalyze the synthesis of the derivatives of kaophenol, astragalin and kaophenol-3-glucose-7-oxygen-rhamnoside. The differences of water-soluble and anti-inflammatory properties between the two derivatives and kaempferol were compared, and the optimal conditions of enzymatic reaction were found through modeling.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/57e4869d-fda0-4d6c-99db-8e60b2436612','video_link_presentation':'https://video.igem.org/videos/watch/32ea26df-9042-4170-8551-a5d6c3ff2802','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NWU-CHINA-B','poster_link':'https://2020.igem.org/Team:NWU-CHINA-B/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 5, Poster Number 223'}, {'name':'NYC_Earthians','link':'https://2020.igem.org/Team:NYC_Earthians','region':'North America','location':'United States','track':'High School','time':'11,14,0830,30','title':'Creating A Chimeric APOL3 protein using CRISPR to cure trypanosomiasis in African Cattle','description':'African trypanosomiasis, caused by the parasitic kinetoplastid Trypanosoma brucei brucei (T.b.brucei), significantly threatens the African cattle population. The Trypanosome Lytic Factor Apolipoprotein L-1 (APOL1) is a pore-forming protein known to kill all types of trypanosomes in baboons. While cattle lack APOL1, from the genome-wide BLAST we found cattle APOL3 (c-APOL3) which is the closest homolog of baboon APOL1 (b-APOL1). Sequence alignment analysis showed that c-APOL3 lacked 38 residues in N-terminus and had differences in C-terminus domain. Further, structure prediction analysis via HHPred and RaptorX indicated that the N-terminus might interact with the C-terminus to maximize pore-forming potential in the b-APOL1, though c-APOL3 lacked these interactions. Therefore, chimeric proteins with a combination of N and C-termini from b-APOL1 in native c-APOL3 were designed and investigated for function using bioinformatics. The capability of CRISPR for insertion of chimeric genes into the host genome and physiological functional assays are being performed.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/2ad37ede-9e7f-441e-9192-bd5fe539b649','video_link_presentation':'https://video.igem.org/videos/watch/83ef0631-f00b-4146-939f-a3800004ee5a','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NYC_Earthians','poster_link':'https://2020.igem.org/Team:NYC_Earthians/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 5, Poster Number 52'}, {'name':'NYMU-Taipei','link':'https://2020.igem.org/Team:NYMU-Taipei','region':'Asia','location':'Taiwan','track':'New Application','time':'11,15,0730,30','title':'Off the crown','description':'Due to the serious pandemic of COVID-19, this year, iGEM NYMU-Taipei 2020 tries hard to tackle the problem in a much more elementary approach. By utilizing the nature of strong binding interactions between hACE2 and the spike of SARS-CoV-2, we deeply believe that we would be able to reap the benefits of viral evolution. In order to achieve our goals, we engineered a protein construct that includes the hACE2 receptor binding domain, a linker, and a protease that is specific at cleaving spike proteins. The protein construct functions as a capture device and can be implemented on many occasions, such as masks, contact lenses, and even filtration devices, as a mean to capture, destroy, and even quantify the amount of virus particles on a particular surface, so as to reduce the number of SARS-CoV-2 and, moreover, decline the possibility of infection on human beings.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/01f09624-0175-4c0e-80c6-783c10ecdd09','video_link_presentation':'https://video.igem.org/videos/watch/f174e0fc-9579-4eb1-ae70-4f13f5aa19ea','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NYMU-Taipei','poster_link':'https://2020.igem.org/Team:NYMU-Taipei/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 4, Poster Number 131'}, {'name':'NYU_Abu_Dhabi','link':'https://2020.igem.org/Team:NYU_Abu_Dhabi','region':'Asia','location':'United Arab Emirates','track':'Diagnostics','time':'11,14,0730,30','title':'Fungal Diagnostics','description':'NYUAD iGEM is developing a rapid, point-of-care, field fungal diagnostic device. Since the mid-1900s, a flesh-eating fungal disease, chytridiomycosis, has been condemning more amphibian species to extinction than any other pathogen ever recorded wiping out over 90 species and causing declines in at least 500. Similar fungal diseases have also been affecting other animals such as bats, disrupting their hibernation and leaving millions dead in their paths. Usage of diagnostics for managing spread has been limited due to the testing methods being latent, expensive, and non-portable. Following a rigorous approach at research and design, the first stage of the project involves prototyping DNA extraction methods such as bead beating and lysis buffers, reaction mediums such as microfluidics and paper-based biosensors, amplification methods such as RPA CRISPR-Cas12a and reporting mechanisms such as fluorescence and LFA, in addition to a database and API that can integrate with any existing surveillance system.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/140b455b-2ab4-4a63-b1a7-2a5d98f31084','video_link_presentation':'https://video.igem.org/videos/watch/b57eb73d-6f9d-4401-a17b-81888a9edd0f','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=NYU_Abu_Dhabi','poster_link':'https://2020.igem.org/Team:NYU_Abu_Dhabi/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 6, Poster Number 57'}, {'name':'OhioState','link':'https://2020.igem.org/Team:OhioState','region':'North America','location':'United States','track':'Foundational Advance','time':'11,15,1030,30','title':'Biocontainment Reimagined','description':'The field of synthetic biology has one major barrier to being accepted by the broader public: safety. While we may know that the organisms we use are harmless, most people don`t have the background knowledge needed to come to the same conclusion. We believe that the best way to raise safety and confidence in synthetic biology products is by adding genetic biocontainment systems, which are genes and genome edits that give us control over the life of our microbes. These systems range from small genetic circuits of promoters and toxins to complete genomic rewrites, and we`ve compiled all of them into a simple, flexible database. To accompany this, we`ve developed predictive models and educational media, all with the express purpose of making biocontainment easier to implement and making synthetic biology safer for public use.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f520dc8b-3228-4ff7-869c-f8a9a64984d1','video_link_presentation':'https://video.igem.org/videos/watch/c60a811c-4c02-4672-a7c2-bae54c01ff91','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=OhioState','poster_link':'https://2020.igem.org/Team:OhioState/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 5, Poster Number 136'}, {'name':'OSA','link':'https://2020.igem.org/Team:OSA','region':'Asia','location':'China','track':'High School','time':'11,15,0800,30','title':'metZyme: A DNAzyme-based Heavy Metal Ion Detection Kit','description':'High-density metals like lead and mercury, also known as heavy metals, have severely harmed the environment and our bodies. Every year heavy metal exposure results in millions of disabilities worldwide. Surprisedly, previous detecting methods for this urgent issue either require bulky instruments or professional technicians. Thus, it is imminent for us to devise a cheap, portable, accessible, accurate detection kit. We use DNAzyme, which can cleave ssDNA when combined with Zn2+, Mn2+, Pb2+. Cu2+. To maximize outputs, four amplification systems (HTDC, Toehold Switch, TO-DNA, and CRISPR-Cas12a) are also used. While we test these theories in lab, our human practice team interviews experts and discovers such a kit is not only needed for water detection but also for soil, which becomes the new focus of our project. We have achieved fluorescence and lateral flow detection of heavy metal ions which contribute to alleviating this severe environmental issue worldwide.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/d532b3e1-f2b6-4a14-b25a-dffa04cea664','video_link_presentation':'https://video.igem.org/videos/watch/b795138b-5f83-4b82-a7f6-b80f4101b445','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=OSA','poster_link':'https://2020.igem.org/Team:OSA/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 5, Poster Number 133'}, {'name':'OUC-China','link':'https://2020.igem.org/Team:OUC-China','region':'Asia','location':'China','track':'Information Processing','time':'11,16,0800,30','title':'Logitch: Logic Gates and RNA Switch','description':'In the future, more work must be done by computer, such as detecting virus and monitoring health in vivo. Such a function can only be achieved by biological computer working in wet environment, which plays an important role that traditional computer cannot replace. Since the basic function unit of electronic computer is implemented through logic gates, we incorporated a series of logic gates which were built by toehold and 3WJ repressor, and supplemented current lack of types with our own design. We also built more complex multi-input logic gates using basic logic gates. In order to show the wide application prospect of these logic gates, we used them in the construction of adder and subtractor, as well as virus detection. Biocomputer may have various possibilities in the next few years, and we hope our project can have some impact on its development.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/abfc0296-12a8-4c3b-a9af-59b59e4c2bb8','video_link_presentation':'https://video.igem.org/videos/watch/fe511793-3f28-4e64-a65d-8936eba2b3e0','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=OUC-China','poster_link':'https://2020.igem.org/Team:OUC-China/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 5, Poster Number 224'}, {'name':'Paris_Bettencourt','link':'https://2020.igem.org/Team:Paris_Bettencourt','region':'Europe','location':'France','track':'Foundational Advance','time':'11,14,0800,30','title':'SynDerma : a foundational advance toward synthetic dermatology','description':'In SynDerma we envisioned therapeutics being administered by engineered microbes integrated into the skin microbiome. First, to understand the perturbaility of the skin microbiome by individual habits such as hygiene, social interaction and exercise, which are all affected by this current unprecedented context of COVID-19 pandemia, we developed a community science project called Quaranskin. In Quaranskin we developed an at-home sampling kit, protocol and survey, where participants swabbed four body sites for metagenomic analysis. We correlated the diversity and composition of these collected microbiome data to behaviours noted in the surveys to uncover any trends. In parallel, we chose the skin commensal microbe Staphylococcus epidermidis to be a chassis for our future vision of microbial therapeutics enabled by synthetic biology. In projects EpiFlex, EpiGlow, and EpiGrow, we built a MoClo kit, expressed fluorescent proteins as a proof of concept, and optimised growth conditions, respectively.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ea51a2eb-615e-4d24-a620-2637887f07b5','video_link_presentation':'https://video.igem.org/videos/watch/bae293df-34c4-4d4a-beb3-ce7ddd114fa6','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Paris_Bettencourt','poster_link':'https://2020.igem.org/Team:Paris_Bettencourt/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 5, Poster Number 54'}, {'name':'Patras','link':'https://2020.igem.org/Team:Patras','region':'Europe','location':'Greece','track':'Diagnostics','time':'11,15,0800,30','title':'Hippocrates: Genomic Analysis & Artificial Intelligence at your heart`s disposal','description':'According to the World Health Organization, cardiovascular diseases are one of the main causes of death worldwide due to the blood`s high LDL cholesterol level. Statins are the drug category that is administered to regulate the levels of LDL cholesterol. However, 1/3 of patients do not respond effectively, resulting in several side effects. There are human genes that regulate a particular drug`s metabolism. Depending on individuals` genetic profiles, the required therapeutic drug-dose can be accurately determined by available but optional tests. The SLCO1B1 gene is involved in the uptake of statins by liver cells. So, we present an innovative, time-saving, and portable genotyping method based on BentoLab (iGEM UCL 2013) for detecting genome polymorphism related to statins` metabolism, combined with Artificial Intelligence, to make a fast and accurate analysis of results to facilitate those who perform the test.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/c9fa2dce-9d9b-4c10-b389-34dfab312ae5','video_link_presentation':'https://video.igem.org/videos/watch/90d90873-cb70-4ceb-94e1-b0103161837e','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Patras','poster_link':'https://2020.igem.org/Team:Patras/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 5, Poster Number 138'}, {'name':'Peking','link':'https://2020.igem.org/Team:Peking','region':'Asia','location':'China','track':'Open','time':'11,15,1000,30','title':'Music Updating by Storage and Editing','description':'As a high-capacity, high-density storage medium, DNA has attracted the interest of many scientists. Based on the function of DNA to store information, using gene editing methods to change the information stored in DNA has great operability. In our project, music information is stored in plasmid DNA of E. coli with designed coding rules, and gene editing technology is used for artificial mutation. This is also brought out with in silico experiment. Through the scoring rules based on music theory and references, the mutated music information is screened, and music pieces with certain value are obtained, to achieve music evolution. At the same time, we have also used similar principles and methods to store and evolve video information. Together, this is a biological process of artistic creation, we hope to give an example of bio-art creation and inspire more artists to create in this interesting way.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/a60577df-cfda-4d8f-a0a7-dbc10f3dec3a','video_link_presentation':'https://video.igem.org/videos/watch/b4482b39-59dc-4a30-9668-1e06a1c48b57','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Peking','poster_link':'https://2020.igem.org/Team:Peking/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 5, Poster Number 135'}, {'name':'Pittsburgh','link':'https://2020.igem.org/Team:Pittsburgh','region':'North America','location':'United States','track':'Foundational Advance','time':'11,14,0830,30','title':'Bluetooth Bacteria','description':'Our ability to control the function of engineered microbes is limited within hard to reach places, such as deep within human tissue, the rhizosphere surrounding crops, or pipes in manufacturing facilities. The field of magnetogenetics has begun to consider how magnetic fields could affect biological molecules and cells. In our project, we aim to control the function of bacteria via the remote activation of an alternating magnetic field (AMF). E. coli will be engineered to respond to magnetic stimuli by attaching magnetic nanoparticles to the surface of the bacterial membrane in conjunction with cytoplasmic temperature-sensitive transcriptional repressors to regulate gene expression of the green fluorescent protein. Upon AMF stimulation, magnetic nanoparticles heat up and increase cytoplasmic temperature, thereby inducing a conformational change of the repressor dimers and allowing transcription of target genes. This technology critically couples alternating magnetic field stimulation with thermal sensitive parts to enable `wireless` control of bacteria.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/2b76a647-cfa6-49b8-9dc8-1fe3959c64b7','video_link_presentation':'https://video.igem.org/videos/watch/82157496-94b0-4148-a5d3-7ce963646e0f','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Pittsburgh','poster_link':'https://2020.igem.org/Team:Pittsburgh/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 6, Poster Number 56'}, {'name':'PuiChing_Macau','link':'https://2020.igem.org/Team:PuiChing_Macau','region':'Asia','location':'Macao','track':'High School','time':'11,16,1030,30','title':'FirE. coli : Engineering E. coil to produce safe and eco-friendly flame retardant proteins','description':'Current flame retardant materials are known to be hazardous to human body and our environment. To solve this problem, we here developed Eco-friendly and harmless flame retardant E. coli. While previous iGEM teams and research groups attempted to produce flame retardant proteins, the proteins they produced cannot retain on the surfaces of objects and can be washed away easily, precluding the application of these proteins. To address the problem, we engineered E. coli to produce flame retardant proteins (SR or casein) fused with surface adhering proteins (cellulose binding domain or mussel adhesive proteins). Thereby, we improved previous iGEM flame retardant systems, which contain only flame retardant proteins. We here proved the protein expression, fire retardancy and sustainability of our flame retardant systems, matching our previous modelling results. Additionally, we also engineered an easy-to-make vertical burning test, helping us and future iGEM teams to test flame retardants.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/0d63e46a-eb9d-4b85-8159-d0af167e0940','video_link_presentation':'https://video.igem.org/videos/watch/684ebb1e-6f16-4ef2-a169-181b9cc1a730','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=PuiChing_Macau','poster_link':'https://2020.igem.org/Team:PuiChing_Macau/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 5, Poster Number 226'}, {'name':'Purdue','link':'https://2020.igem.org/Team:Purdue','region':'North America','location':'United States','track':'Diagnostics','time':'11,14,1000,30','title':'Microfluidic Argonaute Mediated COVID-19 Point of Care Diagnostic Device.','description':'The COVID-19 pandemic has strained global diagnostic capacities and highlighted the limitations of conventional lab-based assays, which can take between 1-14 days to receive conclusive results. Current on-site kits have false-negative rates as high as 33%. In an effort to provide accurate, non-invasive, affordable, and rapid Point of Care(POC) diagnostic tests for COVID-19 and other emerging pandemics, Purdue iGEM is developing cArgo: a COVID-19 Argonaute mediated microfluidic diagnostic device. cArgo extracts viral RNA from saliva for amplification and conversion into dsDNA. TtAgo that we will express and purify from e.coli then cleaves the dsDNA using COVID-19 DNA guides producing ssDNA fragments. These fragments hybridize to molecular beacons emitting a quantifiable fluorescent signal for conclusive result determination. Coupling the biologics with chip barcoding and app integration, we hope to revolutionize POC Diagnostics while making data more accessible for simultaneous detection and contact tracing.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/e0cf78dc-f2a7-4447-9fa1-215ab8db3456','video_link_presentation':'https://video.igem.org/videos/watch/b4202c7a-05df-41c5-a46c-26d82fb4498b','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Purdue','poster_link':'https://2020.igem.org/Team:Purdue/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 6, Poster Number 59'}, {'name':'PYMS_GZ_China','link':'https://2020.igem.org/Team:PYMS_GZ_China','region':'Asia','location':'China','track':'High School','time':'11,15,0830,30','title':'Too Much Infection: general assay platform to test infectivity of current and future SARS-CoV-2 strains','description':'Traditionally, measuring the infectivity of SARS-CoV-2 requires a live virus which creates serious biosafety concerns. We wanted to create a safe alternative, utilizing a general assay system, to identify the infectivity of different current and future strains of SARS-CoV-2, as it is critical for assessing outbreak control and immunity of potential vaccines. Infectivity of different strains can be measured by the binding affinity between the receptor-binding domain (RBD) of Spike protein (S protein) and its human ACE2 receptor, which is how the virus gains entry into human cells. Various genetic mutations in the S protein affect the RBD-ACE2 interaction, therefore contributing to different infectivities. We engineered a pseudovirus to recap this crucial interaction by expressing S proteins corresponding to the original and the predominant G614D SARS-CoV-2 strains and used a luciferase assay to quantitatively measure infectivity.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/97646a76-b216-4711-a4bd-1c825e05fd40','video_link_presentation':'https://video.igem.org/videos/watch/016c0742-dcd7-4b07-b1d6-3017c8d3ccc2','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=PYMS_GZ_China','poster_link':'https://2020.igem.org/Team:PYMS_GZ_China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 5, Poster Number 137'}, {'name':'Qdai','link':'https://2020.igem.org/Team:Qdai','region':'Asia','location':'Japan','track':'Environment','time':'11,16,0730,30','title':'P. coli: Engineering E.coli to have an increased capacity of phosphorus accumulation','description':'While phosphorus is one of the most important resources for agricultural food production, it becomes a great driver of water pollution when it enters the environment. Sometimes the pollution causes health problems to humans and animals. Further, phosphorus is expected to be depleted in about 50 years, so the recovery and recycling is a big issue. We looked into phosphorus metabolism of bacteria and hope to enhance its capacity of phosphorus accumulation by engineering E.coli to increase polyphosphate kinase and decrease exopolyphosphatase. We believe that our project contributes to sustainable development goals (SDGs).','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/48a16675-10bf-4dee-8a3b-d0c65ddac4f8','video_link_presentation':'https://video.igem.org/videos/watch/2ce9ca26-f36d-4c62-a2dc-11bc8ecc9fbd','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Qdai','poster_link':'https://2020.igem.org/Team:Qdai/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 5, Poster Number 228'}, {'name':'QHFZ-China','link':'https://2020.igem.org/Team:QHFZ-China','region':'Asia','location':'China','track':'High School','time':'11,16,0830,30','title':'Super-Serum for Engineered Bacteria','description':'Various engineered bacteria showed useful functions. However, the storage of these bacteria usually requires -80℃ refrigerators, which substantially limited their transportation and usages in daily life. Therefore, we decided to utilize TDPs from tardigrades (water bears) to supply a new storage method. By introducing the TDPs as the protectants into bacteria during lyophilization (freeze-drying), we could produce dry powder that can be stored at room temperature without any equipment. The powder can be stored at room temperature for a long time, without any usage of professional equipment. This year, we confirmed that certain TDPs have the ability to maintain the survival rate of E. coli. We also optimized the method by regulating the expression level and combining different TDPs. In addition, we proved the modularity and studied the degradation of TDPs after freeze-drying. We hope the method would promote the practical application of engineered bacteria.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/86c9b0e3-866a-4fb8-bf8a-d61bb6b60f11','video_link_presentation':'https://video.igem.org/videos/watch/0e69a7f7-bc30-40c9-b2ed-6dd4bd0cc96f','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=QHFZ-China','poster_link':'https://2020.igem.org/Team:QHFZ-China/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 5, Poster Number 229'}, {'name':'Queens_Canada','link':'https://2020.igem.org/Team:Queens_Canada','region':'North America','location':'Canada','track':'Diagnostics','time':'11,16,0930,30','title':'Velcrion - A transdermal biosensor to detect critical metabolites in chronic kidney disease.','description':'Team Queens_Canada will be designing a novel transdermal biosensor for point-of-care diagnostic quantification of phosphate, potassium, parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) for chronic kidney disease (CKD) patients. Knowledge of the concentration of these analytes is critical for guiding effective treatments and improving patient outcomes. We will generate genetically encoded Förster resonance energy transfer (FRET) sensors by fusing the N- and C-termini of phosphate-binding protein (PBP), potassium-binding protein (KBP), PTH 1 receptor (PTH1R), and α-Klotho to fluorescent proteins (FPs). To quantify physiologically relevant levels of phosphate, potassium, PTH and FGF23, highly optimized mNeonGreen and mCherry will be used as the FPs. Site-directed mutagenesis will be employed on protein-fluorophore constructs to add a Cysteine residue, to which a glutamate (E)/ lysine (K) coiled-coil system will be added to immobilize the construct onto a microfluidic surface. Through frequent monitoring and early disease detection, we hope to revolutionize CKD diagnostics.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/8944b985-a81f-4914-ac93-76ceb513b0c6','video_link_presentation':'https://video.igem.org/videos/watch/bba29ead-a1bb-4386-bcaf-fcf8e6cc263c','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Queens_Canada','poster_link':'https://2020.igem.org/Team:Queens_Canada/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 5, Poster Number 225'}, {'name':'RDFZ-China','link':'https://2020.igem.org/Team:RDFZ-China','region':'Asia','location':'China','track':'High School','time':'11,15,0730,30','title':'Tea-HEE','description':'Depression is a common yet serious disease worldwide effecting more than 322 million people. It has been accepted that serotonin deficiency is the major cause of depression and medications are made to improve this situation. Yet patients often feel pressure and refuse to take antidepressants due to social stigmas. Our project, Tea-HEE, focused on a novel way to prevent this problem. We engineered E. coli Nissle 1917 (an FDA approved probiotic) to be placed in patients` intestine. It can be activated by PCA, a tea metabolite derived from tea intake, and to produce 5-HTP, the precursor of serotonin naturally present in intestines that has multiple advantages for serotonin synthesis. Therefore by ingesting tea, a common beverage, patients can get an ample supply of 5-HTP in their intestine and hence an ample supply of serotonin in their brain to fight depression toward a better quality of life without pressure.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f2b4e35f-6d87-4501-b2db-51df87ff3d47','video_link_presentation':'https://video.igem.org/videos/watch/dfaf8a3c-bc2b-4840-9539-27243a3560f8','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=RDFZ-China','poster_link':'https://2020.igem.org/Team:RDFZ-China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 5, Poster Number 139'}, {'name':'ROADS_SY','link':'https://2020.igem.org/Team:ROADS_SY','region':'Asia','location':'China','track':'High School','time':'11,16,0730,30','title':'Rice Arsenate Accumulation Reduction','description':'Thanks to hybridization and genetic modification, rice sustains a huge proportion of the world population. However, arsenate accumulation poses a severe threat to the rice-consuming population, who are generally unaware of the threat and unable to deal with it. We decided to lower the arsenate accumulation of rice by identifying and modifying the genetic sequence related to the arsenate level. Specially, we adopted both the conventional method and the bioinformatic method to identify the related genetic sequence. By doing so, we intended to promote the fusion of bioinformatics and bioengineering. The assumption is that Ospt4 is responsible for the arsenate accumulation of many crop species, including rice. We planned to knock out the genetic sequence and perform contrast experiments to examine whether Ospt4 is related to arsenate accumulation.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/dcaae9b6-7f0b-41f9-a847-73a520d109bd','video_link_presentation':'https://video.igem.org/videos/watch/72996b1a-11b4-45bd-981e-0fc85344f062','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=ROADS_SY','poster_link':'https://2020.igem.org/Team:ROADS_SY/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 5, Poster Number 231'}, {'name':'Rochester','link':'https://2020.igem.org/Team:Rochester','region':'North America','location':'United States','track':'Diagnostics','time':'11,14,0830,30','title':'Creation of a Novel, Noninvasive Diagnostic for Endometriosis using Menstrual Effluent','description':'The 2020 University of Rochester iGEM Team, Team UteRus, created a novel, non-invasive diagnostic for endometriosis using menstrual effluent (ME). Endometriosis is a chronic disease, affecting 200 million women worldwide, that causes abnormal endometrial-like tissue growth outside of the uterine cavity. The only diagnostic available is exploratory surgery. Our team created lateral flow immunoassays (LFA) that can qualitatively and quantitatively measure the presence of endometriosis biomarkers in ME and built a model to optimize the assay design. Using a Plug and Play approach, our team designed plasmids for antibody production in SHuffle stain Escherichia coli and reduced the cost of our diagnostic. Additionally, we created menstrual cups best suited for the comfort of endometriosis patients as well as inexpensive laboratory equipment for clinics without laboratory access. Our team also built a predictive model that we integrated into a software tool as an endometriosis diagnostic based solely on clinical variables.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/4f0667f2-9d56-4ecd-a8d1-1f5ef5091589','video_link_presentation':'https://video.igem.org/videos/watch/7fdfbb41-ea36-4812-b798-41df13d883bc','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Rochester','poster_link':'https://2020.igem.org/Team:Rochester/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 6, Poster Number 61'}, {'name':'RUM-UPRM','link':'https://2020.igem.org/Team:RUM-UPRM','region':'Latin America','location':'United States','track':'Environment','time':'11,15,0830,30','title':'Mer-Nite to the Rescue: A Solution to Decrease Contamination in Vieques','description':'For over six decades, Vieques, an island-municipality of Puerto Rico, was used as a military training site. An array of contamination was left behind due to the materials and explosives used, devastating the biodiversity, and increasing health risks for the Viequenses. Initiatives to clean the waters and soil of Vieques exist; however, it has been a costly and lengthy process. iGEM RUM-UPRM proposes Mer-Nite, a solution to decrease the contamination in Vieques due to the military practices. Phase 1 of the project consisted of designing a genetic system to absorb and bioremediate mercury through the expression of the mer operon, combined with a second circuit that will be activated upon the presence of RDX and degrade the contaminant through the expression of the xplA and xplB genes. Mer-Nite represents an alternative solution to decrease the contamination, conserve biodiversity, and improve the quality of life in Vieques.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/6aa374a3-c6a4-4e3e-81b9-c839d2e26941','video_link_presentation':'https://video.igem.org/videos/watch/f10ab7a9-ad9f-412d-88ba-97fa9a4c6ac2','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=RUM-UPRM','poster_link':'https://2020.igem.org/Team:RUM-UPRM/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 5, Poster Number 140'}, {'name':'SCU-China','link':'https://2020.igem.org/Team:SCU-China','region':'Asia','location':'China','track':'New Application','time':'11,14,1030,30','title':'RNAlphABA','description':'Late spring cold (LSC) is a common climatic phenomenon in many areas of the world, which refers to the sudden appearance of continuous low temperature after the weather warms up in middle of spring. Every year, LSC causes huge agricultural and economic losses through freezing the bud of crops. Currently, spraying abscisic acid (ABA) is the main way to deal with LSC. However, chemically synthesized ABA usually contains by-products and toxic waste, while purified ABA is expensive. Therefore, we hope to give a new application to Saccharomyces cerevisiae, so that it can synthesize ABA before the onset of LSC, and develop a software to predict degree of LSC. In addition, in order to solve the deficiency of eukaryotes` monocistronic gene expression system in the field of exogenous product biosynthesis, we develop a new application of the CRISPR-Csy4 system in the construction of eukaryotic multicistronic exogenous gene expression system.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/03dff86b-8629-4616-9bf2-a131c782b22a','video_link_presentation':'https://video.igem.org/videos/watch/961b8b5a-1df8-404a-9776-cac12c621f04','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SCU-China','poster_link':'https://2020.igem.org/Team:SCU-China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 6, Poster Number 60'}, {'name':'SCU-WestChina','link':'https://2020.igem.org/Team:SCU-WestChina','region':'Asia','location':'China','track':'Therapeutics','time':'11,16,0730,30','title':'Lung Knight- Recombinant protein carried by liposomes for Idiopathic Pulmonary Fibrosis','description':'There are more than 3 million people worldwide suffering from pulmonary fibrosis. However, the price of the mainstream therapy whose curative effect and targeting ability is poor, is too high to afford for most patients. Based on this fact, we offer an entirely new treatment: TGF-beta II truncated receptor was fused with collagen-targeted peptides to construct recombinant protein drugs. The recombinant protein was embedded in liposomes to construct the molecular drug delivery system. The patients are given the drug into the lungs by inhaling it through an atomizer. We have proved this product is effective anti-fibrosis drug through three-stage experiments. This product has the following advantages: 1. Directly block the worsening signal and significantly slow down the process of pulmonary fibrosis. 2. Accurately target the lesions with little side effect 3. Accurate liposome delivery, which is gentle and efficient. 4. Makes it convenient for patients to get treatment by themselves.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/86d97141-3f8b-4f83-a17d-ea4b91c728a1','video_link_presentation':'https://video.igem.org/videos/watch/4aa19e47-f1ef-4b91-afcb-23984db61909','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SCU-WestChina','poster_link':'https://2020.igem.org/Team:SCU-WestChina/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 6, Poster Number 232'}, {'name':'SCUT_China','link':'https://2020.igem.org/Team:SCUT_China','region':'Asia','location':'China','track':'Therapeutics','time':'11,16,0800,30','title':'LyDT Phage','description':'In this project, we show that a specific gene in the genome of the lytic P. aeruginosa phage vB_PaeM_SCUT-S1 (S1) can be engineered by a CRISPR-Cas editing strategy based on a two-plasmid system, in which the first plasmid expresses a Cas nuclease and recombinases (λ-red), the second plasmid harbors a crRNA cassette and a repair template. Briefly, we constructed a lysis-deficient phage mutant (LyDT S1) expressing the antibacterial toxin RelE. The mutant was obtained by replacing the gene of holin, a lysis-promoting phage toxin, with the relE gene, which can still inhibit bacterial growth through the expression of RelE but cannot induce cell lysis because the holin gene is eliminated. This is expected to reduce the amount of endotoxins released from the bacteria, with a corresponding reduction of systemic cytokine response and inflammation during bacterial infection.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/748e7542-e769-4252-911b-5d57c4c7df6c','video_link_presentation':'https://video.igem.org/videos/watch/e3e4fddf-2bd6-434e-9c18-2909d8785621','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SCUT_China','poster_link':'https://2020.igem.org/Team:SCUT_China/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 6, Poster Number 234'}, {'name':'SDU-Denmark','link':'https://2020.igem.org/Team:SDU-Denmark','region':'Europe','location':'Denmark','track':'Diagnostics','time':'11,15,0730,30','title':'PROSTATUS','description':'The current procedures to test for prostate cancer (PCa) in Denmark are all either based on invasive tests or based on the presence of the prostate specific antigen (PSA). The doctors must take a small biopsy of the patient`s prostate or let the patient undergo a digital rectal exam. Our team decided to develop a risk assessment for prostate cancer, that makes use of the CRISPR-Cas13a system. We focused on three mRNA biomarkers found to be present in the urine of PCa patients, specifically TMPRSS2:ERG, AMACR and PCA3. We also conducted interviews with end-users and initiated an email correspondence with experts from different fields to discuss and gain insight on how to improve our project. Apart from this, we designed a set of playing cards and a card game that takes early detection as a theme and was distributed to different social areas to spread PCa awareness.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/cd382a07-4b2a-4336-8f3e-f4068693066c','video_link_presentation':'https://video.igem.org/videos/watch/fb9610a0-5774-4c7e-926e-43663c1b2674','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SDU-Denmark','poster_link':'https://2020.igem.org/Team:SDU-Denmark/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 5, Poster Number 142'}, {'name':'SEHS-China','link':'https://2020.igem.org/Team:SEHS-China','region':'Asia','location':'China','track':'High School','time':'11,14,0800,30','title':'Histamine Killer: A system Provides Early Warning and Symptom Relief for Allergy Sufferer','description':'Hay fever, a common allergy caused by pollen invading and stimulating the immune system to release histamine which is the main substance causing tissue edema, is reported that more than 40% of the world`s population are affected. To reduce its harm, SEHS-China created a bio-system that can alert people and relieve allergic symptoms in the early allergy stage. Our main idea is to build a Histamine Sensor in bacteria or cell-free systems which can emit a fragrance when histamine level rises on the skin and nasal mucosa and also release rDAO, a histamine oxidase, to alleviate symptoms. This system is not limited as a drug to prevent allergies, but available for other applications such as clinical testing and detection of allergens in food. We hope that people susceptible to allergy can be greatly benefited from our product in the future.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/959a8207-e03a-4e58-80fd-8d11553c8096','video_link_presentation':'https://video.igem.org/videos/watch/867115a2-8df5-4ed5-998e-3b47b5a199f3','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SEHS-China','poster_link':'https://2020.igem.org/Team:SEHS-China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 6, Poster Number 62'}, {'name':'Shanghai_city','link':'https://2020.igem.org/Team:Shanghai_city','region':'Asia','location':'China','track':'High School','time':'11,14,1000,30','title':'AtreXtinct: To Find Efficient way of Detecting Herbicide Pollution Caused by Atrazine in the Environment','description':'Atrazine is a contaminant for natural resources, which is dangerous for both people and wildlife. To be specific, atrazine can lead to serious diseases like prostatic cancer and breast cancer. However, owing mainly to the superior efficacy and economy of atrazine, the current policy in most countries is to strengthen registration instead of explicitly restrict the use of it. Furthermore, all the atrazine detection equipment in the market today have major flaws - expensiveness, heaviness, and difficulties in application. Thus, atrazine will leak into farms, lakes, and ocean without an effective and economical solution. To solve this problem, our team aims to envision a sytstem that degrades convert atrazine into cyanuric acid, which can be detected by human eyes under the condition of the excitation spectrum. In this way, it will be possible for us to create a convenient way to detect atrazine.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/12e10e6e-e2ee-4729-b469-e603c83bb0c6','video_link_presentation':'https://video.igem.org/videos/watch/ad7c266b-e1d8-4009-9000-6ed37529da87','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Shanghai_city','poster_link':'https://2020.igem.org/Team:Shanghai_city/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 6, Poster Number 64'}, {'name':'Shanghai_high_school','link':'https://2020.igem.org/Team:Shanghai_high_school','region':'Asia','location':'China','track':'High School','time':'11,16,1030,30','title':'ER Sensor','description':'Exogenous endocrine disruptors are called environmental hormones. EDCs are compounds that affect metabolism. These substances mimic natural hormones or hinder the action of normal human hormones. EDC surged in the environment in the past decades. Chemical substances created by industrial world are the cause of environmental hormones. About 70 kinds of chemical substances are widely used in fungicides, preservatives, insecticides, pesticides, food additives, plastic products, and so forth. In addition, harmful substances are also detected from rivers to the ocean in the world. Over 30 types of endocrine hormones were detected from the seeping water at the industrial waste disposal site. Since estrogen in the environment causes severe endocrine disorders, threatening the health of the fetus and children (obesity caused by cancer and metabolic disorders is also thought to be linked), we aim to create an estrogen sensor, namely ER Sensor, to detect the estrogen in the environment around us.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/1cea989b-70a7-4d94-8ac2-ebee8c5f6b2f','video_link_presentation':'https://video.igem.org/videos/watch/634ee7d2-d9ec-4891-9b4b-f0833591ebfe','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Shanghai_high_school','poster_link':'https://2020.igem.org/Team:Shanghai_high_school/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 6, Poster Number 235'}, {'name':'Shanghai_HS','link':'https://2020.igem.org/Team:Shanghai_HS','region':'Asia','location':'China','track':'High School','time':'11,15,0930,30','title':'Combining PhoA and eGFP to Create a Biosensor that Detects Phosphate Concentration Rapidly','description':'Phosphorus pollution is the leak of phosphorus compound into water, which causes serious problems to people`s health. Complicated technologies have already been invented to test the purity of water, however, those procedures always cause huge amount of money and energy. We found that a certain gene activity in E.coli will be inhibited with the presence of phosphorus. As a result, combing with a fluorescent protein, the gene will show its reaction when encountering certain concentration of phosphorus. Using this strategy we will be able to conduct pre-test of water pollution before investing much money and energy on processing unpolluted water. And through editing the gene, we will be able to detect water sources` phosphorus concentration that will harm human health by an easy and inexpensive method. We expect our experiment to become the starting point of detecting water pollution through biological method.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/47a3494b-d6ed-4798-bb6c-e24a1c397795','video_link_presentation':'https://video.igem.org/videos/watch/14416e73-bd65-4f3d-8c5b-ca6de4947b3f','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Shanghai_HS','poster_link':'https://2020.igem.org/Team:Shanghai_HS/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 5, Poster Number 141'}, {'name':'Shanghai_HS_United','link':'https://2020.igem.org/Team:Shanghai_HS_United','region':'Asia','location':'China','track':'High School','time':'11,16,0730,30','title':'Be Friends with Galactose—Build a probiotic to transform galactose into beneficial acids','description':'Saccharine diseases troubled humanity for thousands of years since we started to expand our diets. In China, the number of affected patients already towered over 100 million and still rising. We wanted to help relive patients with galactosemia, one of the saccharine diseases with the highest prevalence rate and detrimental influence. Our team came up with an innovative idea which is to engineer a probiotic with the function to decompose galactose into butyric acid, a useful short chain fatty acid. We engineered three different plasmids, each with its own capabilities that is essential for galactose breakdown. Using a competent E.Coli Nissle 1917cell, we transfer the plasmids into the cell, creating our final product. Eventually, the probiotics was successfully engineered in the laboratory. We plan to produce it as a health-care beverage product after analyzing over 400 pieces of survey and suggestions from experts in medicine and milk industry.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/dbc8288b-07b4-431b-811b-86cb901e740b','video_link_presentation':'https://video.igem.org/videos/watch/50789dda-95b0-4771-a2ca-6d112abe12a2','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Shanghai_HS_United','poster_link':'https://2020.igem.org/Team:Shanghai_HS_United/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 6, Poster Number 237'}, {'name':'Shanghai_SFLS_SPBS','link':'https://2020.igem.org/Team:Shanghai_SFLS_SPBS','region':'Asia','location':'China','track':'High School','time':'11,15,0800,30','title':'Not hair die, hair DYE: Biosynthesis of natural hair dyes with engineered bacteria','description':'Hair-dyeing is becoming increasingly popular, and the demand for harmless dyes is constantly rising. However, more common synthetic dyes may damage the hair cortex and cause allergies. Despite increasing attention to natural dyes, its production is limited and products are expensive. We propose using engineered bacteria to mass-produce natural, harmless hair dyes. We successfully synthesized melanin, indigo, dopaxanthin, and indoline-betacyanin and dyed hair into black, blue, and red. We used Vibrio natriegens to increase the rate of production. V. natriegens could produce melanin faster than E. coli. Furthermore, considering that synthetic dyes are composed of oxidants and pigment precursors, we envisage combining oxidases and pigment precursors to dye hair. We have expressed bacterial laccase and tested its activity. Next, we will try to optimize dyeing protocols and discuss the safety aspects of potential products. If successful, our products could bring dramatic changes to the market and introduce substantial social benefits.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/5b9c75d5-60ae-4491-ac82-783f501407f4','video_link_presentation':'https://video.igem.org/videos/watch/a62f3803-6adc-4ca4-9875-fa325a6a3393','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Shanghai_SFLS_SPBS','poster_link':'https://2020.igem.org/Team:Shanghai_SFLS_SPBS/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 5, Poster Number 143'}, {'name':'Shanghai_United','link':'https://2020.igem.org/Team:Shanghai_United','region':'Asia','location':'China','track':'High School','time':'11,16,1030,30','title':'Degradation of P-cresol by Engineered Probiotics in treatment of Chronic Kidney Disease','description':'Uremic toxin p-cresol sulfate (pCS) accumulate inside the kidney due to Chronic Kidney Disease, further exacerbating harm. We aim to engineer probiotics that can be consumed by patient, express the target gene into enzymes to degrade p-cresol, the precursor of pCS. Since p-cresol is produced from phenylalanine and tyrosine in diet, we created tyrosine inducer gene, which controls the expression of polyphenol oxidase (PPO) – enzyme that can degrade p-cresol. This system was tested with the Green Fluorescent Protein gene on the p15A linear plasmid. We extracted the pchC – pchF – pchA operon gene segment from Pseudomonas citronellolis and connected onto the p15A linear plasmid skeleton to assist PPO with degrading p-cresol under oxygen-deficient environment (intestine). Lastly, the plasmid was converted onto E.Coli Nissle 1917, an edible and harmless probiotic, while High Performance Liquid Chromatography was used to examine the ability of our finished product in degradation of p-cresol.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/9421a111-f1e4-469d-bcbe-d55e7287ae68','video_link_presentation':'https://video.igem.org/videos/watch/8d0d8a66-70b9-458f-8b7a-3316a0f05817','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Shanghai_United','poster_link':'https://2020.igem.org/Team:Shanghai_United/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 6, Poster Number 239'}, {'name':'ShanghaiTech_China','link':'https://2020.igem.org/Team:ShanghaiTech_China','region':'Asia','location':'China','track':'New Application','time':'11,16,0800,30','title':'CESAR (Cas12a-based Efficient Solution to Antibiotic Resistance)','description':'This year, ShanghaiTech_China developed an enhanced method of detecting antibiotics and antibiotic-resistance genes (ARGs), first applying Cas12a to this field. Antibiotic-resistance has become a global health concern. The antibiotic-abuse in clinical therapies and industries has led to antibiotics` leakage and unexpected rapid spreading of ARGs, causing the emergence of drug-resistant microbes. In order to solve this problem, ShanghaiTech_China designed a new detection system -- CESAR (Cas12a-based Efficient Solution to Antibiotic-Resistance), to identify antibiotic-residue and ARGs. CESAR contains two devices with different purposes: (1) CESAR-I is a portable rapid-response device for on-site antibiotic-residue detection. By integrating the aptamer-sensing module, Cas12a-reporting module, and fluorescence-measuring module, it simplifies the process and lowers the cost of antibiotic-abuse surveillance. (2) CESAR-II is designed for doctors` detecting ARGs. Current techniques are either time-consuming or too expensive for hospitals in less-developed regions. CESAR-II is cost-effective and can help eliminate the medical disparity caused by unbalanced economic development.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/4835f355-ddc7-488d-bcff-ed814544d107','video_link_presentation':'https://video.igem.org/videos/watch/893dc00f-9c07-4c78-9c6a-a23d808a3335','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=ShanghaiTech_China','poster_link':'https://2020.igem.org/Team:ShanghaiTech_China/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 6, Poster Number 240'}, {'name':'SHSBNU_China','link':'https://2020.igem.org/Team:SHSBNU_China','region':'Asia','location':'China','track':'High School','time':'11,14,0800,30','title':'Strangle locust plague at birth','description':'Locust plague is a harmful disaster, because gigantic locust swarms can eat crops and cause food crisis. However, the existing prevention measures are expensive and not environmentally friendly. Locust plague is mainly caused by the colonizing locusts, while the scattered locusts need to be initiated by serotonin and guaiacol to form colonized locusts. Therefore, we proposed a design to allow E. coli to express four enzymes to degrade serotonin and guaiacol in the intestines of the locusts. To enhance the degradation efficiency, we introduced a self-lysis system in E. coli to allow the enzymes release to the intestinal lumen of locust, which helps ultimately disturb the swarming behavior of locust and avoid the occurrence of locust plagues. For biosafety, we have also introduced a heat-induced suicide switch, which allows E. coli to commit suicide in response to the summer heat when the plagues are reduced.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/3fd188af-8391-4f28-a205-df04458a4af8','video_link_presentation':'https://video.igem.org/videos/watch/1284f50f-7cc2-45c4-bd32-f378c88b12d5','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SHSBNU_China','poster_link':'https://2020.igem.org/Team:SHSBNU_China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 6, Poster Number 66'}, {'name':'SHSID','link':'https://2020.igem.org/Team:SHSID','region':'Asia','location':'China','track':'High School','time':'11,16,0730,30','title':'Efficient Detection of Listeria monocytogenes by a Cas12a-crRNA complex and ssDNA','description':'Food is usually stored in the fridge to keep it as fresh as possible and far from the contamination of bacteria. However, a species of poorly known bacteria, Listeria monocytogenes, is able to endure cold conditions, and causes serious health risks such as fever, diarrhea, miscarriage, and even death. Unfortunately, as we learned from browsing related articles, field research, and surveys, modern detection methods are all very costly and time-consuming. So, we aim to create a biological kit, made out of crRNA, Cas12a, ssDNA, that allows for efficient detection of L. monocytogenes. crRNA and Cas12a will form a complex, and when crRNA binds to the oligo sequences that model the DNA of L. monocytogenes, it will activate the Cas12a protein, thus causing Cas12a to cut the surrounding ssDNA which produces visible fluorescence. Ultimately, our kit is able to produce a fluorescence after 10 minutes of exposure to oligo sequences.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/591eeec9-c1d7-4824-b287-75dcb70c8d5b','video_link_presentation':'https://video.igem.org/videos/watch/eea91c50-af80-4514-a6fd-ec0d476217e0','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SHSID','poster_link':'https://2020.igem.org/Team:SHSID/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 6, Poster Number 242'}, {'name':'SJTU-BioX-Shanghai','link':'https://2020.igem.org/Team:SJTU-BioX-Shanghai','region':'Asia','location':'China','track':'Foundational Advance','time':'11,14,0930,30','title':'LUCAS: Locational Unique Cas9','description':'The off-target problem of CRISPR technology is the most troublesome factor for its in vivo operations. Regarding this, our project conducted optimization methods to obtain a CRISPR-Cas9 system for specific target with high accuracy. To achieve this goal, we adopted directed evolution and rational design methods. We proposed a pipeline integrating machine learning and Markov process in off-target prediction. Meanwhile, molecular dynamics and graph theory were also applied to guide and interpret directed evolution and rational design. In experiment, the transcriptional activation and inhibition circuits were built to reflect the on/off-target rate, serving as indicators for screening and reporting process. Finally, we hope that our method can be a guidance for further application.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/1dd4520f-9bef-4760-ad3f-ed9a1f901893','video_link_presentation':'https://video.igem.org/videos/watch/e3f22333-9184-4ec0-860d-857b0a148831','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SJTU-BioX-Shanghai','poster_link':'https://2020.igem.org/Team:SJTU-BioX-Shanghai/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 7, Poster Number 68'}, {'name':'SJTU-software','link':'https://2020.igem.org/Team:SJTU-software','region':'Asia','location':'China','track':'Software','time':'11,16,0800,30','title':'RICAID','description':'China has a miserable memory of suffering poverty and starving. On the other hand, China has been making rapid progress in tackling hunger. Thirty years ago, one in three Chinese people was hungry. Today, less than one in 10 is hungry. No other country has helped so many people out of hunger in such a short period as China. Encouraged by the scientists and their contributions in China, our project will provide a lot of new knowledge of rice genetics and provide a solid theoretical foundation for rice breeding. Our project will be designed to help experimental research of stress-tolerance related to one of Oryza sativa L., commonly named rice. We will set up a database including gene, RNA-seq, protein information, etc. of Oryza sativa and also help to evaluate and tag the undiscovered genes so that we can recommend genes most possibly related to stress-tolerance to researchers.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/912f0b77-0939-4f5e-be29-c7846b373fb2','video_link_presentation':'https://video.igem.org/videos/watch/4e7bcb6d-1244-406a-a7d6-c53b9818debf','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SJTU-software','poster_link':'https://2020.igem.org/Team:SJTU-software/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 7, Poster Number 243'}, {'name':'SMS_Shenzhen','link':'https://2020.igem.org/Team:SMS_Shenzhen','region':'Asia','location':'China','track':'High School','time':'11,16,0800,30','title':'Special Kit Invented for Parkinson`s disease','description':'Parkinson`s Disease, a syndrome causing patients to present static tremor and rigidity, has become a major disease in people over 60. Until now, it is still common that patients forget to take meds or are unable to do so due to tremoring and dystonia. The predicament has severely affected the potency of drugs and accelerating the progress of the disease. Therefore, we design SKIP (Special Kit Invented for Parkinson`s disease). Light-inducible bacteria, along with devices that carry LED, are first implanted into patients` intestine. A bracelet will detect tremors when it occurs and sends signals to doctors, who would administrate L-dopa and send the signal back into the device that is implanted in the intestine. Receiving the signal, the LED will illuminate, which induces the light-inducible bacteria to produce L-dopa. Being capable to achieve instant feedback and remote regulation, SKIP has the potential to be applied to variable conditions.','event_type':'Team Presentation','video_link_promotion':,'video_link_presentation':'https://video.igem.org/videos/watch/8c29f938-bb48-42cd-a02b-bbd53b2f7700','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SMS_Shenzhen','poster_link':'https://2020.igem.org/Team:SMS_Shenzhen/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 7, Poster Number 245'}, {'name':'Sorbonne_U_Paris','link':'https://2020.igem.org/Team:Sorbonne_U_Paris','region':'Europe','location':'France','track':'Environment','time':'11,15,1000,30','title':'The Chlamy Cleaner, a microalgae filter to purify water.','description':'During the 2024 Olympic Games, Paris wants to host the triathlon swimming events in the Seine. However, the water is polluted: pesticides, hormones and antibiotics are present and might have a negative effect on the environment and human health. Our goal is to develop a solution to purify water. Using Chlamydomonas reinhardtii as a chassis, we designed a microalgae filter capable of retaining and degrading these harmful compounds. We focused our efforts on Atrazine, a banned herbicide but still detectable in the Seine. We expressed four enzymes from the bacteria genera Pseudomonas in C. reinhardtii using the Golden Gate Modular Cloning (MoClo). This newly added degradation pathway aims at degrading Atrazine into a less hazardous product. To ensure additional safety, we integrated a `kill switch` device based on UV-sensitive nuclease genetic circuit leading to the death of microalgae which could escape in the wild.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/e478c17e-3d45-49c5-a688-3ddeaed8bbb1','video_link_presentation':'https://video.igem.org/videos/watch/b0e874a7-9abd-409f-85ac-aa5656dfeb48','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Sorbonne_U_Paris','poster_link':'https://2020.igem.org/Team:Sorbonne_U_Paris/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 6, Poster Number 144'}, {'name':'St_Andrews','link':'https://2020.igem.org/Team:St_Andrews','region':'Europe','location':'United States','track':'Environment','time':'11,16,0930,30','title':'The in-silico design of an environmentally friendly probiotic sunscreen','description':'The St Andrews iGEM team have used synthetic biology to create a novel skin probiotic which protects against UV radiation. Current sunscreens contain multiple inorganic nanoparticles and UV-absorbing compounds known to enhance the bleaching response of corals, making them more vulnerable to other environmental stressors. Using Nissle E. coli as a chassis, we sought to design a living sunscreen expressing a potent photoprotective compound, shinorine. Our human practices reinforced our belief that the biosafety is integral to the success of our probiotic. We have developed a novel killswitch that uses environmental stimuli to prevent long-term colonisation of both the skin and the environment. We conducted an international survey on attitudes towards sunscreen and genetic engineering, allowing us to better appreciate public consensus on these topics. In-silico modelling served a vital role; we modelled the dynamics of our gene circuit and used these results to predict its evolutionary stability.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/afca7a02-65e3-4eb3-9f4a-6c4248747aea','video_link_presentation':'https://video.igem.org/videos/watch/5527604e-7def-40f0-b011-81d5fbc64b44','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=St_Andrews','poster_link':'https://2020.igem.org/Team:St_Andrews/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 5, Poster Number 227'}, {'name':'Stanford','link':'https://2020.igem.org/Team:Stanford','region':'North America','location':'United States','track':'Diagnostics','time':'11,16,1030,30','title':'SEED: Self-replicating Embedded Environmental Diagnostic','description':'The Stanford iGEM team is engineering a customizable nucleic acid diagnostic that can be performed with Bacillus subtilis, a GRAS gram-positive bacteria. Our goal is to create persistent environmental nucleic acid surveillance by taking advantage of the natural competence found in B. subtilis. In the presence of a target nucleic acid sequence cells will produce a visible signal through two detection systems. The first approach uses RNA toeholds, composed of an RNA hairpin complementary to the target sequence and a reporter protein that produces a visual readout in the presence of the target. The second approach uses B. subtilis` recombination system to remove a negative selection marker in the B. subtilis genome flanked by regions of homology to the sequence of interest. The goal of this project is to create a diagnostic system that will help address future viral testing shortages by leveraging the natural scalability of cellular systems.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/21e2c8ac-cb6d-4430-b0ba-10098a1b19df','video_link_presentation':'https://video.igem.org/videos/watch/e4a48758-98a8-4444-9dec-40aaff795376','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Stanford','poster_link':'https://2020.igem.org/Team:Stanford/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 5, Poster Number 230'}, {'name':'Stockholm','link':'https://2020.igem.org/Team:Stockholm','region':'Europe','location':'Sweden','track':'Environment','time':'11,15,1030,30','title':'S-POP: a modular biosensor for the detection of POPs in water','description':'After centuries spent using oceans for waste management, we`ve finally realized impact of water pollution. Persistent Organic Pollutants (POPs), including PFOS (perfluorooctanesulfonic acid) and PCBs (polychlorinated biphenyls), have been of great concern, due to their toxicity in low concentrations and bioaccumulating properties that lead to alarming concentrations in the ecosystem. Current detection methods, which are performed by analyzing massive amounts of water samples in the lab, cannot properly measure the low levels of POPs nor differentiate between the various iterations that exist. Our project S-POP aims to solve this issue by creating a monitor containing two major parts, a modular E. coli biosensor coupled with a Microbial Fuel Cell. When E. coli is activated by the pollutant a Quorum sensing (QS) molecule is produced. Upregulated by the QS-molecule, engineered Shewanella oneidensis produces an oscillating electrical signal that corresponds to the type and quantity of pollutants in the sample.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/9b1a796e-6c59-46a0-9fbc-8dcfe68b9484','video_link_presentation':'https://video.igem.org/videos/watch/ca082239-fd45-40a8-a5ad-b574bf385ca6','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Stockholm','poster_link':'https://2020.igem.org/Team:Stockholm/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 6, Poster Number 146'}, {'name':'Stony_Brook','link':'https://2020.igem.org/Team:Stony_Brook','region':'North America','location':'United States','track':'Environment','time':'11,15,0830,30','title':'Light-triggered knockdown of the WUSCHEL gene in Nicotiana benthamiana','description':'Genetically modified (GM) crops have seen widespread adoption in large-scale agriculture, given their potential to improve commercial farming yields and mitigate crop losses from pests and pathogens. With widespread adoption, they could also increase the incidence of gene flow—the transfer of genetic variation across populations—from transgenic to wild crops, threatening biodiversity. Hence, a solution is proposed wherein an optogenetic killswitch, introduced in Nicotiana benthamiana, preventing plant development upon exposure to UV-B light (~311 nm). Through the optogenetic pair comprised of ULTRAVIOLET RESPONSE LOCUS 8 (UVR8) with attached tetracycline repressor domain (TetR) and CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) with attached VP16 transactivation domain, the transcription of synthetic trans-acting small interfering RNAs (syn-tasiRNAs) will be controlled. These syn-tasiRNAs will disrupt the CLAVATA-WUSCHEL signaling pathway through the knockdown of the WUSCHEL (WUS) gene. Stem cells in the shoot apical meristem (SAM) will differentiate, causing stem cell depletion and prevention of further plant growth.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/d163a1d7-0573-443a-9060-fa16f4bf5e2f','video_link_presentation':'https://video.igem.org/videos/watch/d53ae878-0633-4b89-9b7f-d0f25870645f','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Stony_Brook','poster_link':'https://2020.igem.org/Team:Stony_Brook/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 6, Poster Number 148'}, {'name':'Stuttgart','link':'https://2020.igem.org/Team:Stuttgart','region':'Europe','location':'Germany','track':'Environment','time':'11,14,1000,30','title':'LAC MAN - The effective water filter to counter drug residues in wastewater','description':'Our project LAC-MAN focusses on water purification from the pharmaceuticals diclofenac (pain relivers) and carbamazepine (antiepileptika) using laccases. These substances still cannot be filtered out of the wastewater completely. The laccases, a class of enzymes able to degrade numerous pollutants, are immobilized to a mesoporous silica foam, making them long-term sustainable and more pH- and thermostable. Silica-based materials are well suited because they are environmentally friendly, biocompatible and resistant to organic solvents and microbial attacks. Because the enzymes are bound to a matrix via our innovative poly-lysine tag, no genetically modified organisms are released into the environment. Furthermore, the degradation products have no negative effects on nature anymore. We were able to express the laccase of S. cyaneus and to synthesize the silica foam. Furthermore, we were able to predict the substrate conversion rate in regard to the amount of immobilized laccases via a kinetic model according to Michaelis-Menten.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ea0c40c3-948f-4e75-8e1b-76fe75bfa5af','video_link_presentation':'https://video.igem.org/videos/watch/066fa768-8070-4ae6-afb8-30a21185888c','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Stuttgart','poster_link':'https://2020.igem.org/Team:Stuttgart/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 6, Poster Number 63'}, {'name':'SUNY_Oneonta','link':'https://2020.igem.org/Team:SUNY_Oneonta','region':'North America','location':'United States','track':'New Application','time':'11,15,0830,30','title':'Confirming A2 Alleles using Luminescence in the Field (Ca2LF)','description':'Small dairy farmers in upstate New York are struggling to survive in a factory-farming marketplace. To increase profits, some farmers are producing specialty products; one such product in the US is A2 milk. A2 milk differs from the more common A1 milk in the sequence of beta-casein, one of the main milk proteins. The gene that codes for the A1/A2 alleles of beta-casein differs by a single nucleotide polymorphism (SNP). A2 milk is growing in popularity in the US due to purported health benefits. Our team aims to create a field-deployable genetic test to facilitate breeding of A2 herds. Our system utilizes a 5` Flap endonuclease (Flappase) and quenched-oligonucleotides that differentially bind to the A1/A2 alleles of beta-casein. When in the correct conformation, Flappase will cleave the oligonucleotides, dequenching the fluorescent tag. Dairy farmers using this system will be able to rapidly identify cows carrying the A2 allele for breeding.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ae056098-c33a-4f06-b263-76ea47c2b9b3','video_link_presentation':'https://video.igem.org/videos/watch/07f1050f-6800-4392-9f14-c0327825fbe2','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SUNY_Oneonta','poster_link':'https://2020.igem.org/Team:SUNY_Oneonta/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 6, Poster Number 150'}, {'name':'SUSTech_Shenzhen','link':'https://2020.igem.org/Team:SUSTech_Shenzhen','region':'Asia','location':'China','track':'Environment','time':'11,14,0930,30','title':'Developing a Small Molecule to Inhibit Phage Infection of Bacterium Pseudomonas','description':'Pseudomonas have great potential for different biotechnological applications, particularly in the areas of bioremediation and biocatalysis. For instance, more than 80% vitamin B12 is synthesized by P.denitrificans in factories. Here we present a chemical biology approach of developing a small molecule that can protect Pseudomonas from phages infection. We attempt to utilize the Target-Directed Screening technique to find a small molecule which disrupts the translation of a critical protein during phages infections. In silico screening was performed using the software Molecular Operating Environment and an effective compound was confirmed through further tests.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/fb8127ad-89ed-448c-8c3f-895037d29cdb','video_link_presentation':'https://video.igem.org/videos/watch/87ad5ff2-aa50-4b1e-985c-7c7a7d709e94','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SUSTech_Shenzhen','poster_link':'https://2020.igem.org/Team:SUSTech_Shenzhen/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 7, Poster Number 70'}, {'name':'SYSU-CHINA','link':'https://2020.igem.org/Team:SYSU-CHINA','region':'Asia','location':'China','track':'Foundational Advance','time':'11,16,0830,30','title':'Semi-rational evolution of ADAR1 inhibitors','description':'RNA binding proteins(RBPs) play an essential role in tumors and neurodegenerative diseases, while most of them lack of effective inhibitors. Since directed evolution has shown its high efficiency, this year we provided a sample combining rational design and directed evolution to obtain dsRNA inhibitors of RBPs and took ADAR1, a dsRNA adenosine deaminase, as an example. In our project, an algorithm-guided model was trained from natural substrates of ADAR1 and used to established a candidate dsRNA library. Those candidates were connected to a self-splicing stem-loop sequence and transferred into HeLa cells with toxic genes regulated by ADAR1 and Tet-on system, which only survived when endogenous ADAR1 was inhibited by transferred dsRNAs. Efficient substrates were extracted and used to train the model above for the next round. Through the continuous cycle of this screening process, we could obtain high-efficiency inhibitors of ADAR1 efficiently, and extend this model to other RBPs.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f787e197-1e36-4aff-84b1-fd9de271872c','video_link_presentation':'https://video.igem.org/videos/watch/ef7ca05b-44a5-437f-8b08-944d6fbd8da3','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SYSU-CHINA','poster_link':'https://2020.igem.org/Team:SYSU-CHINA/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 7, Poster Number 246'}, {'name':'SYSU-Software','link':'https://2020.igem.org/Team:SYSU-Software','region':'Asia','location':'China','track':'Software','time':'11,15,1030,30','title':'Maloadis (Machine Learning based Optimization and automated Design Platform with Image Search)','description':'Synthetic biologists lack an integrated circuit design platform featuring DBTL (design, build, test, and learn) workflow. Many steps in the design can be automated to enhance efficiency and smooth their work. Besides, the massive data of genetic circuits and parts are not fully utilized. To address these problems, we create Maloadis, an integrated automated genetic circuit design platform. Maloadis implement automated top-down design with GeneNet algorithm, and is capable of designing and rating possible genetic circuits according to users` requirements. It also exploits the abundant information provided by genetic circuit images by extracting parts and structures from them to search for related previous work through trained neuro network. To improve success rate in wet-lab experiment, Maloadis predicts gene expression level with integrated models, and offers suggestions to shorten experiment cycle using Bayesian Optimization algorithm. We present Maloadis as a de novo approach to facilitate synthetic biology design automation.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/e51f09be-4b3d-49f1-9c08-7a0cdb55f9d8','video_link_presentation':'https://video.igem.org/videos/watch/46281b1d-0069-47a1-b2e7-c2678c5b12ab','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SYSU-Software','poster_link':'https://2020.igem.org/Team:SYSU-Software/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 6, Poster Number 145'}, {'name':'SZ-SHD','link':'https://2020.igem.org/Team:SZ-SHD','region':'Asia','location':'China','track':'High School','time':'11,15,1000,30','title':'Insecticidal Missile: construction of a novel biopesticide using engineered Escherichia coli','description':'Locust plague is a common natural disaster striking many regions, that would severely damage agriculture activities and result in commercial loss. The control of locusts via spraying of pesticides has been widely applied despite the high industrial cost and ecological problems could potentially be contributed. Conversely, the research in Bt toxins (a class of toxic proteins produced by Bacillus thuringiensis) and the chitinolytic enzymes suggested expectant toxicity against locusts. In our project, we constructed two strains of engineered bacteria to synthesis both proteins, whereas the insertion of a plasmid contains a UV inducible promoter and a T4 lysis gene was used as a `suicide switch`, programed for automatic lysis to release these toxins under ultraviolet radiation.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/e184c410-807f-4d33-8d82-f1af368fcbe1','video_link_presentation':'https://video.igem.org/videos/watch/1095de44-04e8-4ec4-95e6-5a91c17afd57','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SZ-SHD','poster_link':'https://2020.igem.org/Team:SZ-SHD/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 6, Poster Number 147'}, {'name':'SZPT-CHINA','link':'https://2020.igem.org/Team:SZPT-CHINA','region':'Asia','location':'China','track':'New Application','time':'11,15,1030,30','title':'Toothkeeper——A novel scheme for early diagnosis and care of dental caries','description':'Tooth decay is a chronic disease caused by dental plague turning sugars into acid. The prevalence of tooth decay has been increasing steadily in the past 20 years and gradually becoming a major global health problem. Several research articles signify that Streptococcus mutans is the major pathogen of dental caries. This year the SZPT-CHINA team will present an environment friendly and effective method to solve this problem. We have used synthetic biology methods to design an E. coil detector and a point-of-care test(POCT) device to detect caries, and an antibacterial gum to prevent caries in advance. After using our product, we can prevent dental caries effectively. This product will provide an economical solution and will improve the quality of life.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/274abc81-1ade-43cd-a956-033c1d911a6d','video_link_presentation':'https://video.igem.org/videos/watch/34fcc627-58fe-4cee-96f3-2895da914f5d','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SZPT-CHINA','poster_link':'https://2020.igem.org/Team:SZPT-CHINA/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 6, Poster Number 149'}, {'name':'SZU-China','link':'https://2020.igem.org/Team:SZU-China','region':'Asia','location':'China','track':'Manufacturing','time':'11,14,1030,30','title':'Blueism - A novel eco-friendly scheme for jeans dyeing and washing','description':'Producing every ton of jeans will pollute 200 tons of water due to the discharged 2500 toxic chemical substances, causing catastrophic effects on the environment. What`s worse, in South China`s Pearl River Delta, the use of traditional methods for jeans fraying such as strong corrosive chemical reagents and sandblasting cause irreversible damage to the workers` health. This year we designed an eco-friendly, efficient system for jeans factory. Our system includes two parts. In the first part, we produced thermostable beta-glucosidase via recombinant E.coli to synthesize Gardenia Blue, a stable, environmental friendly pigment with high dyeing efficiency. After dyeing, we used recombinant cellulase (endo-glucanase) for fraying in replacement of the stone-washing process. Besides, we designed a hardware to adjust our products to jeans manufacturing process. In brief, our automatic green system can replace manual dyeing and fraying process, while reducing pollution and protecting the health of workers.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/180033f9-a5fc-4899-a36d-3fa73ecf1f39','video_link_presentation':'https://video.igem.org/videos/watch/779cd1e9-6dc7-40a8-a764-0f02bbd1195b','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=SZU-China','poster_link':'https://2020.igem.org/Team:SZU-China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 7, Poster Number 73'}, {'name':'TAS_Taipei','link':'https://2020.igem.org/Team:TAS_Taipei','region':'Asia','location':'Taiwan','track':'High School','time':'11,16,0730,30','title':'Viral Spiral: An Accurate, Fast and Simple Viral Diagnostic Test','description':'Seasonal flu and pandemics, which account for millions of infections and hundreds of thousands of deaths, require rapid and reliable detection mechanisms to implement preventive and therapeutic measures. Current detection methods of viral infections have limitations in speed, accuracy, accessibility, and usability. This project presents a novel, widely applicable viral diagnostic test that uses a modified version of rolling circle amplification (RCA) to be sensitive, specific, direct RNA targeted, colorimetric and operable at room temperature. We are specifically detecting the following high-impact viruses: SARS-CoV-2, Influenza A (H1N1pdm09), and Influenza B (Victoria Lineage), although our test can be adapted to any viral infection. Results using synthetic viral DNA and RNA sequences show that our diagnostic test takes approximately one hour, detects femtomolar concentrations of RNA strands, and differentiates between virus strains. We believe implementing our diagnostic test will provide faster responses to future viral-related outbreaks for quicker societal recovery.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/79891502-dde2-435d-9e8b-153125816640','video_link_presentation':'https://video.igem.org/videos/watch/4d58a9ca-677d-485f-9513-0b9e53a358ee','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=TAS_Taipei','poster_link':'https://2020.igem.org/Team:TAS_Taipei/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 7, Poster Number 248'}, {'name':'TAU_Israel','link':'https://2020.igem.org/Team:TAU_Israel','region':'Asia','location':'Israel','track':'Foundational Advance','time':'11,15,0800,30','title':'sTAUbility - an innovative approach to increase the genetic stability of heterologous genes','description':'A key challenge in the field of synthetic biology is genomic instability of introduced genes. Once a gene is inserted into a host organism, it can cause an additional metabolic load, significantly reducing host fitness. Mutations that damage the introduced gene are therefore likely to be selected for, diminishing its expression. These mutations could render synthetic-biology products obsolete and require constant maintenance. We propose interlocking a target gene to the N-terminus of an essential gene in the host`s genome, under the same promoter. This way, mutations on the target gene are likely to affect the expression of the essential gene, leading to mutated host mortality. We are developing a software called sTAUbility, that would match the best-fitting essential gene and linker to a given target gene, based on bioinformatic models and novel approaches for measuring stability. Furthermore, sTAUbility optimizes the combined construct for efficient gene expression and increased stability.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/6a19b3c1-5eb9-4b92-8b0a-b86cc72c4e1e','video_link_presentation':'https://video.igem.org/videos/watch/9a79b162-a088-4b0c-9e07-eb464a643db8','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=TAU_Israel','poster_link':'https://2020.igem.org/Team:TAU_Israel/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 6, Poster Number 151'}, {'name':'Technion-Israel','link':'https://2020.igem.org/Team:Technion-Israel','region':'Asia','location':'Israel','track':'New Application','time':'11,15,0930,30','title':'ACT. Anti-COVID-19 Technology: A hydrogel-based skin-screen containing proteins that act as `decoy proteins`','description':'It is now known that SARS-CoV-2 enters human cells through binding between its spike proteins (`S`) and the ACE2 membranal proteins that are found on our cells. Hence, by occupying these `S`, infection of the host cells could be drastically reduced or completely blocked. To achieve our goal, we developed a novel hydrogel-based skin-screen containing `decoy proteins` particles that reduce the virus`s ability to infect. Our product will be effective for hours, won`t damage the skin`s microbiome and will be easily removed with water. To capture the `S`, we`ll use a mutated ACE2 (engineered for stronger linkage), and/or Sybodies (synthetic single-domain nanobodies) with the full antigen-binding capacity specifically to those `S`. We have two delivery directions for both proteins: Microgel beads that strongly bind His-tagged proteins, and B.subtilis spore surface display technique. ACT. provides an active prophylactic solution that ensures further hurdles for the viral infection, thus flattening the curve.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/119b1351-1817-4893-9098-562628a72c2e','video_link_presentation':'https://video.igem.org/videos/watch/8a722ca6-bd87-4f83-8b94-3e762e5ee29c','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Technion-Israel','poster_link':'https://2020.igem.org/Team:Technion-Israel/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 6, Poster Number 153'}, {'name':'Thessaly','link':'https://2020.igem.org/Team:Thessaly','region':'Europe','location':'Greece','track':'Food and Nutrition','time':'11,15,0800,30','title':'Amalthea: a modular platform for monitoring gastrointestinal health','description':'Amalthea is a complete, personalized, modular platform, which provides diagnosis, evaluation of the gut flora, and treatment of IBDs. A non-invasive encapsulated detection module, consisting of a genetically engineered bacteria-based system and an electronic system, will identify metabolite deficiencies directly correlated to IBDs, that may lead to malnutrition. Exploiting a bio-electronic interface to enable real-time monitoring on the patient`s smartphone. Based on this personalized data, a biosynthetic module will respond with selective production of the missing metabolites, thus eliminating that nutritional deficit and relieving the patient from the symptoms. Our product is designed according to healthcare experts and international standards, to ensure biosafety. With this work, we aspire to provide cost-efficient and innovative solutions for detecting intestinal deformities and improving the gut microbiome, while facilitating one of humans` essential needs – to enjoy one`s food.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/36130d4c-2fc0-4648-ba73-6d37c8cabf8c','video_link_presentation':'https://video.igem.org/videos/watch/baee5754-4e84-4107-9e15-24a0c164aa69','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Thessaly','poster_link':'https://2020.igem.org/Team:Thessaly/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 6, Poster Number 152'}, {'name':'TJUSLS_China','link':'https://2020.igem.org/Team:TJUSLS_China','region':'Asia','location':'China','track':'Environment','time':'11,15,0730,30','title':'PET-CRUSHER','description':'PETase has the highest degradation activity of highly crystallized PET of all PET-degrading enzymes reported to date. However, its low thermal stability limits its ability for efficient enzymatic degradation. Considering the glass transition temperature of PET is around 75°C, above which the polyester chain of PET performs in a high elastic state and the degradation is promoted, we accordingly modify PETase with a series of rational protein engineering strategy to enhance its thermal stability and therefore improve degradation efficiency. Variants are screened and verified through a series of bioinformatics strategy including computational evaluation, molecular visualization, docking and molecular dynamics simulation. Particularly, a variant with 12 mutations is expected to have a Tm value of 80.08°C, increased by 31.27°C in comparison with PETaseWT. Our project helps to increase the possibility of achieving the biodegradation of highly crystallized PET, contributing to solving environmental and health problems caused by the abuse of PET.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/1c6a698c-5298-429e-8fd6-2efce00ac5af','video_link_presentation':'https://video.igem.org/videos/watch/c2fcf67e-492b-4607-b966-9596121dd6df','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=TJUSLS_China','poster_link':'https://2020.igem.org/Team:TJUSLS_China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 7, Poster Number 155'}, {'name':'Tongji_China','link':'https://2020.igem.org/Team:Tongji_China','region':'Asia','location':'China','track':'Diagnostics','time':'11,14,0800,30','title':'SHARK: Seek Heme And Reflect cracK','description':'Chronic lower gastrointestinal bleeding is a manifestation of lower gastrointestinal disorders. It features small amount of bleeding and patients` unawareness. To locate the bleeding site, endoscope is commonly used in clinics. However, endoscope puts heavy discomfort to patients and the time-consuming process postpones subsequent treatment, which becomes great obstacles of diagnosis and therapy. To solve this throng problem, team Tongji China designed Hetoul, the engineered bacteria that can realize more rapid localization of the bleeding site in lower gastrointestinal tract. The mechanism is: Hetoul recognizes the heme released by broken red blood cells. When heme is recognized, Hetoul will express gas vesicle protein, which can be detected by ultrasonic imaging. The location of Hetoul shows the location of bleeding site, which can provide guide to subsequent treatment. Further, Hetoul can also play the role of a diagnosis tool for lower gastrointestinal diseases like colorectal cancer.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/71bdde29-ccdd-42b0-a750-9cd0ccb8b307','video_link_presentation':'https://video.igem.org/videos/watch/d44e9172-dd2d-4754-b648-f273343c17c5','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Tongji_China','poster_link':'https://2020.igem.org/Team:Tongji_China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 7, Poster Number 75'}, {'name':'Tongji_Software','link':'https://2020.igem.org/Team:Tongji_Software','region':'Asia','location':'China','track':'Software','time':'11,15,0930,30','title':'Synthesis Navigator','description':'Nowadays，there is a rising demand for designing and implementing metabolic pathways. However, Some biology researchers are faced with complicated metabolic pathways just like sailors trapped in the ocean, and our team`s integrated platform, `Synthesis navigator`, can assist them in the design of metabolic pathways. The first part of our project is an integrated database named `Synthetic Bay `, which contains much more data than last year, for synthetic biology sailors to get supplied. Secondly, in order to construct a route in metabolism oceans, synthetic biology sailors can input the starting and target compound (or one of them) then Synthesis navigator can search out a number of possible metabolic pathways from the database. Last, what counts is that facing unknown ocean environment, sailors can utilize the Hybrid Metabolic Simulation to predict the metabolic situation of chassis organisms thus avoiding the frustrated adventure in metabolic ocean.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/93284aef-e50c-40e7-84bb-edf5f1a88fb1','video_link_presentation':'https://video.igem.org/videos/watch/6de12129-1411-40b2-a1e3-19fe7949e181','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Tongji_Software','poster_link':'https://2020.igem.org/Team:Tongji_Software/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 7, Poster Number 158'}, {'name':'Toulouse_INSA-UPS','link':'https://2020.igem.org/Team:Toulouse_INSA-UPS','region':'Europe','location':'France','track':'Food and Nutrition','time':'11,14,0930,30','title':'iGEMINI, a coculture for food supplements production in space','description':'Space exploration drives us further away from Earth and will lead to year-long space travel. Some essential nutrients, such as vitamins, cannot be stored on the spacecraft since they rapidly lose nutritional value over time. iGEMINI aims to supplement astronauts` food with nutritional and tasty yeast supplement. We designed a quasi-autonomous coculture between the acetogen bacterium Clostridium ljungdahlii and the yeast Saccharomyces cerevisiae. This system uses minimal resources which are currently considered as waste on spacecraft. As a proof of concept, the yeast has been engineered to produce provitamin A, an essential vitamin for human health. Since astronauts` tastes are altered by physiological changes in their body, we give them the choice to choose their favorite flavors by using optogenetic systems. Our project builds new bridges between space research and microbiology, and multiple efforts have been done to promote space synthetic biology as a truly promising and exciting scientific field.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/02a9ba65-6ec1-4be7-b3e7-07cc5a3ff566','video_link_presentation':'https://video.igem.org/videos/watch/0195342d-4c1d-4908-ae87-328fbcbbbc22','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Toulouse_INSA-UPS','poster_link':'https://2020.igem.org/Team:Toulouse_INSA-UPS/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 6, Poster Number 65'}, {'name':'TPR_China','link':'https://2020.igem.org/Team:TPR_China','region':'Asia','location':'China','track':'High School','time':'11,15,0730,30','title':'Locust Master','description':'Locust plague has been one of the devastating disasters to humans and the environment. Both chemical and biological pesticides were widely used, but because of the rapid movement and unpredictability of locust swarms, these methods are costly and cause serious environmental problems. We designed a rapidly deployable locust attraction scheme, the core of which is to synthesis specific locust aggregation pheromone 4-Vinylanisole to attract locusts and prepare for further rapid and effective eradication in the attraction area. Furthermore, an engineered bacteria which can degrade phenylacetonitrile was successfully created, avoiding its interference to the trapping effect. Through synthesis of 4-Vinylanisole and degradation of Phenylacetonitrile, locusts are `attracted` together and the site-specific control of locust swarms is realized. Our project provides a more environmentally friendly and greener way to kill locusts in the future.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/e25ac87b-fbdb-4a89-bd63-836e7e5bd7f6','video_link_presentation':'https://video.igem.org/videos/watch/6a0a8dbf-ca67-43e4-9071-82b9d3b6a2d2','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=TPR_China','poster_link':'https://2020.igem.org/Team:TPR_China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 7, Poster Number 160'}, {'name':'Tsinghua','link':'https://2020.igem.org/Team:Tsinghua','region':'Asia','location':'China','track':'Environment','time':'11,15,0930,30','title':'NO mediated Biofilm Allayer(NBA)','description':'The formation of the complex bacterial community, termed as biofilm, has proved to be critical events in both industry and medical fields. P.aeruginosa, as a common opportunity pathogen, could form resistant bioflim on pipelines which allows it to evade antibiotics and disinfectants. The diatomic gas nitric oxide(NO), a significant signal molecular in both eukaryotes and prokaryotes, has been demonstrated to regulate the formation of the biofilm in P.aeruginosa. Here we designed the engineered bacteria, E.coli in this project, which coudld sense the presence of P.aeruginosa via introduced Rhl quorum sensing(QS) system, triggering the synthesis of NOS gene and the production of NO, and eventually resulting in the biofilm dispersion. Compared with NO gas and chemical donors, our engineered bacteria provides another solution to degrade the biofilm with better efficiency and cost.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/49923b39-ec64-4df6-b5d8-7bc48b1e221d','video_link_presentation':'https://video.igem.org/videos/watch/c025e263-4549-4c37-8d3e-9aa70a36c805','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Tsinghua','poster_link':'https://2020.igem.org/Team:Tsinghua/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 7, Poster Number 162'}, {'name':'Tsinghua-A','link':'https://2020.igem.org/Team:Tsinghua-A','region':'Asia','location':'China','track':'Information Processing','time':'11,15,1000,30','title':'Medical Database Based On DNA Storage','description':'Medical data is one of the most important kinds of data for a person. It has much to do with a person`s health and privacy. DNA storage is a brand new way of storing information with many advantages. By using DNA storage to store text, images, waveform etc., we can build a medical database which helps the management of this important data for even everyone, bringing convenience without the concern of personal privacy.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/35083ff0-ada8-40f6-b72c-b3d8cff134c2','video_link_presentation':'https://video.igem.org/videos/watch/d3f015f5-3c31-4b85-b860-1fb9e70d71d7','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Tsinghua-A','poster_link':'https://2020.igem.org/Team:Tsinghua-A/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 7, Poster Number 164'},

{'name':'TU_Darmstadt','link':'https://2020.igem.org/Team:TU_Darmstadt','region':'Europe','location':'Germany','track':'Environment','time':'11,16,1000,30','title':'B-TOX: reduction of waste water toxicity using a B. subtilis biofilm','description':'

Water is undoubtedly one of our most precious goods and basis of life. But somehow, we humans have managed to neglect and pollute this meaningful resource. Nonetheless, most of us aren`t even aware of the consequences.

In this year`s iGEM project, we have made it our mission to make a difference in wastewater treatment and develop an innovative future for pharmaceutical degradation: B-TOX, a modular biofilm able to degrade a variety of detrimental micropollutants like the anti-inflammatory drug diclofenac.

By devising an enhanced and modular B. subtilis biofilm, we can render pharmaceutical residues less toxic, utilizing the degrading properties of enzymes. We immobilize our degradation enzymes in the extracellular biofilm matrix, thereby providing a self-sustaining system without the necessity downstream processing.

A safe implementation and the prevention of bacteria release is given through our kill switch system, connecting the survival of our bacteria to the presence of determined molecules.

','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/c98c46b1-8377-4a8c-a0ac-5f4caa04c9d6','video_link_presentation':'https://video.igem.org/videos/watch/17e80e80-5bdf-4aef-9b0a-09e978e0924c','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=TU_Darmstadt','poster_link':'https://2020.igem.org/Team:TU_Darmstadt/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 6, Poster Number 233'},

{'name':'TU_Kaiserslautern','link':'https://2020.igem.org/Team:TU_Kaiserslautern','region':'Europe','location':'Germany','track':'Environment','time':'11,15,0730,30','title':'Microdestruction','description':'Micropollutants are a massive concern in wastewater treatment, as their accumulation can seriously impact ecosystems. Anti-inflammatory medications such as Ibuprofen or Diclofenac are primary examples of micropollutants becoming an ever-growing problem through patient overuse and relaxed disposal practices. Laccase has been shown to chemically deactivate Diclofenac, leading to functional degradation. Different laccase genes (MarLac, from uncultivated marine bacteria, and BaLac, from a mutant Botrytis aclada) were cloned into both our control bacterium, Escherichia coli, and primary organism, the green algae Chlamydomonas reinhardtii. Produced laccases would be incorporated into a bioreactor set up. Our project will use synthetic biology in an innovative and cost-effective way to produce a self-sufficient system. We want to reduce the need for specialized and still experimental equipment with easy integration into existing sewage treatment plant systems. It is our vision to create a cost-effective and efficient approaches to a cleaner and healthier environment.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/747697fc-602c-4c15-89ea-f047100664ce','video_link_presentation':'https://video.igem.org/videos/watch/c270e151-5ade-4067-8158-31412929573c','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=TU_Kaiserslautern','poster_link':'https://2020.igem.org/Team:TU_Kaiserslautern/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 6, Poster Number 154'}, {'name':'TUDelft','link':'https://2020.igem.org/Team:TUDelft','region':'Europe','location':'Netherlands','track':'Food and Nutrition','time':'11,16,0800,30','title':'PHOCUS - Target locusts from within','description':'Since ancient history, locust plagues have been devastating crops and pastures, threatening food security across the globe. Current strategies to fight locust swarms rely on unspecific and dangerous chemical pesticides that harm other insects, or on biopesticides that are too slow. Our mission is to provide a novel biopesticide against locusts that is fast-acting and safe. We introduce PHOCUS, a biopesticide based on engineered bacteriophages that infect the gut bacteria of the locust. After infection, the bacteria produce a crystal protein (Cry7Ca1) from Bacillus thuringiensis (Bt) that specifically harms locusts, and RNA interference (RNAi) precursors, all encoded within the phage genome. Cry7Ca1 punctures the gut lining, harming the locust and allowing the RNAi precursors to reach the hemolymph, where they mature and silence the expression of vital locust genes. With this unique complementary approach, PHOCUS kills the locusts from within.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/4c7ec21c-89eb-4491-97ca-b2f06e039d8d','video_link_presentation':'https://video.igem.org/videos/watch/448a8d72-7463-4893-8e14-09647a1bd72e','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=TUDelft','poster_link':'https://2020.igem.org/Team:TUDelft/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 6, Poster Number 236'}, {'name':'Tuebingen','link':'https://2020.igem.org/Team:Tuebingen','region':'Europe','location':'Germany','track':'Environment','time':'11,14,0800,30','title':'PacMn: Phytochelatin-actuated complexation of Manganese','description':'Environmental heavy metal pollution has raised concerns for water quality and human health. In fact, it was found that due to climate change, and thus, rising groundwater temperatures in Germany, manganese (Mn2+) concentrations in local water resources increase. Accordingly, we propose an approach for the measurement and retention of Mn2+-ions in which we use genetically engineered E. coli as a bifunctional biosensor. Our system contains a riboswitch, which triggers a fluorescent signal in the presence of Mn2+-Ions, in combination with induced complexion for clearance of Mn2+-Ions with phytochelatin proteins. Due to its sequence complexity, we modified the phytochelatin sequence in silico, and modeled the variants` structures to subsequently evaluate their stability using Molecular Dynamics simulation. Upon successful cloning, the functionality and detection range of our system is assessed using titrated Mn2+, prior to investigating the signal kinetics and effects of cell density, as well as heavy metal retention in vivo.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/47d34e33-678c-4d01-b48d-a2761aa46a66','video_link_presentation':'https://video.igem.org/videos/watch/b6e25c48-ce63-470b-aa42-5355796060e3','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Tuebingen','poster_link':'https://2020.igem.org/Team:Tuebingen/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 7, Poster Number 67'}, {'name':'UC_Davis','link':'https://2020.igem.org/Team:UC_Davis','region':'North America','location':'United States','track':'Software','time':'11,16,1030,30','title':'Expanding the gene regulatory toolkit in filamentous fungi through bioinformatics-directed genome mining.','description':'We developed computational tools to identify potential filamentous fungal transcription factors and their cognate binding sites to expand the available parts list for these organisms. Our tools enable a comparative genomic approach to mine more than 600 fungal genomes for transcription factors associated with Biosynthetic Gene Clusters and motif finding algorithms to identify their putative binding sites. We have designed the tools we`ll need to validate these constructs experimentally which will create a library of transcription factor-binding site pairs.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/cb4c426c-d291-4112-b47a-7194e7bf4285','video_link_presentation':'https://video.igem.org/videos/watch/000c9141-ea22-4f74-931f-d796c10bffcb','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UC_Davis','poster_link':'https://2020.igem.org/Team:UC_Davis/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 6, Poster Number 238'}, {'name':'UC_San_Diego','link':'https://2020.igem.org/Team:UC_San_Diego','region':'North America','location':'United States','track':'Therapeutics','time':'11,14,1030,30','title':'BACSYGEN: BACteriotherapy via SYnthetic GENomes','description':'Despite cancer being one of the leading causes of death, successful treatment remains a challenge due to the heterogeneous nature of tumors. While a multitude of treatment options exist including chemotherapy, radiotherapy, and immunotherapy, they all have significant limitations and have prompted the development of alternative therapies such as bacteriotherapy. While certain bacteria have shown great therapeutic potential, different bacteria are involved in unique tumor suppressing pathways, and as a result, a combination of various tumor-suppressing bacteria have been shown to achieve the greatest efficacy. However, these microbes require genetic modification to lower potential toxicity and eliminate any side effects on normal cells. Our team proposes a classification algorithm to first classify whether a bacteria affects a tumor-resisting pathway, and then feeding this information into our Generative Adversarial Network to create a synthetic bacterial genome with multiple tumor-suppressing features while also being clinically significant.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/b8fad4c5-d2ac-4c46-a0cd-deee51d69be8','video_link_presentation':'https://video.igem.org/videos/watch/2e60bcb5-5d72-4947-9ec4-ef74aaa7b79e','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UC_San_Diego','poster_link':'https://2020.igem.org/Team:UC_San_Diego/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 7, Poster Number 69'}, {'name':'UCAS-China','link':'https://2020.igem.org/Team:UCAS-China','region':'Asia','location':'China','track':'Therapeutics','time':'11,15,0730,30','title':'Stomach Homeostasis Establishment for Eluding the Plethora of H. pylori (SHEEP)','description':'On asteroid B612, the little prince was busy pulling up shoots of the baobabs. Because once they had occasionally grown up, their roots could split the entire asteroid into pieces. Fortunately, B612 eventually gets a sheep that eats up the soaring baobab shoots without uprooting them. In this way, the little prince, baobab trees and sheep form a stable ecological balance. This story presents our new ideas on the treatment of H. pylori related diseases. H. pylori has been symbiotic with humans in the stomach for more than 60,000 years. Either its plethora or disappearance inflicts various diseases on human bodies. Complete elimination recommended by current treatment is not satisfying. Thus we proposed `SHEEP` therapy, which introduced engineered L. acidophilus into the stomach to realize the balance of microecology. Aiming for personalized treatment, we obtain data from capsule robots` stomach sampling and photographing. The ternary-balanced-relation module is simulated as well','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ae11d868-5176-4211-ab63-c24ca2558825','video_link_presentation':'https://video.igem.org/videos/watch/7e6298e9-483c-45f0-88b6-aa2b00b22ccc','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UCAS-China','poster_link':'https://2020.igem.org/Team:UCAS-China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 8, Poster Number 166'}, {'name':'UChicago','link':'https://2020.igem.org/Team:UChicago','region':'North America','location':'United States','track':'Environment','time':'11,14,1030,30','title':'Optizyme: A Novel Open-Source Computational Modelling and Optimization Package for Design of Cell-Free Systems','description':'Optizyme is an open source package in the computer language R that aims to streamline computational approaches to synthetic biology problems. Optizyme contains a suite of functions that allow for Michaelis-Menten model construction and visualization given only biological parameters. Most importantly, Optizyme allows for optimization of enzyme concentrations within cell-free systems through a gradient descent algorithm that accepts models built using Optizyme`s capabilities, as well as any user constructed model that fulfills certain requirements detailed in the package documentation. Accuracy of the optimization algorithm is tested on the model described in `A combined experimental and modelling approach for the Weimberg pathway optimisation` (Shen et al). Using their model, Optizyme identifies a higher performing optimum than the optimal ratio identified by Shen et al. We then apply the capabilities of Optizyme to optimize the design of a cell-free system we intend to construct next year that degrades polyethylene terephthalate into catechol.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/9501d3d0-246f-4576-88a9-e57d8443b999','video_link_presentation':'https://video.igem.org/videos/watch/761aa983-86f0-431f-9d47-2668ce357984','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UChicago','poster_link':'https://2020.igem.org/Team:UChicago/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 7, Poster Number 72'}, {'name':'UCL','link':'https://2020.igem.org/Team:UCL','region':'Europe','location':'United Kingdom','track':'Environment','time':'11,14,0730,30','title':'PETZAP: Integrating enzymatic PET degradation into Microbial Desalination Cell technology','description':'The world`s oceans are suffocating from an annual addition of 8 million tons of plastic which threaten marine ecosystems and exacerbate water scarcity affecting over 2 billion lives. Our project aims to tackle these two global challenges by integrating enzymatic polyethylene terephthalate (PET) degradation into a Microbial Desalination Cell (MDC). The system involves a 2-step process co-culturing engineered E. coli to express a PETase-MHETase fusion degrading PET and P. putida to achieve further degradation and produce lactate, which then supports the biofilm growth of exoelectrogen, S. oneidensis, generating bioelectricity for desalination. Desalination efficiency was maximised by optimising lactate secretion, co-culture design, and MDC configuration based on the results from flux balance analysis (FBA) and agent-based model, simulating bacterial plastic degradation and bioelectricity production, respectively. Insights for further technical optimisation and feasible implementation at large scales were obtained through iterative engagement with experts and stakeholders.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/8d7f918e-9e84-4c5b-be6f-24fccad9b947','video_link_presentation':'https://video.igem.org/videos/watch/cd2626d8-fa27-49c9-bc10-28df2e201097','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UCL','poster_link':'https://2020.igem.org/Team:UCL/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 7, Poster Number 74'}, {'name':'UCopenhagen','link':'https://2020.igem.org/Team:UCopenhagen','region':'Europe','location':'Denmark','track':'Diagnostics','time':'11,14,0830,30','title':'CIDosis - Just Sweat It! Developing a Biosensor for Monitoring Chronic Inflammatory Diseases','description':'Chronic Inflammatory Diseases (CIDs) are debilitating diseases affecting three out of five people worldwide. Optimal treatment requires constant monitoring, but current testing methods are invasive, time-consuming, and costly. CIDosis strives to change this with a non-invasive patch for self-monitoring. Backed by extensive computer modeling, we are developing a biosensor that continuously collects sweat from the skin, and produces a color reflecting the level of inflammation. The biosensor in our patch is based on Saccharomyces cerevisiae cells equipped with interleukin-specific receptors that will associate in the presence of interleukins, resulting in the intracellular complementation of a split protein. A transduction pathway is then triggered, leading to the production of a color, whose intensity is logged by an app and shared with a medical professional. By integrating the wishes of patients living with CIDs, as well as experts within these fields, CIDosis brings a next generation tool for patient empowerment.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/3b21e193-aefc-4d45-a65d-6fa4f7a3b93a','video_link_presentation':'https://video.igem.org/videos/watch/eb3e16b7-932d-4fdc-9283-42157a9072c2','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UCopenhagen','poster_link':'https://2020.igem.org/Team:UCopenhagen/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 7, Poster Number 76'}, {'name':'UCSC','link':'https://2020.igem.org/Team:UCSC','region':'North America','location':'United States','track':'Environment','time':'11,16,1030,30','title':'Komaplastics: Creating a biodegradable bed mulch from bacterial cellulose','description':'Plastic bed mulch films are an essential agricultural tool; they limit fumigant emissions, provide UV and water resistance, prevent weed and pest growth, and maximize crop yield. However, current disposal methods are unsustainable; the majority of bed mulches are dumped into landfills, degrade into harmful chemicals, and pollute local communities. Komaplastics will lay the foundation for creation of a biodegradable bed mulch from bacterial cellulose (BC) produced by Komagataeibacter rhaeticus. BC is highly crystalline due to hydrogen bonding between hydroxyl groups of adjacent strands which is a barrier to homogenous incorporation of plasticizing molecules. Thus, we investigated carbohydrate-binding modules (CBMs) for their potential to disrupt these hydrogen bonding networks and facilitate addition of plasticizing molecules. We also tested various compounds for their ability to plasticize chemically decrystallized BC. Our work will provide a scaffold for the development of a cellulose-based biodegradable plastic bed mulch film produced in a biological system.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f388a0bb-0d50-4f46-b377-f9bc6c63505b','video_link_presentation':'https://video.igem.org/videos/watch/f7f3d143-6403-416b-8783-e6dec4116699','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UCSC','poster_link':'https://2020.igem.org/Team:UCSC/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 6, Poster Number 241'}, {'name':'UESTC-Software','link':'https://2020.igem.org/Team:UESTC-Software','region':'Asia','location':'China','track':'Software','time':'11,16,0830,30','title':'CPD3DS-Classification of Protein Domains in 3D Shape to design a standard set of protein bricks','description':'Proteins are responsible for most of the physiological functions in the cells, and many synthetic biologists focus on designing customized proteins according to demands. Nowadays, the protein design starts from a new amino acid sequence in most cases, the workload is undoubtedly huge. At the same time, the structure of a protein is often closely related to the function of protein. Our project, CPD3DS, directly uses the structural domains as the basic unit to analyze protein structures. To get a set of protein bricks, domains were classified by their shape features, and 3D-Zernike descriptor were used to cluster all domains in existing databases. We developed a user-friendly website, termed CPD3DS, for retrieval, analyses and visualization of classified protein domains. In addition, we printed a set of our protein bricks for teaching and popularize synthetic biology.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/8f3dca58-64b9-41fd-9a38-ae75b4a8b9ca','video_link_presentation':'https://video.igem.org/videos/watch/d8a88241-f839-4d1f-854c-ce362b8bb79e','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UESTC-Software','poster_link':'https://2020.igem.org/Team:UESTC-Software/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 7, Poster Number 250'}, {'name':'UFlorida','link':'https://2020.igem.org/Team:UFlorida','region':'North America','location':'United States','track':'Environment','time':'11,15,1030,30','title':'Aquatic Phosphorus Detection Using SCRIBE','description':'Team Florida 2020 takes inspiration from their 2019 project to improve and apply the novel biosensor technology that detects and records phosphorous levels to real-world ecological implications. This project couples the Synthetic Cellular Recorders Integrating Biological Events (SCRIBE) system with the naturally occurring PhoB-PhoR system in E.coli. In response to phosphorus, SCRIBE utilizes a reverse transcriptase enzyme to produce single stranded DNA which can be incorporated into the host-genome during DNA replication using the Beta Recombinase protein which results in a mutation within the bacterial chromosome. This system can be utilized to measure the amount of phosphorus in a body of water by modeling the fraction of cells that gain the mutation per generation. In the absence of a lab, the UF iGEM team seeks to model this hypothetical biosensor as part one of a two-part project.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/43de8ac0-77f8-4cf3-bcca-bd899ce5c53e','video_link_presentation':'https://video.igem.org/videos/watch/0cb63e67-306c-4da8-bedd-730d76e2f1a0','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UFlorida','poster_link':'https://2020.igem.org/Team:UFlorida/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 7, Poster Number 156'}, {'name':'UGent_Belgium','link':'https://2020.igem.org/Team:UGent_Belgium','region':'Europe','location':'Belgium','track':'Environment','time':'11,14,0730,30','title':'Vsycle: providing ecological rain on demand','description':'Drought, water scarcity as well as floods are becoming a worldwide problem. Influencing the weather to control rainfall by the use of cloud seeding, a technique where certain particles are dispersed in clouds, could be a remedy. Cloud seeding is already executed, but is mainly done by using the toxic silver iodide. With team Vsycle, we designed an alternative cloud seeding agent that is biological, nontoxic and biodegradable. For this, we used the ice nucleation proteins (INPs) from Pseudomonas syringae, which facilitates ice formation. As the formation of ice crystals in clouds plays an essential role in many environments, this protein could be very interesting to use as a potential alternative to silver iodide in cloud seeding. To anticipate on legislation issues regarding GMO`s, we designed INP producing E. coli cells that can be induced to leak their cellular contents according to the bacterial ghost principle.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/d4be54fc-7dc2-4076-bc9a-403485028775','video_link_presentation':'https://video.igem.org/videos/watch/67d7c49b-30e0-45a6-8cca-cee4d653d191','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UGent_Belgium','poster_link':'https://2020.igem.org/Team:UGent_Belgium/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 8, Poster Number 78'}, {'name':'UGent2_Belgium','link':'https://2020.igem.org/Team:UGent2_Belgium','region':'Europe','location':'Belgium','track':'Food and Nutrition','time':'11,15,0830,30','title':'Bubbly: an edible pearl for intestinal microbiome modulation','description':'The WHO estimates that more than 300 million people worldwide suffer from depression. Research has shown that the gut microbiome alterations play a key role in a person`s stress reactivity and influences anxiety-like and depression-like behaviors. In brief, if we can manage to alter the gut microbiome`s functionality, the bidirectional communication might shift and lead to less anxiety and depression-like behaviors. We believe that Bubbly can revert depression and to bring relief to people suffering from depression. Our pearl, a novel food supplement, is composed of three major components: naringenin, a flavonoid that works anti-inflammatory, kojibose, a prebiotic sugar with beneficial effects on the gut microbiome and vitamin-B12. Now, we are producing naringenin in the lab and working on the formulation of the pearl. Our pearl can be sold as an independent product and could also be added to already existing foods as probiotics.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f118a71c-f451-40ef-b31c-b183b0271d58','video_link_presentation':'https://video.igem.org/videos/watch/5796fea3-4c26-4845-ada9-025b112d7080','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UGent2_Belgium','poster_link':'https://2020.igem.org/Team:UGent2_Belgium/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 7, Poster Number 159'}, {'name':'UiOslo_Norway','link':'https://2020.igem.org/Team:UiOslo_Norway','region':'Europe','location':'Norway','track':'Diagnostics','time':'11,15,0800,30','title':'Sal.Coli - A detection system and approach for treating amoebic gill disease','description':'The biological and environmental concerns that the aquaculture industry faces require innovation in both detection and treatment of disease in fish. Among these is amoebic gill disease caused by Paramoeba perurans affecting Atlantic salmon. Paramoeba perurans is a parasite that latches onto the gills of salmon and causes discomfort and possibly death by reducing the respirational surface area on the gills. Our project aims to create an automatic detection system. To create this system we are investigating collective behaviors and how one can use them to diagnose diseases. We also aim to use genetically modified Escherichia coli to produce salinomycin, an antiparasitic compound. The gene cluster for salinomycin production will be transferred into E. coli step by step, with the goal to provide an alternative route to production of this compound. We hope that our system will complement current diagnostic tools and treatments used in aquaculture today.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/539db517-5695-44fa-8352-6d9291b0ace0','video_link_presentation':'https://video.igem.org/videos/watch/41384eed-8010-493e-b9a2-69198c98baff','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UiOslo_Norway','poster_link':'https://2020.igem.org/Team:UiOslo_Norway/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 7, Poster Number 161'}, {'name':'UIUC_Illinois','link':'https://2020.igem.org/Team:UIUC_Illinois','region':'North America','location':'United States','track':'Software','time':'11,16,1000,30','title':'Viralizer – Modeling Covid-19 mutations and binding energies to design potential antibodies','description':'Covid-19 is caused by the SARS-CoV-2 virus, a highly mutative virus for which developing effective antibodies is difficult. Thousands of spike protein mutations have been detected but fewer than 1% of them have solved crystal structures. To address this shortage, we created Viralizer: an interactive online database that contains over 26,000 mutated spike protein sequences and their corresponding structures, developed using homology modeling in PyRosetta. This allows the user to analyze the effects of spike protein mutations on the functionality of the protein and its binding with potential antibodies. The spike protein database is paired with a phylogenetic tree that characterizes the propagation of the virus over space and time. We also developed a genetic algorithm that uses spike protein structures and their binding energies to design hundreds of potential antibodies that bind to the spike protein and reduce its binding affinity to the ACE-2 receptor on cells.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/2b4447a1-1a4e-4a4e-a84b-46f7649e307f','video_link_presentation':'https://video.igem.org/videos/watch/8332d5bd-139c-4a87-b473-8fdd382ec868','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UIUC_Illinois','poster_link':'https://2020.igem.org/Team:UIUC_Illinois/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 7, Poster Number 244'}, {'name':'ULaval','link':'https://2020.igem.org/Team:ULaval','region':'North America','location':'Canada','track':'Food and Nutrition','time':'11,15,0930,30','title':'aSAP: a solution against maple polymers','description':'Maple syrup has a great cultural and economic importance for Canada. However, several issues can lower the quality of the final product. We engaged in conversations with experts to identify potential solutions to these problems, ultimately targeting ropy maple syrup. Ropy syrup has a very high viscosity, is not marketable, and damages maple syrup production equipment, which results in important economic losses, particularly for smaller producers. It is caused by the presence of dextrans produced by specific types of bacteria in the sap. aSAP, by team iGEM ULaval 2020-2021, will aim to develop an enzymatic treatment to degrade dextran and turn ropy maple syrup into a marketable product. Since maple syrup is stored at room temperatures, we are planning to use a dextranase from a psychrophile (cold-adapted) bacteria. In 2020, we have validated our candidate enzyme in silico, planned experiments to characterize and optimize it, and designed our implementation proposal.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/63a4e440-3c7a-4478-a093-5bd69a83c622','video_link_presentation':'https://video.igem.org/videos/watch/206393d4-0a42-43f3-9161-78e44039344c','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=ULaval','poster_link':'https://2020.igem.org/Team:ULaval/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 7, Poster Number 163'}, {'name':'UM_Macau','link':'https://2020.igem.org/Team:UM_Macau','region':'Asia','location':'Macao','track':'Environment','time':'11,14,1030,30','title':'Biofilm-Removing E. coli for Aquarium Cleaning (BREAC)','description':'As biofilm grows rapidly, it attaches to the inner surface of aquariums and aquatic organisms, which lowers the water quality if not cleaned regularly. However, the removal of biofilm in large aquariums is time-consuming and relies on inefficient labor through scrubbing. To address these concerns, we engineered the BL21 bacteria strain of E.coli to detect and biodegrade biofilms. The T7 promoter drives the expression of LuxR, which recognizes the signaling molecule AHL that is secreted by biofilms. Combined with AHL, LuxR would bind to the pLuxR to express the adhesive protein, Ag43, and digestive enzymes, DNase and protease. Our engineered bacteria will bind to the biofilm and degrade it efficiently.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/85340386-e80c-48b2-9020-8443ca740097','video_link_presentation':'https://video.igem.org/videos/watch/b0527194-04a3-4c46-b22a-68c2c818c918','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UM_Macau','poster_link':'https://2020.igem.org/Team:UM_Macau/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 7, Poster Number 77'}, {'name':'UMaryland','link':'https://2020.igem.org/Team:UMaryland','region':'North America','location':'United States','track':'Diagnostics','time':'11,15,0830,30','title':'A New CDC: Colorimetric Detection of COVID','description':'Accelerating the pace and improving the accessibility of COVID-19 testing is critical for the world`s response to the pandemic, especially in university settings. UMaryland iGEM set out to design a low-tech COVID-19 diagnostic test that is reliable, easy to use, and easy to interpret. Lacking access to a wet lab, the team has designed and modeled an isothermal CRISPR-based diagnostic that employs two DNA-programmed catalytically dead Cas13 (dCas13) recognition domains, each fused to part of a split beta-lactamase. A color change occurs upon reconstitution of the enzyme, and we predict with reasonable confidence that the signal will be visible to the human eye after 30 minutes. Three separate G-blocks will be used in conjunction with 3A assembly to clone the two dCas13-split-lactamase ORFs. Besides designing this test, we have rolled out a COVID-19 informational clearinghouse web site targeted to the UMD student population.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/95e618be-168b-41f0-9e75-882476d566fa','video_link_presentation':'https://video.igem.org/videos/watch/f3b26275-c274-47f8-ba4e-ce13ca436df8','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UMaryland','poster_link':'https://2020.igem.org/Team:UMaryland/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 7, Poster Number 165'}, {'name':'UNILausanne','link':'https://2020.igem.org/Team:UNILausanne','region':'Europe','location':'Switzerland','track':'Therapeutics','time':'11,15,0800,30','title':'B.O.T: Bacterial Oscillation Therapy','description':'Colorectal cancer incidence has heavily increased over past decades, notably in more-developed regions. It is now the third-most common cancer worldwide. Recovery still relies heavily on standard chemotherapy, radiotherapy and surgery. A promising new approach in cancer treatment is chronotherapy. By administering drugs according the circadian rhythm, chronotherapy aims at maximizing efficacy and minimizing side effects. For our project, we introduced a synthetic circuit producing oscillations into E. coli Nissle 1917, a tumour-targeting probiotic strain of E. coli, to explore the potential benefits of chronotherapy. The final engineered strain delivers azurin, an anti-cancer peptide in an periodic manner. In the interest of biosafety, we also built a kill-switch to be incorporated into the final design.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/540954cd-003b-41d7-83b3-86ee15d9f9e5','video_link_presentation':'https://video.igem.org/videos/watch/b9274eb7-ee98-445c-a2d0-5ca91d53c8d8','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UNILausanne','poster_link':'https://2020.igem.org/Team:UNILausanne/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 8, Poster Number 167'}, {'name':'UNSW_Australia','link':'https://2020.igem.org/Team:UNSW_Australia','region':'Asia','location':'Australia','track':'Environment','time':'11,16,0730,30','title':'PROTECC (Prevent Reactive Oxygen and Thermal Extreme Caused Carking) Coral','description':'Home to three-quarters of the world`s coral population, Australia`s Great Barrier Reef (GBR) is experiencing its third bleaching event in five years. With increasing ocean temperatures, coral reefs and the ecosystems that depend on them are at risk of serious, irreversible damage. Coral bleaching is a result of heat-induced oxidative stress, which triggers the ejection of corals` microalgal-symbiont Symbiodinium spp. PROTECC Coral aims to improve the heat tolerance of coral by introducing small heat shock proteins alongside a glutathione recycling enzyme system into Symbiodinium spp., in order to reduce cellular stress. By engaging in conversations with various stakeholders (tourism industries, local councils, bioprospecting practices, commercial and recreational fishing and the GBR`s traditional owners) and integrating their advice, our team hopes to contribute to a worldwide conservation effort that enables future generations, both Australian and non-Australian alike, to enjoy the GBR in its entirety.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/419f1b87-a827-4138-a85f-5cd60d65c820','video_link_presentation':'https://video.igem.org/videos/watch/79713a3b-1158-4040-9c22-ccf450a483ae','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UNSW_Australia','poster_link':'https://2020.igem.org/Team:UNSW_Australia/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 7, Poster Number 251'}, {'name':'UofUppsala','link':'https://2020.igem.org/Team:UofUppsala','region':'Europe','location':'Sweden','track':'New Application','time':'11,16,0830,30','title':'NANOFLEX','description':'Our project aims to create a cellular biosensor adaptable to detect your analytes of choice. Its design contains a sensory module, where nanobodies interact with the targets, activating the signal amplification module, which will result in an output signal visible to the naked eye. Placing this system in an easy-to-use format we intend to offer a standardized, flexible and accessible detection system.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/bebec79b-b012-4ccd-ac56-5b14c6231f51','video_link_presentation':'https://video.igem.org/videos/watch/3fe6609d-8c17-4933-8e99-18295f028a7b','section':'Overgrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UofUppsala','poster_link':'https://2020.igem.org/Team:UofUppsala/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 7, Poster Number 247'}, {'name':'UPCH_Peru','link':'https://2020.igem.org/Team:UPCH_Peru','region':'Latin America','location':'Peru','track':'Food and Nutrition','time':'11,14,1000,30','title':'CrioPROT: An innovative solution for crop loss due to frost','description':'In the Peruvian highlands, frosts during the winter cause crop damage leading to significant economic losses for small and medium scale farmers, perpetuating their already vulnerable condition. Our team wants to approach this problem by bringing an innovative solution. We aim to develop a system of production of an antifreeze agent which has a protective capacity in frost-susceptible crops, administrable by spraying. This product consists of a solution of recombinantly expressed and purified antifreeze proteins (AFPs). Our core genetic designs comprise the sequences of three types of AFPs, of plant and insect origin, with inducible and constitutive promoters, and a peptide signal for secretion to the culture medium. The chassis we have selected is a psychrophilic bacteria of the Pseudoalteromonas genus in order to guarantee an efficient work at low-temperature settings. In this way, our system will be capable of producing AFPs in low-tech environments in frost-affected regions.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/f2959eb1-80e2-43e0-95e8-3c44cb308e9b','video_link_presentation':'https://video.igem.org/videos/watch/8b6e92d8-5cab-4dcd-b5d9-20fe1c4ae39a','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UPCH_Peru','poster_link':'https://2020.igem.org/Team:UPCH_Peru/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 8, Poster Number 80'}, {'name':'UPF_Barcelona','link':'https://2020.igem.org/Team:UPF_Barcelona','region':'Europe','location':'Spain','track':'Therapeutics','time':'11,14,0730,30','title':'Hormonic: restoring thyroid homeostasis via an intein-mediated biosensor','description':'One-third of the treated hypothyroidism patients do not respond correctly to current therapies. To solve that, a system capable of restoring hormonal feedback was designed, offering an alternative to the 10% of Spaniards and 5% of the global population that suffer from this endocrine disorder. Its functioning is based on our successfully engineered intein-mediated Escherichia coli biosensor, which showed a great response to distinct T3 thyroid hormone levels giving rise to different superfolder GFP concentrations. This was designed to be coupled to a PID controller, which computes the dosage that compensates for hormonal disbalances. As a proof of concept for the validation of this regulatory mechanism, a lactone cell circuit incorporating a turbidostat was developed, showing a high correlation between the experimental and modelling results. Finally, a detailed future implementation plan was defined so that it included the necessary steps towards a feasible implementation of this innovative treatment.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/356e4630-9be5-4a8e-b249-cad9b133b56f','video_link_presentation':'https://video.igem.org/videos/watch/d02225f6-f36e-434c-8f18-e0991241dc0c','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UPF_Barcelona','poster_link':'https://2020.igem.org/Team:UPF_Barcelona/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 8, Poster Number 82'}, {'name':'USAFA','link':'https://2020.igem.org/Team:USAFA','region':'North America','location':'United States','track':'Environment','time':'11,16,1030,30','title':'Detection and Degradation of Perfluoroalkyl Substances through Bioengineering','description':'Per- and polyfluoroalkyl substances (PFAS) contaminate public ground and surface waters, posing serious threats to wildlife and human health. Despite the ubiquitous nature of these compounds, there are limited technologies available to both detect and degrade these chemicals. To address this urgent need, the US Air Force Academy iGEM team engineered a novel PFAS responsive promoter to act as an efficient bioreporter for rapid detection of PFAS. Concurrently, the team screened PFAS-laden soil samples and identified several microbes that survive in high concentrations of PFAS. Delftia acidovorans, one of the microbes identified, contains the genes for several dehalogenases with potential activity to break down PFAS compounds. Alternate vectors and organisms for dehalogenase expression are being explored to determine maximum efficiency at removing fluorine ions from the PFAS carbon-fluorine backbone. Collaboration with water treatment experts and military research labs provides a multi-faceted attack on the PFAS issue.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/d6088c83-bfbe-4baa-a877-60e4e1681582','video_link_presentation':'https://video.igem.org/videos/watch/d224ccf9-ed35-478a-a317-c6f29ac33f75','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=USAFA','poster_link':'https://2020.igem.org/Team:USAFA/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 7, Poster Number 249'}, {'name':'USTC-Software','link':'https://2020.igem.org/Team:USTC-Software','region':'Asia','location':'China','track':'Software','time':'11,16,0930,30','title':'Protein molecular simulation toolchain','description':'We gather some molecular simulation software tools like pyDTI, building up an easy-to-use and out-of-box web platform, to provide a molecular simulation toolchain, and find out the possibility to combine these classic molecular simulation tools and current cloud platform technology, such as containering and distributed computation, to allow our platform to serve not certain one, but a large amount of researchers.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/d3fde59f-c6d8-4fb1-8123-02ad6686173b','video_link_presentation':,'section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=USTC-Software','poster_link':'https://2020.igem.org/Team:USTC-Software/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 7, Poster Number 253'}, {'name':'UTTyler','link':'https://2020.igem.org/Team:UTTyler','region':'North America','location':'United States','track':'Diagnostics','time':'11,15,0830,30','title':'Diagnosis of viral infections using photonics and biomolecular techniques','description':'Viral diseases are common to have a long incubation period with mild symptoms while carriers can still spread these pathogens via airborne transmission. These properties lead to a critical challenge in preventing the spread of these diseases. Potentially, routine diagnosis of the entire population can identify all virus carriers to block transmission. However, advanced equipment and skills are required for most diagnostic methods, making it difficult to frequently test all individuals in our society. To address this problem, we propose to develop a diagnostic platform that allows users to perform testing at home on a daily basis. Our approach involves using cellular techniques to generate probes for recognizing viral genomes and using photonics technologies to monitor association between our probes and viral DNA. We anticipate that a test will only take a short period of time and it can be easily performed by all users.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/9139be59-4ee5-4a02-ac23-2fbd199f1b1e','video_link_presentation':'https://video.igem.org/videos/watch/15c8df0f-f08c-487a-8784-59241bf5de52','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UTTyler','poster_link':'https://2020.igem.org/Team:UTTyler/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 8, Poster Number 170'}, {'name':'UUlm','link':'https://2020.igem.org/Team:UUlm','region':'Europe','location':'Germany','track':'Environment','time':'11,14,0830,30','title':'Biodegradation of Polystyrene on the Basis of Genetically Modified Intestinal Bacteria of Tenebrio molitor larvae','description':'Polystyrene is one of the most abundant plastics on earth and often ends up in large quantities in our environment. Sustainability is our central credo and we present a new approach of biodegrading polystyrene with the help of genetically modified bacteria introduced into the intestines of mealworms (Tenebrio molitor larvae). Previously, it has been shown that these larvae can use polystyrene foam as sole carbon source, thus it is a biodegradable substance. We designed a recombinant Escherichia coli strain capable of converting acetyl-CoA to acetone. The genetic modifications intend to integrate a plasmid carrying several genes of the ABE fermentation. We want to have acetone produced by bacteria in the intestines of the larvae. Here, it is supposed to help breaking down the plastic, because acetone can dissolve polystyrene. Acetone intercalates in between the polymer chains and increases the surface area that can be attacked by the bacteria.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/afbaf16b-05b3-4315-9e98-2a8350e8192b','video_link_presentation':'https://video.igem.org/videos/watch/91542237-651d-428a-ab7f-b3b7f780fc96','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UUlm','poster_link':'https://2020.igem.org/Team:UUlm/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 8, Poster Number 84'}, {'name':'UZurich','link':'https://2020.igem.org/Team:UZurich','region':'Europe','location':'Switzerland','track':'New Application','time':'11,15,0800,30','title':'Plant Immunity based Biosensing','description':'Bacterial contamination in water is a global issue that affects developing nations and first world countries. Even Switzerland, famed for its drinking water, faces over 400 cases of Legionnaires disease annually. But plants have been combating microbial pathogens for far longer than humans and we believe there is a lot to learn from them. That is why we are developing a biosensor based on plant pattern-recognition receptors (PRRs), which are cell surface receptors of the plant immune system, that dimerize in the presence of microbes. We designed a system based on EFR, FLS2, CORE and their coreceptor BAK1, which recognize a broad spectrum of bacteria. We fused a split-luciferase to our receptors in order to quantify the total bacterial load of a water sample based on the luminescence-output. We achieved the expression of PRRs in yeast, which opens the door to future applications of PRRs as biosensors.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/a3f630b8-8470-4c38-9937-a664519685ff','video_link_presentation':'https://video.igem.org/videos/watch/86177f6b-8fb6-4ebf-bb3f-fb51e5214db6','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=UZurich','poster_link':'https://2020.igem.org/Team:UZurich/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 8, Poster Number 172'}, {'name':'Vilnius-Lithuania','link':'https://2020.igem.org/Team:Vilnius-Lithuania','region':'Europe','location':'Lithuania','track':'Environment','time':'11,15,0930,30','title':'FlavoFlow - a comprehensive exogenous fish infections detecton, treatment and prevention strategy','description':'Growing fish consumption rates encouraged marine culture farms to implement recirculating aquaculture systems that make intensive fish production compatible with environmental sustainability. Even if these systems reduce the use of terrestrial resources, water recirculation in such systems can cause significant losses because of bacterial or viral infections. A common pathogen of fish infections is the Flavobacterium genus bacteria, which can cause fish death in a few days after the initial infection. To detect the infection as soon as possible, we developed a rapid detection test based on helicase-dependent amplification and lateral-flow assay methods. Additionally, we created a novel treatment method which relies on a quorum sensing mechanism and exolysin protein with the aim of decreasing antibiotic consumption levels. Finally, to prevent forthcoming infections, our third goal is to provide a prevention system based on subunit vaccines encapsulated in alginate beads.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/831569f1-ed65-41b3-bc9c-f68ab4d2c95c','video_link_presentation':'https://video.igem.org/videos/watch/57a08599-3590-465a-898a-33f2018ff136','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Vilnius-Lithuania','poster_link':'https://2020.igem.org/Team:Vilnius-Lithuania/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 8, Poster Number 174'}, {'name':'Virginia','link':'https://2020.igem.org/Team:Virginia','region':'North America','location':'United States','track':'Manufacturing','time':'11,15,0830,30','title':'Manifold: Protein Shells with Encapsulated DNA Scaffolds for Increasing Efficiency of Biosynthetic Pathways','description':'The lack of a versatile and reliable way to improve metabolic flux channeling, pathway orthogonality, and product yields is a major impediment to the expanded utilization of biosynthesis for the production of drugs and industrially valuable chemicals. Manifold, a platform technology that addresses this problem, consists of bacterial microcompartments (BMCs) with encapsulated dsDNA scaffolds that sequester and spatially organize, at fixed concentrations, biosynthetic enzymes presented as zinc-finger fusion proteins. Here we deliver the designs for an E. coli cell capable of synthesizing resveratrol using the Manifold platform. The Manifold platform will help lower costs and expand the applications of chemical biosynthesis.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/60f26449-d32b-4fb3-abe3-709d888615f1','video_link_presentation':'https://video.igem.org/videos/watch/ca8a09c1-df99-45ad-a2cb-5148915b0176','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Virginia','poster_link':'https://2020.igem.org/Team:Virginia/Poster','poster_session':'Session D','poster_location':'Building 2, Floor 8, Poster Number 176'}, {'name':'Warwick','link':'https://2020.igem.org/Team:Warwick','region':'Europe','location':'United Kingdom','track':'Diagnostics','time':'11,14,0800,30','title':'An early detection system for bowel cancer based on the presence of colibactin derivative','description':'Colon cancer worldwide affects over 1.80 million people with approximately 862,000 deaths each year. Recent scientific literature highlights a correlation between colon cancer and the presence of colibactin in patients` bowels, produced by Escherichia coli found in the colon of 20% of people. Therefore, to aid early detection we will develop a better diagnostic tool for the detection of colon cancer reliant upon modifying a DNA-binding protein. By engineering the transcriptional repressor MmfR of the TetR family, the binding of a colibactin derivative will prevent the binding of our new protein to DNA. The ligand-binding pocket of MmfR will be modified in-silico to ensure it accommodates a colibactin derivative - N-myristoyl-D-asparagine - instead of its native ligand. Specific amino acids mutated within the MmfR protein will be identified. Finally, the engineered protein will be overproduced and isolated. We expect resulting engineered proteins to be accurate and precise biosensors for colibactin.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/cb668dd1-5872-4476-a16b-3fbefd1ee7c8','video_link_presentation':'https://video.igem.org/videos/watch/3f4ad614-e54b-4f06-8d6e-85006a006173','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Warwick','poster_link':'https://2020.igem.org/Team:Warwick/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 8, Poster Number 86'}, {'name':'Waseda','link':'https://2020.igem.org/Team:Waseda','region':'Asia','location':'Japan','track':'Information Processing','time':'11,15,0930,30','title':'Zombie vs Samurai -Strategic struggle in cell-free systems-','description':'Cell-free systems are a flexible, quick, and powerful tool in synthetic biology that enables us to conduct back and forth the lab experiments and modeling. In order to continue our project under restricted lab access by COVID-19, We conducted projects (modeling and wet experiment, education, entrepreneurship) with cell-free systems. The modeling is based on the struggle between Zombie and Samurai. Zombies attack humans and turn them into zombies. On the contrary, humans help zombies and return them to humans. In modeling, completion of the system was achieved by adapting the quorum sensing systems. We have confirmed working quorum sensing systems in the cell-free system. It`s important to know the smell to distinguish between Zombie and Samurai. We have created multiple monoterpene (Limonene, Sabinene) from glucose in cell-free systems. Finally, we are attempting to make gene circuit of model of these story.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/9864a4c8-8f01-4065-9ce4-a16e245b2408','video_link_presentation':'https://video.igem.org/videos/watch/9026762d-cab0-434b-92c2-82b4d0ed8cec','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Waseda','poster_link':'https://2020.igem.org/Team:Waseda/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 8, Poster Number 168'}, {'name':'Waterloo','link':'https://2020.igem.org/Team:Waterloo','region':'North America','location':'Canada','track':'Manufacturing','time':'11,14,1000,30','title':'REMINE','description':'REMINE is a packed column bioreactor containing metal-binding proteins which remove and recover toxic but valuable heavy metals from electronic manufacturing wastewater. The REMINE system can be customized to target specific metals by increasing the metal affinity of the proteins using molecular dynamics and protein engineering tools. Process engineering methods will be used to design the packed column reactor and optimise it to specific waste streams and regulatory constraints. With REMINE, the electronic industry can continue to grow while reducing its impact on our environment and health.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ef5abb88-bbb0-4a81-96c1-8d5e2a2ca39d','video_link_presentation':'https://video.igem.org/videos/watch/87d8bdc9-1c8c-436f-a413-ce27ff641478','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Waterloo','poster_link':'https://2020.igem.org/Team:Waterloo/Poster','poster_session':'Session B','poster_location':'Building 1, Floor 8, Poster Number 87'}, {'name':'WHU-China','link':'https://2020.igem.org/Team:WHU-China','region':'Asia','location':'China','track':'Therapeutics','time':'11,16,0930,30','title':'The Negotiator','description':'We aimed at rationally engineering probiotics to address the problem of nosocomial infections in respiratory tract, especially ventilator-associated pneumonia (VAP) during COVID-19 pandemic. The chassis of our project was Escherichia coli Nissle 1917, recognized as the most amenable probiotic, and the target pathogen was Pseudomonas aeruginosa, a representative nosocomial pathogen notorious for its quorum sensing-based virulence behaviours. We constructed two modules to endow our chassis with the capability as `the negotiator`: (i) Quenching Module: heterologously overexpressing quorum quenching enzymes to parley with `criminals` (P. aeruginosa) by degrading AHLs; and (ii) Sensing Module: sensing PQS and excreting appropriate amounts of chemokines to recruit `police squads` (immune cells) for eradicating pathogens. Notably, we leveraged E. coli lysate-based cell-free system for rapidly prototyping genetic parts of interest, in order to accelerate the design-build-test-learn cycle of our project as well as to give insights into the elegance of cell-free expression renaissance.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/28ed8649-ca2f-4b24-a880-5a4f8c3619a3','video_link_presentation':'https://video.igem.org/videos/watch/9db3f1d9-046b-44f0-adf4-4af41b4472be','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=WHU-China','poster_link':'https://2020.igem.org/Team:WHU-China/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 8, Poster Number 254'}, {'name':'William_and_Mary','link':'https://2020.igem.org/Team:William_and_Mary','region':'North America','location':'United States','track':'Therapeutics','time':'11,16,0830,30','title':'TheraPUFA','description':'The COVID-19 pandemic has emphasized the urgent need for broad-spectrum antiviral therapies. To address this need, we have 1) designed an antiviral nasal probiotic and 2) investigated its feasibility through extensive mathematical modeling. The designed probiotic secretes polyunsaturated fatty acids (PUFAs), which may lyse viral envelopes and suppress replication by positive strand RNA viruses, in addition to regulating inflammation. Our `smart` probiotic is designed to sense excessive inflammation by detecting high levels of TNF-alpha and IFN-gamma, and to respond by switching PUFA production from arachidonic acid to anti-inflammatory docosahexaenoic acid. To determine our probiotic`s feasibility, our mathematical model quantifies the amount of PUFA produced by the probiotic, and how secreted PUFA affects viral load and cytokine production. This complex model extends beyond current probiotic models by accounting for spatial heterogeneity and transcriptional stochasticity. With our novel design and rigorous modeling, TheraPUFA provides a framework for implementing smart, living antiviral therapies.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/0919fa03-4632-4451-b2e6-0e715540e37f','video_link_presentation':'https://video.igem.org/videos/watch/84f3105a-f308-4ecb-aa6d-8a7164388007','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=William_and_Mary','poster_link':'https://2020.igem.org/Team:William_and_Mary/Poster','poster_session':'Session F','poster_location':'Building 3, Floor 7, Poster Number 252'}, {'name':'Worldshaper-Nanjing','link':'https://2020.igem.org/Team:Worldshaper-Nanjing','region':'Asia','location':'China','track':'High School','time':'11,16,1000,30','title':'Turning Waste into Treasure: Reuse of Substandard Grains as Fermentation Substrate to Produce Biodiesel','description':'Substandard grains, such as long-term stored grains, cannot be eaten due to the existed toxin and contaminants. Therefore, these grains attracted much attention as the fermentation substrate. Meanwhile, the biodiesel attracted increasing attention as a promising biofuel to replace fossil diesel for the last two decades. In this work, Yarrowia lipolytica has been selected as the model host for biodiesel production. Taking into account the disability to degrade the raw starch of Y. lipolytica, we separately express heterologous alpha‑amylase and glucoamylase enzymes in it. The results showed that the strains expressing glucoamylase were able to grow on starch as the sole carbon source. By optimizing the C/N=100, the total lipid content increases up to 21 % of DCW, which sets up the basis for further studies. In the future, we aim to provide a practical, economical, and environment-friendly method to treat substandard grains and produce biodiesel.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/91d2fa50-303c-41ad-b5cf-a53f44a3c0f8','video_link_presentation':'https://video.igem.org/videos/watch/73dd1a5a-c598-49fc-8d0f-af8764921896','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Worldshaper-Nanjing','poster_link':'https://2020.igem.org/Team:Worldshaper-Nanjing/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 8, Poster Number 256'}, {'name':'Worldshaper-Shanghai','link':'https://2020.igem.org/Team:Worldshaper-Shanghai','region':'Asia','location':'China','track':'High School','time':'11,16,0800,30','title':'New non-invasive technique for early stage prostate cancer diagnosis','description':'The most common clinical diagnosis nowadays for prostate cancer is digital rectal examination，serum PSA test and prostate biopsy, which, to some extend, is invasive or can cause physical discomfort. The goal of Worldshaper-Shanghai 2020 is to develop a new non-invasive technique for early stage prostate cancer diagnosis, mainly by expressing the color variation of the tested urine since urine test could be the simplest, painless and rapid test method for prostate cancer diagnosis.Our equipment design combined the technology of reverse transcription, gene amplification (PCR/RPA) and RNA hairpin structure (Toehold switch), to detect the specificity of RNA biomarkers of prostate cancer in the urine (PCA3 and KLK3), the final red fluorescence protein output will be report as visible results, so as to achieve the purpose of our visual diagnosis of prostate cancer.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ce8f6b91-cd82-45db-9200-cb614890fadf','video_link_presentation':'https://video.igem.org/videos/watch/1518aba9-6c93-47ad-a20c-78245afe4753','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Worldshaper-Shanghai','poster_link':'https://2020.igem.org/Team:Worldshaper-Shanghai/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 8, Poster Number 257'}, {'name':'Worldshaper-Wuhan','link':'https://2020.igem.org/Team:Worldshaper-Wuhan','region':'Asia','location':'China','track':'High School','time':'11,14,1030,30','title':'miR-155 Sensor based on LncRNA Sequence Predict Chemoresistance in Breast Cancer patients','description':'Breast cancer is the most common cancer among women and is the second cancer frequently occurring worldwide of newly-diagnosed cancers. Resistance to chemotherapy and radiotherapy remains the major factor for treatment failure and death in breast cancer patients. Thus, there is an urgent search for new, non-invasive, biomarkers to evaluate the effect of chemotherapy and radiotherapy in breast cancer patients. A growing number of studies highlights the role of miR-155 in breast cancer drug and radio resistance development. Moreover, studies indicated that lncRNAs could act as sponges to compete miRNAs, participating in various biological processes. This mechanism gives rise to our idea that a sponge RNA based on the sequences of lncRNA with binding sites complementary to the sequence of miR-155 could monitor the expression of miR-155, which offers a non-invasive approach for evaluate the effect of chemotherapy and radiotherapy in breast cancer patients.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/8fcd67c3-0104-4dec-9f78-d805e4174fce','video_link_presentation':'https://video.igem.org/videos/watch/057e4f95-b101-486b-b8a7-32805393d385','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Worldshaper-Wuhan','poster_link':'https://2020.igem.org/Team:Worldshaper-Wuhan/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 8, Poster Number 79'}, {'name':'XH-China','link':'https://2020.igem.org/Team:XH-China','region':'Asia','location':'China','track':'High School','time':'11,15,0930,30','title':'Keratinase Skin Product','description':'Applying synthetic biology, our team addressed several skin concerns by devising a gentle skincare product. Compared to the traditional way: either chemical peeling or physical rub, we applied enzyme keratinase to safely exfoliate the skin. Our products, based on thorough research and empirical applications, guarantee the gentleness, exfoliating excess cuticles without destroying the skin barrier. A series of skin issues, like dryness, itching, and redness, will be, therefore, greatly relieved.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/c14b412a-de38-4f83-8b5e-9093323a8114','video_link_presentation':'https://video.igem.org/videos/watch/78025366-bfd4-49b1-b024-1caee4621279','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=XH-China','poster_link':'https://2020.igem.org/Team:XH-China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 8, Poster Number 171'}, {'name':'XHD-ShanDong-China','link':'https://2020.igem.org/Team:XHD-ShanDong-China','region':'Asia','location':'China','track':'High School','time':'11,15,0730,30','title':'DisHeat: increase heat adaptability of E. coli by changing the distance between genes','description':'Escherichia coli is one of the most widely-used bacteria in biological industry. However, its optimum growth temperature (37℃) needs to be carefully maintained to show the best activity. It will be more effective if E. coli can tolerate with a higher temperature. In this project, we tried to increase the heat adaptability of E. coli by changing the distance between a heat adaptation gene (degP) and its two regulator genes (cpxR and rpoE) belonging to a feed forward loop (FFL) network motif. Our new approach provides an alternative to the traditional methods such as enhancing promoter and plasmid transfection. This new engineered E. coli can not only improve reaction efficiency but also meet more requirements of special usage scenario (such as tropical regions). Meanwhile, we also investigated the relationship between distance and expression of genes in the network motif, which has foundational significance to synthetic biology.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/1a409107-a7ac-4dc2-a4d5-f95a95b9077f','video_link_presentation':'https://video.igem.org/videos/watch/55f0043d-b917-4f6b-8870-f81ca94f2f6d','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=XHD-ShanDong-China','poster_link':'https://2020.igem.org/Team:XHD-ShanDong-China/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 8, Poster Number 173'}, {'name':'XHD-Wuhan-China','link':'https://2020.igem.org/Team:XHD-Wuhan-China','region':'Asia','location':'China','track':'High School','time':'11,16,0800,30','title':'Mars-PhD: decrease Mars soil pH with Deinococcus radiodurans','description':'Phosphorus is an essential element for plants. Martian soil, while rich in phosphorus, is still unable to sustain a growing plant because the insoluble phosphorus cannot be absorbed directly by plants. Some microorganisms can secrete organic acids, decrease pH and promote dissolution of insoluble phosphates. Considering the higher radiation level on Mars, in this project we choose Deinococcus radiodurans (DR) as our chassis organism. We transformed DR by cloning gcd gene from Escherichia coli to promote dissolution of insoluble phosphates. Glucose dehydrogenase (GDH) and Pyrroloquinoline quinone (PQQ) genes are constitutively expressed in DR to form holoenzyme to realize the conversion of glucose into gluconic acid. To improve efficiency, we also transformed a synthesized gabY gene into DR to promote the binding between GDH and PQQ to increase the activity of GDH. We hope to provide new solutions to transform martian soil and explore the possibility of growing crops on Mars.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/0c1f15e8-d3ae-4712-a60e-ce16195e707c','video_link_presentation':'https://video.igem.org/videos/watch/932b1332-3061-4f0c-8981-cc101d910a37','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=XHD-Wuhan-China','poster_link':'https://2020.igem.org/Team:XHD-Wuhan-China/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 8, Poster Number 259'}, {'name':'Xiamen_city','link':'https://2020.igem.org/Team:Xiamen_city','region':'Asia','location':'China','track':'High School','time':'11,14,0830,30','title':'Construct Probiotic E. coli that Cleans Reactive Oxygen Species in the Gut','description':'Sleep deprivation causes death by accumulating Reactive Oxygen Species (ROS) in the gut. One way of preventing the accumulation is gut-targeted transgenic expression of antioxidant enzymes. Therefore, we use probiotics living in the gut to express Superoxide Dismutase (SOD) and Catalase (CAT) to eliminate the excess ROS. We first overexpressed SOD and CAT in E. coli separately and purified the overexpressed proteins. Both proteins were overexpressed successfully in E. coli and functioned properly. Furthermore, using plasmid p15A, we constructed the E. coli with in vitro display technology. This E. coli is effective for cleaning ROS, so our experiment lays the foundation for cleaning ROS in the human gut.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/a3dd1754-7493-410e-b299-60d9587d3226','video_link_presentation':'https://video.igem.org/videos/watch/258f26d5-6ebd-430e-aea7-d79f1efc7e94','section':'High School','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=Xiamen_city','poster_link':'https://2020.igem.org/Team:Xiamen_city/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 8, Poster Number 81'}, {'name':'XJTU-China','link':'https://2020.igem.org/Team:XJTU-China','region':'Asia','location':'China','track':'Environment','time':'11,14,0730,30','title':'Sand Fixers Alliance','description':'Upon the excessive deforestation, grazing and reclamation of human beings, desertification has been intensified. A natural sand-fixing system, biological soil crusts, was discovered to fight for desertification. But this natural sand fixation strategy always has little effect when facing the aggressive sand. Thus in our project, an engineered Bacillus subtilis was constructed to effectively produce extracellular polysaccharide, the key component of soil crust via introducing different combinations of key enzymes GalU and PGM. An arabinose-regulated suicide switch was also build to initiate suicide once the engineered bacteria release from the desert environment for biosafety. Furthermore, a symbiotic system of engineered Bacillus subtilis and cyanobacteria was developed to form sand fixers alliance, fighting for desertification. Our project is committed to educating the public about the current situation, hazards and solutions of desertification, and to providing a more convenient and effective strategy for desertification control.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/c9107ca8-80ff-4b64-8bac-5c053c811102','video_link_presentation':'https://video.igem.org/videos/watch/b025f938-6bc0-47f9-b1be-c16a4df24524','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=XJTU-China','poster_link':'https://2020.igem.org/Team:XJTU-China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 8, Poster Number 83'}, {'name':'XMU-China','link':'https://2020.igem.org/Team:XMU-China','region':'Asia','location':'China','track':'Food and Nutrition','time':'11,16,0730,30','title':'Antea-Glyphosate','description':'Tea is deeply rooted in Chinese culture. For a long period, a large amount of glyphosate has been used as a herbicide, which raises a severe problem of pesticide residues in tea food. XMU-China aims at developing an efficient glyphosate detection and degradation system. For the detection system, glyphosate is degraded by several enzymes and then transferred into a measurable fluorescence signal caused by the NADPH; and the degradation system plans to disintegrate glyphosate to be AMPA to minimize the toxicity. Two suicide switches controlled by different inducers are also projected. It is hoped that this project could provide new ideas for the detection and degradation of pesticide residues. Taking care of the earth by tiny bacteria, we here promise a better future of tea.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/02f6b705-eeb3-41db-ae7b-67e20cdc6497','video_link_presentation':'https://video.igem.org/videos/watch/3c832f2b-f812-4d30-82e9-e9ef107f8e33','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=XMU-China','poster_link':'https://2020.igem.org/Team:XMU-China/Poster','poster_session':'Session E','poster_location':'Building 3, Floor 8, Poster Number 261'}, {'name':'ZJU-China','link':'https://2020.igem.org/Team:ZJU-China','region':'Asia','location':'China','track':'Diagnostics','time':'11,14,0930,30','title':'MagHER2some','description':'Breast cancer is the main malignant tumor that threatens women`s health. In an effort to overcome the unspecificity and side effect of the current contrast agent used for MRI, we reconstructure the magnetosomes from magnetotactic bacteria Magnetospirillum gryphiswaldense to produce a contrast agent with high biocompatibility that specifically targets HER2 positive breast cancer cells. With biological modifications, magnetosomes can link with anti-HER2 antibodies. By antigen-antibody interaction, engineering magnetosomes can conjugated with HER2 positive breast cancer cells, demonstrating a special pattern on the image under magnetic field. Armed with our engineered contrast agent MagHER2some, the efficiency of evaluating the response of the treatment of HER2-postive breast cancer treatment can be optimized, thus assisting the progress of therapy process. Further application can be made through establishment of a platform with biomarkers targeting various diseases as inputs, paving avenue for precise evaluation of other diseases.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/78434aa2-5d28-4da0-ade7-897b735342c1','video_link_presentation':'https://video.igem.org/videos/watch/b5c9efd9-dc61-45f8-9bdd-881d50865b00','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=ZJU-China','poster_link':'https://2020.igem.org/Team:ZJU-China/Poster','poster_session':'Session A','poster_location':'Building 1, Floor 8, Poster Number 85'}, {'name':'ZJUT_China_B','link':'https://2020.igem.org/Team:ZJUT_China_B','region':'Asia','location':'China','track':'Diagnostics','time':'11,15,1000,30','title':'Multivirus Monitor','description':'The global pandemic of COVID-19 highlights the great importance of detecting viruses. We aim to construct a `Multivirus Monitor` as an application of CRISPR Cas13 in point-of-care diagnostics, which could detect multiple viruses in one pot. We tested the feasibility of the platform by testing the specificity between Cas13 orthologs and their sequence-specific reporters. We designed a multivirus detecting device which combines sample processing,amplification and detecting chambers. Based on fluorescence detecting,the detecting results can be processed and transmitted to mobile terminals to make the results visible. We are designing an interactive platform called `virusee` which could provide optimal solutions and suggestions to users. Furthermore,we are constructing a database called `vivalibrary`,which could provide users with viral information and its corresponding crRNA. Conceived as a multivirus detecting and feedback platform for rapid point-of-care diagnostics, Multivirus Monitor can be a promising weapon in the unpredictable fight against viruses.','event_type':'Team Presentation','video_link_promotion':'https://video.igem.org/videos/watch/ec30912a-0370-484a-937f-fb62ae5c8baa','video_link_presentation':'https://video.igem.org/videos/watch/ce56befc-e4b0-45d6-a174-33b7c4368a1f','section':'Undergrad','parts_link':'http://parts.igem.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2020&group=ZJUT_China_B','poster_link':'https://2020.igem.org/Team:ZJUT_China_B/Poster','poster_session':'Session C','poster_location':'Building 2, Floor 8, Poster Number 175'}];